ライフサイエンスコーパス: allostatic

1 However, such allostatic adaptation results in a physiological cost (a

2 characterize specific chronic stress-induced allostatic adaptations in the HPA network.

3 triction (SR) sleep may be regulated by both allostatic and homeostatic mechanisms.

4 ng premature pruning of dendritic spines and allostatic atrophy of dendritic arborization in early ad

5 he hypothesis that chronic stress induces an allostatic attenuation of the mesolimbic dopaminergic sy

6 ay be explained by a maladaptive feedforward allostatic cascade model and how understanding migraine

7 at moderate intoxicating levels, induces an allostatic change in the brain functional connectivity t

8 l forebrain and cingulate cortex may mediate allostatic changes in sleep time and intensity observed

9 Our finding points to putative allostatic changes that affect the functioning of the br

10 rlying these adaptive, or more specifically, allostatic, changes in sleep homeostasis are unknown.

11 ng behaviors by reversing an alcohol-induced allostatic DA deficiency in the mesolimbic system.

12 also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching an

13 nged by findings suggesting a domain-general allostatic function for oxytocin by promoting future-ori

14 The concept of tissue-level allostatic goal-directedness is already bearing fruit in

15 Allostatic habituation of the HPA axis, such that glucoc

16 he neural reward deficiency syndrome nor the allostatic hypotheses are supported by the results.

17 ording to the reward deficiency syndrome and allostatic hypotheses, hyposensitivity of mesocorticolim

18 theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomeno

19 a new research agenda for understanding how allostatic interoception involves brain predictive codin

20 ss the biological mechanisms associated with allostatic interoception, including whole-body cascades,

21 ew, we explore the disruptions in integrated allostatic interoceptive mechanisms in psychiatric and n

22 ascades, brain structure and function of the allostatic interoceptive network, heart-brain interactio

23 We synthesize new pathways to understand how allostatic interoceptive processes modulate interactions

24 Recent allostatic-interoceptive explanations using predictive c

25 The predictive coding theory of allostatic-interoceptive load states that brain networks

26 ses underlying these impairments, termed the allostatic-interoceptive network (AIN).

27 mentia (bvFTD), including alterations of the allostatic-interoceptive network (AIN).

28 uggest that bvFTD may be characterized by an allostatic-interoceptive overload manifested in ongoing

29 we hypothesize that bvFTD is typified by an allostatic-interoceptive overload.

30 contribute to the complex associations among allostatic load (a marker of chronic stress), educationa

31 cer death between educational attainment and allostatic load (adjusted for age, income, and smoking s

32 neighborhood risk of psychosocial stress on allostatic load (AL) among adolescents as a mechanism th

33 w studies on human populations have examined allostatic load (AL) as it relates to cancer risk, progr

34 Elevated allostatic load (AL) has been associated with adverse so

35 Allostatic load (AL) has been proposed as a new conceptu

36 Allostatic load (AL) is a measure of overall physiologic

37 Allostatic load (AL) is an intermediary outcome through

38 Allostatic load (AL) is the lifetime adverse physiologic

39 Allostatic load (AL) measures multisystem physiological

40 Allostatic load (AL), a biomarker of chronic stress, has

41 ssociation between residential greenness and allostatic load (AL), a marker of composite physiologica

42 ing biomarkers of stress, including IL-6 and Allostatic Load (AL), can also serve as early indicators

43 consequences of chronic stress, measured by allostatic load (AL), may contribute to these disparitie

44 study is to examine the relationship between allostatic load (AL), neighborhood opportunity, and all-

45 rrelates of adverse SDHs, operationalized as allostatic load (AL), with mortality due to lung cancer.

46 nsiderable heterogeneity of methods to score Allostatic Load (AL).

47 ved that TL had a negative relationship with allostatic load (beta = - .320 p = .017) and a cardiomet

48 With increasing severity and over time, the allostatic load (increase in glycemia) may have patholog

49 , high ADI group had higher median levels of allostatic load (P = 0.046) and lower median levels of g

50 group were 20% more likely to have increased allostatic load and 51% less likely to have increased le

51 CI, 3.36-6.60) compared with those with low allostatic load and a college degree or higher.

52 In summary, we observed that levels of allostatic load and global DNA methylation are influence

53 king speed, lower fluid intelligence, higher allostatic load and increased mortality risk.

54 men (HR, 5.77; 95% CI, 4.06-8.20) with high allostatic load and less than high school educational at

55 imulated leukocytes would show signs of high allostatic load and low levels of protective psychosocia

56 the brain and body that can lead to disease (allostatic load and overload).

57 ssors could provide molecular correlates for allostatic load and predict healthy or maladaptive stres

58 GR gene expression can lead to an increased allostatic load and result in an "aging-like" phenotype

59 ing a high school degree, combined with high allostatic load as a marker of chronic stress, with canc

60 We identify allostatic load as a potential clinically actionable too

61 physiological measures reflecting pediatric allostatic load assessed at 6 y of age.

62 Consequently, allostasis and allostatic load can jointly affect vulnerability to brai

63 Our findings indicate that mitochondrial allostatic load contributes to BD, suggesting mitochondr

64 Allostatic load data were stratified by educational atta

65 In this Personal View, we propose an allostatic load framework to account for biomarkers of p

66 Participants were considered to have high allostatic load if their score was 3 or more.

67 Allostatic load may alter brain networks both functional

68 was used to assess IL-6 and create composite allostatic load measure including: IL-6, blood pressure,

69 These results support an allostatic load model of psychosomatic health, in which

70 understanding migraine within the context of allostatic load model suggests alternative treatments fo

71 od experience was positively associated with allostatic load of children at 6 y of age at higher leve

72 Inflammatory-related DNAm captures the allostatic load of inflammatory burden in preterm infant

73 we then posit the potential implications of allostatic load on patient care and research in cardio-o

74 ts of CRS or an example of adaptation to the allostatic load produced by CRS.

75 reflects an allostatic process, and that the allostatic load produced by SD has direct effects on the

76 Cortisol is a core hormonal mediator of allostatic load produced in response to various stresses

77 Chronic allostatic load provides a unifying perspective with imp

78 ect long-term risk associated with increased allostatic load resulting from the stimulation of insuli

79 Allostatic load score (ALS) was defined using laboratory

80 Allostatic load score was calculated as the sum of total

81 most deprived quintile had 1.13 times higher allostatic load than those living in the least deprived

82 gins by noting two new terms, allostasis and allostatic load that are intended to supplement and clar

83 y as a feed-forward drive to an unrecognized allostatic load that drives the addiction process.

84 instead generally associated with heightened allostatic load that was unknown in this cohort.

85 to biological dysregulation consistent with allostatic load theory.

86 ipheral physiology and can contribute to the allostatic load throughout the body.

87 We defined allostatic load using ten biomarkers of dysregulated met

88 the association between cumulative risk and allostatic load was attenuated for adolescents who score

89 Allostatic load was derived from 14 clinical biomarkers

90 Allostatic load was measured at baseline and at ages 13

91 ence of multiple risk factors) on children's allostatic load were assessed in 260 children (46% femal

92 Suppression and allostatic load were not significant.

93 raffic Lden, and PM2.5), renal function and "allostatic load" (all exposures).

94 d; cross-systemic phenotypes, combined into "allostatic load") and agnostic (DMR-based) pathway enric

95 es can become dysregulated and maladaptive ("allostatic load").

96 tics and experiences of societal inequality (allostatic load) increase the complexity of studying bre

97 adaptation results in a physiological cost (allostatic load) that might impair the homeostatic stres

98 n, disability and markers of chronic stress (allostatic load).

99 llostasis) and maladaptive in the long term (allostatic load).

100 ociation between chronic stress exposure and allostatic load, a biological marker of chronic physiolo

101 Chronic stress is measured by allostatic load, a biological marker of cumulative wear

102 iation between neighbourhood deprivation and allostatic load, a biological marker of wear and tear, t

103 We explore the concept of allostatic load, a measurement of the physiological burd

104 dults from low-income families manifest more allostatic load, an index of chronic physiological stres

105 could potentially be associated with higher allostatic load, but few studies to date have quantified

106 systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers repr

107 ople with type 2 diabetes experience chronic allostatic load, manifest as dynamic disturbances in rea

108 We consider chronic stress/allostatic load, mental distress, coping skills and reso

109 eoretical constructs, such as weathering and allostatic load, regarding the power of chronic environm

110 specific physiological norms, allostasis and allostatic load, stochasticity, and decline in stress re

111 actors and cancer outcomes, including higher allostatic load, stress hormones, altered epigenome and

112 selected markers of biological aging (e.g., allostatic load, telomere length, and global DNA methyla

113 Allostatic load, the cumulative strain that results from

114 Known as mitochondrial allostatic load, this (phenomenon) occurs when mitochond

115 This increases allostatic load, which is the cost of physiological fluc

116 counterparts with college education and low allostatic load.

117 mes in, cardiovascular disease (CVD) through allostatic load.

118 in general or mental health or estimates of allostatic load.

119 n, Klemera-Doubal method biological age, and allostatic load.

120 increases incentive salience of HP foods and allostatic load.

121 hat can, in a vicious cycle, lead to further allostatic load.

122 ared with men with college education and low allostatic load.

123 esilience and acting as a source of systemic allostatic load.

124 ntext of health; (b) the stress response and allostatic load; (c) some of the key biological mechanis

125 We found that repeated seizures cause an allostatic maladaptation of AEA signaling in the amygdal

126 depressive-like behavior, indicating that an allostatic mechanism exists in this difference.

127 ossible key factor resulting from a putative allostatic mechanism.

128 the existence of organ-specific compensatory allostatic mechanisms are robust enough to drive an unex

129 hat this phenomenon is regulated by cellular allostatic mechanisms that elevate the muscle glycogen s

130 heightened EDA, consistent with the proposed allostatic model of health and disease.

131 The allostatic model of maintaining "stability through chang

132 g homologous activation of the interoceptive-allostatic network across primate species during affecti

133 tization, aberrant learning, and anti-reward allostatic neuroadaptations.

134 to severe or repeated stressors-can lead to allostatic (over)load, causing wear and tear on tissues,

135 totemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits.

136 ntervention for the prevention of subsequent allostatic overload that auto-perpetuates obesity.

137 Two types of "allostatic overload" are described: type 1 is an essenti

138 xt of repeated sleep restriction reflects an allostatic process, and that the allostatic load produce

139 There is also evidence of a slower, allostatic process, which modulates the sleep homeostati

140 n as a motivational incentive because due to allostatic reference resetting, more stimuli are require

141 ts in withdrawal mediated through persistent allostatic reference resetting.

142 ticipatory processing which is essential for allostatic regulation.

143 Finally, allostatic regulatory adaptations are predicted to cause

144 unrelated to physiological needs induces an allostatic regulatory state that defends a supranormal a

145 These cells not only mediate the allostatic response to hypoglycemia but also modulate th

146 ogical stressors are frequent and/or severe, allostatic responses can become dysregulated and maladap

147 ctors, injury (or stressors), and the body's allostatic responses.

148 or is lost in either neuronal population, an allostatic shift will occur leading to a long-term dysre

149 mical dysregulations that ultimately form an allostatic state (decreased dopamine and opioid peptide

150 er metabolism could contribute to an altered allostatic state and therefore be involved in continued

151 This allostatic state is hypothesized to be reflected in a ch

152 local physical stimulation, cells trigger an allostatic state that maximizes energy and overcomes a m

153 and are hypothesized to repeatedly drive the allostatic state.

154 c health inequities via negative emotion and allostatic stress process up-regulation.

155 PO(Vglut2) neurons facilitating sleep during allostatic (stressful) challenges.

156 We review evidence for a distributed allostatic system that organizes whole-brain signaling,

157 necessary step in the development of complex allostatic systems and suggest that intrinsic and social