ライフサイエンスコーパス: allosteric activation

1 hrough dephosphorylation and, more potently, allosteric activation.

2 ctivation depends on SOS1 expression but not allosteric activation.

3 le mechanistic link between the two types of allosteric activation.

4 nderstood, namely, sequential metabolism and allosteric activation.

5 hosphorylation, although it does not lead to allosteric activation.

6 gainst dephosphorylation, as well as causing allosteric activation.

7 ntally characterize the evolutionary path of allosteric activation.

8 many PDZ proteases use a common mechanism of allosteric activation.

9 active-site pairs, providing a mechanism for allosteric activation.

10 h transmission of intrasteric inhibition and allosteric activation.

11 HR) were involved in methylated DNA-mediated allosteric activation.

12 Conversely, deletion of T7 or T8 abolished allosteric activation.

13 one, corroborating the proposed mechanism of allosteric activation.

14 d an increase in V(max), suggesting positive allosteric activation.

15 l occupancy of the enzyme catalytic site via allosteric activation.

16 ng to the anionic interface and a consequent allosteric activation.

17 ondrial mRNA correlates with the property of allosteric activation.

18 affinity and suggest a role for the loop in allosteric activation.

19 ms that underpin PAM recognition and Cascade allosteric activation.

20 a conserved salt bridge network critical for allosteric activation.

21 nity within each class, uniting binding with allosteric activation.

22 G binds TDG on Arg275 providing an enzymatic allosteric activation.

23 his noncatalytic site facilitates homotropic allosteric activation.

24 ing movement of the beta1 strand even during allosteric activation.

25 previously been implicated in mediating the allosteric activation.

26 teric activating PAMs, which also bind to an allosteric activation (AA) site in the extracellular dom

27 Our studies enable tracing of the path of allosteric activation across p97 and establish a common

28 hat these mutations affect nucleotide-driven allosteric activation across the three principal p97 dom

29 into the regulation of SAMHD1 with regard to allosteric activation and active site specificity.

30 fasting) and when 2) AAs provide leucine for allosteric activation and glutamate from transaminations

31 as the synthetic activator A-769662 to cause allosteric activation and inhibition of dephosphorylatio

32 y locating dynamic structural changes during allosteric activation and inhibition of glycogen phospho

33 Allosteric activation and inhibition of PFK1 by over ten

34 ct residues support different mechanisms for allosteric activation and inhibition.

35 t potentially plays an important role in the allosteric activation and modulation of the Cys loop fam

36 the S-loop is critical for cofactor binding, allosteric activation and oligomerization.

37 ion occurs by a dual mechanism that involves allosteric activation and phosphorylation by upstream ki

38 ently developed computational model for CB1R allosteric activation and positive allosteric modulation

39 were inconsistent with a two-state model of allosteric activation and suggested multiple activated s

40 e apoptosome, ruling out the requirement for allosteric activation and supporting an induced proximit

41 in the N-terminal 17-residue linker mediates allosteric activation, and its mutation to alanine leads

42 With no exceptions, signature residues of allosteric activation appear in bacterial sequences alon

43 nges in the repressor monomer that accompany allosteric activation are not known.

44 at 2.9 A and provide a structural model for allosteric activation based on comparisons with other in

45 co docking of 2,3,5,6TMP-TQS in the putative allosteric activation binding site suggested a specific

46 tent with the Monod-Wyman-Changeux model for allosteric activation but also suggest that rigidificati

47 to the feedback inhibitor UTP, and decreased allosteric activation by 5-phosphoribosyl-1-pyrophosphat

48 insulin was enhanced 4-fold, in part due to allosteric activation by a glucosamine metabolite.

49 that betaY137 is involved in NAD binding and allosteric activation by ADP.

50 respective kinetic defects in catalysis and allosteric activation by AMP.

51 ate binding by IDH1 being a prerequisite for allosteric activation by AMP.

52 cooperativity with respect to isocitrate and allosteric activation by AMP.

53 Allosteric activation by B-973B appeared more protracted

54 mers provides a mechanistic understanding of allosteric activation by cAMP.

55 guanylyltransferase, which does not require allosteric activation by Cet1.

56 ling that it is a dGTPase that is subject to allosteric activation by dATP, specifically.

57 ion, but has no effect on the equilibrium of allosteric activation by deoxynucleotides.

58 etween active site inhibition and defects in allosteric activation by disease-causing mutations and h

59 psilon null mice were also supersensitive to allosteric activation by ethanol and flunitrazepam.

60 tory protein phosphorylation, or 3) mimicked allosteric activation by Fru-1,6-BP.

61 idue in bacterial PFK, prevented binding and allosteric activation by fructose 2,6-bisphosphate.

62 bits positively cooperative (ultrasensitive) allosteric activation by fructose-1,6-bisphosphate (FBP)

63 aling is generally thought to be mediated by allosteric activation by G proteins and Ca(2+).

64 inase demonstrated that it is the subject of allosteric activation by GlcNAc-6-P.

65 on of GSase, which alters the sensitivity to allosteric activation by glucose 6-phosphate (G6P), is a

66 ys revealed that PykA displays potent K-type allosteric activation by glucose 6-phosphate and by inte

67 Following allosteric activation by high phenylalanine levels, the

68 d by a number of different inputs, including allosteric activation by its product, H3K27me3.

69 reonine kinases that share a requirement for allosteric activation by lipids.

70 sed mechanisms for substrate recognition and allosteric activation by low pH and chloride.

71 ncovered several residues crucial for PmiR's allosteric activation by MIC.

72 Mimicking the allosteric activation by mutation yields a vinculin mole

73 glutamine as a nitrogen donor, and required allosteric activation by N-acetylglutamate (AGA), a sens

74 We show that allosteric activation by NDFIP1 or engineered ubiquitin

75 This allosteric activation by PA could involve a conformation

76 stal structure of TcTDH and characterize its allosteric activation by potassium.

77 In contrast to allosteric activation by RHEB, Rag heterodimer binding d

78 ivity of Fe(III)-CBS, and still responded to allosteric activation by S-adenosyl-L-methionine.

79 after this protein, suggests a mechanism for allosteric activation by S-adenosylmethionine.

80 izes binding, whereas the BAH domain enables allosteric activation by the H3K9me mark.

81 is subject to complex regulation, including allosteric activation by the methyl donor, S-adenosylmet

82 cooperativity of AdoMet binding mediated by allosteric activation by the methylated CG steps.

83 variant, which has been shown to be inert to allosteric activation by the natural activator TF, sugge

84 on and multimerization properties respond to allosteric activation by the substrate phenylalanine (Ph

85 d by the partial agonist tryptamine, and the allosteric activation by the terpenoids, carvacrol, and

86 centrosomes in the early stages of mitosis, allosteric activation by TPX2 of dephosphorylated Aurora

87 We then address the allosteric activation by TPX2 through activity assays an

88 residues from TrpB that are crucial for its allosteric activation by TrpA.

89 Allosteric activation by VWF D4 requires T7, T8, and the

90 tion of the loop and suggest a mechanism for allosteric activation: calcium binding results in partia

91 This demonstrates that allosteric activation can be recapitulated throughout a

92 f1 and Nef thus play interconnected roles in allosteric activation, cargo recruitment, and coat assem

93 ites responsible for feedback inhibition and allosteric activation control filament length, implying

94 model through which membrane recruitment and allosteric activation could be structurally integrated.

95 ce very effective channel activation (direct allosteric activation (DAA)) by operating at two distinc

96 nd thus displayed the expected phenotype for allosteric activation-deficient PrfA mutations.

97 0 amino acids, indicating the presence of an allosteric activation determinant between amino acids 12

98 ing seen as switches with fixed responses to allosteric activation, ensembles can evolve to be "funct

99 ansitions can decouple regions important for allosteric activation from receptor binding specificity.

100 Arachidonic acid-induced allosteric activation has not been directly observed wit

101 n the fully activated state, and the bulk of allosteric activation has occurred in the intermediate.

102 its active isomer GAT107, can produce direct allosteric activation in addition to potentiation of ort

103 studied, structural changes associated with allosteric activation in mammalian PheH have been elusiv

104 affinity and leads us to propose a model for allosteric activation in nuclear receptor dimers, in whi

105 nd T3, highlighting a dominant role of M2PYK allosteric activation in the regulation of cancer prolif

106 nus domain, has been signaled as pivotal for allosteric activation in TRP channels.

107 Our data are consistent with a model for allosteric activation in which sGC undergoes a simple sw

108 dings support a minimal three-state model of allosteric activation in which the P14 mutations perturb

109 can be interpreted in terms of differential allosteric activation, including DNA binding in the abse

110 ither EZH2 or EED mutants that abrogate PRC2 allosteric activation, indicating that H3K27M impairs th

111 L-Phe-mediated allosteric activation induces a repositioning of the reg

112 CARF domain mutations that abolish allosteric activation inhibit Csm6 activity in vivo, and

113 Here we install a conformational switch for allosteric activation into the kinesin-1 microtubule mot

114 (DTW) and NOD("DR2")) demonstrates that this allosteric activation is critical for the function of NO

115 nd to be unable to bind AMP, suggesting that allosteric activation is dependent both upon binding of

116 Classic allosteric activation is in play where either activation

117 They also indicate that PrfA allosteric activation is not required for early intracel

118 The Y355F mutant exhibited allosteric activation kinetics in the presence of arachi

119 tly from PARP1, raising the possibility that allosteric activation may also differ.

120 ively active JAK mutants supports a two-step allosteric activation mechanism and reveals opportunitie

121 previously unrecognized, membrane-dependent allosteric activation mechanism between FVIIa and TF, in

122 Our underlying allosteric activation mechanism derives from a collectio

123 our study provides a compelling and unifying allosteric activation mechanism in STKR1 kinases that re

124 xyl-terminal domain so that the endothermic, allosteric activation mechanism of CRP by cAMP is restor

125 and substrate-bound CASP complex reveals an allosteric activation mechanism that reorganizes Csx29 c

126 arged residues of the GH disaccharide in the allosteric activation mechanism was investigated with va

127 And 2) in the allosteric activation mechanism, G protein allostericall

128 results are discussed in light of a proposed allosteric activation mechanism.

129 em diversified rapidly, while conserving the allosteric activation mechanism.

130 rally attributed to lipid cofactor-dependent allosteric activation mechanisms at membranes.

131 s which will ultimately enable us to predict allosteric activation mechanisms from structures.

132 framework of a modified Monod-Wyman-Changeux allosteric activation model.

133 This allosteric activation occurred if the sequence was attac

134 enzymes are exquisitely tuned to ensure that allosteric activation occurs only when concentrations of

135 Allosteric activation of 5(')-AMP-activated protein kina

136 Accumulation of citrate could lead to allosteric activation of ACC, further augmenting malonyl

137 atelet-rich thrombi, and cleavage depends on allosteric activation of ADAMTS13 by the substrate VWF.

138 -)2,3,5,6TMP-TQS was shown to antagonize the allosteric activation of alpha7 by the structurally unre

139 Our data show that both orthosteric and allosteric activation of alpha7 nAChR require cooperativ

140 Compound 6 represents a chemotype for allosteric activation of alpha7 nAChRs, with therapeutic

141 n of the (-) enantiomer with alpha7T106, and allosteric activation of alpha7T106 mutants was not inhi

142 ysis in white adipocytes directly results in allosteric activation of AMPK through the generation of

143 t is shown to derive from three sources: (i) allosteric activation of antithrombin by a sequence-spec

144 A revised model for the mechanism of the allosteric activation of antithrombin is proposed.

145 ons of the NBS and the inferred mechanism of allosteric activation of ArsA provide a useful model for

146 charide, is mediated exclusively through the allosteric activation of AT towards efficient inhibition

147 eet A, which is known to be critical for the allosteric activation of AT.

148 parin-responsive molecular switch during the allosteric activation of ATIII anticoagulant activity.

149 erved RNA-binding residues revealed that the allosteric activation of ATPase activity is primarily co

150 An allosteric activation of auto(poly-ADP-ribosylation) by

151 Activated tBID results in an allosteric activation of BAK, inducing its intramembrano

152 to act as a redox switch that precludes the allosteric activation of bGP by AMP.

153 Kunitz inhibitors based on current ideas for allosteric activation of BK(Ca) channels by voltage and

154 better antagonist than the (+) isomer of the allosteric activation of both wild-type alpha7 and the n

155 Here, we demonstrate the direct allosteric activation of C-Raf by GPCR-Barr1 complexes i

156 The molecular events in the cAMP-induced allosteric activation of cAMP receptor protein (CRP) inv

157 lfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.

158 erol and fatty acid correlated with enhanced allosteric activation of CCTalpha by the membrane lipids

159 Allosteric activation of CD11b via pretreatment with the

160 face plays a critical modulatory role in the allosteric activation of CfaE.

161 he nuclear localization of ChREBP through an allosteric activation of ChREBP/14-3-3 interactions and

162 The results are interpreted in terms of the allosteric activation of CRP by cAMP by a conformational

163 C-derived astrocytes and neurons showed that allosteric activation of CYP46A1 lowers CE specifically

164 Allosteric activation of DAT via the Zn(2+)-binding site

165 ing conformation of DAT, which allows for an allosteric activation of DAT, in both, the forward trans

166 provide a compelling molecular mechanism for allosteric activation of DegS by OMP-peptide binding.

167 with a conformational change accompanying an allosteric activation of DNA-binding.

168 understanding more broadly the mechanisms of allosteric activation of downstream targets by betaarrs.

169 RING/U-Box E3/E2 pairs, as the linchpin for allosteric activation of E2~Ub.

170 Understanding the allosteric activation of EcPFK by MgADP has been complic

171 Understanding of the structural basis of allosteric activation of EcPFK by MgADP is complicated b

172 The mechanism for this requirement is not allosteric activation of Epac2 by Ras but the compartmen

173 se data implicate a dual role for FAS in the allosteric activation of ExoS, involving both substrate

174 fied in myeloid disorders, where it prevents allosteric activation of EZH2 catalysis.

175 heparin pentasaccharide (300-500-fold), (ii) allosteric activation of factor IXa by calcium ions (4-8

176 r VIIa with high affinity and supported full allosteric activation of factor VIIa toward tripeptidyl-

177 teraction and show that a fast and sustained allosteric activation of FimH can also occur under stati

178 Allosteric activation of fructose-1,6-bisphosphatase (FB

179 In the case of allosteric activation of G protein-coupled receptors (GP

180 metabolism by oxidative decarboxylation and allosteric activation of glutamate dehydrogenase (GDH).

181 egulatory arm of the HBP that involves rapid allosteric activation of glycogen synthase (GS) and stim

182 inis muscle reach levels sufficient to cause allosteric activation of glycogen synthase and inhibitio

183 that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decr

184 ion promotes muscle glycogen accumulation by allosteric activation of GS through an increase in gluco

185 GlcN-6-P levels within minutes, resulting in allosteric activation of GS, stimulation of GBS, and a r

186 migration--to promote cell motility, through allosteric activation of guanylyl cyclases by autophosph

187 effectors will be useful to confirm whether allosteric activation of hLPYK will control glycolytic f

188 The structural insights into allosteric activation of hPAH reported here may help inf

189 suggests an important physiological role for allosteric activation of IDH during changes in environme

190 at of 3beta-HSD2 isomerase and abolishes the allosteric activation of isomerase by NADH.

191 helps to generalize a novel paradigm for the allosteric activation of kinase function and may open op

192 ues critical for complex formation abrogated allosteric activation of LegK7 both in vitro and within

193 Tyr-1 is also essential for binding and allosteric activation of mammalian guanylyltransferase b

194 -alpha(1L14)-alpha(2L14)), are essential for allosteric activation of MKP3 and formation of a product

195 One of these postulates an allosteric activation of monomeric caspase-9; the other

196 ieved through physical tethering rather than allosteric activation of Munc18-1.

197 Allosteric activation of NCX by [Ca]i was comparable in

198 ATPases and provide the structural basis for allosteric activation of nucleotide hydrolysis by As(III

199 ytic activity of EGFR is switched on through allosteric activation of one kinase domain by another, a

200 o form an asymmetric dimer that supports the allosteric activation of one kinase.

201 bipartite binding in BRD4-NUT/p300 triggers allosteric activation of p300 and acetylation-driven liq

202 rease in surface AMPAR levels because of the allosteric activation of PDE2.

203 er describe the domain movements involved in allosteric activation of PheH in solution and present th

204 bradyphylaxis is mediated by cGMP-dependent allosteric activation of phosphodiesterase 5, which shap

205 lytic cleavage by caspase-3, suggesting that allosteric activation of PKCdelta is sufficient to trigg

206 9, embedded in lipid vesicles to readout the allosteric activation of PLC-gamma2.

207 iated inhibition of holo-PRC2 is relieved by allosteric activation of PRC2 by H3K27me3 and JARID2-K11

208 We find that H3K27me3-mediated allosteric activation of PRC2 substantially increases th

209 e Eed core component of PRC2 and triggers an allosteric activation of PRC2's enzymatic activity.

210 f BH3-only proteins ultimately culminates in allosteric activation of pro-apoptotic BAX and BAK, the

211 region of Hook3 specifically required for an allosteric activation of processive motility.

212 Heterotropic allosteric activation of protein function, in which bind

213 ion of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory dom

214 Here we demonstrate the direct allosteric activation of proto-oncogene kinase Src by GP

215 o glucose through greater hepatic acetyl-CoA allosteric activation of pyruvate carboxylase flux.

216 hese modifications are the consequence of an allosteric activation of pyruvate kinase via cytosolic N

217 ysteine affect Ras membrane localization and allosteric activation of Raf kinase.

218 In this study, we investigate allosteric activation of SAMHD1 by deoxynucleotide-depen

219 Apart from the lack of direct allosteric activation of SNF1 by AMP, the regulation of

220 of Sos bound to two Ras molecules show that allosteric activation of Sos by Ras occurs through a rot

221 The expected allosteric activation of SOS by Ras-guanosine triphospha

222 Replacing key interfacial residues prevents allosteric activation of SPRTN by ubiquitin, leading to

223 We suggest that there might be allosteric activation of substrate binding.

224 lone (AP), regulate neuronal excitability by allosteric activation of synaptic and extrasynaptic GABA

225 at a key feature of the mechanism of heparin allosteric activation of the anticoagulant serpin, antit

226 erminal cyclic nucleotide binding domain and allosteric activation of the C-terminal acyltransferase

227 The second step involves the allosteric activation of the catalytic site through dist

228 These results suggest that the normal allosteric activation of the chemotaxis receptor has bee

229 the pores of MP-SiO(2), and particularly the allosteric activation of the DNAzymes through cooperativ

230 Binding of AMP causes allosteric activation of the enzyme and binding of eithe

231 nd acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affec

232 st the catalytic domain where it could drive allosteric activation of the enzyme.

233 inhibits protein synthesis by preventing the allosteric activation of the essential GTPase Initiation

234 dies reveal determinants for the binding and allosteric activation of the Fe-S assembly complex and p

235 Allosteric activation of the hexameric arginine represso

236 structure of a HslUV complex, a mechanism of allosteric activation of the HslV protease, wherein bind

237 unctions, such as DNA repair, to augment the allosteric activation of the main protective system, Kef

238 chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity

239 n of MKP3 and ERK2 and specific ERK2-induced allosteric activation of the MKP3 C-terminal phosphatase

240 osttranslational regulation seems to involve allosteric activation of the ML beta-glucan synthase Bgs

241 med that limiting rate constants for heparin allosteric activation of the mutants were altered in con

242 Allosteric activation of the PDZ is achieved by local re

243 ith an armlike structure in DPP9, leading to allosteric activation of the peptidase.

244 he substrate selectivity and Na(+)-dependent allosteric activation of the protease domain of human co

245 ng that this residue may be required for the allosteric activation of the protease.

246 he serpin, antithrombin, to the mechanism of allosteric activation of the protein by heparin was dete

247 rosine 341 (Y341) and are thought to provide allosteric activation of the Raf dimer.

248 bond in the zymogen-like pro-HGF results in allosteric activation of the serine protease-like beta-c

249 factor Xa by antithrombin mainly through an allosteric activation of the serpin inhibitor, but an al

250 parin pentasaccharide, denoted DEFGH, in the allosteric activation of the serpin, antithrombin, we st

251 The allosteric activation of the T127-->L mutant of 3',5'-cy

252 ally unrelated ago-PAM B-973B as well as the allosteric activation of the TQS-sensitive alpha4beta2L1

253 cium signaling in diverse cell types through allosteric activation of their K(+)-conducting pore by s

254 n with EGFR, HER2, and c-Met, as well as the allosteric activation of these dimerized partners; howev

255 If allosteric activation of type II IPPs by PI(4)P and PS i

256 ur results provide a mechanistic example for allosteric activation of USPs by their regulatory partne

257 wn, however, whether this loop has a role in allosteric activation of VIIa.

258 analyzed the structural determinants of the allosteric activation of yeast pyruvate kinase (YPK) by

259 f the multiligand interactions governing the allosteric activation of YPK.

260 tor protein (CRP) from Escherichia coli, the allosteric activation, or apo-holo transition, involves

261 CovET residue pairs recovered accurately the allosteric activation pathway characterized for Class A

262 ot only perturb the classical cAMP-dependent allosteric activation pathway of PKA, but also amplify s

263 At least two interdependent allosteric activation pathways originate at the FVIIa:sT

264 we harnessed our understanding of LbuCas13a allosteric activation pathways through molecular dynamic

265 supporting the existence of two TF-mediated allosteric activation pathways.

266 ough PKC isotypes are characterized by their allosteric activation, phosphorylation also plays a key

267 nhibition occurs by physical blockage of its allosteric activation, preventing the alignment of its f

268 on-cognate ligand binding sites to alter the allosteric activation process are classified as alloster

269 te binding site of the active subunit blocks allosteric activation regardless of the activity of the

270 underlying molecular mechanisms behind this allosteric activation remain elusive.

271 t do not affect the cooperativity), and this allosteric activation requires an intact PH domain.

272 Allosteric activation results from an increase in k(cat)

273 teric modulator" and an antagonist of alpha7 allosteric activation, shares the same scaffold with thr

274 s unambiguously show that the conformational allosteric activation signal extends to the EGF1 domain

275 KL confirmed binding of NA-11 to the AMP/ADP allosteric activation site and explained why NA-11 faile

276 e, we identify a receptor (ephrinB2)-induced allosteric activation site in Nipah virus (NiV) G involv

277 assess the conformational flexibility of the allosteric activation site.

278 cs were observed, suggesting the presence of allosteric activation sites.

279 ations' effects on parameters reflecting the allosteric activation state of the serpin were inconsist

280 he conformational space network, whereas the allosteric activation step covers a much wider region an

281 s Asp residue in nSMase2 disrupts catalysis, allosteric activation, stimulation by phosphatidylserine

282 ector, NADH (0.7-0.9 per site), and exhibits allosteric activation, suggesting that the proteins reta

283 findings implicates the gammaCRD as being an allosteric activation switch in PhK that interacts with

284 hese results indicate that RasGRF1 lacks the allosteric activation switch that is crucial for Sos act

285 acid dynamics that remarkably resembles the allosteric activation that takes place upon effector bin

286 omains surrounding the kinase active site in allosteric activation, the nature of that site and the r

287 the enhanced thrombin specificity was due to allosteric activation, the remainder being realized with

288 he adjoining helices TM5 and TM6 in enabling allosteric activation; the role of particular structural

289 a, we propose a model in which PLN undergoes allosteric activation upon encountering SERCA.

290 GS is regulated by allosteric activation upon glucose-6-phosphate binding a

291 zyme activation, confirming the mechanism of allosteric activation via binding to the rear channel.

292 y towards RhoA, but full activation requires allosteric activation via Galphaq.

293 Allosteric activation was reduced in the double point mu

294 n-activated state and support a new model of allosteric activation we recently proposed in which a ba

295 rms of a two-state model for the interfacial allosteric activation, where the enzyme-substrate comple

296 , ADAMTS13 is regulated by substrate-induced allosteric activation, which may optimize VWF cleavage u

297 nge could be responsible for the interfacial allosteric activation, which thermodynamically relates t

298 nt physiological activation is an outside-in allosteric activation with strong structural coupling ac

299 n/K-Ras4B interaction, to accomplish K-Ras4B allosteric activation, with a minor contribution from cS

300 ADAMTS13 is regulated by substrate-induced allosteric activation; without shear stress, the distal