ライフサイエンスコーパス: allosteric effect

1 a23Tm decreases these interactions (negative allosteric effect).

2 receptor's affinity for a second substrate (allosteric effect).

3 of inflammasome signaling was mediated by an allosteric effect.

4 there is little sequence specificity to the allosteric effect.

5 a to the GAF domains suffices to induce this allosteric effect.

6 3) Carboxylation reduces the allosteric effect.

7 Higher levels of glycerol cause loss of the allosteric effect.

8 e Tf binding site rather than by exerting an allosteric effect.

9 ic site occurred even when MgADP produced no allosteric effect.

10 tential binding site), leading to a negative allosteric effect.

11 reased [(3)H]NMS binding to M1 receptors, an allosteric effect.

12 GTP region of beta-tubulin is a long range, allosteric effect.

13 hich inhibits C-type inactivation through an allosteric effect.

14 wo CYP121 basic surface residues removed the allosteric effect.

15 g B-arrestin recruitment, pointing toward an allosteric effect.

16 powerful computational approach to probe the allosteric effect.

17 ith K600 interactions explaining ~70% of the allosteric effect.

18 onding activation appears to involve a major allosteric effect.

19 ion of the second substrate with no specific allosteric effects.

20 ies to probe the biochemical basis for their allosteric effects.

21 fic motifs and regulate protein activity via allosteric effects.

22 hat this residue is a key player in relaying allosteric effects.

23 membrane-dependent substrate recognition and allosteric effects.

24 quently disrupt protein function by indirect allosteric effects.

25 at the LAG-3/MHCII interface with potential allosteric effects.

26 king of the ligand pocket through long-range allosteric effects.

27 ns extend beyond the active site, suggesting allosteric effects.

28 74H, which likely affect the epitope through allosteric effects.

29 for the D170A variant, indicating long range allosteric effects.

30 odels yield valuable methods for quantifying allosteric effects.

31 ns; and those that decrease affinity through allosteric effects.

32 st in designing pharmaceuticals that exploit allosteric effects.

33 domains modulate FcRn binding site in Fc by allosteric effects.

34 e binding is likely achieved by DNA-mediated allosteric effects.

35 tions that substantially alter a modulator's allosteric effects.

36 hatase activity and could promote exon 7 via allosteric effects.

37 of a biochemical process such as binding and allosteric effects?

38 The propagation of allosteric effects across the domain interface may depen

39 at are responsible for this inversion of the allosteric effect, all 6 evolutionary TrpA and TrpB inte

40 dies of allosteric mechanisms, prediction of allosteric effects and allostery-related physicochemical

41 molecular dynamics simulations, we identify allosteric effects and communication pathways in two pro

42 on caused by SH modification of Kir6.2 is an allosteric effect, and is not caused by direct pore bloc

43 dy provides an example of dynamics-dependent allosteric effects, and due to the structural conservati

44 (b) stress the need for quantitation of the allosteric effects; and finally, (c) propose that each s

45 te that metal uptake and this newly observed allosteric effect are buffer dependent.

46 These allosteric effects are focused among a relatively few re

47 These allosteric effects are in agreement with previous foldin

48 These cAMP-mediated allosteric effects are lost in the double-mutant L47P/E1

49 These decreases suggest that positive allosteric effects are not mediated by structural change

50 Their allosteric effects are observed only at high concentrati

51 This allosteric effect arises from interactions between N-cap

52 IMP produces only a very small allosteric effect as indicated by a near-zero value for

53 tive interactions also could cause ripple or allosteric effects at a distance in protein-protein inte

54 ith terminal amino/guanidino groups improved allosteric effects at both human and mouse A(3)ARs.

55 Little is known about the allosteric effects at play in E1A-CBP-pRb interactions,

56 This appears to be caused by an allosteric effect because these residues are not localiz

57 nds reflects the difference between a narrow allosteric effect between two well-defined sites in the

58 roposed to play a major role in transmitting allosteric effects between oxygen binding sites.

59 is hypothesized to modulate BKR activity via allosteric effects between the ER and BKR NADPH sites.

60 ic and stereospecific interactions (positive allosteric effect) between actin and myosin, but Delta23

61 at are involved in bile acid recognition and allosteric effects, but also suggests the presence of di

62 ilibria measurements indicate a differential allosteric effect by inositol hexaphosphate for HbC appr

63 in-1-yl-phenyl)ethyl]amide] displayed biased allosteric effects by blocking cAMP inhibition mediated

64 HSA, and cis/trans-clomiphene gave positive allosteric effects caused by the binding of warfarin to

65 at binding of heparin to thrombin induces an allosteric effect causing destabilization of the thrombi

66 (whereby the magnitude and direction of the allosteric effect change with the nature of the interact

67 s been achieve using light, applied voltage, allosteric effects, chemical reagents, pH, and mechanica

68 etitive inhibition by BFA and the nucleotide allosteric effect combine to stabilize such abortive com

69 AChR and mediate robust positive or negative allosteric effects, depending on the orthosteric ligand

70 reover, RING:Ube2g2 binding induces a second allosteric effect, disrupting Ube2g2:G2BR contacts, decr

71 r with Glu-tRNA(Gln), results either from an allosteric effect due simply to binding of these analogu

72 inding of RecO to SSB-Ct peptides elicits an allosteric effect, eliminating the positive cooperativit

73 ed linker region, and indirectly, through an allosteric effect exerted by the kinesin-binding C-termi

74 le and multiple mutations, but the degree of allosteric effect exerted on the endogenous ligand acety

75 tate kinetics of hydrolysis and resolves the allosteric effects from apparent modes of interfacial ac

76 Insight into the high-affinity allosteric effect has been hampered by the receptor's co

77 ither an allosteric site nor a compound with allosteric effects has been described.

78 losteric effects; however, the nature of the allosteric effects has been elusive.

79 protein, but the impact of glycans on these allosteric effects has not been investigated.

80 osteric and active sites does not decide the allosteric effect; however, it does define the propagati

81 ipate in chemistry but are thought to confer allosteric effects; however, the nature of the allosteri

82 Allosteric effect implies ligand binding at one site lea

83 Electrostatic interactions may mediate allosteric effects important for C3d-CR2(CCP1-2) associa

84 tion of both the nature and magnitude of the allosteric effect in ATCase.

85 pairs that show high cooperativity and their allosteric effect in the interface of G protein-coupled

86 A recent study described an allosteric effect in which the binding of a protein to D

87 hange with mass spectrometry (HDX/MS) to map allosteric effects in a paradigm ligand-responsive trans

88 he absence of a rate equation to explain the allosteric effects in a tetramer, the data have been com

89 tructural insight into the recently proposed allosteric effects in Abs.

90 itute a mechanism for the recently suggested allosteric effects in Abs.

91 The investigation of allosteric effects in biomolecular structures is of grea

92 ment to locate binding sites and to identify allosteric effects in drug/target interactions.

93 Allosteric effects in hemoglobin arise from the equilibr

94 Allosteric effects in monomers were exclusively negative

95 Allosteric effects in oligomers could be positive or neg

96 The extent of allosteric effects in proteins points out the importance

97 in Ras opens opportunities for understanding allosteric effects in Ras function.

98 of an enzyme has been extended to deal with allosteric effects in serine proteases.

99 Remarkably, Ca(II) binding causes allosteric effects in the C-terminal region of helix a(I

100 ns within the binding pocket, causing unique allosteric effects in the enzyme.

101 rectly interacts with substrates and induces allosteric effects in the protease domain of FVIIa.

102 These results implicate allosteric effects in the regulation of actomyosin funct

103 These results suggest that allosteric effects, including changes in oligomeric stat

104 ations indicated that these mutations induce allosteric effects, increasing fluctuations of unstructu

105 EBs is improved by DnaC and DnaG, likely via allosteric effects induced by direct protein-protein int

106 We propose that allosteric effects induced upon zinc finger association

107 alpha-N, excluding that their binding caused allosteric effects influencing the interaction; nonethel

108 igands is that the magnitude of the mediated allosteric effect is dependent on the orthosteric probe

109 That is, the allosteric effect is determined by the extent of preferr

110 The inter-domain allosteric effect is likely mediated by the flexibility

111 This allosteric effect is most noticeable in the electrostati

112 ee energy, which signifies the nature of the allosteric effect, is opposite that of the enthalpy cont

113 RM domain stimulates CD44 binding through an allosteric effect, leading to the formation of a neighbo

114 comes less mobile, providing evidence for an allosteric effect linking the HA and heparin-binding sit

115 he thrombin-HCII(L444R) complex and that the allosteric effect may be mediated by the 60-loop.

116 Such allosteric effects may play a prominent role in modulati

117 s in a cryptic state, but after DNA binding, allosteric effects mediate an exposure of the acetylatio

118 Here, we sought to understand allosteric effects modulated by the knotted topology.

119 ding produce small conformational changes or allosteric effects, not captured in the crystal structur

120 nsequence of their inability to override the allosteric effect of 2-oxoglutarate on NifA activity.

121 onformations is reflected in the much weaker allosteric effect of ADP on the ssDNA binding with the a

122 blished conditions for fully quantifying the allosteric effect of AMP on glycogen phosphorylase b.

123 The presence of target miRNA triggered the allosteric effect of CHA amplification, which brought ab

124 ctions of Cl- at three levels: 1) a negative allosteric effect of Cl-, which limits the ability of AT

125 However, the potential allosteric effect of ClpP on the mechanism of ClpA catal

126 Free energy calculations suggest that the allosteric effect of CPEB3-RBD/SUMO2 interaction can amp

127 n the catalytic subunits of PDE6 rule out an allosteric effect of E4021 by direct binding to these no

128 very from use-dependent block, indicating an allosteric effect of external QX-314 binding on the reco

129 that Mg(2+) potentiates by a factor of 2 the allosteric effect of GDP.

130 Here, we studied for the first time the allosteric effect of geometrical membrane curvature on t

131 ranscriptional regulation by GR, a potential allosteric effect of GR-binding ligands on specific GR-D

132 The allosteric effect of GTP in promoting synapsis by P elem

133 is similarly inhibited, possibly through an allosteric effect of molecular O2 on the enzyme.

134 Our results suggest that this allosteric effect of Na(+) does not underlie the voltage

135 ation method using B1AR and demonstrated the allosteric effect of Nb80 binding in assisting displacem

136 the DnaC protein eliminates the antagonistic allosteric effect of NTP and NDP on the ssDNA affinity o

137 ast in part, involved in transduction of the allosteric effect of pentobarbital to enhance alpha1beta

138 ed deoxy-RmFixL, exposes the strength of the allosteric effect of RmFixJ on the reaction.

139 , W246A(6.48), and N280A(7.45)) the negative allosteric effect of sodium ions on agonist binding.

140 at least two conformational changes: (i) an allosteric effect of TBP that mediates the activation of

141 change more than one parameter, implying an allosteric effect of the binding to the interface on KS,

142 The allosteric effect of the IgG is altered by deletion of P

143 weak DNA-binding subsite is to modulate the allosteric effect of the strong subsite.

144 bited exaggerated cooperativity, implying an allosteric effect of tropomyosin on actin and allowing t

145 lu-225 are also required to achieve the full allosteric effect of Zn(2+) on agonist binding.

146 ns of pore and vestibule-lining residues and allosteric effects of a pathological substitution on cha

147 lows receptor deactivation, and enhances the allosteric effects of alcohol on the receptor.

148 43) and N274A(7.45) mutations eliminated the allosteric effects of all three modulators but had littl

149 Allosteric effects of alpha-tryptase protomers on neighb

150 ach enabled to characterize and quantify the allosteric effects of ALPL mutations and role of alloste

151 dylinositol phosphates as second messengers, allosteric effects of ATP binding, changes of actin cyto

152 r as a single allosteric unit to mediate the allosteric effects of ATP binding, without altering the

153 In addition, acetylation attenuated the allosteric effects of ATP on NAT1.

154 on is an important residue for mediating the allosteric effects of both acidic and alkaline pH change

155 in the rate of modification consistent with allosteric effects of complex formation.

156 their ability to cause this disruption, the allosteric effects of conformational changes in disorder

157 electron transfer to the P450 oxy complex or allosteric effects of cytochrome b(5) favoring active si

158 intracellular metabolites, however, how the allosteric effects of distinct ligands are integrated to

159 dely different ATPase activities reflect the allosteric effects of DNA ligation and demonstrate that

160 onse to ligand is strongly influenced by the allosteric effects of DNA-bound heterodimers.

161 1.50) and D58N(2.50) mutations abolished the allosteric effects of DU124183 and VUF5455, but not HMA,

162 loop residues 123-129 of Eallo underlies the allosteric effects of FAs and allosteric COX-2 inhibitor

163 but studies in which obidoxime reversed the allosteric effects of gallamine and other ligands sugges

164 beta-arrestin, our data demonstrate that the allosteric effects of GPCR ligands could directly modula

165 lysine residues are not associated with the allosteric effects of inorganic anions on the rates of m

166 navirus polymerases is greatly influenced by allosteric effects of ligand binding that are likely to

167 Our studies revealed allosteric effects of mutations and mechanistic differen

168 Allosteric effects of mutations, ligand binding, or post

169 The subtype-selective allosteric effects of N-chloromethyl brucine on M2 and M

170 Examination of the allosteric effects of Na(+) on heterologously overexpres

171 Interestingly, the allosteric effects of NAS on GABAergic inhibition were i

172 Additionally, although allosteric effects of NAS on GABAergic inhibition were s

173 otif V, which may be involved in transducing allosteric effects of nucleotide binding and hydrolysis

174 ing in the absence of ATP overlook important allosteric effects of nucleotide binding that increase S

175 tifs II and VI may function to transduce the allosteric effects of nucleotides on DNA binding.

176 rties of PD 81,723) was found to enhance the allosteric effects of PD 81,723 (15 microM) in brain, bu

177 In the presence of 1 mM GTP, the allosteric effects of PD 81,723 (15 microM) were increas

178 at have previously been shown to enhance the allosteric effects of PD 81,723.

179 Our findings demonstrate the allosteric effects of SMKIs beyond the confines of kinas

180 contrast, W246A(6.48) increased some of the allosteric effects of sodium ions and amiloride, whereas

181 e have characterized these reactions and the allosteric effects of the alpha subunit.

182 highlight the need to validate the reported allosteric effects of the endogenous ligands lipoxin A4

183 ynamics (D-NEMD) simulations, we explore the allosteric effects of the FA site in the fully glycosyla

184 and S247A(6.52) mutations did not influence allosteric effects of the modulators.

185 xplained experimental findings regarding the allosteric effects of the PH domain from numerous activi

186 ms of delta/lambda-chelate conformations and allosteric effects of the substrates.

187 Drugs mimicking the allosteric effects of these mutants may rescue pVHL func

188 h, increases the potency and efficacy of the allosteric effects of this ligand, likely through optimi

189 These results show an absence of allosteric effects of TMR on subdomain 2, while confirmi

190 Here we explored the allosteric effects of two pyrimidine diamines, PDA1 and

191 Thus, ANF has as an allosteric effect on a kinetic branch point.

192 he presence of Tn and Ca2+ exerts a positive allosteric effect on actin to make actomyosin linkage mo

193 ted that extracellular Cl- exerts a negative allosteric effect on ATP-gating of P2X7R channels, we te

194 coefficients greater than 1 in its negative allosteric effect on binding and response.

195 lts indicate that CpAMs do not have a single allosteric effect on capsid structure.

196 using a novel series of ligands with varying allosteric effect on CRF binding (inhibition to enhancem

197 We next investigated the allosteric effect on CRF-stimulated G-protein coupling.

198 Cl- has a positive allosteric effect on Cu-loading of apoFet3p.

199 e plasma membrane and by exerting a negative allosteric effect on GHS-R1a signaling, respectively.

200 weakly in solution, and hClpX must exert an allosteric effect on hClpP to promote a conformation tha

201 mutation and the bound nucleotide exhibit an allosteric effect on membrane binding, as observed from

202 llosteric binding cooperativity and negative allosteric effect on orthosteric ligand maximal signalin

203 PARPi AZD5305 also exhibited a clear reverse allosteric effect on PARP2.

204 nearby N-terminal region, consistent with an allosteric effect on PIPn sensitivity because of altered

205 The allosteric effect on Pit-1, in combination with other DN

206 mic domain of Band 3 protein also produce an allosteric effect on S-nitrosated Hb.

207 studies with tamoxifen, this had a positive allosteric effect on tamoxifen/HSA binding, giving a cou

208 A-FIXa's increased activity is not due to an allosteric effect on the active site, but that the Arg-3

209 product of heme catabolism-causing a strong allosteric effect on the activity of a subset of neutral

210 direct interaction with toxin, or through an allosteric effect on the alpha subunit.

211 - may also bind to Fet3p and that Cu+ has an allosteric effect on the binding of Cl- to the enzyme.

212 ion of the activation-loop has a significant allosteric effect on the dynamics of the C-lobe.

213 eEF3, strongly suggesting that it exerts an allosteric effect on the hydrolytic activity of eEF3.

214 mulation suggests that cholesterol exerts an allosteric effect on the intracellular regions of the re

215 bits nucleotide exchange on actin implies an allosteric effect on the nucleotide binding cleft.

216 ry near the M4 helix and exerts a long-range allosteric effect on the pore across domain-interfaces.

217 tive indicated that tamoxifen had a negative allosteric effect on warfarin/HSA binding, providing a c

218 +) via the Zip14 transporter to exert unique allosteric effects on AC.

219 These findings uncover a mechanism whereby allosteric effects on an E2 enhance E2-RING finger inter

220 l properties, such as dynamic correlation or allosteric effects on binding.

221 e CB2 receptor PAM, with unforeseen opposite allosteric effects on cannabinoid receptors, suggests it

222 RNA-bound MDA5 prior to MAVS activation via allosteric effects on CARDs-polyUb complex.

223 tential mechanisms, including pore block and allosteric effects on channel gating.

224 FusB induces allosteric effects on dynamics in EF-G, causing signific

225 he two enzymes in proximity and by producing allosteric effects on ERAP1, dimerization of ERAP1/2 cre

226 ing interface, loss of protein stability, or allosteric effects on G protein coupling.

227 he C-terminal tail but rather exerts its own allosteric effects on Int function in response to the in

228 al inference (NRI), is applied to assess the allosteric effects on intracellular regions attributable

229 data of epithelial 15-hLO-2, which probe the allosteric effects on its mechanistic behavior.

230 ges in low-frequency dynamics correlate with allosteric effects on ligand binding without the require

231 Ligands for which the nature of their allosteric effects on mGluRs is experimentally known wer

232 alent cations, such as zinc and copper, have allosteric effects on misfolded aggregates of comparable

233 er arm of beta-cardiac myosin have divergent allosteric effects on myosin function, depending on whet

234 tances but not others, suggesting additional allosteric effects on orthosteric ligand efficacy.

235 ed receptors can result in novel and nuanced allosteric effects on receptor signaling.

236 ties may induce destabilizing or stabilizing allosteric effects on Spike, with implications for neutr

237 the ester substrate MUGB, sTF exerts greater allosteric effects on substrate binding than on the late

238 tion mechanism of PA200 is expressed via its allosteric effects on the 20 S core particle, perhaps fa

239 n be regulated by actin-binding proteins via allosteric effects on the actin.

240 ecular Interface I were most consistent with allosteric effects on the catalytic 3D polymerase molecu

241 stabilized the ligand-binding pocket and had allosteric effects on the dimerization interface.

242 antibiotic resistance mechanism mediated by allosteric effects on the dynamics of the drug target.

243 -calmodulin to the C-terminus has long-range allosteric effects on the extracellular segments of the

244 lament regulatory proteins exert significant allosteric effects on the interaction of crossbridges wi

245 motype determined the extent of the observed allosteric effects on the kinase domain and correlated w

246 g of alpha-site ligands (ASLs) exerts strong allosteric effects on the reaction of substrates at the

247 plies that HAP1-DNA interactions have direct allosteric effects on transcriptional activation.

248 The allosteric effect operates by means of an allosteric cav

249 utants in other cytoplasmic loops, either by allosteric effects or via additional sites of action.

250 es (i.e., the small amino acids have minimal allosteric effects), PEP binding elicits different chang

251 n lines that likely mediate these long-range allosteric effects, predominantly across the intercasset

252 tructures and, by solution methods, observed allosteric effects propagating >50 A from the binding si

253 nds to milliseconds, which clearly implicate allosteric effects propagating from the extracellular fa

254 romotes Ste5 phosphorylation, rather than an allosteric effect proposed to regulate Fus3 activity.

255 s in the presence of bt10, which point to an allosteric effect rather than destabilization of the dim

256 rom the charge on the analyte, occur through allosteric effects related to the binding process, or re

257 by Zn(2+) binding, which induces cooperative allosteric effects related to those of the pH-dependent

258 ibits the enzymatic activity of LpxC through allosteric effects reminiscent of LpxC activation by Mur

259 that NNI2 inhibitors act through long range allosteric effects, reveal important conformational chan

260 Our results also imply that the allosteric effect should be independent of the base sequ

261 These allosteric effects suggest an ordered, cyclical mechanis

262 The triggering of the allosteric effect takes place by binding of the first an

263 wild-type enzyme, binding of dCTP induces an allosteric effect that affects the subunit interactions

264 e binding of one recognition motif causes an allosteric effect that enhances the subsequent binding o

265 show that certain clinical PARPi exhibit an allosteric effect that retains PARP2 on DNA breaks in a

266 tion of the transition state and an indirect allosteric effect that stabilizes the GDP-bound form.

267 demonstrate mutation W260A exerts local and allosteric effects that impact multiple steps of the PKA

268 prevent VWF binding, but instead because of allosteric effects that impair VWF cleavage, likely by a

269 In addition, certain PARPi exert allosteric effects that increase PARP1 retention on DNA.

270 at some of the crystallographically observed allosteric effects that result in the connection of subs

271 loops remains unchanged, but as a result of allosteric effect the structural fluctuations are altere

272 aggregation of target proteins, and through allosteric effects, their activity.

273 momechanical coupling by combined steric and allosteric effects, thereby reducing both the length of

274 eceptors to form dimers and thus demonstrate allosteric effects through binding at the orthosteric si

275 These allosteric effects thus reduce ATP hydrolysis by inactiv

276 s spatially and temporally coordinates these allosteric effects to drive substrate translocation into

277 i.e., mutant E187A) causes MgADP to lose its allosteric effect upon Fru-6-P binding.

278 s towards its exosite and a further negative allosteric effect upon sandwich complexation of the thro

279 f Env antigenicity and immunogenicity and of allosteric effects upon receptor binding.

280 roach for quantitatively characterizing such allosteric effects using protein columns.

281 e GlyR alpha subunit and exerts its positive allosteric effect via an interaction with the Cys loop t

282 rved in the absence of Mg(2+), suggesting an allosteric effect via associated Kir6.2 subunits.

283 In one variant (K43A), the allosteric effect was absent, whereas in the other (G329

284 This allosteric effect was confirmed in a biochemical assay,

285 In contrast, an allosteric effect was not observed for 2-pyridylcarbinol

286 Although we cannot exclude allosteric effects, we propose that 7E3 binds between C1

287 ydroxyoctadecadienoic acid (13-HODE), and no allosteric effects were seen on diffusion or hydrogen at

288 the binding interfaces for all compounds and allosteric effects where present.

289 This sensitivity is the result of allosteric effects where the structure around the buried

290 a general base but rather contributes to an allosteric effect, which includes a major transition sta

291 conformational changes may contribute to the allosteric effects, which regulate metal binding.

292 tion and are beginning to be used to explore allosteric effects within GPCR hetero-dimers.

293 on the binding affinity suggests long-range allosteric effects within IgG.