ライフサイエンスコーパス: allosteric regulation

1 lin contacting regions of Ska1 suggesting an allosteric regulation.

2 unable fluorescent behaviours via long-range allosteric regulation.

3 ordinated in time and space owing to complex allosteric regulation.

4 plemented with a single protein, by means of allosteric regulation.

5 pable of high turnover rates and amenable to allosteric regulation.

6 enzyme is essential for optimal activity and allosteric regulation.

7 o be implicated in substrate recognition and allosteric regulation.

8 growing computational tools for modeling of allosteric regulation.

9 ne tethering and provide a mechanism for its allosteric regulation.

10 s crucial for catalysis, ligand binding, and allosteric regulation.

11 ers new opportunities for drug discovery and allosteric regulation.

12 er dimers, which are presumed to function in allosteric regulation.

13 ent BmrR ligands is in line with promiscuous allosteric regulation.

14 conformational and/or dynamic changes in the allosteric regulation.

15 ssibility of an as yet undiscovered means of allosteric regulation.

16 t putatively caused Aurora kinases to evolve allosteric regulation.

17 of the classic two-state, concerted model of allosteric regulation.

18 , and helix D is a site (in antithrombin) of allosteric regulation.

19 OR can activate G proteins and be subject to allosteric regulation.

20 implies that the enzyme might be subject to allosteric regulation.

21 ct with distinct partners and be involved in allosteric regulation.

22 ding a structural rationale for loss of this allosteric regulation.

23 in plays a critical role in the mechanism of allosteric regulation.

24 tetrapeptide for both catalysis and negative allosteric regulation.

25 ns distal T domains that are dispensable for allosteric regulation.

26 cassette acts as a master switch to override allosteric regulation.

27 et, potentially in substrate specificity and allosteric regulation.

28 S dimer and confirms the design strategy for allosteric regulation.

29 to provide new insights into specificity and allosteric regulation.

30 a comprehensive picture of the mechanism of allosteric regulation.

31 ncer therapies targeting regions involved in allosteric regulation.

32 ikely through a combination of targeting and allosteric regulation.

33 binding activities are subject to intricate allosteric regulation.

34 exes, which we suggest is closely related to allosteric regulation.

35 ential for catalysis, they are important for allosteric regulation.

36 domains and which facilitate disorder-based allosteric regulation.

37 ils of this important regulatory element for allosteric regulation.

38 n of the role of correlated dynamics in this allosteric regulation.

39 ains and may shed light on the energetics of allosteric regulation.

40 l membrane curvatures can enforce a dramatic allosteric regulation (1000-fold inhibition) of alpha-HL

41 erties such as cooperative ligand binding or allosteric regulation(3).

42 e relationships between protein dynamics and allosteric regulation, allowing for high-throughput mode

43 scover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch

44 scover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch

45 tion factors but also at the enzyme level by allosteric regulation and feedback inhibition.

46 n either ATP binding or hydrolysis, to study allosteric regulation and intersubunit communication.

47 ing, macromolecular binding, ligand binding, allosteric regulation and post-translational modificatio

48 NTD, is loosely arranged, mediating complex allosteric regulation and providing a rich target for dr

49 to resemble pigeon ADAMTS13 retained normal allosteric regulation and shear-dependent cleavage of VW

50 vides a unique, synthetic context to explore allosteric regulation and should pave the way to sophist

51 ) complex, studied for decades as a model of allosteric regulation and substrate channeling within pr

52 ynamic processes are responsible for ATP-PRT allosteric regulation and that similar mechanisms might

53 endosperm AGPase to determine their roles in allosteric regulation and thermal stability.

54 rplay between PARP-1 DNA damage recognition, allosteric regulation, and catalytic activity.

55 iciency, reduced aggregation, amenability to allosteric regulation, and greater adaptability.

56 catalytic mechanism, substrate specificity, allosteric regulation, and inhibition by a class of smal

57 ed us to differentiate defects in catalysis, allosteric regulation, and membrane targeting of individ

58 The quaternary structure, allosteric regulation, and properties of the diiron-oxo/

59 tory mechanisms, including redox modulation, allosteric regulation, and protein oligomerization, that

60 cal processes including enzymatic catalysis, allosteric regulation, and the mediation of protein-prot

61 nal CM-linked DAH7PS, catalytic function and allosteric regulation appear to be delivered by a common

62 e propose a new strategy that targets PARP-1 allosteric regulation as a selective way of inhibiting P

63 We used directed evolution to explore allosteric regulation as a source of latent catalytic po

64 eta-strands, suggesting their involvement in allosteric regulation as channels for long-range signal

65 In AtCM1, mutations of Gly-213 abolish allosteric regulation, as observed in AtCM2.

66 ptimally active and amenable to FBP-mediated allosteric regulation at pH(i) 7.5.

67 ependent mechanism that is best explained by allosteric regulation at phosphofructokinase-1 (PFK1) an

68 necessity of interpreting the cAMP-dependent allosteric regulation at the whole-channel level.

69 The key event of integrin signaling is the allosteric regulation between its ligand-binding site an

70 t and calcium flux, which suggests a form of allosteric regulation between the receptors.

71 speculated that there exists a mechanism for allosteric regulation between the two monomers.

72 d the motor protein myosin, show evidence of allosteric regulation between two domains, but it remain

73 DA receptor function is subject to extensive allosteric regulation both by endogenous compounds and b

74 ting of the channel state and observation of allosteric regulation by agonist binding with MD remains

75 it 4-isoform 1 (COX4i1), which modulates COX allosteric regulation by ATP.

76 ets in Cox5a (T65 and S43) that modulate its allosteric regulation by ATP.

77 the catalytic site suggests a mechanism for allosteric regulation by binding to protein partners.

78 e the basis for cooperative O(2) binding and allosteric regulation by coupling the effects of ligand

79 lecular-level insights into the mechanism of allosteric regulation by CzrA and demonstrate the import

80 n which binding of Brh2 to DNA is subject to allosteric regulation by Dss1.

81 ipeptide substrate hydrolysis, demonstrating allosteric regulation by FVa.

82 itor of this enzyme by mimicking its natural allosteric regulation by lysine, and obtained a crystal

83 xhibit differential blocker pharmacology and allosteric regulation by Na(+).

84 Allosteric regulation by pH gradients modulated the swit

85 eric networks and paths that are crucial for allosteric regulation by RAM.

86 on is not essential for this function or for allosteric regulation by S-adenosyl-L-methionine.

87 ure of these receptors is their capacity for allosteric regulation by small molecules, such as zinc,

88 s increased enzymatic activity and decreased allosteric regulation by the glycolytic pathway intermed

89 Yet, the mechanisms of substrate binding and allosteric regulation by the various LOX isoforms remain

90 ism may prove to be a useful method by which allosteric regulation can be introduced into biosensors,

91 As it is becoming accepted that allosteric regulation can occur through a change in loca

92 ving cooperative binding of ligand or robust allosteric regulation cannot account for the extremely n

93 the data are consistent with a mechanism of allosteric regulation described by the interdomain commu

94 visual excitation, the direct, inter-domain allosteric regulation described in this study may play a

95 ry, these findings shed light on the role of allosteric regulation during tumorigenesis and provide a

96 In this study, we decipher the allosteric regulation existing in TrpS from Pyrococcus f

97 in the case of NikA protein and examples of allosteric regulation for HypA, NikR, and RcnR, employed

98 The molecular basis for the ATD-mediated allosteric regulation has been enigmatic because of a co

99 In cases of multimeric proteins, such allosteric regulation has often been described by the co

100 all of the previously proposed mechanisms of allosteric regulation in aspartate transcarbamoylase.

101 n than that of the wild type, confirming the allosteric regulation in capsid assembly.

102 The DRH-3 ATPase may have allosteric regulation in cis that is controlled by the s

103 This suggests a new type of allosteric regulation in divergent cyclophilins, involvi

104 n has crucial ramifications in understanding allosteric regulation in enzymes and proteins, in genera

105 ever, the in vivo functional significance of allosteric regulation in eukaryotes is poorly defined.

106 ype and mutant systems to develop a model of allosteric regulation in IGP synthase that is monitored

107 rrelation analyses to probe the mechanism of allosteric regulation in imidazole glycerol phosphate (I

108 be crucial for understanding disorder-based allosteric regulation in multidomain proteins.

109 This phenomenon is analogous to allosteric regulation in proteins, where a conformationa

110 rmational changes previously associated with allosteric regulation in rabbit muscle pyruvate kinase (

111 We describe a theoretical model for allosteric regulation in receptors that addresses a fund

112 used by G-proteins are predicted to mediate allosteric regulation in response to nucleotide binding

113 istyl binding pocket may serve as a site for allosteric regulation in the C-subunit.

114 d was validated against experimental data on allosteric regulation in the human liver pyruvate kinase

115 To understand the molecular basis of allosteric regulation in the plant chorismate mutases, w

116 ght into the mechanisms of cooperativity and allosteric regulation in this human cytochrome P450.

117 ssibility of as-yet unidentified or untapped allosteric regulation in this PDZ domain and is a very c

118 The structure-function relationship of allosteric regulation in this system is still not fully

119 ology, focusing on promising applications in allosteric regulations, including the investigation of a

120 mechanisms: by altering transcriptional and allosteric regulation, interfering with cellular energy

121 ccomplishes different physical mechanisms of allosteric regulation, involving either the dissociation

122 uctural analysis revealed that the decreased allosteric regulation is a result of the altered FBP bin

123 As in nature, allosteric regulation is afforded by coupling the confor

124 tal mammals, birds, and amphibians show that allosteric regulation is broadly conserved, and phylogen

125 Allosteric regulation is mediated by a cytosolic C-termi

126 on by the substrate phenylalanine (Phe); the allosteric regulation is necessary to maintain Phe below

127 Understanding allosteric regulation is of paramount importance to guid

128 Allosteric regulation is used as a very efficient mechan

129 a residue shown earlier to be important for allosteric regulation, is disrupted, thereby strengtheni

130 ease-associated mutations may impair dynamic allosteric regulations, leading to loss of function.

131 lteration of conformational dynamics through allosteric regulation leads to functional changes.

132 This inverse allosteric regulation likely underlies the ability of PG

133 rbon partitioning rapidly through short-term allosteric regulation may contribute to plant performanc

134 This allosteric regulation may explain how cancer cells coord

135 Thus, the allosteric regulation may result from a discrete inhibit

136 fer a broader understanding of its intricate allosteric regulation mechanism by phosphorylation or ac

137 esults are consistent with an intermolecular allosteric regulation mechanism for the phosphatase acti

138 To increase our understanding of this allosteric regulation mechanism, we present the 2.6A cry

139 tein covers its functional site, is a common allosteric regulation mechanism.

140 tional landscape and transitions, as well as allosteric regulation mechanisms.

141 be linked with specificity and diversity of allosteric regulation mechanisms.

142 oteases with enhanced catalytic activity and allosteric regulation mediated by monovalent cation bind

143 ction but rather are more consistent with an allosteric regulation model in which the presence of sma

144 role in the inter-subunit communication and allosteric regulation observed in GDH.

145 A simple explanation for the negative allosteric regulation occurring in half-the-sites activi

146 tion may also be important to understand how allosteric regulation occurs in related viral polymerase

147 rable conditions a normal [Ca(2+)]-dependent allosteric regulation occurs.

148 ve demonstrated substrate-selective negative allosteric regulation of 2-AG oxygenation.

149 eport evidence for an unconventional type of allosteric regulation of a biomotor.

150 in regard to G protein activation and strong allosteric regulation of agonist binding by G proteins.

151 This asymmetry may link to the intrinsic allosteric regulation of all PKA holoenzymes and could a

152 erpesvirus proteases are an example in which allosteric regulation of an enzyme activity is achieved

153 Allosteric regulation of an intramolecular interaction b

154 rk helps to explain the previously described allosteric regulation of assembly and functional propert

155 reveal that directional activation involves allosteric regulation of ATP turnover through coordinate

156 link between observed conformations and the allosteric regulation of binding events at distal sites

157 iable Cu coordination or plays a key role in allosteric regulation of biological function, or both?

158 Allosteric regulation of biological macromolecules, howe

159 dynamics, analyzing molecular mechanism and allosteric regulation of biological systems.

160 but these results directly demonstrated the allosteric regulation of cell surface E-cadherin by p120

161 h ion conductance by RyRs and the long-range allosteric regulation of channel activities.

162 iguration suggests a molecular mechanism for allosteric regulation of channel gating by intracellular

163 ies have provided detailed insights into the allosteric regulation of client binding by BiP and have

164 racterize the dynamic events involved in the allosteric regulation of cystic fibrosis transmembrane c

165 of the lid upon holoenzyme formation suggest allosteric regulation of deubiquitination.

166 ing represents an important parameter in the allosteric regulation of diverse cell surface receptors.

167 structural conformational changes linked to allosteric regulation of DNA binding in vitro, irrespect

168 ciated with metal binding and metal-mediated allosteric regulation of DNA binding to varying degrees.

169 Allosteric regulation of DNA-PK by DNA termini protrudin

170 would account for a physiologically relevant allosteric regulation of E. coli GlmS.

171 Here we monitored for the first time allosteric regulation of enzymatic activity at the singl

172 Allosteric regulation of enzymatic activity forms the ba

173 tion of optogenetic tools aiming at a direct allosteric regulation of enzymatic effectors.

174 ion transport, transcription regulation, and allosteric regulation of enzyme function.

175 inding sites are commonly used by nature for allosteric regulation of enzymes controlling the product

176 nces can be caused by mutations altering the allosteric regulation of enzymes involved in dNTP biosyn

177 shape and dynamics in a manner analogous to allosteric regulation of enzymes.

178 biomimetic control mechanism that mimics the allosteric regulation of enzymes.

179 putational approach to identify a domain for allosteric regulation of Epac and a novel compound that

180 omain, providing evidence for Pin1-dependent allosteric regulation of ERalpha function.

181 Here, we addressed the allosteric regulation of FAK by performing all-atom mole

182 We speculate that the allosteric regulation of FVIIa activity by TF binding fo

183 the structural communication and long-range allosteric regulation of germline PTEN variants associat

184 e-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis.

185 and oligomerization offer possibilities for allosteric regulation of GPCR activity, but the detailed

186 ified membrane-permeant molecule that causes allosteric regulation of Hb oxygen binding affinity.

187 istatically interacting sites that alter the allosteric regulation of Hb-O2 affinity.

188 We found that functional sites involved in allosteric regulation of Hsp70 may be characterized by s

189 reversible binding of protons is key to the allosteric regulation of human hemoglobin.

190 Allosteric regulation of human lipoxygenase (hLO) activi

191 olecular basis for substrate recognition and allosteric regulation of IDE could aid in designing IDE-

192 assembly, and reveal how filament-dependent allosteric regulation of IMPDH2 makes the enzyme less se

193 es play important physiological roles in the allosteric regulation of IMPDHs by adding an additional

194 tory mechanism of hTS activity that involves allosteric regulation of interactions of hTS with its ow

195 observe complete activation of 5-HT(3A), the allosteric regulation of ion gating elements by 5-HT bin

196 Further, we studied allosteric regulation of isolated GCH1 by X-ray crystall

197 that targeting the cytosolic Hsp70 system by allosteric regulation of its chaperone/co-chaperone base

198 rotein bound to both dGTP and dATP suggested allosteric regulation of its enzymatic activity by dGTP

199 F1's chromatin-binding properties, including allosteric regulation of its histone binding.

200 idines, suggest a complex way of pH-governed allosteric regulation of ligand entry involving a transi

201 ns provide a framework for understanding the allosteric regulation of lipid kinase activity.

202 molecules with high affinity involved in the allosteric regulation of LVIS553, a MarR member from Lac

203 structural insight into the target-specific allosteric regulation of mAChRs by "three-finger" snake

204 d structural motif known to be important for allosteric regulation of many enzymes.

205 al cofactor recycling, a potential system of allosteric regulation of metabolite transport and the me

206 mational selection, the mechanism underlying allosteric regulation of monomeric enzymes is poorly und

207 Thus, our data support allosteric regulation of monomeric enzymes to operate vi

208 At last, we briefly outline the allosteric regulation of myosins with synthetic compound

209 omains (CBD1 and CBD2) are essential for the allosteric regulation of Na(+)/Ca(2+) exchange activity.

210 l cells, we hypothesize that this long-range allosteric regulation of NHERF1 by ezrin enables the mem

211 red cytoplasmic domain are important for the allosteric regulation of NMDA receptor gating.

212 volving all four subunits of the tetramer or allosteric regulation of open probability through voltag

213 emerged as a model system for understanding allosteric regulation of operator DNA binding by transit

214 Allosteric regulation of organometallic catalysts could

215 tion; from the foundational understanding of allosteric regulation of oxygen binding in Hb in the ste

216 A recently introduced model for allosteric regulation of PAH involves major domain motio

217 We conclude that allosteric regulation of PDE6 is more complex than for P

218 at the mobility of ATP lid is central to the allosteric regulation of PDHK2 activity serving as a con

219 tions and show they have distinct effects on allosteric regulation of PFKP activity and lactate produ

220 rom AMPK knockout mice, is best explained by allosteric regulation of phosphofructokinase-1 and/or fr

221 ts support a role of N-myristoylation in the allosteric regulation of PKA-C.

222 We further find that allosteric regulation of PleC observed in vitro does not

223 to the chaperone activity is an ATP-induced allosteric regulation of polypeptide substrate binding a

224 on PpccmFC substrates, indicating potential allosteric regulation of PPR65 by ATP.

225 protease-like beta-chain as a "hot spot" for allosteric regulation of pro-HGF and have broad implicat

226 Engineered allosteric regulation of protein activity provides signi

227 ilayer properties or to specific binding and allosteric regulation of protein activity.

228 ng, enzymatic catalysis, or protein folding, allosteric regulation of protein conformation and dynami

229 Allosteric regulation of protein function is a critical

230 Allosteric regulation of protein function is recognized

231 Allosteric regulation of protein function is widespread

232 Allosteric regulation of protein function, the process b

233 plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly

234 (SOD1), which previously were implicated in allosteric regulation of protein maturation and also pat

235 conserved functional residues and potential allosteric regulation of PTEN.

236 ha)8 barrel are involved in proline-mediated allosteric regulation of PutA-membrane binding.

237 e the expected temperature dependence of the allosteric regulation of rabbit muscle pyruvate kinase b

238 ormational dynamics orchestrates function in allosteric regulation of recognition and catalysis remai

239 The mechanism likely involves the allosteric regulation of ribonucleotide reductase and se

240 ctors - interactions that often result in an allosteric regulation of RNAP activity.

241 first time a detailed molecular mechanism of allosteric regulation of RNMT by RAM.

242 ing a stunning molecular explanation for the allosteric regulation of RNR activity in E. coli.

243 Although long known that allosteric regulation of RNR activity is vital for cell

244 alytically relevant complex and suggest that allosteric regulation of SepSecS might play an important

245 We found that the allosteric regulation of SERCA depends on the conformati

246 nteractions or mutations, thereby conferring allosteric regulation of structure and function.

247 that the CBS domain plays a key role in the allosteric regulation of TbGMPR by facilitating the tran

248 data are explained by a model of reciprocal allosteric regulation of TCR phosphorylation by choleste

249 Allosteric regulation of tetramerically symmetric protei

250 of the SH3C, a region of Crk involved in the allosteric regulation of the Abl kinase.

251 scherichia coli We demonstrate HPr-dependent allosteric regulation of the activities of pyruvate kina

252 ICs and implicate the three-fold axis in the allosteric regulation of the channel.

253 l control of overall structural dynamics and allosteric regulation of the drug-binding pocket.

254 Our results provide insight into the allosteric regulation of the enzyme and support a physio

255 We postulate this region as critical for the allosteric regulation of the enzyme, participating in th

256 Here, we unravel the mechanism and allosteric regulation of the highly cooperative alarmone

257 We are just beginning to understand the allosteric regulation of the human cytosolic sulfotransf

258 and these changes could directly affect the allosteric regulation of the interaction between the I-l

259 FR) involves ligand-induced dimerization and allosteric regulation of the intracellular tyrosine kina

260 mational change in p110alpha consistent with allosteric regulation of the kinase domain by nSH2.

261 ation of biomolecular recognition-triggered, allosteric regulation of the LCST phase transition of a

262 this result highlights a dynamic network for allosteric regulation of the M2 receptor activation.

263 ely varying environments is made possible by allosteric regulation of the metabolic network, interpla

264 Allosteric regulation of the pore by the cytoplasmic dom

265 f a protein to predict directionality in the allosteric regulation of the protein fluctuations.

266 Here we report that allosteric regulation of the serine-rich loop is mediate

267 From these studies, we conclude that allosteric regulation of the SH3-GK intramolecular inter

268 volved for mediocrity to enable inter-enzyme allosteric regulation of the shikimate pathway, is inher

269 Moreover, the allosteric regulation of the three GP isozymes (muscle,

270 ocated on the extracellular domain (ECD) and allosteric regulation of the transmembrane domain (TMD)

271 ted helicases that should be involved in the allosteric regulation of these motor proteins.

272 ons, but the molecular mechanisms underlying allosteric regulation of these transitions are still elu

273 s, and we present a structural model for the allosteric regulation of this enzyme.

274 rscoring a remarkable intra- and interdomain allosteric regulation of this trypsin-like protease.

275 s of topo II, and reveals a new mode for the allosteric regulation of topo II through modulation of A

276 Our findings provide insight into allosteric regulation of UHRF1 E3 ligase activity, sugge

277 nal helix of Arl3*GTP would be available for allosteric regulation of UNC119a cargo release only insi

278 to develop a structural model describing the allosteric regulation of uPAR.

279 Allosteric regulation often controls key branch points i

280 oited to investigate the impact of defective allosteric regulation on one-carbon metabolism.

281 Allosteric regulation plays an important role in a myria

282 Allosteric regulation plays an important role in the con

283 The allosteric regulation produced by glucose is postulated

284 These include allosteric regulation, product inhibition, and covalent

285 Allosteric regulation promises to open up new therapeuti

286 Allosteric regulation provides highly specific ligand re

287 Many aspects of allosteric regulation remain incompletely understood.

288 The molecular basis of allosteric regulation remains a subject of intense inter

289 and affinity, specificity, catalysis, and/or allosteric regulation) remains a challenge.

290 e to the tumorigenesis, and have revealed an allosteric regulation site for its RhoGAP activity.

291 Here we describe an approach to confer allosteric regulation specifically on the catalytic acti

292 psid and glycoprotein assembly is subject to allosteric regulation, that is regulation at the level o

293 (KSR) is a MAPK scaffold that is subject to allosteric regulation through dimerization with RAF.

294 We propose that allosteric regulation through modification of specific r

295 one binding site reciprocally influenced the allosteric regulation through nucleotides interacting wi

296 tiadhesive and antimicrobial therapies using allosteric regulation to inhibit FimH.

297 The allosteric regulation triggering the protein's functiona

298 a therefore support an emerging model of PAH allosteric regulation, whereby Phe binds to PAH-RD and m

299 volving post-translational modifications and allosteric regulation with other protein partners.

300 ind that DNA binding triggers an interdomain allosteric regulation within the GR, leading to tetramer