ライフサイエンスコーパス: allosterically

1 affinity MPP(+) binding influences transport allosterically.

2 gonist-binding sites affect channel activity allosterically.

3 o the pore, and are poised to control gating allosterically.

4 gion of the enzyme and affects transcription allosterically.

5 the Fc binding site, whereas the other acts allosterically.

6 in which its catalytic active sites operate allosterically.

7 o conclude that the former exerts its effect allosterically.

8 te locally, and also opens the opposite gate allosterically.

9 e suggests that this mode of binding induces allosterically a rearrangement of a noncanonical toggle

10 lock the transamidation activity of hTG2 and allosterically abolish its GTP binding ability with a hi

11 hanging the level of basal activity with the allosterically acting anesthetics propofol, pentobarbita

12 te by agonists, competitive antagonists, and allosterically acting channel activators.

13 ranes and that binding of oxLDL to LOX-1 can allosterically activate AT1-dependent signaling events.

14 Pseudoenzymes can allosterically activate canonical enzymes, act as scaffo

15 G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and tr

16 rmediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein t

17 s have suggested that location-specific cues allosterically activate Set1.

18 ify that monounsaturated fatty acids (MUFAs) allosterically activate SIRT1 toward select peptide-subs

19 is necessary and sufficient to empower it to allosterically activate Src.

20 The Rab Ypt7 and vacuole lipids together allosterically activate the bound HOPS for catalyzing SN

21 t evidence that Rap1A, and by extension Ras, allosterically activate the lipase by promoting and stab

22 Although Ras has been reported to allosterically activate the lipase, it is not known whet

23 ddition to the scaffolding role betaarrs can allosterically activate their downstream targets.

24 glutamate flux, lumenal protons and chloride allosterically activate vesicular glutamate transport.

25 titutively active ancestor trypsin, FVIIa is allosterically activated (by TF).

26 mon FAs like palmitic acid, whereas COX-2 is allosterically activated 2-fold by palmitic acid.

27 Our results indicate that, although allosterically activated alpha7 nicotinic ACh receptor m

28 lation of inosine monophosphate (IMP) and is allosterically activated by ATP.

29 tions and that during signaling, NEMO may be allosterically activated by binding to long M1-linked po

30 ykAencodes an active pyruvate kinase that is allosterically activated by glucose 6-phosphate (Glc-6-P

31 7M preferentially interact with PRC2 that is allosterically activated by H3K27me3 at CGIs and impede

32 y that the binding of Eaf3 to H3K36me can be allosterically activated by Rco1.

33 ous findings showed that the Tec kinases are allosterically activated by the adjacent N-terminal link

34 27, when phosphorylated by tyrosine kinases, allosterically activated CDK4 in complex with cyclin D1

35 esult in a GC-B conformation that mimics the allosterically activated conformation, 2) GC-B phosphory

36 Protein kinase C-delta (PKCdelta) is an allosterically activated enzyme that acts much like othe

37 rence between the unregulated enzyme and the allosterically activated form after inhibitor or cofacto

38 The biosensor is based on an engineered, allosterically activated fusion protein, which contains

39 s when it localizes to centrosomes, AURKA is allosterically activated on the mitotic spindle via bind

40 e of Phe, is different from a Phe-stabilized allosterically activated PAH tetramer.

41 d report the first solution structure of the allosterically activated state.

42 e density, ligand binding to this protein is allosterically activated up to 1,300-fold by low concent

43 Binding of AMP to AMPK not only allosterically activates AMPK but also promotes phosphor

44 lated GAF-containing PDEs where cGMP binding allosterically activates catalysis, the physiological si

45 into a cyclic oligoadenylate product, which allosterically activates Csm6 by binding to its CRISPR-a

46 n RhoGEF activation, as it both recruits and allosterically activates cytosolic ARHGEF25 isoforms.

47 nformational change at the Csm1 subunit that allosterically activates DNA cleavage and cOA generation

48 ifluoromethyl)phenyl)sulfamoyl)benzoic acid) allosterically activates ERAP1's hydrolysis of fluorogen

49 Because ATP allosterically activates GC-A and GC-B, we investigated

50 brain GIRK1/2 channel subunits, directly or allosterically activates GIRK1/2 channels in the BLA, an

51 Independently, K-Ras4B allosterically activates p110.

52 terization of a small-molecule compound that allosterically activates PDE4 long isoforms.

53 Thus, FtsN allosterically activates peptidoglycan synthesis by two

54 Thus we report the mechanism by which RAM allosterically activates RNMT, allowing it to function a

55 MTS13 disintegrin-like domain exosite to VWF allosterically activates the adjacent metalloprotease do

56 cOA allosterically activates the CRISPR ancillary ribonuclea

57 ort LC3 lipidation, demonstrating that WIPI2 allosterically activates the E3 complex.

58 synthesized by Cas10 polymerase-cyclase and allosterically activates the effector, typically a promi

59 Calcium binding allosterically activates the enzyme, but the detailed me

60 -homology (RH) domains of several RH-RhoGEFs allosterically activates these proteins, causing them to

61 In addition to allosterically activating IQSec1, ORP3 also extracts PI4

62 s of this protein experimentally shown to be allosterically active exhibit higher network coupling re

63 Eallo; however, structural studies show some allosterically active FAs positioned in COX-2 in a confo

64 s, lacking such well-defined structures, can allosterically affect function.

65 for how ligand binding site alterations can allosterically affect GPCR-transducer interactions and r

66 Monoamine transporter (MAT) ligands that allosterically affect MAT-mediated substrate uptake, rel

67 its ability to accommodate lipid A, which is allosterically affected by bound TLR4.

68 cular dynamics simulation showed that indole allosterically affected the distance between the two DNA

69 to order transition upon YoeB binding, which allosterically affects the conformation of N-terminal DN

70 supports our assertion that the open pH gate allosterically affects the potassium binding affinity of

71 subunit of odorant receptor heteromers, may allosterically alter olfactory receptor function and pro

72 late away from a conserved binding pocket to allosterically alter specificity of ligand interaction.

73 suggest that RAS phosphorylation at Tyr(137) allosterically alters protein conformation and effector

74 Thus occupancy of the active sites of ClpP allosterically alters sites on the surfaces thereby affe

75 During mechanotransduction, force allosterically alters the functions of mechanosensitive

76 it is thought that these clamp sites operate allosterically and promote translocation via an alloster

77 Several of these Fabs allosterically and selectively modulated the interaction

78 ompetitive regulation of CsrA by sRNAs, FliW allosterically antagonizes CsrA in a noncompetitive mann

79 ivators of PP2A) that kill leukemia cells by allosterically assembling a specific heterotrimeric PP2A

80 on of nucleosides or nucleotide analogues or allosterically at a number of well-defined sites.

81 AR) agonists) to enhance radioligand binding allosterically at the human dopamine (DA) transporter (D

82 Usp14 inhibits these processes allosterically because a catalytically inactive Usp14 mu

83 ]-ECL1i [extracellular loop 1 inverso]) that allosterically binds to CCR2.

84 use of small-molecule viral inhibitors that allosterically block CD4 binding represents an alternati

85 ry inhibitors, such as BMS-626529 (BMS-529), allosterically block CD4 binding to HIV-1 envelope (Env)

86 agonists acting at each receptor directly or allosterically blocked the antifibrotic effects of eithe

87 ing with MA trimerization and/or directly or allosterically blocking MA-CT binding sites.

88 5 as a specific antagonist of HIF2alpha that allosterically blocks its dimerization with the HIF1alph

89 ly, substrate binding does not activate EccC allosterically but, rather, by stimulating its multimeri

90 the phospholipid PIP(3) stabilized the dimer allosterically by binding at multiple sites, and that th

91 that potent pharmacophore trans-Ned-19 acts allosterically by clamping the pore domains to VSD2.

92 suggesting that RTF1 activates transcription allosterically by influencing Pol II translocation.

93 ere, we show a mechanism by which an IDP can allosterically control function by simultaneously tuning

94 Target binding is allosterically controlled by Ca(2+) over a distance of a

95 ally encoded analogs of proteins that can be allosterically controlled by either rapamycin or blue li

96 r to structural rearrangements that occur in allosterically controlled enzymes.

97 We hypothesize that allosterically controlled self-association represents th

98 nt following PAR activation and how PARs are allosterically controlled within the plasma membrane wil

99 Our data suggest that AQP2 phosphorylation allosterically controls its interaction with LIP5, illus

100 n evolutionarily mobile ATP-cone domain that allosterically controls overall activity.

101 may directly target sigma region 1.2, which allosterically controls the recognition of -10 element b

102 y the redox switches within complex I, which allosterically couple the dynamics of the quinone bindin

103 served extensive conformational changes that allosterically couple the extracellular regulatory and a

104 These synergistic Na(+)-binding effects allosterically couple the ion and substrate binding site

105 xperiments revealed that these two sites are allosterically coupled and exert reciprocal modulation.

106 p and the substrate-binding cleft in GAC are allosterically coupled and that this coupling determines

107 the activation gate and the channel's SF are allosterically coupled because the conformational change

108 Potassium channels are presumed to have two allosterically coupled gates, the activation gate and th

109 the extracellular substrate binding site are allosterically coupled in BtuB, and that TonB binding ma

110 onsequences of binding of each ligand to its allosterically coupled site(s).

111 The stimuli sensors are allosterically coupled to a pore domain, increasing the

112 were tight and identified computationally as allosterically coupled to active sites.

113 rance from the 806-epitope, which we show is allosterically coupled to an intermediate kinase and hal

114 Several gating processes, allosterically coupled to each other, control BK channel

115 n pore loops into an ordered network that is allosterically coupled to oligomerization, and suggests

116 tivation, which defeats transmission, and is allosterically coupled to protonation of key channel act

117 he bound S-citalopram or imipramine in S1 is allosterically coupled to the ligand binding to S2 throu

118 cytoplasmic domains of the protein that are allosterically coupled to transmembrane helices so as to

119 s it clear how signal-responsive domains are allosterically coupled with ANTAR domains for control of

120 of the Escherichia coli biotin repressor are allosterically coupled.

121 ing when mutated sites were distant from the allosterically-coupled binding sites.

122 evealing a quaternary structural switch that allosterically couples and synchronizes initial ligand b

123 y S2-ligand reported and characterized here, allosterically couples the ligand binding to S1 through

124 alker B motif of Orc1 directly contacts DNA, allosterically coupling DNA binding to ORC's ATPase site

125 o CP and induce a conformational change that allosterically decreases but does not abolish its actin-

126 However, LBCA-TrpA allosterically decreases the activity of LBCA-TrpB, wher

127 castor oil seeds (Ricinus communis) a novel, allosterically desensitized 910-kD Class-2 PEPC hetero-o

128 wo cancer-related mutations, G40E and S118I, allosterically destabilize the monomer and stabilize an

129 We found that glutathionylation of C408 allosterically destabilizes the active-like state of BAK

130 We propose that Ca(2+) binding allosterically destabilizes the terminal regions of C2al

131 dicate that S620T or S631A substitutions can allosterically disrupt drug binding by a mechanism that

132 small-molecule IRE1 kinase inhibitors either allosterically disrupt or stabilize the active dimeric u

133 The distal mutations resuscitate the allosterically driven conformational regulation and alte

134 rough an opening of the intracellular region allosterically elicited by the binding of the agonist.

135 hodox alpha-alpha nicotinic binding site can allosterically enhance the cholinergic pathway considere

136 n fatty acids stabilize the START domain and allosterically enhance Them1 catalysis of acyl-CoA, wher

137 he in vitro demethylase activity of KDM5A is allosterically enhanced by binding of its product, unmod

138 riments reveal conformational changes in the allosterically enhanced state.

139 istered leukadherin-1, a small molecule that allosterically enhances alphaMbeta2-dependent cell adhes

140 sical substrate for extracellular stimuli to allosterically gate the channel.

141 BiP and J-protein co-factors but appears to allosterically impair J protein-stimulated ATP-hydrolysi

142 Allosterically impaired CzrA mutants are characterized b

143 nine in the cytosolic AMT1 C terminus, which allosterically inactivates AMT1 trimers.

144 dern ncTrpA from Neptuniibacter caesariensis allosterically increases the activity of ncTrpB.

145 Three coexisting nucleotide states allosterically induce distinct positioning of tyrosines

146 n appended helical inhibitory module against allosterically induced unfolding.

147 Dihydropyridine binding allosterically induces an asymmetric conformation of the

148 Metal binding to a metalloregulator allosterically influences its ability to bind specific D

149 IKs by binding to an intersubunit space and allosterically influencing pore conductance and gating t

150 NSAIDs allosterically inhibit cytosolic sulfotransferases (SULT

151 ed a possible mechanism through which D2 can allosterically inhibit D1 activity.

152 t stabilize the bent conformation of tubulin allosterically inhibit Eg5 binding, consistent with a mo

153 Orco directed antagonists allosterically inhibit odorant activation of ORs and we

154 8-amine kinase inhibitors were discovered to allosterically inhibit the endoribonuclease function of

155 e ligands for the IRE1alpha kinase site that allosterically inhibit the endoribonuclease.

156 esolution structures have been solved for an allosterically inhibited and agonist-bound form of a fun

157 he first committed step of MK production, is allosterically inhibited by a downstream cytosolic metab

158 ubunit is that their ion channel activity is allosterically inhibited by a nano-molar concentration o

159 Moreover, we observed that DAH7PS is allosterically inhibited by prephenate, the product of t

160 While MTHFR has long been known to be allosterically inhibited by S-adenosylmethionine (SAM),

161 The enzyme is known to be allosterically inhibited by SAM for decades, but the imp

162 by reestablishing the catalytic activity of allosterically inhibited enzyme via modulation of the wo

163 onformational transition pathway between the allosterically inhibited form and the active form, we pr

164 rationalized by crystallographic analysis of allosterically inhibited L-lactate dehydrogenase.

165 osteric inhibitor, ifenprodil, represent the allosterically inhibited state.

166 Additionally, COX-1 is allosterically inhibited up to 50% by common FAs like pa

167 essing nuclease, forming a Cas12a dimer, and allosterically inhibiting DNA binding.

168 ity to maintain eIF2alpha phosphorylation by allosterically inhibiting protein phosphatase PP1:PPP1R1

169 destabilizes a hydrophobic core of GTL1N and allosterically inhibits 3(rd) helix docking to the SDD1

170 9 activation, whereas binding to active MMP9 allosterically inhibits activity.

171 to capital ES, Cyrillicys256 in one monomer allosterically inhibits the covalent binding of BV to th

172 of an autoinhibitory module, which in Ets-1 allosterically inhibits the DNA binding activity.

173 on a synthetic molecular pentafoil knot that allosterically initiates or regulates catalyzed chemical

174 classes of drugs bind to three separate, but allosterically interacting, receptor sites on CaV1.2 cha

175 rs of PU.1 that we developed specifically to allosterically interfere with PU.1-chromatin binding thr

176 s, but also engage in domain dissociation to allosterically invoke a downstream effect.

177 a and IL-2:IL-2Rgamma interactions, but also allosterically lowered the IL-2:IL-2Ralpha affinity thro

178 Although the disruption of this complex, allosterically mediated process has long been implicated

179 a mechanism for how scaffolding proteins can allosterically modify the output from a signaling pathwa

180 acts with the regulatory N-domain of cTnC to allosterically modulate Ca(2+) activation of force, perh

181 D2 antagonists allosterically modulate cannabinoid-induced CB1 coupling

182 tivity and support the hypothesis that RAMPs allosterically modulate CTR peptide affinity.

183 boxy-terminal domains that are positioned to allosterically modulate cytoplasmic Ca(2+) activation.

184 e in activating structural fluctuations that allosterically modulate functional signals.

185 s for similar, short bioactive peptides that allosterically modulate ligand-gated receptor function.

186 Last, we show that some SNPs allosterically modulate PCSK9's substrate sequence speci

187 Many neuroactive steroids potently and allosterically modulate pentameric ligand-gated ion chan

188 ls, the S4-S5(L) of DI, DII and DIII domains allosterically modulate the activation gate and stabiliz

189 hat bind to the regulatory Bateman domain to allosterically modulate the catalytic activity of eukary

190 ate that individual lipid-binding events can allosterically modulate the interactions of integral mem

191 ranscription factors, and nucleic acids that allosterically modulate the RNAP during the transcriptio

192 ensemble that adopt the structured motif is allosterically modulated both by the cis/trans isomeriza

193 TR of mRNA by HSC70, and its activity can be allosterically modulated by DCB-3503.

194 otein scaffolding organizing this process is allosterically modulated by the assembly protein Psb27,

195 g possibility of the rational engineering of allosterically modulated DNA origami.

196 additionally be evoked when the receptor is allosterically modulated in the presence of LUXendin645.

197 lity of its regulatory domains, which can be allosterically modulated through its ATP-binding site.

198 or understanding how opioid receptors can be allosterically modulated to guide the development of mor

199 uggest that hDAT transport properties may be allosterically modulated under conditions promoting dime

200 Homodimeric proteins that behave as allosterically modulated, functional heterodimers, the c

201 We analysed the operational model of allosterically-modulated agonism (OMAM) including modula

202 f huwentoxin-IV, a spider-venom peptide that allosterically modulates channel gating.

203 the molecular mechanism by which AMP and FBP allosterically modulates EcAGPase enzymatic activity sti

204 Cyclic AMP allosterically modulates HCN through the cAMP-dependent

205 Specifically, the lipid membrane allosterically modulates the activity of the embedded ki

206 eotide-controlled conformational switch that allosterically modulates the catalytic activity of eukar

207 eotide-controlled conformational switch that allosterically modulates the catalytic activity.

208 utagenesis and a chemical genetic method for allosterically modulating kinase global conformation to

209 insights regarding potential mechanisms for allosterically modulating KOR with nanobodies and a tool

210 strate to Na(+) release from the Na2 site by allosterically modulating the stability of a partially o

211 th traditional ligands and ligands that bind allosterically outside the orthosteric receptor binding

212 gle disease associated amino acid change may allosterically perturb several functional sites in an ol

213 in which the intracellular helix arrangement allosterically pinches the SF.

214 nctional assays propose that these compounds allosterically prevent narrowing of the drug-binding poc

215 e ultimate selectivity: They target MMP-9 by allosterically preventing activation of its zymogen.

216 other monomer, whereas the presence of Cys15 allosterically promotes BV binding to Cys256 in both mon

217 to Poz1 elicits structural changes in Poz1, allosterically promoting Rap1 binding to Poz1.

218 Changes in dynamics can allosterically propagate to the channel gate.

219 nal switch II causes structural changes that allosterically propagate to the hydrophobic core of the

220 monomerisation relieves a repressive effect allosterically propagated from the dimer interface to th

221 Thus, the glycan cap of GP1 may allosterically protect against inactivation of EBOV by p

222 t causes a global conformational change that allosterically realigns active-site residues, accelerati

223 335 increases potassium flow through KcsA by allosterically reducing inactivation of the channel.

224 Development of drugs that allosterically regulate enzyme functions to treat diseas

225 al structural features and interactions that allosterically regulate its proteolytic activity on von

226 sidues that, upon covalent modification, can allosterically regulate kinase activity and oligomerizat

227 Biological photosynthetic machinery allosterically regulate light harvesting via conformatio

228 he development of more potent molecules that allosterically regulate M(Pro) activity.

229 te rotation of the PAN-ATPase staircase, and allosterically regulate N-domain motions and CP gate ope

230 Various stimuli allosterically regulate PKM2 by cycling it between highl

231 The inserted domains allosterically regulate the active site, responding to r

232 e Ezh2 motif that responds to stimulation to allosterically regulate the active site.

233 Cyclic nucleotide-binding (CNB) domains allosterically regulate the activity of proteins with di

234 pADAMTS13 approach a "minimal" structure for allosterically regulated ADAMTS13.

235 AGPase activity is allosterically regulated by a series of metabolites in t

236 In addition, PdcA PDE activity is allosterically regulated by GTP, further linking c-di-GM

237 me in the histidine biosynthetic pathway, is allosterically regulated by histidine and offers a good

238 rtantly, the PopP2-RRS1-RWRKY association is allosterically regulated by InsP6 binding, suggesting a

239 through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-sp

240 3K9me3-binding of the murine proteins is not allosterically regulated by phosphatidylinositol 5-phosp

241 Here, we show that HDAC8 is allosterically regulated by shifts in populations betwee

242 The notion that protein function is allosterically regulated by structural or dynamic change

243 spread in proteobacteria and that the use of allosterically regulated C-terminal motifs could be a co

244 ity of the identified sites, we construct an allosterically regulated Cas9 by insertion of the estrog

245 Enzymes in heteromeric, allosterically regulated complexes catalyze a rich array

246 early stages of CME and show how sequential, allosterically regulated conformational changes activate

247 ., softening the hinges), thus impairing the allosterically regulated dynamics.

248 in vitro, suggesting that this enzyme may be allosterically regulated in vivo as well.

249 3 tumour suppressor is an example of such an allosterically regulated protein.

250 Rgg-type receptors are allosterically regulated through direct pheromone bindin

251 atalyzes the final step in glycolysis and is allosterically regulated to control flux through the pat

252 rrents through AMPA receptor channels can be allosterically regulated via different sites on the rece

253 An allosterically regulated, asymmetric receptor featuring

254 A-bound and the ligand-bound form, which are allosterically regulated.

255 These two conformations allow the TCRs to be allosterically regulated.

256 20 proteins experimentally identified to be allosterically regulated.

257 w Escherichia coli pyruvate kinase type 1 is allosterically regulated: the "domain rotation model" su

258 Mammalian alphaE-catenin is allosterically regulated: the monomer binds the beta-cat

259 a(2+)/CaM signal transduction mechanism that allosterically regulates DNA-binding activity of GT2-LIK

260 r how substrate DNA bound to one active site allosterically regulates the activity of the other.

261 DCB-3503 allosterically regulates the ATPase and chaperone activi

262 A neighboring X-module domain allosterically regulates the binding interaction and inh

263 findings from Hadzipasic et al: whether TPX2 allosterically regulates the oldest Aurora.

264 studies indicate that the RXRA substitution allosterically regulates the PPAR AF2 domain via an arom

265 e of the START domain as a lipid sensor that allosterically regulates Them1 activity and spatially lo

266 ites at the cytoplasmic face of the membrane allosterically regulating ANO1 channel gating.

267 nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus i

268 ich NMR approaches are best suited for which allosterically relevant questions.

269 de binding region and alpha3 domain of MHC I allosterically, resulting in enhanced peptide selector f

270 Drugs that allosterically shift the quaternary equilibrium from the

271 l during transcription likely occurs through allosterically stabilized histone-histone interactions.

272 NDP52 allosterically stimulates membrane-binding by FIP200 and

273 G-2 induces conformational changes in RAG-1, allosterically stimulating substrate binding and catalys

274 we identified the two separate elements that allosterically suppress otherwise constitutively active

275 proteolysis-targeting chimera (PROTAC) that allosterically target BCR-ABL1 protein and recruit the E

276 This Perspective provides an update on allosterically targeted class A GPCRs and their disease

277 m by which the dynamic TTD-PHD module can be allosterically targeted with small molecules to modulate

278 , as functionally-congruent features linking allosterically the ATP, DNA, and clamp binding sites: re

279 uggest their respective roles in controlling allosterically the conformation of the ligand binding po

280 of key mutations affect each half of the CP allosterically, they do not further couple opposite ends

281 gested that pharmaceuticals activate CYP46A1 allosterically through binding to a site on the cytosoli

282 forming a ternary complex likely facilitated allosterically through DNA.

283 esults indicate that many BAP1 mutations act allosterically to inhibit ASXH binding, thereby leading

284 gh affinity and that many BAP1 mutations act allosterically to inhibit BAP1-ASXL2 binding.

285 ures show that class-bridging mutations work allosterically to open up conformational plasticity at t

286 ilar pheromone-binding domain that functions allosterically to regulate receptor activity.

287 Each spiral couples allosterically to the ATPase and binds alternating, succ

288 respectively, on TbGMPR activity by binding allosterically to the CBS domain.

289 d receptors are vital membrane proteins that allosterically transduce biomolecular signals across the

290 across life, may use analogous strategies to allosterically trap transcription complexes in a moribun

291 e allosteric activation mechanism, G protein allosterically triggers an increase in the specific acti

292 We propose that DNA binding to the ARL allosterically triggers ATP hydrolysis in PriA.

293 e N-terminus (NT) of IP(3) receptor (IP(3)R) allosterically triggers the opening of a Ca(2+)-conducti

294 e polymerization functions as a mechanism to allosterically tune enzyme kinetics, and it may play a p

295 The ligand binding pockets are allosterically tuned by monoprotonation of the tren unit

296 t contains an overall activity site that can allosterically turn the enzyme on or off by the binding

297 uorenyl coordination motif, can be regulated allosterically via the binding of metal ions.

298 and Na2) and the I(-) binding site interact allosterically: when Na(+) binds to a Na(+) site, the af

299 RhoA displaces liprin-alpha3 allosterically, whereas DAD competes with liprin-alpha3

300 P-activated protein kinase (AMPK), interacts allosterically with AMP to maintain an active state.