ライフサイエンスコーパス: allotype

1 MHC-I molecules, human MHC-I HLA-A and HLA-B allotypes).

2 sion level of the patient's mismatched HLA-C allotype.

3 ance in C57BL/6 mice that express the FasL.1 allotype.

4 ial involvement in diseases noted in the EOM allotype.

5 nation of the mec class complex with the ccr allotype.

6 run and simultaneously determined the donor allotype.

7 yogenin and is a unique attribute of the EOM allotype.

8 which are restricted by the host HLA class I allotype.

9 ased on the expression of surface IgM and a2 allotype.

10 pluripotent stem cells (iPSCs) to the Pro33 allotype.

11 ose carrying the G1m3 with no G1m1 (G1m3,-1) allotype.

12 onor is leader-matched and shares a T leader allotype.

13 o adapt and positively respond to the foetal allotype.

14 stricted through one of nine different MHC I allotypes.

15 ity toward closely related or distinct HLA-I allotypes.

16 tested for binding to 95 HLA- A, -B, and -C allotypes.

17 xes bearing common variable segments and MHC allotypes.

18 and 402 was used to identify individual CFH allotypes.

19 compared with the respective related KIR3DL1 allotypes.

20 tide identification of HLA-DRB1, DQB1, and B allotypes.

21 pitope carried by subsets of HLA-A and HLA-B allotypes.

22 that KIR2DL1*003 bound all C2, and only C2, allotypes.

23 elop a protein-based method of detecting CFH allotypes.

24 nd a frictional ratio f/f(o) of 1.2 for both allotypes.

25 ctional differences that distinguish KIR3DL1 allotypes.

26 erimentally verified ligands across 19 HLA-I allotypes.

27 21 cells transfected with single HLA class I allotypes.

28 o compare the functional properties of the 2 allotypes.

29 Abs can be distinguished based on different allotypes.

30 ere derived from different kappa light chain allotypes.

31 sms shared by DPbeta1*0201 and other DPbeta1 allotypes.

32 NK cells that is specific for certain MHC-I allotypes.

33 erent specificities in downregulation of HLA allotypes.

34 HLA-E, whereas K3 downregulated all four HLA allotypes.

35 epitopes presented with various HLA class II allotypes.

36 topes and restriction by all six MHC class I allotypes.

37 eceptors that recognize HLA-Cw1, 3, 7, and 8 allotypes.

38 iatic family members such as HLA-C and HLA-B allotypes.

39 st melanomas endogenously expressing HLA-Bw4 allotypes.

40 s inhibited by the combination of autologous allotypes.

41 other KIR reacting with both groups of HLA-C allotypes.

42 lanomas co-expressing HLA-A*0201 and HLA-Bw4 allotypes.

43 described binding motif for multiple HLA-DR allotypes.

44 dome from cells expressing more active ERAP1 allotypes.

45 Bonobo populations have 3-14 Papa-B allotypes.

46 lebo, these three Papa-B are the only Papa-B allotypes.

47 ectively expressed 27 high-frequency HLA-A,B allotypes.

48 adjacent regions and presented by different allotypes.

49 NK clones expressing these specific KIR3DL1 allotypes.

50 n fields of developing cells with compatible allotypes.

51 of strongly tapasin-dependent or independent allotypes.

52 cell recognition for several different MHC I allotypes.

53 To test this hypothesis, we serologically allotyped 100 persons with well-documented clearance of

54 rheumatoid factor activity against IgG2a of allotype a present in BALB/c, but not C57BL/6, mice.

55 We immunized non-lupus-prone mice with 11 allotype "a" of IgG2a (IgG2a(a)) and 4 IgG2c nonadjuvant

56 We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV)

57 one lineage of conserved activating KIR3DS1 allotypes, also implicated in Bw4 recognition.

58 Ig allotype analysis revealed that rotavirus-specific IgA w

59 Allotype and isotype exclusion is a property of most lym

60 ge was linked to the Igh(a), but not Igh(b), allotype and was associated with induction of relatively

61 Conversely, Km allotypes and CD32B or CD32C expression on NK cells did

62 antibodies specific for donor and host CD45 allotypes and for CD3.

63 ex stability of a large panel of human MHC-I allotypes and generated a body of data sufficient to dev

64 Gm allotypes and phenotypes were determined by the hemagglu

65 nscriptional pathway for regulation of HLA-A allotypes and provide a link between ubiquitination and

66 urface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expre

67 tly greater self-association than the Tyr402 allotype, and small amounts of dimeric SCR-6/8 were foun

68 amyloid angiopathy, apolipoprotein E (ApoE) allotype, and synaptophysin concentration in entorhinal

69 position 2 or 3 with high variances between allotypes, and a less variable anchor at the C-terminal

70 e inhibited by individual autologous class I allotypes, and every clone was inhibited by the combinat

71 ping, staphylococcal cassette chromosome mec allotyping, and vancomycin and teicoplanin MICs were per

72 fic for HLA-C, but that recognition of HLA-C allotypes appears more permissive than indicated by prev

73 that PIR molecules bearing the paternal PIR allotype are expressed whereas PIR-A and PIR-B molecules

74 R-A and PIR-B molecules bearing the maternal allotype are not.

75 ts with mutant bas and wild-type parental b9 allotypes are excellent sources for therapeutic monoclon

76 or a peptide to bind to specific HLA class I allotypes are important for selecting the most promising

77 Although a minority of HLA-A and -B allotypes are KIR ligands, HLA-C allotypes dominate this

78 HLA-C allotypes are ligands for the inhibitory KIRs (iKIRs) KI

79 In addition, HLA-C allotypes are recognized by killer cell Ig-like receptor

80 The wide-ranging properties of KIR allotypes arise from substitutions throughout the KIR mo

81 vitro refolded forms of tapasin-independent allotypes assemble more readily with peptides compared t

82 l variation between human IgG subclasses and allotypes at three amino acid positions (Lys/Asn-392, Va

83 to express a superantigen reactive to IgM of allotype b (IgM(b)).

84 er of V(H)n B cells decreases, whereas V(H)a allotype B cells increase in number and become predomina

85 ogenously processed ligands that bind to the allotypes B*1508, B*1501, and B*1503, but not B*1510.

86 l HSV-1 infection is modified by MHC class I allotypes (B*18, C*15, and the group of alleles encoding

87 , notably Cw*0501 and Cw*0202, and two HLA-B allotypes (B*4601 and B*7301) that share polymorphisms w

88 molecular basis for the appearance of V(H)a2 allotype-bearing B cells in mutant Alicia rabbits.

89 ositive selection results in expansion of a2 allotype-bearing B cells in the appendix of young mutant

90 er competitor for endogenous IgG1 in G1m3,-1 allotype-bearing patients.

91 The V(H)1 gene is the major source of V(H)a allotype because this gene is preferentially rearranged

92 Under conditions of peptide deficiency, both allotypes bound efficiently to TAP and tapasin, and furt

93 peptides, which varies in efficiency between allotypes, but the mechanism of selection is unknown.

94 characterized plasma fibrinogen Aalpha-chain allotypes by electrospray ionization mass spectrometry m

95 This selective downregulation of HLA allotypes by K5 was partly due to differences in amino a

96 ion for differential downmodulation of MHC-I allotypes by Nef.

97 KIR3DL1*004, a common allotype, cannot be detected on the surface of PBLs usin

98 For example, the IgA2m(1) allotype carries an unusual heavy and light chain pairin

99 serine 77 and asparagine 80, bound to HLA-C allotypes carrying either amino acid motif.

100 Using mixed-allotype chimeras and retroviral-mediated gene transduct

101 rvival is partially explained by findings in allotype chimeras that broadly cross-reactive B-1 cell-d

102 ted gnotobiotic and conventionally reared Ig allotype chimeric mice.

103 2 for grade 2-4) and with an M leader shared allotype compared with a T leader shared allotype (OR 1.

104 ipients who have one or two C1-bearing HLA-C allotypes, compared with C2 homozygous recipients, with

105 In this study, PrP allotype composition in protease-resistant prion protein

106 which express the IgM(b) allotype) to IgM(a) allotype congenic mice.

107 g cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the

108 lts show, for the first time, that GM and KM allotypes contribute to the interindividual differences

109 ompatibility leukocyte antigen (HLA) class I allotypes contributes to the array of receptor-ligand in

110 The leader of the matched allotype could be considered to be as important as the l

111 entire MAP repertoire presented by these 27 allotypes covered only 10% of the exomic sequences expre

112 ns (defined by serologic markers known as Gm allotypes), cytokines and their receptors, and certain p

113 istinct peptides than do tapasin-independent allotypes, data supported by computational predictions.

114 es colony of rabbits that were pedigreed, Ig-allotype defined, but not inbred.

115 resonance and KIR binding to a panel of HLA allotypes demonstrated that KIR2DL3*005 differed signifi

116 kappa-chain (IGKC) polymorphisms determining allotypes designated G1m and Km.

117 2 IgA rheumatoid factor bearing the same IgA allotype, developed mesangial deposits consisting of IgA

118 aled little Patr-AL polymorphism: just three allotypes differing only at residues 52 and 91.

119 notyped for FCGR3A158 (the FcgammaRIIIa-158F allotype displays a lower Fc binding affinity) using the

120 th a higher binding score for a specific HLA allotype does not necessarily imply it will be immunogen

121 LA-A and -B allotypes are KIR ligands, HLA-C allotypes dominate this regulation, because they all car

122 We found that compatibility of the allotype encoded by the tgrB1 and tgrC1 genes is require

123 Ig gamma marker (GM) allotypes, encoded by highly polymorphic IGHG genes on c

124 ayed in mutant ali/ali rabbits because the a-allotype encoding V(H)1 gene, which is normally used in

125 and instead, most B-lineage cells use the a-allotype encoding V(H)4 gene [V(H)4(a)], which results i

126 psoriatic arthritis susceptibility, and that allotypes encoding P2 pockets that bind side chains oppo

127 Furthermore, CD16A-158V and G1m3 allotypes enhanced ADCC against opsonized HSV-1-infected

128 ith the observation that all orangutan MHC-C allotypes examined have the C1 motif.

129 finity for IgG, all of the rhesus FcgammaR3A allotypes exhibited responses most similar to the higher

130 at uses primarily the long 3'UTR, whereas an allotype expressing only the short form was unaffected.

131 as important as the leader of the mismatched allotype for GVHD.

132 Caucasian subjects with gastric cancer were allotyped for several GM and KM markers.

133 ement for a combination of at-risk DR and DQ allotypes for the initiation of spontaneous autoimmunity

134 d to determine possible protective candidate allotypes for vaccine development.

135 ot necessarily correlate with the potency of allotype function.

136 Because every HLA-C allotype functions as a ligand for KIR, the interactions

137 Comparative peptide mapping of these B15 allotypes further pinpoints endogenously processed ligan

138 weaker for IgG3 than for IgG4 in the case of allotype G3m(c3c5*/6,24*), whereas G3m(s*/15*) was equal

139 ussed, along with the influence of Km and Gm allotype genes on pneumococcal polysaccharide vaccines.

140 gastric cancer is associated with GM and KM allotypes, genetic markers of IgG heavy chains and kappa

141 mined the role that immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, res

142 Immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, res

143 omain, where 3DL1*004 resembles 3DL1*005, an allotype giving low DX9-binding phenotype.

144 Immunoglobulin gamma-chain allotypes Gm(1), Gm(17) (odds ratio for both 11.3, P = 0

145 The GM 13 allotype has been confirmed as a risk factor in Caucasia

146 sent only on some haplotypes, and each MHC-C allotype has the C1-epitope.

147 ides bound to HLA-DQ and, especially, HLA-DR allotypes have been described in some detail, few ligand

148 The five common Japanese KIR3DLI allotypes have distinguishable inhibitory capacity, freq

149 All MHC-B*08 allotypes have the C1-epitope motif recognized by killer

150 gnized by killer cell Ig-like receptors, and allotypes having neither epitope.

151 hey are each of a different functional type: allotypes having the Bw4 epitope recognized by killer ce

152 y killer cell Ig-like receptors of NK cells, allotypes having the C1 epitope also recognized by kille

153 Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interact

154 K) and the presence of its ligand, the HLA-C allotype HLA-C2, expressed by fetal trophoblasts, reduce

155 luding the non-disease-associated/protective allotypes HLA-B*27:06 and HLA-B*27:09.

156 the specific recognition of the MHC class I allotypes HLA-Cw*0401 and HLA-Cw*0304 by the killer cell

157 ability of the eight most prevalent HLA-B27 allotypes (HLA-B*27:02 to HLA-B*27:09) to form homodimer

158 However, owing to differences across KIR3DL1 allotypes, HLA-Bw4, and associated peptides, the mechani

159 Compared with other classical MHC-I allotypes, HLA-C has low cell surface expression and an

160 nstrate that the peptides bound by these B15 allotypes i) vary in length from 7 to 12 residues, and i

161 cells transfected with different HLA class I allotypes (i.e., -Cw4, -Cw3, -B7) confirmed that the inh

162 Complete allotype identification and designation of its respectiv

163 However, as Alicia rabbits age, VHa2 allotype Ig is produced at high levels.

164 , IgA1 and IgA2, with IgA2 existing as three allotypes, IgA2m(1), IgA2m(2) and IgA2(n).

165 s, IgA1 and IgA2, with IgA2 present as three allotypes: IgA2m(1), IgA2m(2), and IgA2m(n).

166 bound immunoglobulin E antibodies of the 'b' allotype (IgE(b)) as well as IgG2a and IgG2b antibodies.

167 eptor is a RF that recognizes IgG2a of the j allotype (IgG2aj), but not the b allotype, was used in t

168 lls in neonatal Alicia rabbits express V(H)n allotype immunoglobulin (Ig)M.

169 have shown for various HLA alleles, the HLA allotype impacts the composition of the microbiome.

170 HLA-C expression, was assigned to each HLA-C allotype in 1975 patients and their HLA-C-mismatched unr

171 ll response in the context of the Mamu-B*008 allotype in SIV-infected rhesus macaques.

172 ounts of dimeric SCR-6/8 were found for both allotypes in 50 mM, 137 mM and 250 mM NaCl buffers.

173 mbinations were selected in which measurable allotypes in donors were not present in recipients.

174 CR1 has an array of allotypes in human populations and using traditional rec

175 ic analysis cannot be used for measuring CFH allotypes in some sources of human plasma and other biol

176 emonstrates how a difference between KIR3DL1 allotypes in the D0 domain profoundly affects cell surfa

177 HLA-DP401, one of the most frequent class II allotypes in white populations(4).

178 KIR3DL1*004, a common KIR3DL1 allotype, in combination with Bw4(+) HLA-B, slows progre

179 es is possible for virtually all MHC class I allotypes; in comparison, current MHC class II (MHC-II)

180 expressing two different Ig kappa L chains (allotype included) have been occasionally observed.

181 mmary, our studies demonstrate that Ig kappa allotype-included B cells are present in the mouse matur

182 Abs, our studies suggest a potential role of allotype-included B cells in both physiological and path

183 Finally, we found that Ig allotype-included B cells that coexpress autoreactive an

184 y to form homodimers compared with all other allotypes, including the non-disease-associated/protecti

185 nt to FcgammaRIIIA (both Phe-158 and Val-158 allotypes), increased ADCC activity in vitro, and strong

186 , along with Ii's compact 118-192 domain, to allotype-independent class II binding.

187 in the heavy chain, as expected, since these allotypes inhibit lysis by NK cells expressing KIR2DL1.

188 Featured among the selected clones with b9 allotype is a rabbit/human Fab that binds with a dissoci

189 The FasL.2 allotype is expressed in BALB/c mice and exhibits increa

190 *004 membrane traffic in NK cells shows this allotype is largely misfolded but stably retained in the

191 The prevalence of specific ERAP1 allotypes is different between AS cases and controls.

192 ression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-

193 , reduced aggregation of tapasin-independent allotypes is observed.

194 major pathway for the clearance of all IgA2 allotypes is the liver.

195 ch differentiates HLA-B*27:03 from all other allotypes, is responsible for its compromised ability to

196 l experiment, we found that the rare KIR3DS1 allotype KIR3DS1*014 binds HLA-Bw4 even though it differ

197 (odds ratio 7.3, P = 0.005) and kappa-chain allotype Km(3) (odds ratio 7.3, P = 0.005) were risk fac

198 Allotype-marked chimeras indicated that autoantibody pro

199 system in which mice were reconstituted with allotype-marked mature peritoneal B-1a cells and adult b

200 Using allotype markers, it is possible to adoptively transfer

201 It was concluded that the His402 allotype may self-associate more readily than the Tyr402

202 protein that are presented with diverse HLA allotypes may allow widespread protective immunization w

203 rred from recipient plasma CFH Y402H protein allotype, measured using enzyme-linked immunosorbent ass

204 Because IgG1 allotypes might have different half-lives, their influen

205 ain causes Pt-KIR3DL1/2 to bind Bw4(+) HLA-B allotypes more avidly than does KIR3DL1.

206 nctional similarities to HLA-B*57, the human allotype most strongly associated with delayed HIV-1 pro

207 le rule through interactions with several C2 allotypes, notably Cw*0501 and Cw*0202, and two HLA-B al

208 from donors who were homozygous for the H131 allotype of Fcy receptor IIa (CD32), it was found that L

209 phenotype of mice lacking Ii depends on the allotype of the MHC class II molecule.

210 odies against the human platelet Ag (HPA)-1a allotype of the platelet beta(3) integrin GpIIb/IIIa can

211 (Arg(102)) and disease-linked C3F (Gly(102)) allotypes of C3b were experimentally explained for the f

212 ve Tyr402 and the AMD-risk His402 homozygous allotypes of FH and both the recombinant SCR-6/8 allotyp

213 tions, reporter cell lines expressing common allotypes of human and rhesus macaque FcgammaR2A and Fcg

214 CMA restored expression of diverse allotypes of MHC-I in Nef-expressing cells and inhibited

215 he unique genes in USA300 clustered in novel allotypes of mobile genetic elements.

216 Whereas allotypes of rhesus FcgammaR2A were identified with resp

217 is a highly polymorphic molecule comprising allotypes of single nucleotide polymorphisms.

218 Allotypes of the natural killer (NK) cell receptor KIR3D

219 r and their HLA ligands, and CD16A and CD32A allotypes of variable affinity for IgG subclasses were a

220 or KIR2DL3 (KIR2DL2/3) with HLA-Cw3-related allotypes on melanomas resulted in decreased tumor cell

221 red allotype compared with a T leader shared allotype (OR 1.98, 1.39-2.81; p=0.0001 for grade 3-4).

222 are codominantly expressed, and analysis of allotype pairs provided clear stratification of individu

223 Functional analyses demonstrated that ERAP1 allotype pairs seen in AS cases were poor at generating

224 ives, their influence on infliximab (G1m17,1 allotype) pharmacokinetics was investigated in a group o

225 Recipient plasma CFH Y402H protein allotype predicted donor CFH Y402H genotype with 100% ac

226 The macaque A2*05 allotype prefers the basic amino acid arginine at the se

227 ed subjects indicates that tapasin-dependent allotypes present a more limited set of distinct peptide

228 on, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is

229 7 substitution represents yet another Ckappa allotype, provisionally designated Km4.

230 tting technique was used to estimate the two allotype PrP fractions in PrP(res) material from BSE-inf

231 long with KIR specificity for particular HLA allotypes, raises the possibility that any given individ

232 bset responses were defined by donor KIR/HLA allotypes, reflecting the differences in interaction bet

233 tides endogenously bound by a group of HLA-B allotypes related to HLA-B7.

234 m effect is quite different although the ARR allotype remains the least susceptible.

235 ore, endogenous peptide loading into the B15 allotypes requires that a conserved C terminus be anchor

236 n of the NK cell receptor KIR3DL1 by HLA-Bw4 allotypes resulted in inhibition of cytotoxicity against

237 Comparing two MHC allotypes revealed allotype-specific differences in hydr

238 self-associate more readily than the Tyr402 allotype, SCR-6/8 is partly responsible for the folded-b

239 B*1501, B*1503, and B*1508 because these B15 allotypes share identical C-terminal anchoring pockets w

240 The His402 allotype showed a slightly greater self-association than

241 stent with previous findings that some HLA-B allotypes shown to be tapasin independent are associated

242 For some allotypes, single evasins largely abolished T cell recog

243 All isolates had the same speA allotype, speA2.

244 -6.1 and Ly-6.2) Ab with a mouse anti-Ly-6.2 allotype specific Ab, with emphasis on both Ly-6.2 and L

245 lecules are ternary complexes composed of an allotype specific heavy chain, a noncovalently associate

246 ion in these mice was hapten-, carrier-, and allotype-specific as well as MHC restricted.

247 uced by each donor could be distinguished by allotype-specific assays.

248 Comparing two MHC allotypes revealed allotype-specific differences in hydrogen-deuterium exch

249 her distinguished by its dependence on MHC-I allotype-specific epitope recognition for Ag uptake.

250 t different HCMV evasins exhibited different allotype-specific patterns of interference with CD8 T ce

251 as responsible for the post-transcriptional, allotype-specific regulation of MHC-I.

252 r analysis enables us to provide a model for allotype-specific T cell recognition of Ld vs Kb class I

253 the CD8 T cell evasins of HCMV display MHC I allotype specificity, complementarity, and cooperativity

254 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.

255 ttering also showed that both FH and SCR-6/8 allotypes strongly aggregated at >10 muM zinc.

256 th those obtained previously for other HLA-B allotypes, suggest a general trend whereby polymorphism

257 ll lines transfected with HLA-Bw4 80I or 80T allotypes, suggesting that if KIR3DS1 does recognize HLA

258 2DS), did not bind to any of the HLA class I allotypes tested.

259 -life in patients homozygous for the G1m17,1 allotypes than in those carrying the G1m3 with no G1m1 (

260 opes presented by the protective HLA-B*57:01 allotype that facilitate productive interactions with KI

261 RNA increased surface expression of an HLA-A allotype that uses primarily the long 3'UTR, whereas an

262 human dietary change influenced selection of allotypes that affect CHC22's role in metabolism and hav

263 We quantified tapasin dependence of all allotypes that are common in European and African Americ

264 For those orangutan MHC class I allotypes that are detected by human monoclonal anti-HLA

265 pecific clones recognize two groups of HLA-C allotypes that are distinguished by a dimorphism at resi

266 with peptides compared to tapasin-dependent allotypes that belong to the same supertype, and, during

267 o lineages of polymorphic inhibitory KIR3DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A

268 d seven members of the B15 family shows that allotypes that share sequence identity in the alpha 1 he

269 rtoire presented by a protective HLA class I allotype, thereby enhancing our mechanistic understandin

270 th protective and disease-associated HLA-B27 allotypes to form homodimers and the failure of HLA-B*27

271 sed STAT5b-CA mice (which express the IgM(b) allotype) to IgM(a) allotype congenic mice.

272 r human subclasses, including polymorphisms (allotypes), using real-time monitoring of Fab arm exchan

273 A set of four allotype variants of adalimumab (G1m17,1; G1m17,-1; G1m3

274 four human IgG subclasses shows subclass and allotype variations but no clear subclass affinity diffe

275 Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in t

276 Of interest, the GM 13 allotype was a risk factor for juvenile DM in both Cauca

277 The transgene allotype was also expressed in Abs formed on immunizatio

278 sion level of the patient's mismatched HLA-C allotype was associated with increased risks of grades I

279 autoimmune C57BL/6 background, the transgene allotype was expressed on B cell surfaces and in serum I

280 In addition, although no Gm phenotype or allotype was identified as a risk factor in whites, Gm 2

281 In some instances, an additional allotype was present in a recipient but not in a donor.

282 odies (OR 3.4, Pcorr=0.0031), while the GM 3 allotype was protective in adults with anti-threonyl-tra

283 t epitopes presented by the same given MHC I allotype was uniformly reduced.

284 of expression of patients' and donors' HLA-C allotypes was evaluated in multivariable models.

285 or KIR2DL3 in combination with group 1 HLA-C allotypes was more frequent in exposed seronegative avir

286 2a of the j allotype (IgG2aj), but not the b allotype, was used in this study to investigate how the

287 1 and DQA1 alleles, and immunoglobulin Gm/Km allotypes were compared between 138 Mestizos with IIM an

288 rs for IIM in Mestizos; however, no Gm or Km allotypes were risk or protective factors in Caucasians.

289 and DQB1 oligotyping, as well as C4 and CR1 allotyping, were carried out by standard methods.

290 In contrast, HLA-A allotypes, which have a Bw4 motif identical with one of

291 ence on peptide-binding specificity of HLA-B allotypes, while amino acid substitutions in the alpha 2

292 C3b, C3u, C3c, and C3d, using the wild-type allotype with Arg(102).

293 this study, was shown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233.

294 resulting in CD16A-valine/phenylalanine-158 allotypes with different IgG affinity, variations condit

295 Thus, genes encoding allotypes with diminished activity have been suggested a

296 s of mAbs, the interaction of different IgG1 allotypes with FcRn was examined using cellular assays a

297 confined to D0, KIR3DS1 is rare and KIR3DL1 allotypes with similar binding sites predominate.

298 types of FH and both the recombinant SCR-6/8 allotypes with Tyr/His402.

299 hierarchies of specificity for each KIR3DL1 allotype, with KIR3DL1*005 recognizing the widest array

300 ed a small number of cells with incompatible allotypes within fields of developing cells with compati