ライフサイエンスコーパス: alpha B-crystallin

1 and was observed, which comigrated with lens alpha B-crystallin.

2 its purified subunits alpha A-crystallin and alpha B-crystallin.

3 d by alpha-crystallin, alpha A-crystallin or alpha B-crystallin.

4 finally treated with the heat shock protein alpha-B crystallin.

5 ion of highest homology between alpha A- and alpha B-crystallins.

6 was designed to investigate if TM expresses alpha B-crystallin, a small heat-shock protein with chap

7 of a variety of proteins including FLNc and alpha-B-crystallin, a finding (confirmed by immunofluore

8 alpha A-crystallin (alpha A) and alpha B-crystallin (alpha B) are among the predominant p

9 of the protective small heat shock protein, alpha B-crystallin (alpha BC), in cultured cardiac myocy

10 PKN induced phosphorylation of alpha B crystallin and increased cardiac proteasome acti

11 PKN mediates phosphorylation of alpha B crystallin and stimulation of proteasome activit

12 -> Arg, Thr144-->Arg, Ser59-->Ala mutants of alpha B-crystallin and double mutants Ser45-->Ala/Ser59-

13 used by small heat shock proteins, including alpha B-crystallin, and (ii) fragmentation due to mechan

14 Small heat shock proteins (sHSP), HSP27 and alpha-B-crystallin are co-localized to synapses and astr

15 much of the serological data used to assign alpha B-crystallin as an autoantigen.

16 nduces genes for heat shock proteins (HSP70, alpha B-crystallin), as well as enzymes and transporters

17 also demonstrate that ectopic expression of alpha B-crystallin, but not the closely related small he

18 rived from these eyes, were investigated for alpha B-crystallin by immunohistochemistry, two-dimensio

19 In both species, alpha B-crystallin could be detected in fresh and cultur

20 hree human CNS proteins: anoctamin-2 (ANO2), alpha-B crystallin (CRYAB), and glial cellular adhesion

21 nse mutation in the small heat shock protein alpha-B-crystallin (CryAB(R120G)) causes desmin-related

22 nse mutation in the small heat shock protein alpha-B-crystallin (CryAB) causes desmin-related cardiom

23 The R120G mutation in alpha-B-crystallin (CryAB) causes DRM and is characteriz

24 Furthermore, the patterns of alpha A- and alpha B-crystallin expression in the lens are distinctiv

25 amma amino butyric acid and the lens protein alpha B crystallin, have intriguing and distinct functio

26 For 15 y, alpha B-crystallin (heat shock protein [Hsp] B5) has bee

27 ocardium, confocal laser microscopy revealed alpha-B crystallin in subsarcolemmal aggresomes.

28 Taken together, our findings indicate that alpha B-crystallin is a novel negative regulator of myog

29 e expression of the small heat shock protein alpha B-crystallin is selectively induced in C2C12 myobl

30 ed exercise-dependent increases in HSP27 and alpha-B-crystallin levels.

31 Semiquantitation of alpha B-crystallin messenger RNA (mRNA) or protein was o

32 Overexpression of alpha B-crystallin might be an important mechanism for T

33 ts are most abundant in the fiber cells, and alpha B crystallin mRNA is preferentially expressed in e

34 An increase in alpha B-crystallin mRNA also was observed after oxidativ

35 ally processed, and assayed for alpha A- and alpha B-crystallin mRNA expression by in situ hybridizat

36 two sizes (approximately 0.8 and 1.1 kb) of alpha B-crystallin mRNA in Northern blots.

37 heat shock caused a significant increase in alpha B-crystallin mRNA with a peak after 4 hours.

38 ore, we show that the myopathy-causing R120G alpha B-crystallin mutant is partly impaired in its cyto

39 ve function, whereas a pseudophosphorylation alpha B-crystallin mutant that mimics stress-induced pho

40 ardiomyocyte-specific expression of a mutant alpha-B-crystallin, mutant CryAB (CryAB(R120G)), which s

41 Finally, we demonstrate that alpha B-crystallin negatively regulates apoptosis during

42 Transcription of alpha B-crystallin precedes the expression of alpha A-cr

43 igh cardiomyocyte stiffness was corrected by alpha-B crystallin probably through relief of titin aggr

44 eins: two members of the HSP70 family, three alpha B-crystallin-related small heat shock proteins (HS

45 alpha-B crystallin shifted the Fpassive-sarcomere length

46 In contrast, alpha B-crystallin transcripts are present in retinal pi

47 During ocular development, alpha B-crystallin transcripts are present in the lens p

48 ohistochemistry of fresh samples showed that alpha B-crystallin was expressed predominantly in the cr