ライフサイエンスコーパス: alpha(2) adrenergic receptor

1 in for adenylyl cyclase, in complex with the alpha2 adrenergic receptor.

2 h Galphaz coupled strongly to the endogenous alpha2 adrenergic receptor.

3 K1/2 is inhibited by epinephrine through the alpha2-adrenergic receptor.

4 restin is required for ERK activation by the alpha2-adrenergic receptor.

5 inhibition of presynaptic TRPV1 channels by alpha2 adrenergic receptors.

6 y yohimbine, consistent with contribution of alpha2 adrenergic receptors.

7 irming that it was mediated by activation of alpha2 adrenergic receptors.

8 ecline (PHFD) requires central activation of alpha2-adrenergic receptors.

9 n is specific for post-junctional alpha1- or alpha2-adrenergic receptors.

10 ined whether this was specific to alpha1- or alpha2-adrenergic receptors.

11 otein expression of NE transporter (NET) and alpha(2) adrenergic receptor.

12 that control song contain high densities of alpha(2)adrenergic receptors.

13 ted secretion, in the cell surface export of alpha(2)-adrenergic receptors.

14 morphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptors.

15 a(1)- and beta-adrenergic receptors, but not alpha(2)-adrenergic receptors.

16 hat it is primarily mediated by postsynaptic alpha(2)-adrenergic receptors.

17 GABAB receptors and alpha2-adrenergic receptors (activated by bath applicati

18 olin-stimulated cAMP accumulation induced by alpha(2)-adrenergic receptor activation is altered follo

19 G(i/o)-coupled somatostatin or alpha2-adrenergic receptor activation stimulated beta-ce

20 ed the impact of a dexmedetomidine infusion (alpha(2)-adrenergic receptor agonist) on muscle sympathe

21 This study tests whether clonidine, an alpha(2)-adrenergic receptor agonist, alters excitatory

22 ergic receptor antagonist, prazosin, and the alpha(2)-adrenergic receptor agonist, clonidine, reduced

23 ng a baseline condition and an infusion of a alpha(2)-adrenergic receptor agonist, dexmedetomidine (1

24 ne content in the pancreas and blocked by an alpha(2)-adrenergic receptor agonist, implicating functi

25 ohimbine (1.0 microm), and attenuated by the alpha(2)-adrenergic receptor agonist, UK 14,304 (1.0 mic

26 otein kinase activity induced by UK14304, an alpha(2)-adrenergic receptor agonist.

27 te whether transdermal administration of the alpha2 adrenergic-receptor agonist, clonidine, can be us

28 In humans, the alpha2-adrenergic receptor agonist clonidine increases d

29 the NRe and HPC through the infusion of the alpha2-adrenergic receptor agonist UK 14,304 impaired re

30 ermal administration of the centrally acting alpha2-adrenergic receptor agonist, clonidine), and hypo

31 Significance statement: Clonidine, an alpha2-adrenergic receptor agonist, which decreases the

32 Whether alpha2-adrenergic receptor agonist-based sedation, compa

33 e is reduced responsiveness to alpha(1)- and alpha(2)-adrenergic receptor agonists in skeletal muscle

34 mpatholytic effects we observed suggest that alpha2 adrenergic-receptor agonists may offer a pharmaco

35 ), partial agonists (eg, buprenorphine), and alpha2-adrenergic receptor agonists (eg, clonidine and l

36 alpha2-Adrenergic receptor agonists increase in potency

37 syndrome indicates that chronic exposure to alpha2-adrenergic receptor agonists produces strong depe

38 ess in the anti-allodynic effect elicited by alpha2-adrenergic receptor agonists.

39 sly identified spinophilin as a regulator of alpha(2) adrenergic receptor (alpha(2)AR) trafficking an

40 receptor) and inhibitory (Galpha(i)-mediated alpha(2)-adrenergic receptor (alpha(2)-AR)) signals to a

41 The alpha(2)-adrenergic receptor (alpha(2)AR) subtypes A and

42 d the role of the extracellular N termini of alpha(2)-adrenergic receptors (alpha(2)-ARs) in the ante

43 The alpha(2)-adrenergic receptors (alpha(2)-ARs) modulate no

44 olateral localization and trafficking of the alpha(2)-adrenergic receptors (alpha(2)AR) are not; inst

45 alpha(2)-adrenergic receptors (alpha(2)AR) couple to mul

46 everal studies have shown that activation of alpha(2)-adrenergic receptors (alpha(2)ARs) leads to mil

47 The alpha(2)-adrenergic receptors (alpha(2)ARs) play a criti

48 The alpha2 adrenergic receptor (alpha(2)-AR) antagonist yohi

49 ers in cognition and emotion, by alpha1- and alpha2-adrenergic receptors (alpha1-ARs, alpha2-ARs) in

50 alpha2 adrenergic receptor (alpha2-AR) agonists have bee

51 Activation of inhibitory alpha2-adrenergic receptors (alpha2-A(R)) with UK-14,304

52 Here we show that agonists of alpha2-adrenergic receptors (alpha2-AR) have very strong

53 ole of arrestins in the trafficking of human alpha2-adrenergic receptors (alpha2-ARs) and the effect

54 the evolutionary precursor to the vertebrate alpha2-adrenergic receptors (alpha2-ARs) based upon sequ

55 the regulation of cell surface transport of alpha2-adrenergic receptors (alpha2-ARs) by GGA3 (Golgi-

56 strates subserving the inhibitory actions of alpha2-adrenergic receptors (alpha2-ARs) in the locus co

57 alpha2-Adrenergic receptors (alpha2-ARs) mediate a numbe

58 We report that two subtypes of alpha2-adrenergic receptors (alpha2A/D- and alpha2C-AR)

59 ve, and sympatholytic responses in vivo, and alpha2 adrenergic receptor (alpha2AR) agonists are used

60 is study, we investigated how NE release and alpha2-adrenergic receptor (alpha2AR) modulation influen

61 The alpha2-adrenergic receptor (alpha2AR) subtype alpha2C10

62 alpha2-Adrenergic receptors (alpha2ARs) are essential co

63 The alpha2-adrenergic receptors (alpha2ARs) are localized to

64 alpha2-Adrenergic receptors (alpha2ARs) present in the b

65 ined the selectivity of interactions between alpha2-adrenergic receptors (alpha2R) and various combin

66 Norepinephrine and CGRP act through the alpha(2)-adrenergic receptor and CGRP receptor, respecti

67 Concurrently, alpha(2)-adrenergic receptor and TNFalpha-induced inhibi

68 generate unconsciousness selectively through alpha2-adrenergic receptors and related circuits.

69 ng properties on I1 imidazoline receptors vs alpha2-adrenergic receptors and their blood pressure eff

70 sors are tested for the beta2-, alpha1-, and alpha2- adrenergic receptors, and adenosine type 1 recep

71 rolled by negative feedback from presynaptic alpha2-adrenergic receptors, and the targets of the rele

72 (iv) NA overflow for MA was enhanced by the alpha(2)-adrenergic receptor antagonist, yohimbine (1.0

73 bolished the proepileptogenic actions of the alpha2 adrenergic receptor antagonist idazoxan.

74 Yohimbine, an alpha2 adrenergic receptor antagonist, is a well-validat

75 factor 1 (CRF1) antagonist (antalarmin), and alpha2-adrenergic receptor antagonist (yohimbine; used a

76 d PLD activity was completely blocked by the alpha2-adrenergic receptor antagonist rauwolscine and by

77 mmonis 3 (CA3) epileptiform activity through alpha(2) adrenergic receptor (AR) activation on pyramida

78 regulating trafficking and signaling of the alpha(2)-adrenergic receptor (AR) both in vitro and in v

79 In NIH-3T3 alpha(2)-adrenergic receptor (AR) transfectants, the alp

80 can be reversed by a potent centrally acting alpha2 adrenergic receptor (AR) agonist (dexmedetomidine

81 Activation of the beta2- and alpha2-adrenergic receptors (AR) involves hydrogen bondi

82 alpha2-adrenergic receptors (AR) within the bed nucleus

83 beta- and alpha(2)-adrenergic receptors are known to exhibit subst

84 ediated via both post-junctional alpha1- and alpha2-adrenergic receptors are blunted in contracting h

85 Although alpha2-adrenergic receptors are known to modulate the im

86 Activation of G protein-coupled alpha(2) adrenergic receptors (ARs) inhibits epileptifor

87 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors

88 alpha2-Adrenergic receptors (ARs) play a key role in reg

89 was a result of activation of muscarinic and alpha2-adrenergic receptors because a specific alpha2-ad

90 ms using drug treatments targeting beta- and alpha2-adrenergic receptors, but little is known about t

91 that PHFD does not require the activation of alpha2-adrenergic receptors, but that alpha2-adrenergic

92 e activation of either supraspinal or spinal alpha(2) adrenergic receptors can induce antinociception

93 ion of alpha2-adrenergic receptors, but that alpha2-adrenergic receptors can modulate resting and pos

94 ctivity, which was increased by 5-HT(1A) and alpha2-adrenergic receptor co-activation in an activator

95 teract with a photoaffinity derivative of an alpha2-adrenergic receptor-derived peptide from the thir

96 voltage-dependent Ca2+ channels mediated by alpha2-adrenergic receptors desensitizes slowly with pro

97 Chinese hamster ovary-K1 cells impaired the alpha(2)-adrenergic receptor G(s)-mediated stimulation o

98 ed: Galpha(oA) = Galpha(oB) > Galpha(i2) for alpha(2)-adrenergic receptor; Galpha(i2) > Galpha(oA) =

99 d with pharmacological antagonists targeting alpha2-adrenergic receptors (idazoxan), beta-adrenergic

100 Activation of alpha(2)-adrenergic receptors in the central nervous sys

101 T can regulate the density of alpha(2)adrenergic receptors in the avian brain, indicat

102 vious studies in several animal species, the alpha2 adrenergic receptors in the human ciliary body, r

103 Stimulated GTPgammaS binding indicated that alpha2-adrenergic receptors in HET hippocampus were more

104 from locus coeruleus project to the DCN, and alpha2-adrenergic receptors inhibit spontaneous spike ac

105 Activation of alpha2-adrenergic receptors inhibited both NALCN and spi

106 ast to that which occurs in the hippocampus, alpha(2)-adrenergic receptor inhibition of NE release is

107 Activation of the alpha(2)-adrenergic receptor is associated with modulati

108 gulates the Golgi to cell surface traffic of alpha(2)-adrenergic receptors, likely through a physical

109 on a natively expressed signalling pathway, alpha(2)-adrenergic receptor-mediated I(Ca) modulation,

110 NO attenuates alpha(2)-adrenergic receptor-mediated inhibition of aden

111 hile rolipram and PDE4D deficiency shortened alpha2 adrenergic receptor-mediated anesthesia, a surrog

112 eleased glutamate in the mNTS and results in alpha2 adrenergic receptor-mediated inhibition of DMV ne

113 We have previously shown that alpha2-adrenergic receptor-mediated coupling to phosphol

114 ctions by approximately 50% and enhanced the alpha2-adrenergic receptor-mediated inhibition of forsko

115 btype influence signaling efficiency for the alpha2-adrenergic receptor-mediated signaling pathway.

116 e from studies in animals demonstrating that alpha2-adrenergic receptor-mediated vasoconstrictor resp

117 r nerve injury, the cascade of activation of alpha(2) adrenergic receptors-muscarinic receptors-NO in

118 Activation of the alpha(2)-adrenergic receptor on neurons regulates the ac

119 he level of arousal by selectively targeting alpha2 adrenergic receptors on LC neurons, resulting in

120 (3)R) was increased but not signaling of the alpha(2) adrenergic receptor or bradykinin BK(2) recepto

121 Activation of alpha(2)-adrenergic receptors or mu-opioid receptors red

122 ts suggest that spinal (but not supraspinal) alpha(2) adrenergic receptors play a significant role in

123 In addition, alpha(1)- and alpha(2)-adrenergic receptors, present in CA1, could pot

124 aused an approximate 50% decrease in NET and alpha(2) adrenergic receptor protein expression in sever

125 ic actions of norepinephrine are exerted via alpha2 adrenergic receptors residing on targets of norad

126 ine were mediated by ET(A), thromboxane, and alpha(2)-adrenergic receptors, respectively, and were in

127 poptotic effects via activation of beta2 and alpha2 adrenergic receptors, respectively.

128 Activation of alpha2-adrenergic receptors resulted in a fast, voltage-

129 Here we show that mutation in the alpha2 -adrenergic receptor subtype B (alpha2B -AR) is a

130 cular properties of each Gialpha, Gbeta, and alpha2-adrenergic receptor subtype influence signaling e

131 -PCR was performed to detect the mRNA of the alpha(2)-adrenergic receptor subtypes alpha(2)A, alpha(2

132 ecluded understanding the role of individual alpha2 adrenergic receptor subtypes in the antiepileptog

133 The existence of three alpha2 adrenergic receptor subtypes together with the la

134 The three alpha2-adrenergic receptor subtypes (alpha2a, alpha2b, a

135 ugh regulation of TNF expression, transforms alpha(2)-adrenergic receptors such that they function to

136 at low dose SNRIs, by acting on 5-HT(1A) and alpha2-adrenergic receptors, synergistically reduced AMP

137 ation/down-regulation of the chromaffin cell alpha(2)-adrenergic receptors that normally inhibit CA s

138 trimers had little effect on the coupling of alpha(2)-adrenergic receptors to the VD pathway.

139 Here, we show that noradrenaline activates alpha2-adrenergic receptors to control short-term and lo

140 lymorphisms (GPIIb, FcgammaRIIa, P-selectin, alpha2 adrenergic receptor, transforming growth factor [

141 BRET signals were observed for AGS4-RLuc and alpha(2)-adrenergic receptor-Venus, which were Galpha(i)

142 le in vivo interactions between dopamine and alpha(2)-adrenergic receptors was investigated in quail,

143 a high binding affinity of M1 muscarinic and alpha2 adrenergic receptors was associated with a greate

144 The density of alpha2 adrenergic receptors was highest in the iris (440

145 The alpha2-adrenergic receptor was found to be markedly more

146 ution and concentration of beta1, beta2, and alpha2 adrenergic receptors were examined in the frontal

147 mice to sedation elicited by stimulation of alpha2 adrenergic receptors, whereas arrestin 3 knockout

148 ne binding sites in plasma membrane and lack alpha2-adrenergic receptors, which recognize many I1-imi

149 avian brain, indicating that the density of alpha(2) adrenergic receptors within the song system mig

150 volumes of song nuclei, and the densities of alpha(2) adrenergic receptors within the song system of

151 e largest, T was highest, and the density of alpha(2) adrenergic receptors (within HVc and RA) was lo