ライフサイエンスコーパス: alpha-helices

1 en antiparallel beta strands stacked between alpha helices.

2 iparallel beta-sandwich wrapped in two short alpha helices.

3 f a beta sheet flanked with two antiparallel alpha helices.

4 proteins with curved beta sheets topped with alpha helices.

5 ers exhibit three highly conserved predicted alpha-helices.

6 s to a group of charged, E(R/K)-rich, single alpha-helices.

7 a central mixed beta-sandwich surrounded by alpha-helices.

8 transmembrane-spanning and five cytoplasmic alpha-helices.

9 of detergent molecules between transmembrane alpha-helices.

10 ygens and amide H(+)s four residues apart in alpha-helices.

11 beta-strands and random coil with two small alpha-helices.

12 nique beta-sandwich fold with short terminal alpha-helices.

13 ule scaffold that captures the topography of alpha-helices.

14 llel beta-strands along with two surrounding alpha-helices.

15 S domains, each comprising six transmembrane alpha-helices.

16 in (LBD), which consists predominantly of 11 alpha-helices.

17 residues stemming from the beta-strands and alpha-helices.

18 the binding domain entrance, flanked by two alpha-helices.

19 rrangements of four N-terminal transmembrane alpha-helices.

20 nded antiparallel beta sheet and a few short alpha-helices.

21 ng of three gatekeeping residues and several alpha-helices.

22 that porate cellular membranes by the use of alpha-helices.

23 the channel is closed by dense packing of 12 alpha-helices.

24 lel beta-sheet buttressed on one side by two alpha-helices.

25 r space and is likely to be composed of four alpha-helices.

26 y of inhibitory peptides to make amphipathic alpha-helices.

27 P) reveals a novel all-helix fold with seven alpha-helices.

28 interact with lipid bilayers as amphipathic alpha-helices.

29 etylcholine receptor formed by transmembrane alpha-helices.

30 ng the membrane domain of the enzyme via two alpha-helices.

31 llel homodimers formed by transmembrane (TM) alpha-helices.

32 ed of 25 repeats capped by N- and C-terminal alpha-helices.

33 rbcS) or only the surface-exposed algal SSU alpha-helices.

34 actions of macrodipoles between neighbouring alpha-helices.

35 n, resulting in a total of six transmembrane alpha-helices.

36 e of HIV gp41 and represents a bundle of six alpha-helices.

37 ized side chains in the first turn of the M2 alpha-helices.

38 To see whether slow packing of alpha-helices 1 and 3 is reflected in the rate-limiting

39 esis studies suggest that at least predicted alpha-helices 2 and 3 are required for Aar activity.

40 two partially cross-reactive regions around alpha-helices 2 and 4 as well as a novel Art v 3-specifi

41 results, the N-terminal domain contains four alpha-helices, 20 to 30 amino acids long.

42 ic intermediates is structure and packing of alpha-helices 3 and 7 and the degree of structure in bet

43 ndicate structural flexibility is induced in alpha-helices 4 and 5, suggesting this region contribute

44 that restrains conformational flexibility in alpha-helices 4 and 5.

45 erine 145, tyrosine 178, and cysteine 189 on alpha-helices 6, 7, and 8, respectively, within zeta-iso

46 arious activities (AAA) domain, specifically alpha-helices 7 and 9, as relevant contact sites.

47 on for this function was mapped carefully to alpha-helices 7 to 9.

48 hange at the interface between the region of alpha-helices A/A' and the meander loop of the enzyme, w

49 tates involves movement of the even-numbered alpha-helices across the surfaces of the odd-numbered al

50 We found that these alpha-helices act as a transient intermediate to beta-sh

51 In E. coli and G. stearothermophilus, the alpha-helices adopt an "up" state where the alpha-helice

52 beta-strands (beta1-beta4) connected by four alpha-helices (alpha1-alpha4).

53 del is that activated Bak and Bax insert two alpha-helices, alpha5 and alpha6, as a hairpin across th

54 pectroscopy, that COR15A starts to fold into alpha-helices already under mild dehydration conditions

55 in fold containing three orthogonally packed alpha helices and a 310 helix, FF6 contains an additiona

56 domain and extensive nucleotide contacts via alpha helices and a C-terminal loop.

57 Here we show that alpha helices and beta strands differ significantly in t

58 red structures composed of domains formed by alpha helices and beta strands.

59 ions play a role in capping the C-termini of alpha-helices and 310-helices.

60 meric forms with each monomer composed of 12 alpha-helices and 9 beta-sheets.

61 amino-terminal domain (NTD) comprising seven alpha-helices and a beta-hairpin, a carboxy-terminal dom

62 ure displays a novel fold comprised of seven alpha-helices and a highly curved three-stranded antipar

63 s a core scaffold composed of a layer of two alpha-helices and a layer of three-stranded antiparallel

64 s core region is composed almost entirely of alpha-helices and assembles into stable homodimers in so

65 helmingly a random coil, with the structured alpha-helices and beta-sheets being confined to the geno

66 The folds of alpha-helices and beta-sheets interacted together to for

67 25 nm, and the energy difference between the alpha-helices and beta-sheets is 4.9 kcal/mol per helica

68 act parallel and antiparallel arrangement of alpha-helices and beta-strands, enumerated all possible

69 rization interface, primarily contacting the alpha-helices and beta2-beta3 loops from each monomer.

70 ng proteins with a conserved fold made up of alpha-helices and can possess diverse properties.

71 The epitopes of Pin p 1 were found in alpha-helices and coils in the 3D protein structure.

72 we demonstrate that PaaR2 mainly consists of alpha-helices and displays a concentration-dependent oct

73 HaSCP-2 composed of five alpha-helices and four stranded beta-sheets.

74 Many of them fold into membrane-bound alpha-helices and function by causing cell wall disrupti

75 he N-terminal domain of CdaS consists of two alpha-helices and is attached to the C-terminal catalyti

76 suggests that pATOM36 is composed largely of alpha-helices and its assembly into the outer membrane i

77 ighly stable central beta-sheet and flanking alpha-helices and loop regions are formed.

78 w sense, pitch, and polarity between peptide alpha-helices and oligourea 2.5-helices suggest that a t

79 The monomeric molecule consists of 10 alpha-helices and one short beta-hairpin, and, although

80 was found in a subset of buried positions in alpha-helices and pervasively in the underlying beta-str

81 A2 contains a bundle of alpha-helices and replaces one dimer of coat proteins at

82 re is assembled from amino acids in both the alpha-helices and ribbon element.

83 eavages were consistently observed for three alpha-helices and the adenosine binding regions for AK c

84 -defined secondary structures, in most cases alpha-helices and their orientation is given by a tilt a

85 common evolution from disordered monomers to alpha-helices and then to beta-sheets when the proteins

86 is formed by regular (i.e. beta-strands and alpha-helices) and non-periodic structural units such as

87 Heating led to a decrease in alpha- helices, and an increase in aggregated strands, r

88 arboxy-terminal domain (CTD) comprising four alpha-helices, and a flexible linker with a 310-helix co

89 ts structure, comprising eight transmembrane alpha-helices, and catalytic site are distinct from thos

90 s protein contained three beta-sheets, seven alpha-helices, and coils.

91 omains share a six-stranded beta-sheet, five alpha-helices, and conserved motifs similar to those req

92 d by layered arrangements of beta-sheets and alpha-helices, and how these arrangements became globula

93 which are intermittently surrounded by four alpha-helices, and the C terminus, including the alpha5-

94 the ISRs reside in a cluster of five surface alpha-helices, and the carboxyl-terminal region (CTR), a

95 core structure composed of six antiparallel alpha-helices, and this structure is considered instrume

96 ructure with an alpha/beta topology in which alpha-helices are at the N- and C-terminal ends of the m

97 those of native Rubisco, suggesting that the alpha-helices are catalytically neutral.

98 e of a beta-sheet topped by two semiparallel alpha-helices are discussed in this review, highlighting

99 ds proceed via global unfolding, whereas the alpha-helices are free to swap locally in the native bas

100 minal alpha-helices; when ATP is scarce, the alpha-helices are proposed to inhibit ATP hydrolysis by

101 of the binding cavities is restored if these alpha-helices are repositioned extrinsically, suggesting

102 In solution, alpha-helices are stabilized at the termini by a variety

103 peptides, giving new insight into how single alpha-helices are stabilized.

104 iled-coil assemblies formed between or among alpha-helices are the most regular feature of tertiary a

105 These regions, mainly composed of alpha-helices, are located on a surface opposite the DNA

106 This work showcases the versatility of alpha helices as scaffolds for metalloprotein design and

107 nds report on the hydration of transmembrane alpha-helices as concluded from vibrational coupling exp

108 have evolved to efficiently utilize protein alpha-helices as molecular electrets, the synthetic coun

109 ubulin secondary structure at the H8 and H10 alpha-helices as well as at the S9 beta-sheet, where alp

110 ly charged residues on predicted amphipathic alpha-helices, as shown for murine gasdermin-D.

111 ctrostatic interactions that keep the portal alpha-helices at a constant separation.

112 sordered in water, but fold into amphipathic alpha-helices at high osmolyte concentrations in the pre

113 the nuclear receptor PPARalpha (increase of alpha-helices at the expense of decreasing beta-sheets),

114 op spanning K61 to I72 and flanked by longer alpha-helices at the outer edges, and basic side grooves

115 , consisting of a beta-roll, followed by two alpha-helices (B- and C-helices).

116 hanges in skin protein secondary structures (alpha-helices, beta-sheet, random coils and turns), as e

117 tifies the secondary structures of proteins (alpha-helices, beta-sheets and other structures) in EM m

118 ing peak areas associated with turns, bends, alpha-helices, beta-structures, and random coils for ina

119 affect T cell alloreactivity, whereas in the alpha helices, both compatible and noncompatible amino a

120 , each consisting of 42 aa arranged in three alpha-helices, build an elongated superhelical structure

121 are significantly more extended than linear alpha-helices but less extended than straight chains.

122 ices across the surfaces of the odd-numbered alpha-helices by rotation of the domains.

123 Two alpha-helices C-terminal to the core domain, but unique

124 e that interfacial tertiary contacts between alpha-helices can regulate siRNA cytoplasmic delivery an

125 Conserved polar residues in the two alpha-helices closest to the c-ring probably line the pr

126 nalysis of SERPINA1 identified 3 amphipathic alpha-helices clustered in the N-terminal domain of the

127 dues at the C-terminus form a bundle of five alpha-helices co-linear with the five-fold axis of symme

128 Subunit D (ScD) consists of a long pair of alpha-helices connected by a short helix ((79)IGYQVQE(85

129 The nascent chain forms two alpha-helices connected by an alpha-turn and a loop, ena

130 The homotrimer of parallel, coiled coil alpha-helices contains a His3-Cu(I) metal site where CO

131 C-terminal domain of ORF57, which is rich in alpha-helices, contributes to homodimerization of ORF57

132 ble beta-sheet structure with tightly packed alpha-helices decorating the exterior of the fibrils.

133 Each subunit is comprised of 18 alpha-helices designated "A-R" and an intracellular carb

134 rolysis by assuming an "up" state, where the alpha-helices, devoid of ATP, enter the alpha3beta3-cata

135 o the stable beta-sheet core, the peripheral alpha-helices display significant local fluctuations lea

136 g altered thermostability and disruptions to alpha helices, disulfide bonds, or the permeation pore.

137 n, peptides corresponding to two out of four alpha helices dominated the response in both vaccinees a

138 The folding of polypeptide side chains into alpha-helices dramatically enhances the polymerization r

139 consisting of a ring of seven transmembrane alpha-helices enclosing a large (>12,000 angstrom(3)) in

140 ms a novel fold consisting of 12 amphipathic alpha-helices enclosing an exceptionally large hydrophob

141 alpha-helices adopt an "up" state where the alpha-helices enter the alpha(3)beta(3)-domain and preve

142 ld symmetrical structure that comprises four alpha-helices enwrapping a pair of antiparallel beta-str

143 eveal that the variance in structure maps to alpha-helices flanking the central beta-sheet and not to

144 Two antiparallel alpha-helices form a coiled-coil domain linked by a larg

145 s as an ATP molecule is not bound to the two alpha-helices forming its C-terminal domain, probably be

146 N-terminal domain of yeast Scc1 contains two alpha helices, forming a four-helix bundle with the coil

147 chimeric Arabidopsis SSUs containing the SSU alpha-helices from Chlamydomonas reinhardtii can form hy

148 "head-to-tail" homodimer, formed between two alpha-helices from each monomer, with three Zn(II)-bindi

149 rylates a cluster of serine residues linking alpha-helices G and H of the Wee1 kinase domain.

150 short intracellular loop connecting membrane alpha-helices H and I (H-I loop), the AD, CBS1, and CBS2

151 The results revealed that amphipathic alpha-helices h1 and h3 comprise a lipid-binding site th

152 Remarkably, the catalytic iron and alpha-helices harboring its ligands were displaced up to

153 The odd-numbered alpha-helices have an L-shape, with proline or serine re

154 The dynamics of peptide alpha-helices have been studied extensively for many yea

155 The amphipathic alpha-helices have relatively low stability, in the rang

156 are four-helix bundles with a core of three alpha-helices held together by a [4Fe-4S] cluster.

157 ligands through aspartates on transmembrane alpha-helices III (canonical Asp(3.32)) or V (non-canoni

158 a unique binding domain consisting of three alpha helices in addition to a typical GT-A-type glycosy

159 dly, we find that at low ionic strength, the alpha helices in H2A-H2B are frequently sampling partial

160 GA was found to exist as alpha helices in solution with a hydrodynamic radius of

161 Here we show that alpha helices in the Linker2 (L2) region of rhesus TRIM5

162 The association of amphipathic alpha helices in water leads to alpha-helical-bundle pro

163 or bind lipid surfaces via their amphipathic alpha-helices in a manner typical of apolipoproteins.

164 re packed against one another and flanked by alpha-helices in an alphabetabetaalpha arrangement remin

165 f the beta2AR, the S1P1, or the kappaOR form alpha-helices in crystal structures but lack significant

166 l divalent cations, which induces end-to-end alpha-helices in many conantokins.

167 932-967 form a coiled-coil of two monomeric alpha-helices in parallel orientation.

168 late the binding affinity and specificity of alpha-helices in proteins, resist proteolytic degradatio

169 The isolated protein folds into amphipathic alpha-helices in response to increased crowding conditio

170 els are probably located in a bundle of four alpha-helices in the a-subunit that are tilted at approx

171 oned at key conserved sites within predicted alpha-helices in the C terminus.

172 s 21-46, the long alpha-helix binds to other alpha-helices in the C-terminal region of predominantly

173 hod is guided by correspondences between the alpha-helices in the density map and model, and does not

174 l of orientation in the cross-beta core, and alpha-helices in the disordered portions of the fibrils.

175 um, ATP and a magnesium ion are bound to the alpha-helices in the down state.

176 the molecular arrangement of the N-terminal alpha-helices in the filament core, including a melted c

177 p110beta as consisting of two perpendicular alpha-helices in the helical domain that are adjacent to

178 skeleton of each wedge is provided by three alpha-helices in the membrane domains of the b-subunit t

179 that tBid is monomeric with six well defined alpha-helices in the micelles.

180 lements in the acid unfolded and presence of alpha-helices in the molten globule state lead to intern

181 The high content of alpha-helices in Tra1 enabled tracing of the majority of

182 t a proline kink in M1 that separates pi and alpha helices, in both alpha (N217, V218 and P221) and n

183 polar residues provided by a bundle of four alpha-helices inclined at approximately 30 degrees to th

184 , the 3D structure is predicted to have four alpha-helices interlinked by three loops and a long C-te

185 hat serves as a scaffold for the hydrophobic alpha-helices involved in pH-dependent pore formation.

186 The critical extension of the alpha-helices is 0.25 nm, and the energy difference betw

187 chains at the first turn of the pore-lining alpha-helices is a key determinant of the rate of ion pe

188 re also differs: A significant population of alpha-helices is found in chemically denatured configura

189 The flexibility of alpha-helices is important for membrane protein function

190 r of polyglutamine is very stable, dimers of alpha-helices lack the kinetic stability necessary to su

191 onclude that the structural integrity of the alpha-helices lining the central hole and this loop are

192 22Y substitution alters the positions of the alpha-helices lining the central hole of the PCNA ring,

193 ha-helix, M4, and the adjacent transmembrane alpha-helices, M1 and M3, retains the ability to flux ca

194 ormation of a monomeric state, where its two alpha-helices, N-terminal heptad repeat (NHR) and C-term

195 the right-handed twist of the DNA, with the alpha helices occupying the major groove.

196 es the subnanometer image contrast such that alpha helices of individual proteins are resolved.

197 the development and validation of stabilized alpha helices of son of sevenless 1 (SAH-SOS1) as protot

198 se VirB homologs, and the transmembrane (TM) alpha helices of VirB10-like TraF form a 55-A-diameter r

199 experimental dimeric structures formed by TM alpha-helices of 21 single-pass membrane proteins (inclu

200 that octanoyl-CoA establishes with the four alpha-helices of ACBP and showed that the unfolding path

201 te detection of a single C=O stretch band of alpha-helices of CcO in H2O medium.

202 the mutation disrupts the N-terminus of the alpha-helices of dimeric beta-tropomyosin, a change pred

203 Here we identify residues in the alpha-helices of ParG that are critical for DNA segregat

204 udy with yeast two-hybrid suggests that most alpha-helices of R16/17, except for the R17 alpha1 helix

205 the third (M3) and fourth transmembrane (M4) alpha-helices of the alpha4 subunit.

206 l elements within the Linker2 region dock to alpha-helices of the coiled-coil domain, likely establis

207 t two Rab33B molecules bind to the diverging alpha-helices of the dimeric Atg16L1 coiled-coil domain.

208 lycan interacts with the loop connecting two alpha-helices of the F-box-combining site.

209 phenylalanine residues in the transmembrane alpha-helices of the GPCR CXCR4.

210 ce is formed by the C-terminal anti-parallel alpha-helices of the histone fold extension (HFE) of the

211 r pore-forming mechanism of action involving alpha-helices of the N-terminal domain, whereas structur

212 models of PrP(Sc) retain most of the native alpha-helices of the normal, noninfectious prion protein

213 ted bacterioruberin is bound parallel to the alpha-helices of the peptide backbone.

214 mino acid composition of two surface-exposed alpha-helices of the SSU: higher plant-like helices knoc

215 ylalanine (Phe) residue within the S2 and S3 alpha-helices of the voltage sensor domain (VSD) of Kv c

216 pha6' extending over the 2(nd) and the 3(rd) alpha-helices of Vta1NTD microtubule interacting and tra

217 nese domain, as well as on the transmembrane alpha-helices of YgaP.

218 stranded, antiparallel beta-sheet flanked by alpha-helices on each side, representing a unique oligom

219 ptide complex, which displays cation-induced alpha-helices on each terminus of the peptide.

220 mposed of a sheet of eight strands with four alpha-helices on one side of the sheet.

221 The stalk extends via two parallel long alpha-helices, one in each of the related b and b' subun

222 ted secondary structure, where it folds into alpha helices or unstructured loops.

223 ccur without a hydrophobic core, and without alpha-helices or beta-sheets.

224 ein complexes in the Protein Data Bank where alpha-helices or beta-strands form critical contacts.

225 lly generated three-dimensional models of TM alpha-helices positioned in membranes; (iv) amino acid s

226 TAM comprises amphipathic alpha-helices predicted to form a protein-binding pocket

227 is that the stabilization of the individual alpha-helices provides an optimum stability and allows f

228 amolecular (native) beta-sheets (55.08%) and alpha-helices/random coils (30.51%), but upon heating fr

229 ) beta-sheets (60-80%) in gamma-livetin, and alpha-helices/random coils (60.59%) in alpha-livetin.

230 te, the beta-hairpin is unfolded whereas the alpha-helices remain predominantly formed.

231 Coiled-coil interactions, between or among alpha-helices, represent the most common tertiary and qu

232 inner and outer circles of N- and C-terminal alpha-helices, respectively.

233 Naturally-occurring single alpha-helices (SAHs), are rich in Arg (R), Glu (E) and L

234 The domains form two amphipathic alpha helices separated by a rigid kink, which prevents

235 ere it interacts with the juxtaposed ends of alpha-helices shaping the narrow membrane-spanning pore.

236 re and it consists of three partially folded alpha-helices spanning residues 7-38, 41-46, and 58-73.

237 The long N-terminal GrpE alpha-helices stabilize the linker of DnaK in the comple

238 mensional (3D) structure is composed of four alpha-helices stabilized by four disulfide bonds, and a

239 loid-like architecture, in which amphipathic alpha helices stacked perpendicular to the fibril axis i

240 s reveal 12, mostly irregular, transmembrane alpha-helices surrounding a cavity with sugar- and H(+)-

241 Moreover, the alpha-helices tend to hybridize and to promote protein a

242 alpha helices that carry information through long distan

243 flytrap (VFT) perception domains followed by alpha helices that extend into the cytoplasmic membrane.

244 of specific roles to particular residues and alpha helices that mediate individual steps of the BAX a

245 tified a novel Pincer domain composed of two alpha helices that physically tethers the C-terminal dom

246 erminal domain formed from a cluster of four alpha-helices that appears to distinguish this protein f

247 tein pores formed by two concentric rings of alpha-helices that are stable and monodisperse in both t

248 ces cerevisiae allowed identification of the alpha-helices that belong to the a subunit and revealed

249 ter sakazakii PriC forms a compact bundle of alpha-helices that brings together residues involved in

250 based macromolecule with spatially organized alpha-helices that can catalyse its own formation.

251 SERPINA1 contains a cluster of amphipathic alpha-helices that enable apolipoproteins to bind phosph

252 RTF1 also forms four alpha-helices that extend from the Plus3 domain along th

253 lia revealed a structure comprising the five alpha-helices that form the phospholipase catalytic modu

254 unique E2-binding domain that includes three alpha-helices that interact extensively with the "backsi

255 onally beneficial dynamic motion between the alpha-helices that is critical for the transmission of s

256 two structural repeats, coupled by flanking alpha-helices that project from the membrane.

257 ral motifs formed by two or more amphipathic alpha-helices that twist into a supercoil.

258 sin (PR), a protein with seven transmembrane alpha-helices that was found to assemble to hexamers in

259 simplistic combinations of beta-strands and alpha-helices, the actual properties and functions of th

260 For alpha-helices, there is also a weak correlation in the H

261 e to reduce the kink in the pore-lining (S6) alpha-helices, thereby forming the helix bundle crossing

262 ed hydrophobicity to the hydrophobic half of alphaS helices, thereby stabilizing alphaS-membrane inte

263 nvolves allosteric realignment of C-terminal alpha-helices thus generating a binding surface for coac

264 otomers faced each other through the F and G alpha-helices, thus blocking the substrate access channe

265 the first and second putative transmembrane alpha-helices (TMalpha1 and TMalpha2).

266 dues introduced into different transmembrane alpha-helices (TMs).

267 cient nucleosome binders use short anchoring alpha helices to bind DNA, whereas weak nucleosome binde

268 nalysis revealed the hydrophobic face of two alpha-helices to be critical for membranous localization

269 ural behavior of individual beta-strands and alpha-helices to be targeted selectively by stopped-flow

270 ransformations, for example from coiled-coil alpha-helices to beta-sheet strands.

271 econdary structure of proteins unfolded from alpha-helices to beta-sheets, loops and beta-turns.

272 es and undergo a dynamic transition from the alpha-helices to the beta-sheets, which marks the onset

273 ore pronounced tilt of the closed-channel M2 alpha-helices toward the pore's long axis narrows the pe

274 In the plastic regime, the three-stranded alpha-helices undergo a noncooperative phase transition

275 ing protein, each forming three well-defined alpha-helices upon binding.

276 on liposome-reconstituted MscL transmembrane alpha-helices, using a 'virtual sorting' single-molecule

277 TOXCAT assay for interactions of isolated TM alpha-helices, we found that TM1, a Cx26 pore domain, ha

278 penetrating peptides (CPPs) form amphipathic alpha-helices when bound to lipid membranes.

279 an ATP molecule bound to its two C-terminal alpha-helices; when ATP is scarce, the alpha-helices are

280 nal end was quite capable of forming several alpha-helices which was correlated with CD spectroscopic

281 encapsulated ferritin (EncFtn) has two main alpha helices, which assemble in a metal dependent manne

282 rophobic interactions among their N-terminal alpha-helices, which also anchor the pilin subunits in t

283 highly stereoselective attachment to protein alpha-helices, which permits accurate measurements of or

284 bound InsP3 rotates 55 degrees closer to the alpha-helices, which provide most of the protein's inter

285 o a site at the opening of two transmembrane alpha-helices, which results in the scissile bond being

286 binding domains are composed of two extended alpha helices with no apparent surfaces for small-molecu

287 elices 6, 7, and 10 are separate amphipathic alpha-helices with a calculated periodicity of T = 3.34

288 sient increase in hydration of transmembrane alpha-helices with a t(1/2) = 60 mus, which tallies with

289 V POD is formed by one pair of long parallel alpha-helices with another pair in opposite orientation.

290 al barrels, that is, preassembled bundles of alpha-helices with central channels, can be used as buil

291 lical bundle systems consisting of synthetic alpha-helices with either the sequence Ac-(LSLLLSL)3-NH2

292 at this motif is intrinsic to the pairing of alpha-helices with opposite handedness.

293 ticlockwise rotational motion of interlinked alpha-helices with specific tilted helical extension.

294 -stranded parallel beta-sheet flanked by six alpha-helices with the putative catalytic triad, Asp-366

295 The tube is constructed of ten alpha-helices with their amino termini arrayed in a righ

296 They are analogous to alpha-helices, with axial aromatic stacking interactions

297 In the present study, we show that the alpha-helices within glucagon and GLP-1, but not GLP-2,

298 The two alpha-helices within the dimer together with the bound l

299 interpretation of the packing of individual alpha-helices within the fibers, and the construction of

300 Interactions between alpha-helices within the hydrophobic environment of lipi