ライフサイエンスコーパス: alpha-helix

1 ll as regions that were entirely unaffected (alpha helix).

2 BH3 motif, which folds upon binding into an alpha helix.

3 n SMRT comprising a GSI motif followed by an alpha helix.

4 ), which is predicted to form an amphipathic alpha helix.

5 -adsorbed state to fold into a transmembrane alpha-helix.

6 e active site at the lid domain and a nearby alpha-helix.

7 s and trimers, potentially via a coiled-coil alpha-helix.

8 king pin mechanism involving the amphipathic alpha-helix.

9 hods, finding that human calcitonin forms an alpha-helix.

10 hydrophobic face of the amphipathic protein alpha-helix.

11 flexible center to an end-to-end K2hPg-bound alpha-helix.

12 form supramolecular nanofibers consisting of alpha-helix.

13 tional change by a C-terminal domain-derived alpha-helix.

14 ed by an intrinsic N-terminal autoinhibitory alpha-helix.

15 main, a middle region, and a long C-terminal alpha-helix.

16 ain proteins are inhibited by the inhibitory alpha-helix.

17 induces the N-terminal loop to fold into an alpha-helix.

18 , with high intrinsic potential to fold into alpha-helix.

19 Lys substitution destabilizes its N-terminal alpha-helix.

20 ombination through the acquisition of the I2 alpha-helix.

21 domains through a single transmembrane (TM) alpha-helix.

22 sphate moiety sits atop the N terminus of an alpha-helix.

23 r predicted for such a long, nearly straight alpha-helix.

24 t two residues near the N-terminal region of alpha-helix 1 in GPPrP might mediate its susceptibility

25 imulated interprobe distances shows that the alpha-helix 1-3 pair distance displays a slower characte

26 cond thiol of C(15)SQC(18)H, indicating that alpha helix-1 is required for positioning the first cyst

27 s (2-3-fold), providing further evidence for alpha helix-1 positioning the first cysteine.

28 cyts c with deletions of single residues in alpha helix-1, which mimic bacterial cyt c, are poorly m

29 The alpha-helix 2 of PrP contains a string of four threonine

30 sphoregulatory region, comprising loop-3 and alpha-helix-2, contributes to this interaction.

31 central beta-sheet is highly structured and alpha-helix 3, which is partially formed, packs against

32 species with a disordered active site helix (alpha helix 30).

33 We show that deletion of the conserved alpha-helix 30 interferes with the integrity of the cell

34 Additionally, deletion of alpha-helix 30 results in hyperacetylated PG, suggesting

35 motions drive Switch-I region motions, while alpha-helix-3L7 motions control both.

36 r-magnitude piston-like pushdown of the pTsr alpha-helix 4 toward the membrane upon binding of (R)-DH

37 ered that amino acid substitutions affecting alpha-helix-6 within the CED-4 caspase recruitment domai

38 Here, we identify a structural element, alpha-helix-7, in human Argonaute2 (Ago2) that is requir

39 area on RTA and makes primary contacts with alpha-helix A (residues 18-32), alpha-helix F (182-194),

40 shoe-shaped substrate pocket, formed from an alpha-helix, a 310 helix, and a recently evolved tri-pro

41 in which a folded peptide segment (e.g., an alpha-helix, a loop) is replaced by its unnatural counte

42 Here, we demonstrate that the alpha-helix, a much simpler structural motif of enzyme,

43 rotein bind membrane and form an amphipathic alpha-helix (AH).

44 odeling studies suggested that the transient alpha-helix aligns multiple polar residues to interact w

45 nt mutation in the signal peptide breaks the alpha helix allowing co-translational cleavage.

46 ophobic N terminus that is a curved extended alpha-helix, alpha1, in X-ray crystal structures.

47 raction is mainly mediated by an amphipathic alpha-helix (alpha2), which undergoes a substantial conf

48 Our data show that the two A3H alpha-helixes alpha3 and alpha4 represent the Vif-bindin

49 re PansMan26A from Podospora anserina has an alpha-helix (alpha9) which interacts with its family 35

50 own that Fic enzymes are autoinhibited by an alpha-helix (alphainh) that partly obstructs the active

51 independent of unfolding of the connecting A'alpha-helix, an observation that stood in contrast to in

52 The first alpha helix and beta strand of LF and EF unfold and dock

53 ds, a linker loop domain with an amphipathic alpha-helix and a C-terminal mitochondrial carrier domai

54 n of CRES amyloids correlated with a loss of alpha-helix and a gain of beta-sheet content.

55 ng partners, RcdA, we find evidence that the alpha-helix and adjoining amino acids extending to posit

56 es with structural changes in the C-terminal alpha-helix and an increase in the distance between the

57 the DNA binding mechanisms of the N-terminal alpha-helix and AP2/ERF domain.

58 ally folded at pH 4.3 with approximately 35% alpha-helix and are unusually resistant to proteolysis.

59 The alpha-helix and beta-sheet contents decreased, while agg

60 rotein, bovine serum albumin, with different alpha-helix and beta-sheet contents.

61 otion is concentrated in regions between the alpha-helix and beta-sheet domains.

62 like a polycrystalline material in which the alpha-helix and beta-sheet regions of the protein are si

63 specific information on dynamics for both an alpha-helix and beta-sheet site of GB1, the immunoglobul

64 n protein structure and the presence of both alpha-helix and beta-sheet was observed, with higher bet

65 observed two distinct secondary structures, alpha-helix and beta-sheet, which were exhibited by the

66 ely selected amino acid residues fall on the alpha-helix and beta-sheets of the peptide-binding domai

67 her proportion of beta sheets, random coils, alpha-helix and beta-turns for all fractions of RB of bo

68 om a conformationally disordered state to an alpha-helix and develops contacts with the C-terminal do

69 dent mechanism that involves the dpBMAL1 TAD alpha-helix and dpCLK W328 and a TAD-independent mechani

70 uctured region features a central 2 1/4-turn alpha-helix and encompasses up to 2/3 of the length of t

71 The beta3-subunit uses its transmembrane alpha-helix and extracellular domain to bind to Nav1.5.

72 ort loop (Asn-Gln-Gly-Glu-Pro) instead of an alpha-helix and forms hydrogen bonds with Gln-281.

73 BSA lost the alpha-helix and gain beta-sheets in the secondary struct

74 mitoribosome-RRF(mt) complex, which reveals alpha-helix and loop structures for the NTE that makes m

75 red and highly dynamic with one four-residue alpha-helix and one three-residue antiparallel beta-shee

76 The alpha-helix and random coil contents of the 600 MPa trea

77 dies showed that water fraction comprised of alpha-helix and random coils, while salt and alkali frac

78 ructure of hMYDGF, which consists of a short alpha-helix and ten beta-strands distributed in three be

79 f the CdiB pore is occluded by an N-terminal alpha-helix and the conserved extracellular loop 6; thes

80 ence (named PMasseq) contains an amphipathic alpha-helix and the FWC signature, which is palmitoylate

81 patch regions through the SMARCB1 C-terminal alpha-helix and the SMARCA4/2 C-terminal SnAc/post-SnAc

82 n placed close to the putative transmembrane alpha-helix and to the active-site entrance; an FAD isoa

83 ertiary contacts, extended secondary motifs (alpha-helixes and beta-sheets) and intrinsically disorde

84 triad, include not only loops but also rigid alpha-helixes and beta-strands, suggesting their involve

85 ated by the folding of residues 3-11 into an alpha-helix, and mediated by membrane water or by previo

86 ructured in the monomeric state but forms an alpha-helix approximately 70 residues long in the self-a

87 ered at the segment Y38-L45, which adopts an alpha-helix as determined by NMR analysis of free peptid

88 a-strand conformation, instead of forming an alpha-helix as observed in the previously solved structu

89 ted helix-loop-helix motif into a continuous alpha-helix, as stabilized by a domain-swapped dimer.

90 tructure leading to a loss of the N-terminal alpha-helix associated with decreased kappa-opioid recep

91 tion of cysteine at the amino terminus of an alpha-helix, associated with activity in thioredoxins, i

92 Estimating energies of transmembrane (TM) alpha-helix association is essential for understanding f

93 them based on the calculated free energy of alpha-helix association.

94 The stability of Trp-cage's alpha-helix at low temperatures suggests a possible evol

95 cy illustrates the feasibility of exploiting alpha-helix backbone in structure-based drug design.

96 Such alpha-helix barrels engineered from peptides could find

97 l demonstrating structural assembly of large alpha-helix-based peptide pores for understanding the ac

98 ese findings may support the changing of the alpha-helix/beta-pleated sheets ratio in protein structu

99 tructural flexibility of the TMD in terms of alpha-helix/beta-sheet transitions in model membranes (m

100 From residues 21-46, the long alpha-helix binds to other alpha-helices in the C-termin

101 This alpha-helix binds to the cytosolic face of the plasma me

102 like the case of the two-state folder [three-alpha-helix bundle (alpha(3)D)], whose drying and core f

103 pologically simple and highly conserved four-alpha-helix bundle protein that acts as an intracellular

104 The-fold consists of a four-alpha-helix bundle with structural similarity to the hig

105 In contrast, mutants lacking the TAD alpha-helix but retaining the most distal C-terminal res

106 active site, including the translation of an alpha-helix by 1 angstrom.

107 g sites in K2hPg Further, the adoption of an alpha-helix by VKK38 upon binding to K2hPg sterically op

108 ere, extending studies on the role of the H2 alpha-helix C terminus of PrP, we found that deletion of

109 all structure of StnA can be described as an alpha-helix cap domain on top of a common alpha/beta hyd

110 rus 5 into the density, it is shown that the alpha-helix close to the RNA became flexible when RNA wa

111 y to mammalian deubiquitinases with a unique alpha-helix close to the substrate-binding pocket.

112 nsequently, while the secondary amphipathic, alpha-helix conformation is a key determinant of the abi

113 er to be collagen losing its original triple alpha-helix conformation, further confirming the diagene

114 their ability to form secondary amphipathic, alpha-helix conformations in membrane mimicking milieu.

115 Despite adopting near identical, alpha-helix conformations in the steady-state in a varie

116 nascent helix (H2) downstream of the single alpha-helix considerably diminishes IC-p150(Glued) compl

117 terminal domain and an incipient amphipathic alpha-helix contained within it.

118 The beginning of the C-terminal alpha-helix contains a strictly conserved and fully trim

119 phipathic CPPs correlates with their adopted alpha-helix content in membranes rather than their helic

120 A residual alpha-helix content in the central part of the peptide (

121 profiles were obtained as a function of the alpha-helix content of different segments of the 17-mer

122 he same kind of changes i.e. decrease in the alpha-helix content with a simultaneous increase in the

123 ructure of the UCS domain (by decreasing the alpha-helix content), leading to a significant change in

124 howed that while HHP treatment decreased the alpha-helix content, free sulfhydryl content, and Rg, it

125 otein solution induced a progressive gain in alpha-helix content.

126 ondary structure resulting in an increase in alpha-helix content.

127 cation profiling, here we show that the Orc4 alpha-helix contributes to the DNA sequence-specificity

128 EGF-D harboring a mutation in the N-terminal alpha-helix, D103A, exhibited enhanced potency for activ

129 2 regulates circadian repression through TAD alpha-helix-dependent and -independent mechanisms.

130 ochondrial outer membrane via its N-terminal alpha helix domain and hosts a redox-active [2Fe-2S] clu

131 ndoplasmic reticulum via its N17 amphipathic alpha-helix domain but is released by oxidation of Met-8

132 Using the same 12-aa beta-strand-hinge-alpha-helix domain, superantigens engage both B7-2 and C

133 rminal alpha-helix, preparing the system for alpha-helix ejection.

134 on of 8 cysteine residues, important for its alpha-helixes enriched structure.

135 ling revealed that the ion pairs within this alpha-helix exhibit dynamic behavior, rapidly forming an

136 ontacts with alpha-helix A (residues 18-32), alpha-helix F (182-194), as well as the F-G loop.

137 PGL-1 DD has a novel 13 alpha-helix fold that creates a positively charged chann

138 types of charged amino-acid residue pairs on alpha-helix folding.

139 The CTD is comprised of an alpha helix followed by an acidic region (AR) and a C-te

140 ~60 residue region that includes a conserved alpha-helix for dimerization.

141 gs, and a near-perfect fit to an ideal model alpha-helix for its residual dipolar couplings (RDCs), m

142 nine R210 on the adjacent subunit's backbone alpha-helix form salt bridges in hexamers and pentamers.

143 A is engaged on cellulose, as models predict alpha-helix formation and decreased cellulose interactio

144 ch that they favor helix formation) speed up alpha-helix formation by up to 50% and slow down the unf

145 The structure reveals how alpha-helix formation directly within the peptidyltransf

146 ons, and on the other hand, they can promote alpha-helix formation in certain peptides.

147 A underwent coupled folding and binding with alpha-helix formation upon interaction with RCD1, wherea

148 was resistant to conformational collapse or alpha-helix formation upon the addition of the osmolyte

149 ight coupling between membrane partitioning, alpha-helix formation, and electrostatic repulsions betw

150 ng a pathogenic, expanded Gln length and N17 alpha-helix formation.

151 face on Nsp9 is located in the two predicted alpha-helixes formed by 48 residues at the C-terminal en

152 terminus, consisting of a long 24 amino acid alpha-helix, forms numerous polar contacts with residues

153 alpha-helix from residues 14-18 and a longer alpha-helix from residue 21, which continues unbroken in

154 idues 8-13 is extended and is followed by an alpha-helix from residues 14-18 and a longer alpha-helix

155 nd suggest that the formation of an extended alpha-helix from the disordered carboxy-terminal region

156 Importantly, the N-terminal part of this alpha-helix, from Phe(93) to Thr(98), is required for bi

157 mmunoglobulin beta-sheet is replaced with an alpha-helix further confirms the extensive structural ma

158 ntified two synthetic molecules targeting an alpha-helix/groove interface essential for RED-SMU1 comp

159 e that: (1) Glu-25 is more frequently in the alpha helix group in the phosphorylated state with the a

160 p-T histone fold domain (HFD) combining with alpha-helix H3 of Cenp-K to create a compact three alpha

161 based on the isoform-specific sequence of an alpha-helix "handle" in the PKMs.

162 Although the alpha-helix has long been recognized as an all-important

163 of replication origins, mediated by the Orc4 alpha-helix, has co-evolved with the gain of ORC-Sir4-me

164 ositioning of the RNMT lobe and the adjacent alpha-helix hinge, resulting in optimal positioning of h

165 These included alpha-helix II and hairpin turns between beta-strands be

166 - angstrom ligand-induced displacement of an alpha helix in the periplasmic and transmembrane domains

167 The K259A mutation, mapping to an alpha helix in the predicted structure of 2C(ATPase), re

168 mechanism involving a regulatory C-terminal alpha-helix in CaMKII.

169 The extent of alpha-helix in E1A from other adenovirus species can be

170 l region of the G-patch always folds into an alpha-helix in five different crystal structures, the C-

171 ubstrate binding of a functionally necessary alpha-helix in human glutathione transferase A1-1 (hGSTA

172 als that fibrillar exon1 has a partly mobile alpha-helix in its aggregation-accelerating N terminus,

173 Surprisingly, the corresponding part of the alpha-helix in mature VEGF-C did not influence binding t

174 n, with the exception of a small amphipathic alpha-helix in residues M10-I17, which is included withi

175 nto membranes and forms a transmembrane (TM) alpha-helix in response to slight acidity, and has shown

176 stigated a deletion mutant lacking only this alpha-helix in stable cell lines and Xenopus laevis phot

177 tructures of these three factors revealed an alpha-helix in the C-terminal inhibitory domain that pac

178 the canonical cleavage site form an extended alpha-helix in the ER membrane, which covers the cleavag

179 a 60:40 ratio of double- and single-stranded alpha-helix in the highly rigid hydrogel of native agaro

180 onclusion, we have identified an amphipathic alpha-helix in the NCX1 large intracellular loop that co

181 des corresponding to a predicted amphipathic alpha-helix in the prodomain N terminus adopt helical st

182 ow that cyclin D-Cdk4,6 docks one side of an alpha-helix in the Rb C terminus, which is not recognize

183 We detected a short alpha-helix in the soluble structure that comprised thre

184 mediated contacts provided by residues in an alpha-helix inserted in the DNA major groove (the recogn

185 Switch I of EF-Tu rapidly converts from an alpha-helix into a beta-hairpin and moves to interact wi

186 beta-sheet, and insertion of the N-terminal alpha-helix into the heterodimer interface, leading to e

187 s such ribosomes by inserting its C-terminal alpha-helix into the vacant mRNA tunnel.

188 are high, the N-terminus of the amphipathic alpha-helix is bound to a cleft in the regulatory domain

189 nsically disordered protein interactome, the alpha-helix is commonly used for binding, which is induc

190 drop, the cleft closes, and the amphipathic alpha-helix is released to bind to the carrier domain vi

191 to this region, suggesting that folding into alpha-helix is required for chaperone-like activity unde

192 8C, W51C, and His52) rigidly arranged on one alpha-helix is responsible for chelating the first Cu(II

193 The alpha-helix is the most commonly found natural secondary

194 onserved tryptophan (W972) in the C-terminal alpha-helix is widely accepted as essential for E2 recru

195 icit and macromolecular crowding induce high alpha-helix levels in vitro, suggesting that prevalent c

196 from a beta-amino acid, to participate in an alpha-helix-like secondary structure.

197 Y from Bacillus subtilis revealing a 10-turn alpha-helix linking otherwise discrete GAF and wHTH doma

198 petition for binding with coactivators on an alpha-helix located within the transactivation domain (T

199 The nAChR transmembrane alpha-helix, M4, is positioned at the perimeter of each

200 erved MGF motif and the presence of a fourth alpha-helix make TDP2 UBA distinct from other known UBAs

201 Each alpha helix makes hydrogen-bond (H-bond) contacts with u

202 produce potent small-molecule inhibitors for alpha-helix-mediated PPIs.

203 valuation of inhibitor selectivities between alpha-helix-mediated PPIs.

204 -helical hot spots was revealed by analyzing alpha-helix-mediated protein-protein interaction (PPI) c

205 pots, offering a new class of small-molecule alpha-helix mimetics.

206 onalized alpha/beta/gamma-peptides assume an alpha-helix-mimicking 12,13-helix conformation in soluti

207 (93)CGPAI(97) portion of a predicted central alpha-helix most drastically suppressed the inhibitory a

208 ificity of origins in S. cerevisiae and Orc4 alpha-helix mutations change genome-wide origin firing p

209 ta-stranded barrel pore, with its N-terminal alpha-helix (N-alpha) bound to its interior.

210 ature-dependent conformational changes in an alpha helix near the common docking and glutamate:aspart

211 jacent to the N130 GlcNAc and the N-terminal alpha-helix near the peptide-binding site while increasi

212 o the three conserved regions of the CTD: an alpha helix, needed for the structural integrity of the

213 ddition to the AP2/ERF domain, an N-terminal alpha-helix of AtERF96 participates in DNA interaction i

214 (SNAREDelta60) suggested that an 'accessory' alpha-helix of Complexin-I inhibits release by inserting

215 ion observed for a number of residues in the alpha-helix of crystalline GB1 is not detected in the co

216 e, formed by contacts between the C-terminal alpha-helix of eL19 and 18S rRNA in concert with additio

217 inst GFP, ubiquitin, an OVA peptide, and the alpha-helix of influenza hemagglutinin's stem; the last

218 tagenesis to demonstrate that the N-terminal alpha-helix of mature VEGF-D (Phe(93)-Arg(108)) is criti

219 sidues situated at the end of the C-terminal alpha-helix of NFU1.

220 a surface groove to capture the critical BH3 alpha-helix of pro-apoptotic members.

221 Nef refolds the first alpha-helix of the beta2 subunit of AP-2 to a beta hairp

222 t a heightened involvement of the C-terminal alpha-helix of the GR-DBD in RNA-binding.

223 tions in either the linker or the C-terminal alpha-helix of the PH domain decreased [2-17]ARF1 bindin

224 protein complexes reveal a disruption in the alpha-helix of transmembrane segment 6 (TM6) not observe

225 d asymmetry can modulate the formation of an alpha-helix on the membrane.

226 not form a pattern consistent with either an alpha helix or beta sheet.

227 t there were changes in both pore length and alpha-helix organization near the cytoplasmic vestibule

228 tive to the invertebrate sequence unwinds an alpha-helix, placing the thiol of Cys69 into the mEndoG

229 ing pockets, the beta-hairpin pocket and the alpha-helix pocket.

230 s and alter interactions with the N-terminal alpha-helix, preparing the system for alpha-helix ejecti

231 rystallography, displayed a short additional alpha-helix probably induced by deamidation, compared to

232 ding has previously been employed to measure alpha-helix propensities among proteinogenic alpha-amino

233 This system allows the measurement of alpha-helix propensities for d-alpha-amino acid residues

234 was surrounded by IDRs, individual intrinsic alpha-helix propensities varied as shown by CD spectrosc

235 AECs), and this activity is dependent on its alpha helix propensity.

236 xhibit high toughness originating from their alpha-helix/random coil conformation structures and thei

237 is interaction primarily involves the single alpha-helix region at the N-terminus of the IC, in Droso

238 in the beta6-alpha5 loop and the C-terminal alpha helix (residue 330).

239 interacting with a highly conserved central alpha helix-rich domain.

240 rDer p 5 was monomeric and adopted a similar alpha-helix-rich fold at both physiological and acidic p

241 The binding pocket is where an alpha-helix runs along the cytoplasmic membrane and inte

242 ddition to Survivin and Borealin, the single alpha-helix (SAH) domain of INCENP supports CPC localiza

243 particularly important in stabilizing single alpha-helix (SAH) domains in solution.

244 on measurements show a significant degree of alpha-helix sampling in the protein regions encompassing

245 de (HPMA) polymer-OP conjugate (PDOP) adopts alpha-helix secondary structure and induces robust immun

246 sidues ("alpha/beta-peptides") can mimic the alpha-helix secondary structure, and that properly desig

247 yloid-beta(1-40) was less prone to adopt the alpha-helix secondary structure.

248 condary protein structures, especially those alpha-helix sections which contain tryptophan residues.

249 rface receptors, a single transmembrane (TM) alpha-helix separates ecto- and cytosolic domains.

250 d flexible, except for a partially populated alpha-helix spanning residues 55-60, and binds RNA oligo

251 t algorithm made further improvements to the alpha-helix SSEs of the backbone trace.

252 tions of Ca(2+)-free (apo) CaM (reduction in alpha-helix structure by 13% (CD) and 15% (2D)).

253 The alpha-helix structure was observed for amyloid-beta(1-42

254 mimetics was designed to target the central alpha-helix subdomain of Abeta (Abeta13-26).

255 beta-barrel domain and a long, mildly kinked alpha-helix tail.

256 e find that the SMARCB1 CTD contains a basic alpha helix that binds directly to the nucleosome acidic

257 nomers while the C-terminal section forms an alpha helix that directly blocks IL-17RA from binding to

258 main consisting of eight beta-strands and an alpha-helix that adopts a substantially different positi

259 mH0ACPb, both of which possess an additional alpha-helix that behaves like a rigid component of the d

260 of fructose 1,6-bisphosphate destabilizes an alpha-helix that bridges the allosteric and active site

261 sues and was found to form a well structured alpha-helix that closely resembles the juxtamembrane hel

262 ility occurs at the N-terminus and the first alpha-helix that connects the HlyIIC domain to the HlyII

263 lved at 2.7 A resolution reveals an extended alpha-helix that contributes to an intermolecular four-h

264 between the two protomers is mediated by an alpha-helix that interacts with the ATP-binding site at

265 ment of MOAG-4 forms a transiently populated alpha-helix that interacts with the negatively charged C

266 onitoring in real time the orientation of an alpha-helix that is conformational-state-specific.

267 terface between the beam domain-i.e., a long alpha-helix that protrudes from the intracellular side o

268 pressor ETV6 (or TEL) is autoinhibited by an alpha-helix that sterically blocks its DNA-binding ETS d

269 domain and a single C-terminal transmembrane alpha-helix (TMH) domain.

270 winged helix-turn-helix (wHTH) motifs use an alpha helix to read the base sequence in the major groov

271 m-loop target RNA and extends a newly-formed alpha helix to the distal loop where it forms protein in

272 1.2/2.1 chimera, including a transition from alpha-helix to 3(10) helix in the C-terminal portion of

273 mechanical pulling force can facilitate the alpha-helix to beta-sheet (alpha-to-beta) transition by

274 A shift from alpha-helix to beta-sheet conformation of proteins indic

275 ons promote the pentapeptides transform from alpha-helix to beta-sheet conformation.

276 Rather, these oligomers undergo an alpha-helix to beta-sheet conversion catalyzed by lipid

277 and secondary structure transformation from alpha-helix to beta-sheets.

278 l-xL where the BH3-like motif adopts a short alpha-helix to snuggle into a hydrophobic pocket in Bcl-

279 The asymmetry caused the terminal alpha-helix to thermodynamically uncouple from the rest

280 re, we conducted an in-depth analysis of the alpha-helix-to-beta-strand and beta-strand-to-alpha-heli

281 e hexon and penton are mediated by a drastic alpha-helix-to-beta-strand structural transition.

282 The functionally relevant random-coil-alpha-helix transition associated with Ca(2+) uptake tha

283 lpha-helix-to-beta-strand and beta-strand-to-alpha-helix transitions and domain motions displayed by

284 tissue (IMCT) of both muscles, a decrease in alpha- helix, turn and unordered structures was compleme

285 ecule was found to contain a large amount of alpha-helix/unordered structures and many signatures of

286 so examined, and the extent of the predicted alpha-helix was found to correlate reasonably well with

287 This alpha-helix was located in the C-terminal region and inc

288 that a JMJD6 peptide (Lys84-Asn96) adapts an alpha-helix when bound to the ET domain.

289 Residues 6-28 form a well-ordered alpha-helix, whereas residues 1-5 and 29-35 display chem

290 up to 50% and slow down the unfolding of the alpha-helix, whereas salt bridges with an unfavorable ge

291 m FPP to GPP, until replacement of the final alpha-helix, whereupon cyclopropanation and branching ac

292 sized that this segment forms an amphipathic alpha-helix whose properties facilitate Cys-739 palmitoy

293 nd a backbone carbonyl oxygen of an adjacent alpha-helix, whose contribution to inhibitory potency il

294 structure of the allosteric site revealed an alpha-helix with a loop connecting a coil fragment.

295 ularly flexible between the first and second alpha-helix with the first helical part exhibiting sligh

296 p f3's peroxidase activity, and extended the alpha-helix with the former peroxidatic cysteine residue

297 We show that SutA comprises a central alpha-helix with unstructured N- and C-terminal tails, a

298 Orc2 inserts into a DNA minor groove and an alpha-helix within Orc4 inserts into a DNA major groove.

299 surface of a series of residues on a stable alpha-helix within the motif with high potential as a pr

300 Furthermore, the incipient alpha-helix (within the purified soluble C terminus) par