ライフサイエンスコーパス: alpha2 integrin

1 alpha2 integrin or a non-signaling chimeric alpha2 integrin.

2 omolecules, cell adhesion, and expression of alpha2 integrin.

3 e myoblast cells stably expressing the human alpha2 integrin.

4 type I collagen and this was mediated by the alpha2 integrin.

5 compared to the slow turnover of unclustered alpha2 integrin.

6 tion-blocking antibodies against alpha1- and alpha2-integrins.

7 h constitutive and TPA-induced expression of alpha2 integrin, a late megakaryocytic marker, are inhib

8 sement membrane formation instead of laminin alpha2; integrin alpha7, GalNac transferase, and ADAM12

9 Function-blocking antibodies to alpha2 integrin also blocked both HRA-19 endocrine linea

10 Antibodies against alpha2 integrin and a3 integrin had little inhibitory ef

11 We further characterized zebrafish alpha2 integrin and discovered that this integrin is hig

12 stablish a direct interaction between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sens

13 Progenitor cells that express activated alpha2 integrins are normally distributed in the bone ma

14 ching, whereas rhCC16 restored branching via alpha2-integrin binding Conclusions: Maternal smoking re

15 tion were suppressed by anti-alpha1 and anti-alpha2 integrin blocking antibodies, and systemic blocka

16 Furthermore, anti-alpha2-integrin blocking antibody or peptide reduced asc

17 at decreased expression of the gene encoding alpha2 integrin, but not genes encoding alpha1, alpha3,

18 together, these studies demonstrate that an alpha2-integrin-collagen interaction is required for act

19 Our data indicate that alpha1 and alpha2 integrins confer invasive behavior by regulating

20 ss-of-function mutation, alpha2E336A, in the alpha2-integrin did not prevent the activation of FAK, n

21 Disruption of alpha2-integrin-ECM interactions with a blocking antibod

22 in, either alone or with variable numbers of alpha2 integrin EF hand metal binding sites, bound colla

23 activate two tandem AP1 binding sites in the alpha2 integrin enhancer.

24 The alpha2 integrin expression was assessed through Western

25 The alpha2 integrin expression was lower in plasma rich in g

26 Strikingly, MAP3K1, MAPK11, PPP2R1A, and alpha2 integrin expression were higher in chemotherapy-r

27 feration, migration, and integrin alpha1 and alpha2 integrin expression.

28 lpha7 nAChR to simultaneous up-regulation of alpha2-integrin expression and activation of Rho kinase.

29 ion kinase and paxillin with displacement of alpha2 integrin from the focal adhesion protein complex.

30 characterized the 5' flanking region of the alpha2 integrin gene and identified three distinct regul

31 inase (MAPK) signaling pathway in regulating alpha2 integrin gene expression.

32 Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic

33 We now focus on the core promoter of the alpha2 integrin gene located between bp -30 and -92 that

34 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer ac

35 c differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kina

36 required for transcriptional activity of the alpha2 integrin gene.

37 alpha7 nAChRs, we quantitated expression of alpha2-integrin gene at the mRNA and protein levels and

38 Erb-B2, which lead to downregulation of the alpha2-integrin gene expression, may proceed through the

39 The human alpha2-integrin gene is transcriptionally downregulated

40 cells expressing the non-signaling chimeric alpha2 integrin had negligible ability for either endocr

41 purified recombinant proteins containing the alpha2 integrin I domain, either alone or with variable

42 an NSP4 point mutant, E(120)A, fails to bind alpha2 integrin I domain.

43 Overexpression of wild-type alpha2 integrin in HRA-19 cells significantly enhanced e

44 To further explore the role of alpha2 integrin in multilineage differentiation, we esta

45 vo the temporal and spatial contributions of alpha2 integrin in selected cell types.

46 expression of activated, but not wild-type, alpha2 integrins in hematopoietic cells in vivo results

47 tely 40% in both cases: Cross-linking of the alpha2 integrin increased [Ca2+]i in these cells exclusi

48 aB activation, expression of MMP1, MMP2, and alpha2 integrin increases on polymerized collagen.

49 ies, and systemic blockade of the alpha1 and alpha2 integrins inhibited VEGF-A-driven lymphangiogenes

50 ents mapped binding sites of the recombinant alpha2-integrin-inserted domain to the GLPGER motif of t

51 Monovalent blocking antibodies to alpha2 integrins, integrins that mediate adhesion to bot

52 over, the recombinant inserted domain of the alpha2 integrin interacts with p176 with a relatively hi

53 Moreover, disruption of alpha2 integrin, MAP3K1, MAPK11, PPP2R1A, and NHE1-media

54 eptide HEP-III is a major, specific site for alpha2 integrin-mediated binding of mesangial cells to C

55 Whereas alpha2 integrin mRNA levels are decreased in alpha6 inte

56 in alpha6 integrin knockdown cells restores alpha2 integrin mRNA levels.

57 nt cells expressing high levels of wild-type alpha2 integrin or a non-signaling chimeric alpha2 integ

58 grin promoter plays an essential role in the alpha2-integrin promoter activity and its downregulation

59 The downregulation of the alpha2-integrin promoter activity could also be achieved

60 , we have used deletion mutations within the alpha2-integrin promoter inserted 5' of the chlorampheni

61 he core region (positions --64 to +1) of the alpha2-integrin promoter plays an essential role in the

62 v-ras on the transcriptional activity of the alpha2-integrin promoter were observed in nontumorigenic

63 of Erb-B2 on transcriptional activity of the alpha2-integrin promoter were observed in transient-cotr

64 face levels of activated, but not wild-type, alpha2 integrin receptors are rapidly down-regulated dur

65 We show here that the internalized clustered alpha2 integrin remains in alpha2-MVBs and is not recycl

66 The same effects were seen when an alpha2-integrin reporter gene construct was transfected

67 ved in transient-cotransfection assays using alpha2-integrin reporter plasmids and plasmids expressin

68 Blocking monoclonal antibodies against the alpha2 integrin resulted in 70% inhibition of adhesion t

69 K562 cells transfected with alpha2 integrin selectively adhere to immobilized EMS16,

70 ypic changes elicited by reexpression of the alpha2 integrin subunit and modulates the function of ot

71 llagen was blocked by antibodies against the alpha2 integrin subunit but not by antibodies against th

72 PK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megak

73 heroids up-regulate expression of CD49b, the alpha2 integrin subunit, and suppress the expression of

74 We recently reported that alpha2 integrin subunit-deficient mice exhibited markedl

75 This paper examines the role of the alpha2-integrin subunit in osteocalcin promoter activati

76 ed by pre-treatment of HEp-2 cells with anti-alpha2 integrin-subunit antibody and type I collagen, (i

77 nd quantitating expression of the alpha1 and alpha2 integrin subunits during the in vivo injury.

78 hat addition of core3 O-glycans to beta1 and alpha2 integrin subunits in prostate cancer cells suppre

79 binding of isolated, recombinant I domain of alpha2 integrin to collagen in an ELISA assay, but not t

80 n echovirus 1 (EV1) causes redistribution of alpha2 integrin to perinuclear multivesicular bodies, al

81 sion of collagen, fibronectin, tenascin, and alpha2 integrin was detected in the TGF-beta1-expressing

82 The Raf/MEK1/ERK1/2 cascade up-regulating alpha2-integrin was activated due to both Ca2+-dependent

83 tions with blocking antibodies to alpha1 and alpha2 integrins were sufficient to inhibit both haptota

84 VEGF-A induced expression of the alpha1 and alpha2 integrins, which promoted their in vitro tube for