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1 inal GvHD that can be inhibited by targeting alphav integrin.
2 cyte migration was dependent on endoglin and alphaV integrin.
3 doglin and reduced endoglin interaction with alphaV integrin.
4 asts that selectively initiate expression of alphaV integrin.
5 rophages through interaction with macrophage alphav integrin.
6  over-representation of peptides that target alphav integrins.
7 emphasis on small-molecule inhibitors of the alphav integrins.
8 tein-protein interactions between P2Y(2) and alphaV integrins.
9 iac fibrosis via a mechanism that depends on alphav integrins.
10 ting that 17E6 is an allosteric inhibitor of alphaV integrins.
11 f Th17 cells is also critically dependent on alphav integrins.
12 an SCC line with retroviral vectors encoding alphav integrins.
13 sing levels of EBP50 and SAP97 compared with alphav integrin, a protein expressed at constant adult l
14 se virus (FMDV) have been shown to use three alphav integrins, alphavbeta1, alphavbeta3, and alphavbe
15  analysis confirmed that galectin-3 binds to alphav integrins, alphavbeta1, alphavbeta5, and alphavbe
16 lphav integrin subunit, eliminating all five alphav integrins, although causing lethality, allows con
17 ocused primarily on the formation of the PLP-alphav integrin-AMPA receptor complex in vivo and whethe
18  through ILC3-mediated antigen presentation, alphaV integrin and competition for interleukin-2.
19 in wild-type cerebellum, PLP associates with alphav integrin and the calcium-impermeable GluR2 subuni
20 t mediation of virus entry by a co-receptor (alphaV integrins and HVEM) has been determined for both
21 al a novel tumor suppressor-like function of alphav integrins and provide a genetically tractable mou
22 s activated at the DC/CD4+ T cell synapse by alphav integrins and that this activation is required fo
23 vailability of beta1 and alpha4, alpha5, and alphaV integrins and the presence of collagenase activit
24 g membrane translocation or stabilization of alphaV-integrin and FAK activation.
25 sulted in upregulation of the iRGD receptors alphav-integrins and NRP-1, particularly in the peripher
26 which is similar to the N-terminal domain of alphaV integrin, and that the C-terminal half contains f
27  the cell surface molecules alpha6-integrin, alphav-integrin, and the c-kit receptor.
28 er evaluation of the mechanisms of action of alphav-integrin antagonists in anti-angiogenic therapeut
29  assays with inhibitory anti-alpha5 and anti-alphav integrin antibodies showed that both subunits con
30                                   Binding of alphav integrins appeared to have more influence than di
31 , our data indicate that (i) alpha5beta1 and alphav integrins are essential for cell-cell fusion and
32           Here, we show that alpha5beta1 and alphav integrins are essential for cell-cell fusion and
33           Here, we show that alpha5beta1 and alphav integrins are essential for hMPV infectivity and
34                                    Increased alphav integrins are found in human kidney disease.
35                  Various beta1 integrins and alphav integrins are present on mouse eggs.
36                Therefore, neither alpha5 nor alphav integrins are required in endothelial cells for i
37                   RPTPalpha colocalizes with alphav-integrins at the leading edge during early spread
38   In addition, a small-molecule inhibitor of alphav integrins attenuates fibrosis, even when pre-esta
39 RGD motif, MFG-E8 helps target HIV-1 VLPs to alphav integrin bearing SMs.
40                                         Like alphaV, integrin beta1b was expressed in DFCs, and beta1
41 ilk OPN increased the expression of integrin alphav, integrin beta3, and CD44 in jejunum of mouse pup
42  conformation of integrin alphaIIbbeta3 with alphav integrin binding motifs resulted in the identific
43 g is important, combining defects in CAR and alphav integrin binding was essential to effectively red
44 pe cell interactions, lack CAR binding, lack alphav integrin binding, or lack both CAR and alphav int
45 lphav integrin binding, or lack both CAR and alphav integrin binding.
46 cin, two of these peptides-one containing an alphav integrin-binding Arg-Gly-Asp motif and the other
47                   These data reveal a common alphaV integrin-binding theme for tropoelastin: alphaVbe
48                                              alphav integrin blockade also reduces TGFbeta activation
49 ons by LMP2A, and a neutralizing antibody to alphaV-integrin blocked migration, suggesting that the e
50 er, in the absence of endothelial alpha5 and alphav integrins, but not of either alone, there are ext
51 ple, adenoviruses are known to interact with alphaV integrins by virtue of a high-affinity arginine-g
52 cies, our results indicate that both CAR and alphav integrins can impact vector distribution in vivo.
53                             Here we identify alphaV-integrin (CD51) as an essential regulator of card
54 kers for cardiac PW1(+) cells and found that alphaV-integrin (CD51) was expressed in almost all cardi
55                                          The alphav-integrins, cell adhesion molecules that are highl
56 rported TSP-1 binding proteins, CS36 and the alphav integrin chain, or TSP-1-derived peptides CGRGDS
57 tion of these cells, suggesting that the PLP/alphav integrin complex was important for the AMPA-media
58 he generation of Th17 cells and suggest that alphav integrins could be therapeutic targets in autoimm
59 monstrate that pharmacological inhibition of alphaV-integrin could reduce pathological outcomes follo
60         Inducible, endothelial cell-specific alphav integrin deletion similarly blunted inflammation
61 expression in human epithelial cells induces alphaV-integrin-dependent migration through a mechanism
62       Mouse embryos genetically null for all alphav integrins develop intracerebral hemorrhage owing
63    By contrast, mice lacking both alpha5 and alphav integrins developed interrupted aortic arches, la
64  the AMPA receptor, but in mice lacking PLP, alphav integrin did not associate with GluR2.
65                     Here, we show that these alphav integrins differentially contribute to sustained
66                   Thus, function of beta3 or alphav integrins does not seem to be involved in compens
67           However, when combined, anti-beta1/alphaV integrin dual targeting achieved relapse-free rad
68 technology to study the in vivo functions of alphav integrins during epithelial cell proliferation an
69 rly spreading, and coimmunoprecipitates with alphav-integrins during spreading on fibronectin and vit
70     After the RGD motif-induced targeting on alphav integrins expressed near tumor tissue, iRGD encou
71 opment, and also reveal a novel function for alphav integrins expressed on axons in the postnatal cen
72 ions as a ligand for binding alpha4beta1 and alphaV integrin-expressing cells.
73 tion/internalization and transduction of CAR/alphav integrin-expressing cells.
74 terfere with neovascularization, we targeted alphav integrin-expressing endothelial cells, which bloc
75                 Strategies to interfere with alphav integrin expression and/or function may therefore
76 d ERK2 knockdown potentiated the decrease in alphaV integrin expression associated with toxicity.
77 dditionally, enhanced neovascularization and alphav integrin expression correlated with GvHD severity
78             We show that genetic ablation of alphav integrin expression in basal epithelial cells of
79 ications such as visualizing and quantifying alphav-integrin expression by PET.
80 phav-integrin; however, the overall level of alphav-integrin expression was not altered by Ras or Raf
81 ing for alpha6-integrin, and negative or low alphav-integrin expression, and resulted in a 166-fold e
82 ction-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm bi
83  Here we show that codeletion of the p53 and alphav integrin genes in mouse stratified epithelia indu
84 -mutant embryos deficient in both alpha5 and alphav integrin genes.
85                                              alphav integrins have been identified as coreceptors for
86                                      CAR and alphav integrins have been identified as the primary cel
87                                              alphav integrins have been implicated in many developmen
88                   The RGD-binding alpha5 and alphav integrins have been shown to be key regulators of
89                                     Although alphav integrins have been shown to play critical roles
90                              Irisin acts via alphaV integrins; however, a mechanistic understanding o
91 ed on the cell surface as a heterodimer with alphav-integrin; however, the overall level of alphav-in
92 inhibited by a neutralizing antibody against alphav integrin in a dose-dependent manner.
93                      Conditional deletion of alphav integrin in both central nervous system glia and
94 ve been used to examine the roles of CAR and alphav integrin in determining the tropism of Ad vectors
95                          In mice deleted for alphav integrin in the myeloid line to reduce phagocytos
96 GFRbeta promoter-driven Cre system to delete alphav integrins in activated fibroblasts identified the
97 rus and adenovirus receptor (CAR), CD46, and alphav integrins in HAdV26 infection of human epithelial
98 s necessitate reevaluation of the primacy of alphav integrins in many functions including vascular de
99                  Here we describe a role for alphav integrins in regulating Toll-like receptor (TLR)
100          These data suggest a novel role for alphav integrins in the association between cerebral mic
101  Thus, the present study suggests a role for alphaV integrins in the mechanotransduction of pressure
102 etheless, in embryos lacking both alpha5 and alphav integrins in their endothelial cells, initial vas
103  notably within the RGD-binding subfamily of alphav integrins, including alphavbeta3, have faced sign
104 ssing Ad35 knobs, which enter cells by a CAR/alphav integrin-independent pathway, fiber shaft length
105 uggest that MKK3, rather than MKK6, mediates alphav integrin-induced p38 MAPK activation.
106 Rho-associated protein kinase inhibitor, and alphav integrin inhibitor all attenuated mechanical stre
107  cardiac PDGFRbeta(+) cells, suggesting that alphav integrin inhibitors may be effective for the trea
108 hat down-regulating or functionally blocking alphav integrins inhibits endogenous p38 mitogen-activat
109                   Disruption of both CAR and alphav integrin interactions may be critical for effecti
110                                Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are pr
111                                              alphaV-integrin is a subunit member of the integrin fami
112 tion in the absence of PLP and GluR2 or when alphav integrin levels were reduced.
113          In the present study, we found that alphav integrin ligation activated small GTPase Rac1 pre
114  ISS-ODN also enhanced surface expression of alphav integrins, making them significantly more suscept
115 in endoglin immunoprecipitates, and enhanced alphaV integrin-mediated activation of TGF-beta.
116                                     CAR- and alphav integrin-mediated infections are influenced by ot
117 ytes encountering apoptotic cells can deploy alphav integrin-mediated mechanisms to induce Tregs and
118                              AMPA stimulated alphav integrin-mediated OPC migration by increasing bot
119 ion, but only dominant negative MKK3 blocked alphav integrin-mediated p38 MAPK activation and uPA up-
120 tially, and dominant negative Rac1 inhibited alphav integrin-mediated p38 MAPK activation.
121 only MAPK-activated protein kinase 2 affects alphav integrin-mediated uPA up-regulation significantly
122 ream signaling molecules of p38 MAPK mediate alphav integrin-mediated uPA up-regulation.
123 ing the myelin proteolipid protein (PLP) and alphav integrin modulated the AMPA-stimulated migration,
124 at intetumumab (CNTO 95), a fully human anti-alphav integrin monoclonal antibody, is a radiosensitize
125         Combining radiotherapy with beta1 or alphaV integrin monotargeting in invading tumors led to
126 e found that renal fibroblasts express three alphav integrins, namely alphavbeta1, alphavbeta3, and a
127       We therefore proceeded to test whether alphav integrins' natural ligands fibronectin and vitron
128       These data suggest a mechanism whereby alphav integrins normally suppress epithelial cell proli
129              Further analysis indicated that alphav integrins on DCs activated latent TGF-beta during
130 llectively, these data provide evidence that alphav integrins on embryonic central nervous system neu
131  that lack alpha5, alphav or both alpha5 and alphav integrins on their vSMCs, using the SM22alpha-Cre
132          These findings suggest that soluble alphav integrins or antagonists of these coreceptors cou
133                     A second shRNA to either alphav-integrin or beta3-integrin, but not to another al
134                  In this study, we show that alphav integrin plays a critical role in regulating B ce
135 e AMPA receptor subunits themselves with the alphav integrin/PLP complex.
136    Thus, after AMPA receptor stimulation, an alphav integrin/PLP/neurotransmitter receptor protein co
137  endoglin in focal complexes, an increase in alphaV integrins present in endoglin immunoprecipitates,
138 t the effects of LMP2A on membrane-localized alphaV-integrin promoted migration.
139              The heterodimeric transmembrane alphav integrin receptors have recently emerged as poten
140                                    Primarily alphav integrin receptors mediated this down-regulation
141 lacking the arginine-glycine-aspartate (RGD) alphaV integrin recognition site from its penton base, w
142                Pharmacological inhibition of alphaV-integrin reduced the profibrotic action of cardia
143              Adenovirus (Ad) endocytosis via alphav integrins requires activation of the lipid kinase
144 blocking monoclonal antibodies revealed that alphaV integrin(s) and integrin alphaVbeta5 specifically
145                      Furthermore, inhibiting alphav integrins (S247), but not alpha5 (ATN-161), in at
146                    The generation of soluble alphav integrins should also permit further detailed kin
147       Mouse embryos genetically null for the alphav integrin subunit develop intracerebral hemorrhage
148 ptide or through CRISPR-Cas9 knockout of the alphaV integrin subunit in target cells increased macrop
149  Immunofluorescence colocalized OVS with the alphav integrin subunit which, along with CD9, resides p
150   Surprisingly, ablation of the gene for the alphav integrin subunit, eliminating all five alphav int
151                   Binding of either beta3 or alphaV integrin subunits increased MMP-1/10 secretion in
152               The ability of chimeric alpha5/alphav integrin subunits, in association with the beta1
153 f short interfering RNAs targeting beta1 and alphav integrin subunits, we downregulate all integrin r
154 the beta3 and the complementary alphaIIb and alphav integrin subunits.
155                             To specify which alphav integrins the virus utilizes, we tested MAbs spec
156 formed B lymphoblastoid cell lines expressed alphav integrins, the adenovirus internalization recepto
157  Ad receptor and undergo internalization via alphav integrins, this mutant does not escape from the e
158 facilitates viral internalization by binding alphav integrins through an RGD motif.
159 y studies demonstrated colocalization of the alphaV integrin to FAPs.
160  further show that prostate cancer cells use alphav integrin to migrate efficiently and directionally
161  of conserved clearance mechanisms employing alphav integrins upstream of tyrosine kinases and Rho GT
162     Furthermore, pharmacologic inhibition of alphav integrins using cyclic RGD peptides blocked TGF-b
163                Synovial tissue expression of alphav integrins was determined by immunohistochemistry.
164                               Interestingly, alphaV-integrin was greatly increased in membrane-enrich
165 tic cells, further studies demonstrated that alphav integrins were required for the next step in infe
166 ncreased expression of the miR-142-3p target alphaV integrin, which supported their survival.
167 re, we report on the roles of the alpha5 and alphav integrins, which are the major endothelial fibron
168 -MB-231 breast cancer cells whereas engaging alphav integrins with vitronectin activates p38 MAPK and

 
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