ライフサイエンスコーパス: already

1 ymatic action of oxidoreductases, which have already a strong presence in various other bioremediatio

2 Already a versatile research tool, the now oxygenated FA

3 ot show further improvement over AXDX and an already active ASP.

4 We had already addressed the two concerns raised-sparse sequenc

5 Drugs that have already advanced through human clinical safety trials ha

6 since the first oxygen is reported to evolve already after 7 flashes.

7 subclonal NT5C2 mutations were undetectable already after relapse induction treatment.

8 owth and development, and climate change has already altered the phenology of wild plants and crops(1

9 g site and the multimerization interface was already an intrinsic feature of the protein's structure.

10 We demonstrate that this bias is already apparent in bone marrow precommitted precursors.

11 This article provides an overview of already approved agents as well as those on the horizon.

12 Multiple human-safe sugar substitutes are already approved by the U.S. Food and Drug Administratio

13 Numerous drugs are already approved for human use, and subsequently, there

14 Although some formulations are already approved for human use, more radiopharmaceutical

15 the information from the diseases a drug is already approved to treat.

16 front at which a pluricellular actin ring is already assembled.

17 lated structure of the airway microbiota was already associated with immune mediator concentrations a

18 s of normal weight more often reported that, already at age 10 years, their body size was below avera

19 hough 80 genes were differentially expressed already at day 4.

20 formation of the two antimicrobial peptides already at low concentrations and the resulting defect f

21 cate that psbA translation activation occurs already at moderate light intensities.

22 ch can penetrate the full absorber thickness already at moderate temperatures.

23 c susceptibility, is present and substantial already at room temperature and grows by an order of mag

24 ble to predict future song copying accuracy, already at the earliest stages of learning, before initi

25 completely released from all breads' matrix already at the oral phase of digestion.

26 this is a highly tuned receptor which may be already at the sensitivity limit for EIS.

27 Many have pointed already at variation in risk factors between individuals

28 the maximum specific sulfatase activity was already attained at lower SUMF1 expression levels, while

29 As comparable systems are already available for clinical research, this approach c

30 Data from phase I and phase II trials are already available for several vaccine candidates, and ma

31 oxic tumors may benefit from EGFR inhibitors already available in the clinic.

32 annels to add an evolutionary context to the already available physiological information.

33 erapeutic doses within localized volumes can already be obtained with existing LPA technology, callin

34 s with a certain degree of functionality can already be obtained.

35 This may already be producing successful treatment outcomes witho

36 ze antisense oligonucleotide drugs that have already been approved by the Food and Drug Administratio

37 fic for tumor necrosis factor alpha that has already been approved for the treatment of several autoi

38 ease, a negative culture status, and had not already been classified as having had an unfavorable out

39 hibitor RVX-208 (now called apabetalone) has already been completed.

40 asion and damage is likely, which indeed has already been demonstrated by cardiovascular and gastroin

41 Various applications have already been demonstrated, ranging from on-site skin car

42 opolitan vector, Triatoma rubrofasciata, has already been detected in many Asian and African countrie

43 we collected 125 DBS cards, of which 45 had already been diagnosed by MS-HRM (20 PWS, 1 AS, and 24 h

44 h some consequences of this instability have already been empirically described, they may have been m

45 most of the common drug transformations have already been extensively described, manual search of dru

46 This adaptation has already been highlighted with various techniques and rep

47 frequently-mutated cancer driver genes have already been identified and are being utilized for diagn

48 restricted by these four MHC molecules have already been identified in SIVmac239, providing an ideal

49 Although some CD22 binding partners have already been identified, the knowledge about the CD22 in

50 and hollow nontubular engineered organs have already been implanted in patients, in vitro formation o

51 Tremendous progress has already been made, with photopharmacological agents now

52 These dependencies have already been observed earlier with diesel passenger cars

53 temperature, rainfall, and snow amount have already been observed.

54 protein inhibitors (FAPIs) 2, 4, and 46 have already been proposed as promising PET tracers.

55 Although some of these approaches have already been pursued for more than 5 decades and even mo

56 It has already been realized that two-dimensional (2D) material

57 It has already been shown that DOTA-bearing FAP inhibitors (FAP

58 undergoing silencing in B. oleracea, but has already been silenced in B. rapa.

59 ce 2012, with some platform companies having already been sold or recapitalized to new investors.

60 Apart from probiotics that have already been tested in human randomized controlled trial

61 The assay has already been used to analyze more than 1800 urine sample

62 Deployment of AI has already begun for a broad range of health issues common

63 Experimental camera trap studies have already begun to play an important role in understanding

64 ure of intraocular lens (IOL) technology has already begun with a number of recent innovations.

65 e determined by repurposing samples that are already being collected as part of clinical trials.

66 ote and CRISPR components, each of which are already being developed for other purposes.

67 d combinations of approved kinase inhibitors already being individually evaluated for chordoma.

68 With several vaccine candidates already being tested in clinical trials, we pose the que

69 therapies developed based on these findings already being tested in clinical trials.

70 Both ESCs and iPSCs are already being used in clinical trials.

71 factors, PTBP1 promotes displacement of UPF1 already bound to potential substrates.

72 used by the novel SARS-CoV-2 coronavirus has already brought unprecedented challenges for public heal

73 These results suggest that simple hydrogels, already built into numerous systems, have a much larger

74 e key components of a soil community develop already by the 24-month stage.

75 recessive alleles if the recipient bacterium already carries a wild-type copy of the gene.

76 ) is a global public health problem that has already caused more than 662,000 deaths worldwide.

77 The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and this

78 lasma p-tau181 is increased if CSF Abeta has already changed prior to Abeta PET changes.

79 therefore only applicable to materials with already characterised structures - or structure-agnostic

80 rn (PAMP)-triggered immunity (PTI) responses already characterized in A thaliana Protein-protein inte

81 or a quarter of the world population, yet it already claims ~60% of the global burden of heart diseas

82 Several ATP kit assays are already commercially available but an user-friendly ATP

83 Thrombocytopenia is already common at extracorporeal membrane oxygenation in

84 t most landfills, where leachate aeration is already commonplace.

85 sly undocumented functional diversity in the already complex stomatopod eye and is a first step towar

86 during drought, when ecosystem processes are already compromised by low water availability.

87 23 ladder materials, where OSMP is relevant, already confirmed our previous theoretical prediction of

88 Despite consequences that are already considerable, the impact of SVD is predicted to

89 lizes the superposition of conventional SWV, already considered as one of the most sensitive voltamme

90 en the increased likelihood that a host will already contain a plasmid when it acquires another throu

91 SHIV-SF162p3S could not be improved, as it already contained the optimal Env375 residue.

92 Scale-up of ART over the last decade has already contributed to substantial reductions in HIV-1 i

93 scovery augments the proxies available at an already critical fossil locality and highlights the pote

94 group VI elements on the periodic table have already demonstrated exciting properties such as near-ro

95 fate oligosaccharides to remove lipoproteins already deposited in both the extracellular matrix of RP

96 For both systems, we observed already described interactions shared by homologs from o

97 In addition to the already described ligand L(4a), two pyclen-based lanthan

98 comparison, 10 of 16 had at least one lesion already detected at baseline (63% PET persistence), 4 of

99 nified by the heat spike and a synergism was already detected at the low concentration when exposure

100 Building on successful case studies of already developed multitarget strategies involving CB2R,

101 Because most Cretaceous marine vertebrates already disappeared in the Gulf of Mexico prior to the l

102 minated by fewer but larger rainfall events, already documented over much of the globe, can be expect

103 trast, corals in highly disturbed areas were already dominated by heat-tolerant symbionts, and despit

104 l research to best advance CICU care for the already dominating and still expanding population of old

105 Considering cells are already "droplets" with hydrophilic surface and elastic

106 es predict higher-order memory and cognition already during childhood, even if still subject to ongoi

107 h-Reynolds-number fractal-scaling properties already during early transitional and nonisotropic stage

108 ndicate that ischemic inflammation initiates already during vascular occlusion.

109 m multi-faceted immunotherapies, given their already elevated tumor CD8+ T cell levels.

110 tion between decoded and perceived direction already emerged before visual stimulus onset, suggesting

111 ses (RAIDs), often by 'borrowing' treatments already employed in one RAID or previously used in an en

112 Transcatheter electrosurgery already enables a range of novel therapeutic procedures

113 se, many are endorheic and ephemeral systems already encompassing different degrees of aridity, land

114 number of primary basal dendritic arbors is already established before eye opening, and that these a

115 evelopment as of December 31, 2019 come from already established drug classes, most in early stages o

116 s lack of therapeutic potential in reversing already established fibrosis.

117 how that significant energetic impairment is already established in moderate AS and suggest that a fa

118 lin-resistance onset and remarkably reverses already established insulin-resistance.

119 nt, improves the differentiation capacity of already-established murine and human PSCs.

120 the canted antiferromagnetism (T(N) = 5.8 K) already evidenced by direct current magnetometry.

121 ine-induced BrS (78%), the RVOT location was already evident at baseline.

122 s of the dopaminergic system of amniotes had already evolved when the amphibian line of evolution div

123 rking in countries whose COVID-linked deaths already exceed their military casualties from all campai

124 he dynamics of the parietal community, which already exhibited increased flexibility and promiscuity

125 GMPs, it is unclear if committed progenitors already exist among these progenitors and how they may b

126 peutically targetable pathogenic Abeta seeds already exist during the lag phase of protein aggregatio

127 Although extracurricular efforts already exist for many computationally intensive discipl

128 Whether or not planets already exist in the disk of IRS 63, it is clear that th

129 metimes possible to repurpose materials that already exist.

130 nean Sea, and from then on, re-colonized the already existing rookeries of the Atlantic.

131 This method is applicable to already existing samples of various qubit types, without

132 ivations, practices and experiences of those already experiencing CMDs.

133 al sites, clustered at the water's edge, are already experiencing some of the most dramatic damage du

134 ens to supramolecular electronics, a concept already exploited in natural organisms.

135 nd trimethylarsine oxide, although they were already first detected in PM in the mid-1970s.

136 elevating red blood cell and plasma flux in already flowing capillaries.

137 Although polyrotaxanes have already found niche applications in exotic materials wit

138 Although abnormal LFTs are already frequently present upon admission before the sta

139 ic resting state functional MRI studies have already furthered our understanding of cerebral reorgani

140 ive arginine sites, as well as by converting already-glycated arginine residues into citrulline.

141 it was then invading Europe also, as France already had 12 cases, Germany 16, the UK 9, Italy 3, Spa

142 dy had 74,576 cases and in South Korea which already had 58 cases, and that it was then invading Euro

143 CoV-2 had spread very rapidly in China which already had 74,576 cases and in South Korea which alread

144 gh-dose ICSs as their first preventer, 13.0% already had documented diabetes, cataracts, glaucoma, or

145 animal species over time, 44% of which have already had local extinctions at one or more sites.

146 yndrome (SARS)-like viruses argued that bats already harbor CoVs with the ability to infect humans wi

147 sing dye-labeled secondary antibodies (which already has a built-in signal amplification mechanism),

148 ansition, where this ultranodal behavior may already have been observed.

149 n advanced-stage malignancy; (3) the patient already have confirmative diagnosis using a serology, pe

150 -gestational-age or fetal death in women who already have gestational comorbidities.

151 virus 2 (SARS-CoV-2), yet these measures are already having similar effects on other directly transmi

152 ate stimulating additional methanogenesis in already heavily biodegraded oil reservoirs, oil sands sa

153 dianion population falls within a m/z range already heavily congested with monoanions from more abun

154 hat a group of 22-month-old infants (N = 32) already held expectations about others' choices in a vio

155 SA) values below 0.5 ng/mL compared with the already high detection rate of (68)Ga-PSMA-11 PET/CT.

156 ural studies performed in Trypanosoma brucei already highlighted the numerous peculiarities of these

157 The Burgundy truffle is already highly suitable for cultivation on ~ 14% of agri

158 rojected seasonal precipitation variation in already highly variable precipitation regimes gives rise

159 ralization asks for improvements, some being already identified.

160 Other methods of altering the power of an already implanted IOL are under development.

161 associated with cardiometabolic risk factors already in childhood.

162 developed at an unprecedented speed and are already in clinical trials, without preclinical testing

163 h as sulforaphane and bardoxolone methyl are already in clinical trials.

164 The first AV fleets are already in service in US cities.

165 late-life, when low-competition females were already in steep reproductive decline and suffered from

166 e Markov state models occur when PK-11195 is already in the membrane and involves only minimal ligand

167 These tools are already in use for evaluating liver fibrosis and in the

168 ine learning and artificial intelligence are already in use in health care and appear to deliver bene

169 patients show increased Th17 differentiation already in vivo.

170 patients show increased Th17 differentiation already in vivo.

171 losum of Tmem106b-/- mice, which was present already in young animals (21 days) and persisted until o

172 This article highlights social determinants already included in USPSTF recommendations and proposes

173 impacts of cross-reactive T cell memory are already incorporated into epidemiological models based o

174 miR-132-3p, miR-146a-5p, and miR-22-3p) were already increased in 6-month-old mice, an age before the

175 coronavirus disease (COVID-19) pandemic has already infected millions worldwide and, with no vaccine

176 nt to limit morbidity and mortality in those already infected.

177 the field of 'Cancer Systems Immunology' has already influenced our understanding of tumor immunology

178 0 mM serine whereas the wild type strain was already inhibited by 1 mM of the amino acid.

179 phile and bond cleavage to the leaving group already initiated.

180 -Mcm2-7 (OCCM) complex in which DNA has been already inserted into the central channel of Mcm2-7.

181 de migrant voices or those professionals not already interested in migrants.

182 As topical rh-NGF is already involved in early clinical trials, this highligh

183 s available to treat this infection that has already killed > 310 000 people worldwide.

184 and informative - conveying what we did not already know.

185 (2+) ](cyt) upon darkness in addition to the already known dark-induced increases in [Ca(2+) ](stroma

186 icuous (HbA1c >= 5.7%), including those with already known DM.

187 the areas of importance in the EPO, that are already known for this species, and the more marginal ho

188 ive steps of the various ferroxidase centers already known in ferritins were successfully discriminat

189 ighest inhibiting activities, similar to the already known inhibitor sodium citrate.

190 e found that one protein, termed NFATc2, was already known to be important for a very early step in v

191 ATB1a, GmPDAT, GmPLDalpha1 and GmDAGAT1) are already known to be related to oil synthesis.

192 c marks were identified near RA target genes already known to be required for body axis and limb form

193 s (20%); for 62 of the 70, the diagnosis was already known, and eight were not candidates for therapy

194 ntentional threat, at the expense of what is already known, and more broadly, they suggest that envir

195 Also, reaction pathways that were already known, for example the generation of gold(III) i

196 egulatory effect of RUNX3 in beta-catenin is already known, our results suggest the possibility of a

197 of resistance even though they cannot clear already-large resistant populations.

198 ant groundwater changes because this area is already largely water limited.

199 spread.IMPORTANCE The COVID-19 pandemic has already led to more than 700,000 deaths and innumerable

200 As extended release 4-AP is already licensed for symptomatic multiple sclerosis trea

201 (>30%) of habitat impacted; 21 of these were already listed as threatened with extinction.

202 tions reveals an intermediate stage that had already lost a large number of genes, including nearly a

203 In contrast, already low extractable phosphorus (Bray P) content decr

204 e also recognized as pharmacophores found in already marketed and well-sold drugs (e.g., esomeprazole

205 body testing and a large number of tests are already marketed or are in the late stage of development

206 closeness, and the underlying mechanisms are already mature by adolescence.

207 nd aetiological factor in a subset of people already meeting CHR criteria.

208 sted for feasibility, i.e., ~1/3 of products already meeting the target, and alignment with existing,

209 times), which we now know was from ancestors already nearing associated thresholds, and provides a fr

210 herbivores by depleting nutrients from their already nutrient-poor diet.

211 ological consequences of climate change have already occurred across the warmer, drier regions of Sou

212 dy size within Vombatiformes, several having already occurred by the late Oligocene.

213 Local cycles of transmission have already occurred in 12 countries after case importation.

214 nt genera in the distributed drinking water, already occurred in the clean water reservoir at the tre

215 First, mass layoffs and closures had already occurred-just a few weeks into the crisis.

216 an delay intervention until after damage has already occurred.

217 reater, while frequent exposure to low DO is already occurring.

218 of the trial clinics, and either starting or already on ART.

219 fication of photonic sensing chips which are already on the market thus having an excellent translati

220 to travel for almost twice as long as those already on treatment.

221 As many states have already or are considering to re-open and relax stay-at-

222 e resources for health care and research are already overstretched, priorities need to be set to guid

223 cial meltwater production is imminent if not already passed, which has profound implications for wate

224 t the intact tropical forest carbon sink has already peaked.

225 inferred that the great ape common ancestor already possessed multicopy sequences homologous to most

226 ial stimulus - an upright face - infants are already prepared to process it.

227 Full-blown cognitive skills were already present at the age of four months with subadult

228 he transcription start site, and if H2A.Z is already present downstream, additional H2A.Z accumulates

229 fferences in heterogeneity in conduction are already present during sinus rhythm and may explain the

230 shows that for standard MOFs based on metals already present in active molecules of the human body, t

231 a core process for furrow formation that was already present in ancestral eukaryotes.

232 Thus, primordial metabolic pathways, already present in bacteria before aerobic respiration e

233 ms of stress-induced growth arrest that were already present in ferns, bryophytes, and possibly in al

234 anced sensory abilities of pterosaurs(9) are already present in lagerpetids, which indicates that the

235 sal ganglia, limbic, and sensory systems was already present in the common tetrapod ancestor.

236 are ancient biological assemblies that were already present in the last universal common ancestor of

237 solve any potential tiny crystals and nuclei already present in the raisins.

238 ings indicate that these characteristics are already present in the thalamus.

239 ations, we discovered that this asymmetry is already present in the wild-type (WT) RIIbeta2C2 but had

240 that the differences among clades I-III were already present in their ancestors.

241 s or it evolved from morphogenetic processes already present in their unicellular ancestors.

242 However, when resistance is already present, removing drug-sensitive cells as quickl

243 VID-19 impacts along with negative pressures already present.

244 ttractive interligand Cl/R(3)Si contacts had already previously been invoked to explain the outcome o

245 Already prior to storage, well storable varieties were c

246 Here, we assess a range of practices already proposed to deliver SCS, and distil these into a

247 tential beyond the refractive aspect and has already proven helpful in cases of iris defects and irre

248 type of cancer targeted sequencing, and has already proven its use in a research laboratory environm

249 ithin the human gut microbiome on drugs, has already provided important insights into these therapeut

250 July 2021 eLife will only review manuscripts already published as preprints, and will focus its edito

251 peratures of surface soils at the study site already reach 19 degrees C during midsummer, the observa

252 afficking of the newly synthesized Cx43 that already reached the Golgi was not affected in Abeta(25-3

253 Eligible patients were 60 years or older, already receiving allopurinol, and had at least one addi

254 In patients not already receiving anticoagulation or on DAPT at the time

255 nly identified 1 LTBI case; 13 patients were already receiving immunosuppressants at the time of scre

256 Of 67 patients not already receiving OAT at baseline, 53 (79%) started OAT.

257 ortality was 11.8% (39.0% if the patient was already receiving ventilation at randomization and 9.5%

258 ven by a more efficient recruitment of LHCII already residing in the grana into functional PSII-LHCII

259 e to the more efficient recruitment of LHCII already residing in the stromal lamellae into PSI-LHCII

260 We found that, although OPA already responded more to scenes than objects by age 5,

261 apacity for data analysis and counselling is already restricting the provision of genetic testing.

262 cystine import continues into cells that are already sated with cysteine.

263 ovide care for AKI, including acute PD, have already saved hundreds of children.

264 g methods, two new studies show that arousal already sculpts visual information as it first enters th

265 protective effects on hepatic metabolism are already seen in the offspring early life.

266 ts had PET-positive nodal disease after SLND already seen on pre-SLND PSMA PET.

267 f 237 Australian catchments-29% of which are already severely salt-affected-from the Australian Water

268 ay appear so where vegetation boundaries are already sharp.

269 rea and retrosplenial complex) by adulthood, already show domain-specific patterns of functional conn

270 he versatility of chelation-based design has already shown promise in hydrogels and highly stretchy n

271 The TME already shows a reduction in type 1 regulatory T cells a

272 navirus disease 2019 (COVID-19) pandemic has already spurred several major public health "lessons lea

273 ver time, adjusting for the time the patient already survived, and for the patient's present disease

274 ted, conditioned on various numbers of years already survived.

275 ideal in the HF population as most patients already take >=5 medications.

276 tion clusters, who were HIV-positive and not already taking ART were offered universal HIV-treatment

277 thin the short laser-accelerated bunches can already today exceed the values achievable at the most a

278 o reverse a dismal situation that has lasted already too long.

279 ly to complete the trial the longer they had already tracked the target.

280 process proved to be a tipping point for an already turbulent mixture, leading to an abrupt and unco

281 s that were highly methylated in gametes had already undergone CHH hypermethylation in the SAM.

282 nterventions are targeted towards, will have already undergone repeated and widespread heat wave indu

283 ical enzyme whose vulnerability to oxygen is already understood.

284 Current studies are already unraveling the transmission and buffering of str

285 Although checkpoint inhibitors are already used as therapy against various cancers, not muc

286 tential to extend the use of glucose strips (already used by millions for diabetes monitoring) to the

287 New, fast-acting T2-targeting biologics (already used for preventing asthma exacerbations) have t

288 Offline MRI is already used for treatment planning at many institutions

289 support the exploration of device platforms already used in energy research to identify new opportun

290 Women aged 16 years or older, not already using hormonal contraception, not on medication

291 ion of IBD patients and to compare it to the already validated IBD-DI.

292 charides containing 2-amino uronic acids, as already verified here for Shigella sonnei O-antigen, Str

293 kely related to the natural instability, was already visible in 2007 on various sectors of the entire

294 s of Americans with opioid use disorder, who-already vulnerable and marginalized-are heavily dependen

295 gether demonstrate that river deposition was already well established >3.7 Ga.

296 arge carrying capacity of the new niche - is already well recognized.

297 his resource by presenting the expression of already well-known genes of COPD and IPF across multiple

298 MMOX processes with partial nitrification is already widespread, especially for sidestream treatment,

299 We show that a dose of ~40 kilograys already yields 50% ferrous iron in a heme protein crysta

300 l and superconducting circuit platforms, and already yields strong enhancements with as few as three