ライフサイエンスコーパス: already-known

1 egions, but this limits the study to what is already known.

2 negative inhibitor of the c-Myb protein was already known.

3 stantial number of operons in the genome are already known.

4 e interaction sites for interaction partners already known.

5 through cGMP phosphodiesterase activation as already known.

6 rocess by linking new information to what is already known.

7 unction where sequence or fold similarity is already known.

8 wards Persei) where the electron fraction is already known.

9 rd cell ion channels and their regulation is already known.

10 tween the reticulocyte isoforms and the ones already known.

11 ptor, for which a large number of ligands is already known.

12 lies in which the actual molecular defect is already known.

13 s can also be generated by combining what is already known.

14 the data obtained do not add much to what is already known.

15 pes of BmSODs in addition to the three types already known.

16 cts in which the DNA regions of interest are already known.

17 the general population, about which much is already known.

18 , for which the vapor concentration field is already known.

19 st data sets, for which expected results are already known.

20 emical and physical properties of structures already known.

21 , as well as the pseudouridine synthase, are already known.

22 ough the basic facts about the ribosome were already known 40 years ago, elucidating its atomic struc

23 ues in the homologs, are compared to what is already known about functionally important residues in t

24 In addition to organizing what is already known about human aggression, this review, using

25 Hopefully, what is already known about IFN will prompt further exploration

26 randomized clinical trials to update what is already known about specific treatments in cardiovascula

27 According to what is already known about the market demand for over-the-count

28 ained by adding neutral evolution to what is already known about the mutation process.

29 Our model is consistent with what is already known about the regulation of CDK and PP2A:B55de

30 ne defects, respectively, adding to what was already known about the validity of contrast enhanced sy

31 ved ncRNA genes in CLL, highlighting what is already known about their function, proposing a novel mo

32 C-C to a C-O bond formation, contrary to the already known alkylations of such ambident nucleophiles,

33 More than 60 DUBs are already known, although little is known about their biol

34 al-world graphs whose community structure is already known and find that the method detects this know

35 We also discuss in the context of what is already known and newly defined signaling pathways that

36 s (20%); for 62 of the 70, the diagnosis was already known, and eight were not candidates for therapy

37 ntentional threat, at the expense of what is already known, and more broadly, they suggest that envir

38 s in adults revealed that six metabQTLs were already known, and one had been described in serum and t

39 al added value of new research given what is already known, and to encourage those conducting researc

40 eater genetic diversity of S. aureus than is already known, and understanding S. aureus host specific

41 (IFN) beta-1a, whose antiviral potential is already known, and which is a drug currently used in the

42 ndependently discovered that FtsZ, a protein already known as a key player in bacterial cytokinesis,

43 Already known as a receptor for endogenous molecules, CD

44 art of the 70 S ribosome, whose structure is already known at a better resolution.

45 that were later grouped into the family were already known at that time.

46 A majority of these candidates have already known atherogenic potential in humans and/or mic

47 Two sites appear as outstanding: One is the already known binding pocket of 2GBI, which is accessibl

48 In addition to already known bioactive molecules, for the first time, x

49 stulated mechanism not only explains what is already known but also suggests that other products and

50 ow air pollutants could affect the brain are already known, but direct evidence of the presence of am

51 A plant peroxisomal CoA transporter is already known, but plant mitochondrial or chloroplastic

52 rting point, identify 59 RLPs, including the already known CLAVATA2 and TOO MANY MOUTHS genes.

53 gens is often constrained by the analysis of already known compounds, there is a need to identify new

54 (2+) ](cyt) upon darkness in addition to the already known dark-induced increases in [Ca(2+) ](stroma

55 family and adds specific prenylation to the already known determinants of Rab localization.

56 he extreme end of the phenotypic spectrum of already known disorders.

57 nspicuous (HbA1c 5.7%), including those with already known DM.

58 icuous (HbA1c >= 5.7%), including those with already known DM.

59 se in vitro data are taken together with the already known effects of cholesterol 5,6-secosterols on

60 ptidases that are simply species variants of already known enzymes from those that represent novel en

61 respectively); three of these compounds are already known experimentally to be ferromagnetic semicon

62 nding sites in proteins whose structures are already known, experimentally measured protein-ligand di

63 returns only correlations not explainable by already-known factors like the cell type landscape; this

64 e generation of 2-oxindole motifs, which are already known for a plethora of pharmacological benefits

65 proteins, including some (ZBTB7A and BCL11A) already known for directly silencing the fetal gamma-glo

66 deacetylase (NuRD) complex proteins that are already known for HbF control; (2) seven C2H2 zinc finge

67 Cutaneous malignant melanoma (CMM), already known for its highly aggressive behavior and res

68 This family of molecules, already known for its key metabolic functions, has been

69 Already known for its role in nictitating membrane respo

70 o immune clearance in an ESBL E coli lineage already known for its virulence is an unsettling develop

71 We showed that in addition to the properties already known for LEDGINs, the binding of tBPQAs to the

72 Cyclodextrins are already known for their ability to encapsulate various d

73 rior superior parietal lobule, and striatum) already known for their critical role in motor sequence

74 the areas of importance in the EPO, that are already known for this species, and the more marginal ho

75 f these new epitopes in the context of those already known for VACV in mice and humans revealed two i

76 and bile salt export pump deficiencies were already known for years.

77 Also, reaction pathways that were already known, for example the generation of gold(III) i

78 In addition to confirming genes that were already known from mGWAS, we were able to identify and v

79 Here we consider broadly what is already known from non-NGS studies about thermal adaptat

80 inor events: wording in the report, findings already known from patient history or prior imaging or c

81 ly used to improve the depiction of findings already known from standard two-dimensional T2*-weighted

82 that would add to the risk-benefit profiles already known from tertiary data sources.

83 proved successful in both reconstructing the already known functional domains and in identifying the

84 in kinase A as a study object and asked what already known functionally important residues can be det

85 are signaling centers, in addition to their already known functions in the mechanics of vertebral co

86 roptosis) have markedly extended the list of already known functions of Cu, such as a cofactor of ess

87 While four PIGs are identical to already known genes (pfeR, pvdS, tonB, and fumC, respect

88 Results obtained to date partly confirm already known genetic vulnerabilities, but also point to

89 IC in the wild-type strain, including three already known IC-repressed genes.

90 ive steps of the various ferroxidase centers already known in ferritins were successfully discriminat

91 nor-recipient pairs evaluated included those already known in the cat to receive donor excitatory mus

92 There are few methods already known in the literature to make these molecules;

93 Much is already known in this system about a form of learning in

94 ed regions in RecQL5 as KIX and SRI domains, already known in transcriptional regulators for Pol II.

95 utomatically discovered 28 TIs (some of them already known) in five different symmetry families.

96 acetyl-trytophan (IA-Trp) in addition to the already known indole-3-acetyl-aspartic acid (IA-Asp) and

97 ighest inhibiting activities, similar to the already known inhibitor sodium citrate.

98 Nevertheless, due to the already known inhibitors of human neuraminidase enzymes,

99 irmed that the isolated FaEO consists in the already known isoform and that it is the most characteri

100 llest distance to its nearest neighbor among already known materials.

101 data demonstrate that, in addition to these already known mechanisms, MT1-MMP is regulated by O-glyc

102 Using the newly-discovered and already-known members of this antibody family, we review

103 dard invertebrate code as well as confirming already known metazoan deviations from it (ascidian, ver

104 Several major improvements of the already known methods to build up such chiral backbones

105 ds (+/-)-19, (+/-)-20, and (+/-)-21 and two (already-known) monosubstituted C1-symmetrical TBTQ analo

106 erately active compounds or the detection of already known natural products (NPs).

107 a 10-fold slower ATP turnover rate than the already-known non-actin-bound, disordered relaxed (DRX)

108 e extract the values of these exponents from already known numerical or theoretical results, and we n

109 ue cDNA fragments encode genes/ESTs that are already known, of which only two have been mapped to thi

110 3 years with particular reference to what is already known on this topic.

111 tes were insignificant, as the diagnosis was already known, or they were considered colonizers/contam

112 egulatory effect of RUNX3 in beta-catenin is already known, our results suggest the possibility of a

113 rug-associated hemostatic complications, the already known pathogenetic mechanisms involved, and the

114 terns cannot be represented or understood by already known patterns of sperms or other micro-swimmers

115 Together with already known phenolics, including caffeic acid, p-couma

116 activating gene 1 (RAG1), in addition to the already known phenotypes of SCID and Omenn syndrome (see

117 Since the action of already known plant beta-amylases (sweet potato and soyb

118 wing from the thoracic notum as well as the already known pleural elements of the arthropodan leg.

119 ral features shared by the new compounds and already-known poliovirus inhibitors.

120 ds that infer properties from the pattern of already known PPIs in the species of interest.

121 audience design effects, or effects based on already known properties of the addressee (e.g., child v

122 elation-based computation, based directly on already-known properties of V1 neurons, can account for

123 idation and deeper characterization of those already known provide a complete and updated picture of

124 Similarly to the already known Q10 parameters for temperature, accelerati

125 issing annotations being limited to a set of already known reactions.

126 ment and poor long-term outcome and confirms already known risk factors for poor prognosis.

127 independent ncRNA genes besides homologs of already known RNAs.

128 Among the already known RO membrane fouling mechanisms, a novel RO

129 Beyond the already known role of macrophages as pathogenic effector

130 e survival of A. baumannii in NHS, including already known serum resistance factors, and many novel g

131 This accomplishment, together with the already-known single-input gates (performing as YES and

132 In addition to the already known small polarons, we identify three species,

133 This mode is reminiscent of the already known South Atlantic Dipole, and it is probably

134 ies of bR(570) and M(412), together with the already known spectroscopic properties of the different

135 se that COFS syndrome be included within the already known spectrum of NER disorders: XP, CS, and tri

136 oach can identify etiological links that are already known (such as between fetal hemoglobin and mala

137 It is based on the already known technique where sulfur is used as a natura

138 This is in contrast with already known techniques which rely on interactions with

139 ed to encode four of these enzymes and it is already known that one of these, LOX2, is dispensable fo

140 It is already known that primary cilia in the RPE are critical

141 e (and point out in our article) that it was already known that subjective measures are sensitive to

142 ctice since the beginning of time, as it was already known that they contained biological components

143 olution structures of the T4SS and pilus are already known, that of the relaxosome has not been repor

144 enes whose time of replication in S phase is already known, the presence of a cell in early or late S

145 If the tree topology is already known, then seven leaves suffice for identifiabi

146 While many of the loci involved are already known, these conditions remain incurable, and ge

147 icase genes, tlh3 and tlh4, which add to the already known tlh1 and tlh2, and found that the tlh1-4 g

148 sions, 8-oxoguanine and thymine glycol, were already known to activate repair in irradiated mammalian

149 a heteroatom into a cyclophane macrocycle is already known to alter all the above properties drastica

150 gnificance level of 5 x 10(-8) including six already known to associate with VTE (ABO, F2, F5, F11, F

151 Trace fossils are already known to be a useful tool for studying of contou

152 Many of these transcripts were already known to be abnormally expressed in neoplastic t

153 with MS and healthy control subjects and is already known to be associated with brain substructure v

154 measured the expression of a set of circRNAs already known to be associated with cardiac diseases (ci

155 ared only by the MDR and XDR genomes and not already known to be associated with drug resistance.

156 mmary and the expression levels of genes not already known to be associated with the pathway provide

157 ponse, measured in the mesoscopic regime, is already known to be conditioned or renormalized by therm

158 lates a number of genes in addition to those already known to be controlled by MarA.

159 Besides genes already known to be directly under the control of Spo0A-

160 38 "candidate EDA targets", 14 of which were already known to be expressed in hair follicles or epide

161 The data set also contained 2 genes already known to be expressed in the aorta, elastin at 5

162 Methylglyoxal is already known to be generated by carbohydrate and lipid

163 nverse methods to interpret observed spectra-already known to be highly averaged representations of i

164 If so, then M(1)dG, already known to be highly mutagenic in human cells, als

165 ting who had at least one sexual contact not already known to be HIV-positive (index cohort).

166 e found that one protein, termed NFATc2, was already known to be important for a very early step in v

167 g the Grainyhead factor Get1/Grhl3, which is already known to be important for epidermal barrier form

168 tein kinase intracellular signaling pathways already known to be important for neoplasia.

169 e for a Wnt-regulated gene, Mybl2, which was already known to be important for proliferation, in dete

170 avioural differences within a population) is already known to be important in group interactions.

171 TRX2 is already known to be induced by oxidative stress dependen

172 AFI genes, gadA, gadX, gadW, and gadE, were already known to be involved in an acid resistance syste

173 9% (19 of 39) of X-chromosomal PSD genes are already known to be involved in human psychiatric disord

174 In addition to two enzymes already known to be involved in its biosynthesis (homoge

175 In addition to identifying genes already known to be involved in leg development, we iden

176 This screen indeed identified 13 genes, some already known to be involved in longevity, plus candidat

177 helial Krts, Krt6a and Krt6b; and Tgm 1 were already known to be involved in nail abnormalities when

178 or close to, genes with putative homologues already known to be involved in pathogen responses in ot

179 Our study identified genes already known to be involved in plant growth but also as

180 Although some of the genes were already known to be MarA regulated, the majority were ne

181 Thus Avy expression, already known to be modulated by imprinting, strain-spec

182 re region in the minimal left-end origin not already known to be occupied by NS1.

183 Some of the genes identified are already known to be overexpressed in ovarian cancer, but

184 nd antiapoptotic pathways, some of which are already known to be regulated by NS5A.

185 Many of these genes were already known to be regulated by particular transcriptio

186 and sequencing of the same gene or of genes already known to be regulated in the system of interest

187 ATB1a, GmPDAT, GmPLDalpha1 and GmDAGAT1) are already known to be related to oil synthesis.

188 d genes including some novel as well as some already known to be relevant to bone metabolism.

189 c marks were identified near RA target genes already known to be required for body axis and limb form

190 including multiple protein products of genes already known to be responsible for renal and systemic d

191 nels other than the TRPV1 and TRPA1 channels already known to be targets in rat and mouse sensory neu

192 Since RoxS is already known to be transcriptionally controlled by mala

193 le for clinical investigation of entinostat, already known to be well tolerated in a pediatric phase

194 zoonotic spillover potential alongside those already known to be zoonotic.

195 gene may be responsible for both conditions, already known to bear clinical resemblance.

196 Although BAFF is already known to bind two receptors, BCMA and TACI, we h

197 Even if a gene has variants already known to cause a disease, rare disruptive varian

198 e of these mistakes generate mutant proteins already known to cause disease, while others generate pr

199 ctors, of which some may be related to genes already known to cause the phenotypically related Mendel

200 STAT1 and STAT2 are already known to combine with p48, a DNA-binding protein

201 tent to which whole-gene lateral transfer is already known to confound evolutionary reconstruction.

202 1) and its G-protein-coupled receptor CXCR4, already known to control many types of normal and pathol

203 bited some of the structural characteristics already known to demonstrate this activity, all of them

204 The guidance molecules Semaphorin 3A and 3F, already known to direct oligodendroglial migration in de

205 re we show that proximal regulatory elements already known to direct promoter activity in T cells are

206 on to increased implementation of strategies already known to effectively prevent and manage acute di

207 s the bZip-domain transcription factor Xrp1, already known to eliminate cells heterozygous for riboso

208 here classical singular spectrum analysis is already known to fail dramatically.

209 ng of the roles of miRNAs in EMT, which were already known to form important regulatory loops with ke

210 ndings reveal new properties of this protein already known to function as a circadian photoreceptor a

211 genes were identified, several of which were already known to function in chromatin modification and

212 ly new material system, with domain patterns already known to generate interesting functionality in t

213 ralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral res

214 Among those, sialylated HMO are already known to have a pivotal role in the antiadhesive

215 HIV-1 is already known to have an extremely fast mutation rate, b

216 unction to a given list of genes (the query) already known to have closely related function.

217 mologs of the components of this pathway are already known to have key roles in cell motility and int

218 cle)), orbiting the star Kepler-20, which is already known to host three other, larger, transiting pl

219 Two mutations already known to inactivate the F(1)F(0) ATP synthase co

220 e trio supplements five CRESS virus families already known to infect eukaryotes, extending the CRESS

221 as well as how Mycobacterium tuberculosis is already known to influence various other cell signaling

222 it diaphragm linker protein MAGI-1, which is already known to interact with several critical podocyte

223 These include genes already known to mediate EGFR inhibitor resistance as we

224 orphan G protein-coupled receptor, which are already known to modulate cell migration.

225 A number of eukaryotic proteins are already known to orchestrate key steps of mRNA metabolis

226 orted by triple evidences, including 6 genes already known to perform specific roles in RA and 6 gene

227 functions; some of these have family members already known to phosphorylate microtubules, actin or th

228 A gene already known to play a crucial developmental role in ch

229 avefront model in which oscillator coupling, already known to play a key role in oscillator synchroni

230 This cluster includes 56 of 115 genes already known to play roles in stationary phase.

231 Adverse working conditions for nurses, already known to pose a risk to patient safety, may also

232 used on Amborella trichopoda, because it was already known to possess one horizontally acquired gene

233 ts whose diagnosis, therapies, and course is already known to predict not only disease severity, but

234 all steps involved in a catalytic cycle are already known to proceed concurrently under the same con

235 C2 of the substrate to C3 of the product is already known to proceed intramolecularly with retention

236 icoid-induced leucine zipper protein (GILZ), already known to regulate effector versus regulatory T c

237 s revealed mutations in MIG1 and REG1, genes already known to regulate glucose repression, as well as

238 components of a histone deacetylase complex already known to repress early meiosis-specific genes in

239 e following intranasal immunization (a route already known to result in high-level systemic anti-TTFC

240 eter along with control Ae. aegypti colonies already known to show divergent behavior in this assay.

241 n-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed as

242 Some of these problems were already known to the authors of the minimizers technique

243 FAT2, ZNF750 and KMT2D, in addition to those already known (TP53, PIK3CA and NOTCH1).

244 bout the underlying mechanisms for novel and already known trait loci.

245 phobic surface properties, compared with the already known vertebrate beta-defensins.

246 ell epitope prediction programs can identify already known viral epitopes of FMDV in the context of t

247 The analysis identifies already known warheads but also reveals hydrazide, pyraz

248 veral HLA-A2-restricted HCV CTL epitopes are already known, we aimed to identify CTL epitopes restric

249 man traits for which the causal variants are already known, we successfully placed the known causal v

250 rom those groups in which the phenomenon was already known, we suggest that state-dependent valuation

251 sphate from nucleosides was catalyzed by the already known wide-spectrum thymidine kinase and the rib

252 domain, whose three-dimensional structure is already known, will facilitate future drug development s

253 The already known X-ray structures of lipases provide little