ライフサイエンスコーパス: alter

1 ith skin blood supply and wound healing were altered.

2 DR] showed that 18 miRNAs were significantly altered (1 downregulated 4 up and 13 downregulated; p <

3 The Thr518Met mutation altered a highly conserved amino acid in the MYRF protei

4 on causing mTORC1 inhibition, rather than by altered acetylation of other autophagy regulators.

5 not strongly activated outside of lethargus, altered activity of the locomotion interneurons during l

6 aging shows these changes are accompanied by altered activity within a network of brain regions inclu

7 , linker chemistry (cleavable versus stable) altered activity, but not accumulation.

8 Although the altered adipogenic programming following MFR was detecta

9 n of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, a

10 t configurations at metaphase I, and in turn alter allelic segregation ratios through double reductio

11 s and caloric restriction in addition to the altered anatomy.

12 critically ill patients, lung microbiota are altered and correlate with alveolar inflammation.

13 e that the exosomal secretion of a psychosis-altered and glial-enriched miRNA that controls neuronal

14 However, the existence of altered and perhaps compensatory neural dynamics, sub-se

15 ed oligomer levels in aneurysm patients with altered aortic wall integrity.

16 PARG inhibition alters AR transcriptional output without changing AR pro

17 g the presence, as well as the evolution, of altered awareness of memory function across the preclini

18 rease in lysosomal V-ATPase activity without altering basal activity.

19 pandemic, review options for maintaining or altering best practices, and establish key recommendatio

20 tory arrest compared with wild type, without altering blood chemistry or displaying hyperthermia or m

21 Chronic social stress alters blood-brain barrier (BBB) integrity through loss

22 esity disrupts physiological homeostasis and alters both systemic and local microenvironments that im

23 nts with temporomandibular disorders exhibit altered brain networks in widespread cortical and subcor

24 onal networks revealed hyperexcitability and altered bursting and synchronicity.

25 coding p190A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human c

26 ayers, the EC cell lineage was significantly altered by both the culture method [air-liquid interface

27 We further show that ompR expression was not altered by changes in osmolarity but instead was induced

28 activity and hazard potential can be greatly altered by chemical exposure history and NP surface tran

29 ect is demonstrating that aspirations can be altered by engaging 16-18-year-old A level biologists in

30 tics were highly variable among subjects and altered by hypothermia.

31 eural representation of the outside world is altered by our prior beliefs even at initial points of t

32 examined for outcomes previously found to be altered by Pb, PS, or combined Pb and PS in F1 offspring

33 The actions of norepinephrine are profoundly altered by recreational drugs like ethanol, but the cons

34 ogy and disease burden of rotavirus has been altered by rotavirus vaccination with a biennial disease

35 d an in vivo local gene delivery approach to alter CaM function by directly injecting adenoviruses ex

36 bonates, similar to those found in aqueously altered carbonaceous chondrite meteorites.

37 ease itself, which is challenging due to the altered cardiac physiology in these patients and current

38 tastatic seeding, suggesting that Rab27a may alter cell-autonomous invasive properties of the tumor c

39 ss of the funis, defective axoneme exit, and altered cell shape.

40 hether germ layer specification is robust to altered cell-to-cell positioning, we separated embryonic

41 on of the amino acid starvation response and altered cellular fatty acid composition.

42 nockout line it was possible to continuously alter chlorophyll b levels and correspondingly light-har

43 Altered circadian rhythms and CRY expression were also o

44 dministration for more than 2 months without altering cocaine self-administration.

45 plant growth-promoting effect, and displays altered colony and cell morphology, motility, antagonism

46 rmed new domains, partitioned existing ones, altered compartmentalization and initiated contacts refl

47 eased bacterial loads, reduced diversity and altered composition, which partly recovered after treatm

48 ated creep, phase instability, and radiation-altered corrosion.

49 ells of Ovol1-deficient skin that reflect an altered course of epidermal differentiation and enhanced

50 usness of regulatory SVs, particularly those altering CTCF sites and provides a simple approach for f

51 Altered cytokine responsiveness to endotoxin is also obs

52 ncluding land-atmosphere coupling, which can alter deforestation-induced temperature changes.

53 identify cases in early stages to prevent or alter disease progression via appropriate interventions.

54 ugh the molecular mechanisms remain unclear, altered distribution and function of gap junctions have

55 es in proliferation and apoptosis as well as altered distribution of initiated tumors in the lung, re

56 Additionally, we observed an altered distribution of nuclear cyclic guanosine monopho

57 is change in foraging may have resulted from altered distributions and behavior of their prey species

58 DRB gene promoter polymorphism might lead to altered DRB gene expression, which could possibly affect

59 sses that are required for cognition and are altered during old age is crucial to develop preventive

60 ukin-22 (IL-22)/IL-17-producing ILCS was not altered during SIV infection.

61 under different mechanical load regimes and altered dynamics of feedback loops, illustrate that the

62 ormal IOP control, while ablation results in altered ECM repair/homeostasis and conventional outflow

63 ould influence the gut environment in ICP to alter enterohepatic signalling.

64 eralization as a mechanism for resistance to altered environmental conditions and predation impacts i

65 nformational change that may account for its altered enzymatic properties.

66 TNC knockout mice had an altered eosinophil recruitment profile in development.

67 mbination suppression, which correlates with altered epigenetic landscapes and can be overcome by wil

68 a(2+) dyshomeostasis and apoptosis, and iii) altered ER Ca(2+) homeostasis in kidney disease, includi

69 on that augments spontaneous release without altering evoked release, suggesting that aberrant sponta

70 One hundred and forty-seven genes altered expression in both injury ages (63% of P7SCI dat

71 tochondria and decreased cell proliferation, altered expression levels of pyruvate dehydrogenase phos

72 fferentiation of CRSwNP epithelium due to an altered expression of microRNAs.

73 mtCa(2+) in tumorigenesis is highlighted by altered expression of proteins mediating mtCa(2+) uptake

74 treatment, Endo-N and Endo-T cells displayed altered expression of the DNA methyltransferase 1 (DNMT1

75 significantly higher autoantibody titers and altered expression of the immune system, autophagy, and

76 lung evolution and others with substantially altered expression profiles, revealing extensive plastic

77 The effects of altering extracellular ionic concentrations on immune re

78 The presence of altered FAZ topography in patients with retinal or syste

79 he LD-specific protein (PLIN2) that exhibits altered fluorescence in response to LD interactions with

80 ies for the first time in SRWs, we show that altering foraging strategies may not be sufficient to ad

81 The manner in which these polymorphisms alter function varies from conserving normal pyroptotic

82 t of lateral ventricles, smaller volumes and altered functional connectivity between brain areas impo

83 Further, RNA sequencing analysis revealed altered gene expression in Tph1 deficient ILC2s includin

84 al regulators in prokaryotes and function by altering gene expression in response to environmental st

85 ckdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morp

86 The most frequently altered genes were APC (81%), TP53 (77%), and KRAS (37%)

87 two molecules that could have a role in the altered genome-wide methylation profile: the long noncod

88 tingly, the loss of maternal SMCHD1 does not alter germline DNA methylation imprints pre-implantation

89 nia, exhibit mitochondrial hyperactivity and altered group behavior.

90 Altered gut microbiome was associated with complications

91 LA-A29 may predispose chorioretinitis via an altered gut microbiome.

92 Lean patients demonstrated an altered gut microbiota profile.

93 Effectors alter host metabolism and immunity for the benefit of pa

94 Mechanistically, MAARS knockdown alters HuR cytosolic shuttling, regulating HuR targets s

95 mprehensively characterize mutants that have altered hypothalamic patterning, identifying Nkx2.1 as a

96 enced by HIV infection and may contribute to altered immunity, the biogeography of immune-microbiome

97 hese SEs may contribute to human disease and altered immunity.

98 e did not enhance clearance or significantly alter immunopathology.

99 tractor topography of nutrient metabolism is altered in amyotrophic lateral sclerosis (ALS), as early

100 cated that early prenatal development may be altered in autism.

101 sed in EVs and 16 thereof were significantly altered in basal EV upon IL-13 treatment.

102 d the dorsal striatum as the brain area most altered in DIO-susceptible rats and molecular studies wi

103 12alpha-Hydroxylated BAs (12HBAs) are altered in multiple disease settings, but the consequenc

104 and it remains unknown whether Kac level is altered in patient microbiomes.

105 (I(2)-IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative d

106 methylation and gene expression are commonly altered in pediatric acute lymphoblastic leukemia (PALL)

107 ies, explaining how cambium-driven growth is altered in response to environmental changes.

108 Approximately 40% of proteins were altered in ruptured versus stable areas of human carotid

109 itional genes and metabolites, however, were altered in Sin3A+Sam-S dual knockdown cells.

110 of the same functional categories that were altered in SR-uPA(+/0) aortas.

111 has indicated that both of these factors are altered in the context of diabetes, it is unclear what r

112 ays, it remains unknown how the APE2 gene is altered in the human genome and whether APE2 is differen

113 l studies have found that ILC3 responses are altered in the intestine of defined patient populations

114 dentifies candidate client proteins that are altered in vivo in disease models and whose degradation

115 tention time when the applied AC voltage was altered (increased).

116 V-unexposed, uninfected (HUU) children, with altered innate immunity hypothesized to be a cause.

117 entry, dauer recovery and adult lifespan by altering insulin sensitivity according to the prevailing

118 tiation towards the tumor cell-of-origin and alter interactions between lymphoma B-cells and other ce

119 hat disrupting 32-38 and anticodon sequences alters interactions with the ribosome that directly cont

120 Although altered interneuron development and function are clearly

121 r enzymes, pathways of oxidative stress, and altered intestinal barrier function.

122 TTR binds Abeta, alters its aggregation, and inhibits its toxicity both i

123 enes, results in decreased proliferation and altered jaw skeletal differentiation and cleft palate.

124 nts retained catalytic activity, albeit with altered kinetics and cooperativity.

125 ite was preferentially dissolved, forming an altered layer 200-500 mum thick with a porosity of 63-68

126 Oncogenic transformation alters lipid metabolism to sustain tumor growth.

127 mal Lama5 regulated immune responses through altering LN structures and T cell behaviors.

128 ation of pleomorphic "megamitochondria" with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1

129 t these changes in the cardiac ECM result in altered mechanical properties of ischemic or infarcted m

130 roviding an example of how ordered membranes alter membrane protein structure.

131 e intracellular protease release, suggesting altered membrane integrity after the field exposure.

132 model sheds light on the pathophysiology of altered memory and cognitive function in BBSOAS.

133 We demonstrate this by functionally altering memory CD8 T cells using CRISPR/Cas9-mediated t

134 most common symptoms at PIIRS diagnosis were altered mental status and vision changes.

135 c analyses show that alpha2-Na/K ATPase loss alters metabolic gene expression with consequent serine

136 Our results suggest that altered metabolism induced by SXR loss of function resul

137 The higher oxygenation altered methionine, lipid, and purine metabolism, and in

138 Altered methylation in promoters, enhancers, and gene bo

139 To understand the altered mobility of an oncogenic KRAS4b, we used complem

140 el-measurement discrepancy in dry deposition alters modeled CCN and radiative forcing.

141 humans by examining whether sleep disruption alters morphine's analgesic and hedonic properties.

142 learned fear inhibition are associated with altered mPFC function.

143 resorption when cultured on bone slices, and altered mRNA expression of related chemokine receptors a

144 pes whose loss of mitochondrial activity and altered mtDNA copy number that result in organ dysfuncti

145 mitochondrial dynamics can be manipulated to alter muscle contractility.

146 Upper crossed syndrome (UCS) refers to the altered muscle activations and movement patterns in scap

147 sults in increased mutation frequency and an altered mutational spectrum compared with the repair of

148 This therapeutic strategy may alter myocardial energy metabolism in a manner that reve

149 almodulin-dependent kinase II activation and altered myocyte bioenergetics.

150 idities, these findings serve as evidence of altered neurochemistry in BD youth that is sensitive to

151 lopmental endocrine disruption, resulting in altered neuroendocrine control of hormonal signaling, al

152 ssociated with mitochondrial dysfunction and altered neurotransmission.

153 euroendocrine control of hormonal signaling, altered neurotransmitter control of nervous system funct

154 Finally, treatments that alter nitrate supply affect levels of hypoxic metabolite

155 ariations in the latent protein, LMP1, which alters NK responses to EBV.

156 To understand HSC-niche interactions in altered nonmalignant homeostasis, we selected beta-thala

157 intestine than in the circulation, where it alters nutrient metabolism in intestinal epithelial cell

158 changes in N-linked glycosylation sites can alter other properties of viral surface antigens and vir

159 This work alters our understanding of the events that drive the ac

160 These intron retention events appear not to alter overall expression levels of the affected transcri

161 Neural correlates of altered pain perception in C9orf72 expansion carriers we

162 appreciate how multisensory integration can alter patterns of neural activity in time, and even coor

163 In line with this, we identified an altered perinatal and/or postnatal expression of genes i

164 isms by which variants can cause diseases or alter phenotypic traits.

165 with a build-up of aggregated proteins with altered physicochemical properties (misfolded proteins).

166 ts in the maintenance of Fe homeostasis will alter plant productivity and the quality of their derive

167 The global movement of pathogens is altering populations and communities through a variety o

168 n about whether mindfulness meditation might alter pro-social behavior.

169 refrontal excitatory-inhibitory balance, and alter processing of afferent information from the ventra

170 r that changing a protein binding motif will alter protein binding, it has been shown that single nuc

171 findings indicate the E62K mutation does not alter RAC2 structure or stability.

172 PARPi efficacy in BRCA1-deficient cells and altered repair of damaged telomeres, can be explained fr

173 ibution of organisms, especially plants, can alter resource landscapes for mobile consumers driving b

174 os have a reduced ipsilateral projection and altered RGC neurogenesis associated with perturbed melan

175 ractions from outside binding motifs through altered RNA secondary structure.

176 Anthropogenic emissions alter secondary organic aerosol (SOA) formation chemistr

177 Most strategies to alter seed oil composition involve the overexpression of

178 ommon in high-ploidy tumors and thus support altered selection pressures upon WGD.

179 lowing immunosurveillance for signatures of "altered self" on target cells, via a membrane-linked gam

180 specific, suggesting that suppression of PM altered sensory integration or the decision-making proce

181 ion may contribute to disease states through altered sEV signaling.

182 agnetic field significantly and beneficially alters sheath based ion acceleration and creates two dis

183 of extant floral diversity and examining how altered signaling conditions under global change will im

184 Furthermore, we identified that aging alters Sirtuin-1-hepatic nuclear factor 4alpha circuit i

185 Decreased lung CYP2A expression may alter smoking-related lung cancer risk and tissue damage

186 n systems and mouse models have demonstrated altered sodium current properties.

187 imentally that natural aerial dispersal rate alters soil microbial responses to disturbance.

188 ze that rhizobacterial species richness will alter sorghum (Sorghum bicolor L.) growth, soil nutrient

189 Nitrogen (N) fertilizers can potentially alter spatial distribution of soil organic carbon (SOC)

190 ting molecular motors to have, for instance, altered speed, processivity, or functionality.

191 on of identified striatonigral MSNs, and (2) altered spine density and thin-spine morphology on stria

192 DCs from Apc(Min/+)Ffar2(-/-) mice had an altered state of activation, increased death, and higher

193 r and identify novel unexploited targets for altering stomatal behavior and improving crop plant prod

194 motor activity in the elevated plus maze and altered stress-coping strategies in the forced swim task

195 Altered stress-related responses have also been observed

196 med to provide a more detailed evaluation of altered structural brain development in newborn infants

197 The mechanisms underlying altered susceptibility and propensity to severe Coronavi

198 These defects coincided with altered synapse protein organization, and horizontal cel

199 To understand how these compounds alter T cell function, we assessed their therapeutic act

200 results demonstrate that selection favorably altered temporal dynamics of plant protein digestion.

201 cy virus (HIV) acquisition, but whether they alter TFV-DP or 3TC-TP exposure, and therefore compromis

202 ory innate cytokine production to promote an altered Th2 immune response following RSV infection that

203 ta with a female fetus was considerably more altered than the placenta with a male fetus in FOXA2 cKO

204 imulation enhanced PDEV release, but did not alter the average size of EVs compared to those produced

205 in milkweed phytochemistry induced by eCO(2) alter the balance between exogenous and endogenous sourc

206 we find that a key neuromodulator, ACh, can alter the balance of excitation and inhibition at the fi

207 nce demonstrating that cannabinoids can also alter the brain's initial molecular and epigenetic respo

208 In contrast, SERINC5 did not alter the capture of HIV-1 particles bearing the SERINC5

209 centrations allowed the bacteria to strongly alter the chemical environment, causing on average more

210 te persistence of consumer-resource systems, alter the course of pathogen infections within a host an

211 changes induced by the beta3-subunit do not alter the degree of electrophysiological gating cooperat

212 change may increase habitat connectivity and alter the distributions of shrub herbivores in the Arcti

213 ile removing self-interaction error does not alter the energetic ordering of the different water isom

214 ster anion), and urea (a neutral denaturant) alter the folding free energy remains indistinguishable

215 Human disturbances alter the functioning and biodiversity of many ecosystem

216 e thought to act by cysteine modification to alter the functions of immune-relevant proteins; however

217 ncy (PRF); and (3) ultrasound can reversibly alter the inhibitory effects of tetrodotoxin (TTX) in ph

218 We conclude that the N53I-induced changes alter the interaction of the CaM N-domain with RyR2 and

219 Changing ocean chemistries will alter the iron bioavailability when a decrease in pH shi

220 ore favorable toxicity profile are poised to alter the landscape of RET-dependent cancers.

221 yl-d-aspartate receptor (NMDAR) encephalitis alter the levels of dopamine 1 receptor (D1R) and dopami

222 d that sulfation and sialylation drastically alter the MS(2) fragmentation pattern of glycopeptides i

223 on of water molecules does not significantly alter the observed hydrogen-bond topologies.

224 ty, and other factors that can substantially alter the outcomes of B cell responses to complex antige

225 parental effects-when parental environments alter the phenotype of future generations-can influence

226 2) complexes and show how the UBA domain can alter the position of a polyubiquitin chain attached to

227 not known how activating ESR1 mutations may alter the predictive values of molecular imaging agents

228 pecies of Lactobacillus could be utilised to alter the quality of new-make spirit in a distillery.

229 lized S. aureus skin infections persistently alter the resident Mphi subset composition and resistanc

230 In contrast, visual inputs do not alter the running speed-dependent gain in neuronal firin

231 Concerning Ca(V)3.1, the compound did not alter the shape of the instantaneous current-voltage cur

232 The strategies employed in a population may alter the state of the environment, which may in turn fe

233 groove mutations were found to significantly alter the structure and organization of C. elegans sarco

234 he combined effect of germline variants that alter the structure, expression, or function of protein-

235 s with neutralization post-treatment did not alter the thermal stability of nanocrystals, and BCNCs h

236 ence (AI) has the potential to fundamentally alter the way medicine is practised.

237 NR2F2-depletion altered the abundance of C-circles and APBs but the dire

238 knockout of FN3K in human liver cancer cells altered the abundance of redox metabolites, including an

239 Alkaline hydrogen peroxide treatment altered the color, chemical composition, and techno-func

240 ts to low-dose BPA at 25 and 250 mug/kg BW/d altered the estrous cycle and uterine pathology with sim

241 We hypothesize that N325 deamidation altered the local three-dimensional structure, which mig

242 enin isoform 3A; similarly, depletion of APC altered the p120-catenin protein isoform profile.

243 To further support this model, we altered the structure of osteoblast HS genetically to ma

244 lysis rely on cell manipulation, potentially altering the abundance of metabolites in individual cell

245 repression complex regulates target genes by altering the acetylation status at enhancers.

246 and phagocytic targets have demonstrated how altering the actomyosin cytoskeleton affects phagocytic

247 e macrophage-mediated inflammation events by altering the balance between angiotensin II, which activ

248 ce the 'precision-weighting of priors', thus altering the balance of top-down versus bottom-up inform

249 use recurrence of the infection due to their altering the colonic microbiota, which is necessary to s

250 prevents alphaSyn-mediated vesicle fusion by altering the conformational properties of the protein wh

251 ironmental clues, and respond plastically by altering the dispersal rates?

252 lactide-co-glycolide) (PLGA) matrix, thereby altering the drug release behavior.

253 A synthesis by Escherichia coli RNAP without altering the fidelity of nucleotide incorporation.

254 Climate change is altering the intensity and variability of environmental

255 ly increased the level of viral RNAs without altering the level of cccDNA.

256 ertrophy by improving neovascularization and altering the paracrine effect of fibroblasts.

257 e population-level granule cell responses by altering the ratios of excitation and inhibition at the

258 tween 1 and 30 kDa can be targeted simply by altering the stoichiometry of the reaction.

259 Thus, by altering the stringency and partially impairing negative

260 e phenotypic variation could be prevented by altering the temperature for growth.

261 aryngeal arches and show that experimentally altering the timing of Hgf/Met signaling is sufficient t

262 nt with rhythmic Purkinje cell firing, which alters the activity of their target cerebellar nuclei ce

263 The new phased array selectively alters the directional and frequency content of the inci

264 these data reveal that lentivirus infection alters the frequencies, receptor repertoires, and functi

265 ain how a distinctive ubiquitin-like protein alters the functions of its targets, and show how numero

266 ed by QR2 enzymatic activity, a process that alters the intrinsic properties of CA1 interneurons 3 h

267 o determine if dietary nervonic acid content alters the metabolic phenotype in mice fed a high fat di

268 elated, variants and reveal how glioblastoma alters the neuronal microenvironment.

269 late circuit, we find that visual experience alters the number and structure of synapses between the

270 ty effects occur when the infection sequence alters the outcome of interactions among parasites.

271 the interaction between sex and weight gain alters the progression of allergic asthma in mice with f

272 acid substitution (M159I) that fundamentally alters the thermal and regulatory properties of Rca in b

273 ns at the drain contact, which significantly alters the transistor behavior.

274 mportantly, omalizumab did not significantly alter their expression levels.

275 ncertainty, even though it may fundamentally alter their findings and recommendations.

276 Many cancers alter their proline metabolism by up-regulating the prol

277 he domestication process might have uniquely altered their brains; however, we know very little about

278 ose tissue, and umbilical cord blood without altering their ex vivo characteristics.

279 cultivation may enhance dissolution of SIC, altering their local stock at decadal timescales.

280 ach end of the bridge and can be modified by altering these charges.

281 eater than or equal to 65 mm Hg and signs of altered tissue perfusion.

282 n phosphorylation of key structural proteins alters tissue integrity and organ function.

283 nergy of cyclooctatetraene can be physically altered to achieve order of magnitude enhancements in fl

284 a variety of structural options that can be altered to fit a specific purpose.

285 focused on regulation of Hsp70 activities by altered transcription, co-chaperone "helper" proteins, a

286 onstrates that dynamic crowding nontrivially alters transcription kinetics and presents dynamic crowd

287 ct evidence that vRNA-associated Rab11A have altered transport.

288 ical stretch, and pharmacological modulators alter TREK1 channel activity and overlaps with positions

289 edding could suffer from over-correction and alter true biological features (e.g. cell size) due to o

290 ke behavior, fragmented social behavior, and altered ultrasonic vocalization patterns at 6-12 weeks o

291 dient corresponding to cell polarity that is altered upon Rgd3 overexpression.

292 letion of both darT(Mtb) -darG(Mtb) does not alter viability of Mtb in vitro or in mice.

293 use of barriers, reduced light availability, altered water chemistry or any combination of these.

294 whether BDNF-induced signaling cascades are altered when early and recycling endosomes are disrupted

295 5 humans (23 females) how motor resonance is altered when the observer's weight expectations, based o

296 sonance imaging (dMRI) studies have reported altered white matter (WM) microstructure in 22q11DS, but

297 gated WMH risk variants were associated with altered white matter integrity (p = 2.5x10-7) in brain i

298 Changing climates are altering wildlife habitats and wildlife behavior in comp

299 uingly, although ATF6alpha knockdown did not alter Xbp1 splicing dynamics or intensity, it did reduce

300 susceptible to digestive enzymes and did not alter zebrafish embryos' morphology and development.