ライフサイエンスコーパス: alteration in

1 ant metabolic dysfunction as seen by similar alterations in (1) TCA cycle metabolites, (2) tryptophan

2 display normal hematopoiesis without global alterations in 5hmC.

3 s that have assessed psychostimulant-induced alterations in a cell-type-specific manner, from remodel

4 gen-induced maternal autoantibodies produced alterations in a constellation of ASD-relevant behaviors

5 We first quantified shared working memory alterations in a delayed-response task.

6 Results identified alterations in a number of high mannose, hybrid and comp

7 he prevalence and characteristics of somatic alterations in AA and PNH and will explore their prognos

8 diagnosis and include a variety of neuronal alterations in addition to the dopamine system.

9 ion in the first years of life is related to alterations in adult brain structure, despite extended e

10 enitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis.

11 tor (TF) signalling has been associated with alterations in Akt activity influencing cellular surviva

12 samples may have limited our power to detect alterations in all pathway-specific metabolites and thei

13 An alteration in alpha2delta surface expression during crit

14 simultaneously evaluate multiple behavioral alterations in an animal model for the study of depressi

15 c reduction in blood pressure independent of alterations in angiotensin II-mediated aortic stiffness.

16 entia depend upon combinatorial and opposite alterations in APP metabolism rather than simply on Abet

17 Whether these alterations in ART-treated HIV subjects occur in vitro i

18 unction mutations in RB1 and TP53 (88% carry alterations in at least one gene; 60% carry alterations

19 I were reduced, suggesting a neuron-specific alteration in autophagosome turnover.

20 s during the late 1800s did not cause marked alteration in average carbon burial, they did lead to ma

21 DX models and human clinical samples, due to alterations in BCL-2 family proteins that vary among cas

22 , whereas F3 males showed Pb- and PS-related alterations in behavior and total percent DNA methylatio

23 ss lineages, F3 females exhibited Pb-related alterations in behavior, striatal BDNF levels, frontal c

24 AChR) subtypes, leads to subnucleus-specific alterations in BFCN excitability and impaired cognition.

25 Liver tissues from MYO5B(P663L) piglets had alterations in bile salt export pump, a transporter that

26 ary lipid secretion, which is independent of alterations in bile salt output, biliary bile salt hydro

27 s of sex hormone changes, as well as adverse alterations in body composition, lipids and lipoproteins

28 that global Kiss1r KO mice have significant alterations in body temperature and BAT thermogenic gene

29 In contrast, alterations in both pathways led to ACC with pulmonary m

30 Furthermore, this mutant cannot correct alterations in both Syt1 expression and trafficking when

31 ses in older individuals are associated with alterations in both the quantity and quality of the T-ce

32 alterations in at least one gene; 60% carry alterations in both).

33 the hypothesis that mood- and sex-dependent alterations in brain circuitry implicated in the regulat

34 brain injury (TBI) is often characterized by alterations in brain connectivity.

35 se functional changes were followed by rapid alterations in brain microstructure in the order of minu

36 in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated

37 rauma and mood disorders have been linked to alterations in brain volume, function, and connectivity.

38 tate cancer who had tumors with at least one alteration in BRCA1, BRCA2, or ATM and whose disease had

39 Alterations in calcium signaling in pancreatic acinar ce

40 obic glycolysis, a near ubiquitous metabolic alteration in cancer.

41 Replication stress underlies many genomic alterations in cancer cells.

42 Somatic alterations in cancer genes are being detected in normal

43 Metabolic alterations in cancer represent convergent effects of on

44 Importantly, the identification of alterations in cancer-predisposing genes facilitates gen

45 lore ancestry-specific patterns of molecular alterations in cancers and demonstrate the need for nove

46 be an insufficient condition for wettability alteration in carbonate minerals.

47 ns of E-selectin and ICAM-1 with subclinical alterations in cardiac function.

48 eover, KCNQ1 antibodies were able to restore alterations in cardiac repolarization and most important

49 in C2C12 myoblasts and triggered significant alterations in cell cycle, metabolic, and protein transl

50 Further analysis indicated that alteration in cellular energy metabolism was associated

51 response to acute stressors and can undergo alterations in cellular composition as animals age.

52 in large patient cohorts to identify protein alterations in cerebrospinal fluid (CSF), a proximal sit

53 reviously have demonstrated that microtubule alterations in CF are linked to a number of CF phenotype

54 ges in food chemistry that can reveal global alterations in chemical profiles, identify changes in ab

55 elucidate the landscape of germline genetic alterations in children with WT.

56 es and human tissue samples, thereby linking alterations in chromatin condensation patterns to differ

57 Our data reveal that regional alterations in chromosome structure underlie clonal tran

58 d chromatin interaction dynamics, as well as alterations in cis-regulatory loci and transcriptional n

59 The underlying alterations in CNS complement cascade proteins (C1q, C3)

60 ll sequencing and identify prevalent genetic alterations in colorectal cancer stromal cell population

61 es can not only cause genetic and epigenetic alterations in colorectal epithelial cells but also affe

62 ll lines have identified a high frequency of alterations in components of the mammalian switch/sucros

63 No convincing evidence of alterations in concentrations of biomarkers in the CSF w

64 psychedelic experience, mediating both acute alterations in consciousness and long-term effects.

65 e disorder (OCD) is commonly associated with alterations in cortico-striato-thalamo-cortical brain ne

66 e rapid and modular approaches to screen for alterations in CT organization across widely available H

67 (DMF), for rapid determination of individual alterations in CYP activity from human-derived liver sam

68 The alterations in D-loop properties appear to be important

69 results uncover phenotype-specific molecular alterations in D1-MSNs that relate to morphological adap

70 anges in cocaine potency are associated with alterations in DAT affinity for cocaine and demonstrated

71 ed by lamin-chromatin and lamin-cytoskeletal alterations in determining nuclear shape morphology and

72 ht us terabytes of information about genetic alterations in different types of human tumors.

73 CCTG expansions induce similar transcriptome alterations in DM2 blood, which thus serve as disease-sp

74 Alterations in DNA damage response (DDR) genes are commo

75 Because BLBC exhibits alterations in DNA repair enzymes and cell-cycle checkpo

76 hat changes in cocaine potency are driven by alterations in dopamine neuron activity.

77 eostasis in the striatum, including specific alterations in Drd1a versus Drd2 neurons.

78 ending aortic wall and to identify molecular alterations in each cell population of human ATAA tissue

79 But alterations in each of the five CFHR genes in the contex

80 ioavailability of intestinal cholesterol and alterations in endogenous cholesterol synthesis.

81 identify a dramatic loss of osteoblasts and alterations in endothelial cell function.

82 pression of mesenchymal genes, prevented the alterations in endothelial morphology and impaired endot

83 n growth and whether this is associated with alterations in energy balance, blood metabolomics and fe

84 Alterations in ER homeostasis trigger ER Ca(2+) depletio

85 as a degenerative disease, characterized by alterations in extracellular matrix and loss of smooth m

86 lcitonin, proteomic analysis shows extensive alterations in extracellular matrix proteins and pathway

87 ory processes and immunosuppression; indeed, alterations in extracellular nucleotide and adenosine si

88 ular structure and function, so much so that alterations in FA are often associated with cell malfunc

89 rier axis by circadian clock disarrangement, alterations in feeding time or content, or epithelial-sp

90 nutrient enrichment, herbivore exclusion and alterations in future climatic conditions can negatively

91 e and its production of cAMP, independent of alterations in G protein-coupled receptors and/or G prot

92 t a potential therapeutic pathway to correct alterations in GABAergic networks and dampen pathologica

93 papaya diminutive phenotype is caused by an alteration in gene function rather than a loss-of-functi

94 Understanding the mechanisms responsible for alterations in gene and chromatin structure within skin

95 The alterations in gene expression are driven by distinctive

96 riptomics analyses also revealed significant alterations in gene expression levels of key enzymatic r

97 that knockdown of CYP2J2 elicits widespread alterations in gene expression of ventricular cardiomyoc

98 r cells derived from these hiPSCs identified alterations in gene expression patterns which precede mo

99 RA are candidate drivers of disease-relevant alterations in gene regulation.

100 The ability to tailor alterations in genomes, including plant genomes, in a si

101 sis of Gprc6a-(KGKY-knockin) mice identified alterations in glucose, glycogen and fat metabolism path

102 maging studies have found evidence of robust alterations in glutamate and dopamine receptors within b

103 ocybin (0.17 mg/kg) induced region-dependent alterations in glutamate, which predicted distortions in

104 Alterations in groups of TF-binding profiles (i.e. "co-b

105 Our results revealed an overall alteration in gut microbiome and metabolites in associat

106 Alterations in gut microbiota impact the pathophysiology

107 Diet modulates the mucous barrier via alterations in gut microbiota, resulting in either disea

108 issue, and antibiotic exposure is linked to alterations in gut microbiota, which has been related to

109 ompared to mice fed control bacteria and had alterations in hepatic lipids, including oxylipins.

110 nalyses of tumour extracts revealed specific alterations in Hippo pathway core components, as a funct

111 These results suggest that a deficit or alteration in hippocampal synaptic plasticity may contri

112 dings highlight unique and shared epigenetic alterations in histone modifications and potential regul

113 ptoms of sleeping sickness may be because of alterations in homeostatic adenosine signaling.SIGNIFICA

114 In conclusion, our data show alterations in hormone levels and SWLS in response to OC

115 Overall, we find limited support for alteration in HPA axis functioning as a general mechanis

116 To define the functional impact of alterations in huwentoxin-IV sequence, we produced a lib

117 ules and tumor suppressing phosphatases, and alteration in immune modulators.

118 We characterized age-associated alterations in immune cells across multiple mouse organs

119 function, findings of qualitatively similar alterations in individuals experiencing subthreshold PSs

120 Chronic infection provokes alterations in inflammatory and suppressive pathways tha

121 proved cognition in prediabetic rats without alteration in insulin sensitivity.

122 mary cilium and instead can be attributed to alterations in integrin-mediated mechanotransduction and

123 ts of the IT mutation, along with unexpected alterations in ion selectivity, were generally larger in

124 maternal, placental, and fetal responses to alterations in iron status during pregnancy.

125 In addition, we identify recurrent alterations in KEAP1/NFE2L2 and WNT pathway in GBC.

126 luding (1) normal myocardial ketone use, (2) alterations in ketone metabolism in the failing heart, (

127 sociations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metaboli

128 he PI3K/GSK3 pathway, SGK1 and GSK3, induced alterations in levels of neurite markers betaIII tubulin

129 male's presence by itself leads to lifelong alterations in life history in female mice.

130 ation of the transcriptome, leading to gross alterations in lipid storage.

131 Mediation analysis demonstrated that alterations in long-distance connectivity were associate

132 S(G12C) is one of the most common activating alterations in lung adenocarcinoma(1,2).

133 Alterations in lung function consistent with these histo

134 lecular and physiological changes that cause alterations in lung function, diminished pulmonary remod

135 We also discuss how oncogenic alterations in lymphoma cells may affect the cellular co

136 rapamycin (mTOR) pathway and independent of alterations in MAPK and NF-kappaB signaling.

137 des evidence for regional cortical thickness alterations in MDD, mainly involving increased cortical

138 ll metabolism consistent with ongoing immune alterations in ME/CFS that may illuminate the mechanism

139 yelin from peripheral nerves, resulting from alterations in melanocyte survival and differentiation o

140 netic control though mechanisms that include alterations in metabolic enzymes that regulate DNA methy

141 and proliferation, at least in part, through alterations in metabolic gene expression.

142 , which are particularly potent in detecting alterations in metabolic pathways.

143 Here, we investigate alterations in metabolism and volume using [(18)F]fluoro

144 l cells, which display invasive features and alterations in metastatic tropism when xenografted into

145 cal neuronal circuits, leading to behavioral alterations in mice.

146 ic syndrome generally cause pro-inflammatory alterations in microbiota communities in the intestine.

147 Alterations in mitochondrial DNA (mtDNA) sequence and co

148 fusion (OPA1/eat-3, MFN/fzo-1) genes caused alterations in mitochondrial morphology that impacted bo

149 triggers robust mitochondrial fragmentation, alterations in mitochondrial polarization, and blocks th

150 In addition, alterations in mucin expression and glycosylation are co

151 Hepatic transcriptome analysis identified alterations in multiple pathways regulating glucose, fat

152 ite matter connections revealing topological alterations in multiple sclerosis (MS).

153 y through RBD movement combined with smaller alterations in neighboring domains.

154 linical groups, there were multiple discrete alterations in network connectivity, such as disconnecti

155 y, and stroke patients experience widespread alterations in neural activity after sensory loss.

156 derstanding neuron-glial interaction and its alterations in neurological diseases.

157 In turn, alterations in neurotransmitters signaling (or its disco

158 These findings demonstrate that age-related alterations in neutrophils and eosinophils and systemic

159 reactivation was associated with a sustained alteration in NKG2A and NKG2C subsets of CD56 natural ki

160 ith psychotic disorders, and their potential alterations in nonpsychotic relatives, remain to be clar

161 is describes the prevalence of tumor-related alterations in normal appearing tissues.

162 ff-target analysis detected a silent genomic alteration in one model.

163 o identify genetic variants based on somatic alterations in OpSCC samples from an admixed population,

164 ecruitment to the infected tongue but not to alterations in oral antimicrobial peptide expression.

165 for human papillomavirus-induced chromosomal alterations in ovarian tumorigenesis, and they add new g

166 o stressed wild-type plants, suggesting that alterations in PA levels are not likely the cause for th

167 ze findings from human studies on microbiome alterations in Parkinson's disease, Alzheimer's disease,

168 It has been suggested that alterations in parvalbumin-positive interneurons in schi

169 RNA-seq analysis revealed alterations in pathways and genes associated with astroc

170 ance between cfDNA and biopsy tissue genomic alterations in patients with CRPC-NE compared with castr

171 a key role in the pathophysiology of MDD and alterations in peripheral cytokine levels are associated

172 These findings suggested that alterations in peripheral cytokine levels were associate

173 ility to traumatic stress is associated with alterations in phasic dopamine signaling architecture th

174 utral or anionic diclofenac exerted distinct alterations in phosphatidylcholine bilayers, which are u

175 owever, such as periods of hyperactivity and alterations in place preference, are not phenocopied by

176 udy sought to identify TBI-induced molecular alterations in plasma and whether RIC would modulate pro

177 Continued fat alterations in PLWH will have an important effect on lif

178 nd in certain psychiatric disorders in which alterations in PNNs and PV+ interneurons have been descr

179 relevant for psychiatric research, given the alterations in PNNs, PV+ interneurons and their physiolo

180 The alterations in polyamine metabolism in response to chemo

181 nancy drives a significant systemic vascular alteration in pregnant dams, which likely suppresses cri

182 ood in the context of a mutationally induced alteration in protein motions that becomes manifest alon

183 n principles of protein networks by means of alterations in protein domains, thus providing insight i

184 Furthermore, we observed minor alterations in protein levels, 2 hours after drug admini

185 FTIR studies revealed alterations in protein secondary structure induced by pl

186 nd online native ESI-MS were used to monitor alterations in protein structure.

187 sregulated protein translation, although how alterations in protein synthesis contribute to neurodege

188 ese PRSs were associated with 766 detectable alterations in proteomic, metabolomic, and standard clin

189 d their physiological link, as well as their alterations in psychiatric disorders.

190 uropsychiatric conditions, whether it be via alterations in Rap1 expression or through alterations in

191 mised phosphodiesterase activity, as well as alterations in receptor-coupled G-protein activation.

192 te whether NM-MRI signal was associated with alterations in reward processing.

193 Alterations in RSPO genes have been identified in human

194 nt insights into the mechanisms of cognitive alterations in SCA1, we tested cognition in several mous

195 ddition, a substantial portion of epigenetic alterations in schizophrenia and related disorders may b

196 nical and preclinical findings of epigenetic alterations in schizophrenia and relevant disease models

197 thy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple

198 ntify significant cell-specific gene network alterations in SCZ, these studies support a role for dis

199 pha oscillations that are linked with marked alterations in self-referential processing.

200 Molecular alterations in seven tumors profiled in both NCI-MATCH t

201 m of it for treatment of disorders caused by alterations in SHANK3 dosage.

202 it influence nitric oxide signalling through alterations in shear stress stimuli and haemoglobin scav

203 apeutic strategies, we identified actionable alterations in signaling that underlie adaptive and acqu

204 s is the first comprehensive analysis of the alterations in small GTPase proteome during adipogenesis

205 s is the first comprehensive analysis of the alterations in small GTPase proteome regulated by epitra

206 has revealed several potentially actionable alterations in small subsets of patients and the feasibi

207 golipid synthesis inhibitor, suggesting that alterations in sphingolipid metabolism contribute to cel

208 d synaptic transmission phenotypes, specific alterations in spontaneous neurotransmitter release are

209 Alterations in stereocilia dimensions and in EPS8 distri

210 nfluence tumor progression; however, genetic alterations in stromal cell populations remain largely u

211 s for which the mechanisms of action involve alterations in subjective responses to alcohol (e.g., an

212 The results suggest that alteration in substrates could also be involved in regul

213 analysis revealed a S. parasanguinis-driven alteration in sugar metabolism that restricts biofilm de

214 RABL3(xm) displayed a large compensatory alteration in switch I, which adopted a beta-strand conf

215 social affiliative behaviors, likely through alterations in synaptic maturity, pruning, and specifici

216 l days 7, 9, and 11] results in long-lasting alterations in synaptic transmission and reduced PV expr

217 clinical results demonstrate that MI induces alterations in systemic homeostasis, triggering cross-di

218 These data argue that diet-dependent alterations in taste weaken satiation by impairing the c

219 tic resonance to evaluate the association of alteration in the extracellular matrix with diabetic sta

220 Alteration in the overall microbial community following

221 e; and (2) a loss of connexin 36, suggesting alterations in the AII coupling and in visual signal tra

222 This study demonstrates that alterations in the bacterial composition of the sigmoid

223 -1alpha in ccRCC initiation and suggest that alterations in the balance of HIF-1alpha and HIF-2alpha

224 stration of ursodiol resulted in significant alterations in the bile acid metabolome with little to n

225 methylation changes, we observed no profound alterations in the blood transcriptome of individuals wi

226 ongitudinal study tracking dynamic proteomic alterations in the brains of an inducible Drosophila mel

227 exclude other differences, and in particular alterations in the Ca(2+) economy of the photoreceptors,

228 lobal metabolic profiling revealed extensive alterations in the cellular metabolome resulting from ov

229 These findings suggest that simple alterations in the costimulatory domain may enhance CAR-

230 Host gene expression indicates alterations in the cytokine expression that could be rel

231 croscopic pathologic findings as well as the alterations in the cytokine milieu, macrophages/monocyte

232 s that are responsible for the proliferative alterations in the different forms of retinal detachment

233 do not appear to share similar mitochondrial alterations in the DLPFC.

234 Alterations in the expression level of alpha2delta subun

235 ia alterations in Rap1 expression or through alterations in the expression of direct and specific ups

236 nd U343 glioblastoma cell lines to map early alterations in the expression of genes at three levels:

237 However, alterations in the expression of the corresponding wild-

238 The accumulation of alterations in the genetic and epigenetic spaces has bee

239 ation Group to Investigate Cancer Associated Alterations in the Genome consortium (OR 0.90; 95% CI 0.

240 sised that these phenomena were derived from alterations in the grafted cardiomyocyte characteristics

241 t each symptom can be linked individually to alterations in the gut microbiome.

242 bumin+ interneurons, leading to quantitative alterations in the inhibitory circuitry of this layer.

243 he wild type, suggesting that this is due to alterations in the initial invasion of the tissue.

244 It is not clear whether alterations in the intestinal microbiota of children wit

245 Alterations in the intrinsic function of these channels

246 The genetic defects lead to alterations in the ionic currents that determine the mor

247 This included alterations in the levels of several metabolites that ar

248 ng in mgR mice was responsible for structure alterations in the lungs, mice were treated with N-[N-(3

249 action potential afterhyperpolarization and alterations in the maximal rates of voltage change durin

250 Importantly, genetic alterations in the most extensively rewired PPIN nodes o

251 N-glycan alterations in the nervous system can result in differen

252 for chloride changes resulted in substantial alterations in the neuronal input-output function.

253 s in the larval stage and are accompanied by alterations in the nitric oxide metabolism.

254 Although the causal role of these alterations in the patient outcome remains to be determi

255 In some AMD patients, marked alterations in the pattern of AO-IRAF could be seen even

256 In this article, we highlight the alterations in the photoinduced electron transfer (ET) a

257 Up-states was less reproducible, suggesting alterations in the plasticity mechanisms governing netwo

258 ng the uncleaved gp160(JR-FL) precursor with alterations in the protease cleavage site (R508S/R511S)

259 rs exhibit genomic instability with frequent alterations in the protein kinome; however, only a small

260 Transcriptomic analysis revealed alterations in the pyrimidine metabolic pathway and cyti

261 , by exploring obesity-associated microbiota alterations in the quantitative faecal metagenomes of th

262 Alterations in the RAS-ERK1/2 pathway are associated wit

263 Although alterations in the skin microbiome have been described i

264 Similar alterations in the strength of purifying selection durin

265 ce staining and confocal microscopy revealed alterations in the structure and composition of the airw

266 Hypoxia initiates SOD3-dependent alterations in the structure and regulation of hyalurona

267 drug induced more pronounced and/or distinct alterations in the structure of the DMPC bilayer than th

268 attributing their inefficient trafficking to alterations in the subsequent transendothelial migration

269 L-tryptophan and kynurenic acid levels, and alterations in the tryptophan-kynurenine and fatty acid

270 s treated with TM also exhibited concomitant alterations in their electrical activity and cytosolic f

271 cipants, and found that 26 of them (81%) had alterations in their heart rate, number of daily steps o

272 ceptors respond to extracellular stimuli via alterations in their oligomeric state.

273 ILC3 and NK cells exhibited alterations in their trafficking repertoires as a result

274 Alterations in these biological pathways may explain the

275 ast, only a minority of sporadic tumors show alterations in these genes.

276 We identify significantly recurrent somatic alterations in these gliomas including mutant EGFR ampli

277 nd synchronization of cortical circuitry and alterations in these inhibitory neurons, especially in t

278 have learned from mouse studies with genetic alterations in these proteins.

279 elet-derived molecules can induce phenotypic alterations in this cell type.

280 Alterations in this groove decrease the ability of BMF a

281 n appears to map our interpersonal ties, and alterations in this map may help explain why lonely indi

282 n the maintenance of calcium homeostasis and alterations in this mechanism are responsible for severa

283 Our studies suggest that alterations in TNFAIP3 levels are associated with relaps

284 The vma2Delta phenotype may arise from alterations in trafficking of iron directly from cytosol

285 while the hub findings point to OCD-related alterations in trajectories of brain development and mat

286 PABPs, inhibition of rDNA transcription, or alterations in TRAMP activity.

287 Causal variants were also enriched for alterations in transcription factor binding sites.

288 Alterations in transporter activities were further sugge

289 se results demonstrate that mutation-induced alterations in tropomyosin-thin filament interactions un

290 rpose of this study was to determine whether alteration in tumor blood flow could augment drug delive

291 Here, we aimed to uncover genome-wide alterations in uracil pattern upon drug treatments in hu

292 are direct on the offspring or secondary to alterations in uteroplacental physiology is unclear.

293 Although HIV is associated with alterations in vaginal microbiota and inflammation in no

294 Chronic inflammation is known to cause alterations in vascular homeostasis that directly affect

295 we examined chronic variable stress-induced alterations in vHIP-NAc activity in vivo and used ex viv

296 ing a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic devel

297 We assessed structural brain alterations in white and gray matter of frontal-executiv

298 Alterations in white matter (WM) microstructure have bee

299 es suggest that young autistic children have alterations in white matter structure that differ from o

300 se changes in power output were reflected in alterations in work loop shapes.