ライフサイエンスコーパス: alteration of

1 have been shown to be related to disease by alteration of 3D genome structures.

2 y and safety of nivolumab as well as genetic alterations of 9p24.1.

3 ause local changes to gene expression due to alteration of a gene chromatin environment.

4 o understand the full picture of wettability alteration of a rock by injection of low salinity water,

5 n shell deposition as a response to regional alterations of abiotic and biotic conditions in future e

6 as the basal forebrain, and demonstrate that alteration of activity in the two areas changes decision

7 e to the (1) native activity of enzymes, (2) alteration of activity through protein or substrate engi

8 , there is no evidence of success in genetic alteration of Ag-experienced memory CD8 T cells.

9 KT/ERK), which may also involve the distinct alteration of alternative splicing events of specific tr

10 It showed that an alteration of amplitudes and decay times of the GABAergi

11 ve fit between data and simulations supports alterations of an NMDAR-dependent memory mechanism opera

12 levels of pro-inflammatory factors, without alteration of anti-inflammatory mediators, and significa

13 the reward and fear circuits revealed by the alterations of Arc expressions, which are associated wit

14 nd driver changes than nnMCL, with exclusive alterations of ATM in cMCL, whereas TP53 and TERT altera

15 es also suggest that hyperactivation of Src, alteration of autophagy and a mitochondrial deficit unde

16 The subtypes characterized by genetic alterations of BCL2, NOTCH2, and MYD88 recapitulated rec

17 le to prevent physicochemical and functional alterations of beans.

18 pothesized to contribute to well-established alterations of beta and gamma range oscillations in pati

19 l properties as a result of the simultaneous alteration of both atomistic and electronic structure.

20 tudy in literature has ever investigated the alterations of brain glucose metabolism in these subject

21 Alterations of brain perfusion from embolic events, blee

22 a highly heritable illness, associated with alterations of brain structure.

23 ), Amadori products, and resisted structural alterations of BSA subjected to glycation.

24 A subset of HGBCL, NOS displayed recurrent alterations of Burkitt lymphoma-related genes such as MY

25 Here, we discuss cancer-associated alterations of Ca(2+) fluxes at specific organelles as w

26 sed to stressful conditions, which result in alterations of Ca(2+) handling.

27 Alterations of Ca(2+) homeostasis have been implicated i

28 Alteration of CAMs-related genes may be specific patholo

29 mutations that induced genome-wide splicing alterations of cancer-related genes to promote malignanc

30 ggests large-scale, open-system hydrothermal alteration of carbonaceous asteroids in the early Solar

31 duced immunosuppression with lymphopenia and alterations of CD4+ T-cell functions that renders the ho

32 w that activation of TOR is concomitant with alteration of cell expansion, proliferation and speciali

33 in chromatin accessibility and the strongest alteration of cell-cell interactions in SSc lesions.

34 Importantly, we show that the global alteration of cellular proteome during the transition of

35 Ultrastructure alterations of cellular membranes and walls in A. parasi

36 However, chemical and mechanical alteration of cement can reduce the permeability of leak

37 s for primary causes of CA: gain-of-function alterations of CEP19, CEP72, CTNNB1, PTK2, NDRG1, SPATC1

38 NDRG1, SPATC1, TBCCD1; and loss-of-function alterations of CEP76, MCPH1, NEURL4, and NPM1.

39 Strikingly, CSF-1 deficiency and alteration of cerebellar microglia were associated with

40 A new study shows how the dynamic alteration of chemoattractant flux by chemotaxing cells

41 Genome-wide alteration of chromatin accessibility within TSS and enh

42 Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular

43 We sought to characterize acute alterations of circadian rhythms in critically ill patie

44 of corneal endothelial cell (CEC) density to alterations of collagen composition of Descemet membrane

45 The alteration of color was observed to be due to the increa

46 e most common neurologic manifestations were alteration of consciousness (27 of 37, 73%), abnormal wa

47 PPPCD is associated with an alteration of corneal biomechanics and a novel missense

48 ure, while it was not enough for significant alteration of denaturation temperature.

49 Alterations of dendritic architectures are hallmarks of

50 nt in DS and whether this is due to specific alterations of distinct GABAergic circuits is unknown.

51 Alterations of diurnal variation in BP are associated wi

52 polymer and peptide synthesis results in the alteration of DNA helical structure or reduced thermal s

53 tion in clinical trials: Pathway inhibition, alteration of DNA Repair pathways, Immunotherapy, cancer

54 ranscriptome changes independently of global alterations of DNA methylation levels or changes in H3K2

55 robial metatranscriptomic responses to photo-alteration of DOM provide a mechanistic explanation for

56 Thus, persistent alteration of eCB signaling after repeated seizures may

57 Genetic alterations of EGFR are observed in ~50% of glioblastoma

58 Genetic alteration of ENaC-alpha causes aldosterone dysregulatio

59 owever, there is scarce evidence for genetic alterations of endocytic proteins as causative in high i

60 This alteration of ensembles coincided with reductions in alp

61 tivating mutations but also loss-of-function alterations of epigenetic modifiers.

62 in wall kinetics does not originate from the alteration of epitaxial strain; rather, it is correlated

63 Focal copy number alterations of ERG, IKZF1, PAX5, ETV6, RB1, BTG1, EBF1,

64 nical studies have consistently demonstrated alteration of excitation/inhibition (E/I) balance and ab

65 Alterations of excitatory synaptic function are the stro

66 These mutations would trigger an alteration of exon usage during RNA splicing, causing th

67 hat induce differentiation in 4 days without alteration of external soluble or biomechanical cues.

68 in conformational entropy are manifested in alterations of fast internal side chain motion that is d

69 ugmentation also rescued the seizure-induced alterations of fear memory by restoring the phasic contr

70 Finally, alteration of food availability demonstrates the hierarc

71 Photophysics tunability through alteration of framework aperture (metal-organic framewor

72 ed avidin probe, one can directly assess the alteration of functional responses, i.e., degranulation,

73 ubgroup of patients, we also measured direct alterations of functional connectivity with resting-stat

74 usceptibility to seizures, accompanied by an alteration of GABAergic markers were rescued by Rho-asso

75 depressive disorder (MDD) is associated with alterations of GABAergic interneurons, notably somatosta

76 quintuple mutant did not display significant alteration of gene expression at the whole-genome level,

77 he most important determinant of post-injury alterations of gene expression in liver regeneration.

78 er cancers and provide further evidence that alterations of gene expression may have relevant effects

79 Alterations of genes involved in the DNA damage repair p

80 An early and persistent alteration of glial cell activity takes place at the neu

81 Alterations of gluconeogenic metabolites and fluxes in T

82 trophy over the first 2 weeks, and mitigated alterations of glutamate, glycerophospholipids, and carn

83 athway, providing new insight into oncogenic alterations of glutamine metabolism.

84 The underlying mechanism of oncogenic alterations of glutaminolysis remains unclear.

85 This review focuses on alterations of glycocalyx during I/R injury in general (

86 ecific manner and could be playing a role in alterations of goal-directed and habitual behaviors.

87 Our results show that experimental alterations of gravity produce rapid changes in the perc

88 Low-grade intestinal inflammation and alterations of gut barrier integrity are found in patien

89 Our findings suggest that synergistic alterations of gut microbial consortia, rather than indi

90 Distinct alterations of gut morphology and microbiota composition

91 Alterations of H3K36me3 levels in the gene body reflect

92 enemy foraging efficiency via information or alteration of habitat complexity.

93 aemosporidian infection are affected through alteration of habitat structural variables (measured by

94 ges were likely caused by disturbance-driven alterations of habitats and species composition of trees

95 cent advances in understanding the molecular alterations of HCC have not yet translated into biomarke

96 Given that global alteration of HCV E2 glycosylation by expression in diff

97 , food neophobia was associated with adverse alteration of health-related biomarkers and risk factors

98 Cancer induces alteration of hematopoiesis to fuel disease progression.

99 of NCS- treated obesity and investigated the alterations of hepatic function and underlying mechanism

100 regulated Ca(2+) levels lead to a remarkable alteration of histone H3K9 acetylation and activation of

101 n, RB1 loss, or CDKN2A mRNA downregulation), alterations of homologous recombination repair genes, an

102 d (AUC = 0.92, p-value = 3.16E-8) MP-induced alterations of immune cell signaling trajectories, parti

103 ch evolutionary changes arise either through alterations of individual neural components ("mosaically

104 n of viral infection, or indirectly, through alteration of inflammatory status.

105 ate that dark exposure produces an important alteration of inhibitory circuits and molecules related

106 egnancy are due in part to pregnancy-induced alteration of innate immune cell frequencies and cytokin

107 le new mechanism for their dysregulation via alteration of insulator loops.

108 Thus, alterations of interactions of EEEV HVD and likely HVDs

109 hetic starting point for dramatic structural alterations of its complex, fused ring system to synthes

110 oss of functional P2X2 receptors or distinct alterations of its functional properties lead to noise-i

111 Studies showed that alterations of its membrane-related components, includin

112 in phosphorylation causes splicing-dependent alterations of JAK2-ERK signalling and the maintenance o

113 his association may be attributed in part to alterations of Klotho expression induced by albuminuria,

114 ng ER stress may improve proteinuria-induced alterations of Klotho expression, and hence renal and ex

115 The alteration of LD dynamics, combined with abnormal mitoch

116 If alteration of lipid levels also reduced risk of BC, this

117 l embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor ne

118 Collectively, this onslaught leads to alterations of lung, skin, or gut epithelial surfaces, d

119 etween B and T cells during EAU resulting in alteration of lymphocyte repertoire by increasing levels

120 highlights the role of ion transport in the alteration of materials in cultural heritage objects, em

121 tive manipulation mechanism does not involve alteration of maternally-loaded transcripts.

122 Alteration of membrane mechanical properties represents

123 The metabolic kinetic changes revealed the alteration of metabolism and neurotransmission in differ

124 ficantly extends Drosophila lifespan, causes alterations of metabolites associated with increased lif

125 These deficits correlate with alterations of microglia-neuron crosstalk pathways and h

126 ffect is long-chain fatty acid accumulation, alteration of mitochondrial structure and function, repu

127 In particular, we found sex-specific alterations of mitochondrial dynamics following cohabita

128 ling through regulating alternative splicing alterations of mitochondrial genes.

129 The alteration of modified amino acid (MAA) profiles in biol

130 iation modes (covalent vs ionic), as well as alteration of molecular geometries and supramolecular ag

131 ed during this study demonstrates the subtle alterations of morphology characterized by reduced vesse

132 The gradual alteration of mortality risk after ICU admission was ass

133 ng process, we characterized the sequence of alterations of multiple phenotypes at organismal scale.

134 ) and CysLT(1) receptors, without showing an alteration of muscarinic M(3) receptors.

135 o) mice have minimal myelination defects, no alteration of myelin thickness, and normal KROX20 expres

136 ingle treated patient, we also evaluated the alteration of myeloid cell functional activity.RESULTSWe

137 d with cardiac fibrosis and stiffness due to alteration of myocardial extracellular matrix.

138 We find complex alterations of neuronal responses that reflect fatigue a

139 Particularly, alteration of NLGN1 expression is known to affect the dy

140 Alteration of normal ploidy (aneuploidy) can have a numb

141 Impaired microbiota has been associated with alterations of offspring cognitive development and behav

142 electrographic, neuroanatomical and synaptic alterations of Ophn1 deficient mice.

143 ose of extant analogues, strongly suggesting alteration of original melanosome chemistry.

144 Mouse and dHL-60 cells bearing genetic alteration of PAD4 showed that chromatin decondensation,

145 ired for virus entry or syncytium formation, alteration of palmitoylated cysteine residues in the cyt

146 epidermal differentiation and tight junction alterations of patients with AD (loricrin, filaggrin, an

147 or the first time, to our knowledge, massive alterations of peripheral monocyte subsets in response t

148 with transcriptional repression through the alteration of Pol II phosphorylation states, thereby con

149 rable microbial, physicochemical and sensory alterations of pomegranate arils.

150 Indeed, alterations of potassium levels can be related to neurol

151 Experimentally mimicking the alterations of predicted helper genes in cancer and pre-

152 imals, and both may be similarly impacted by alteration of production and transport pathways in a cha

153 thus also suggesting that a chemical-induced alteration of protein homeostasis is a mechanism for int

154 lthough proposed underlying pathways include alterations of protein homoeostasis and immune and infla

155 have potential implications for the induced alterations of protistan community and their ecological

156 Alterations of PrPC posttranslational processing can cha

157 Organ bath studies revealed severe alteration of pulmonary artery contraction and relaxatio

158 Light application and associated firing alteration of pyramidal and interneuron populations led

159 of underlying interaction potentials and the alteration of reaction rates using quantum statistics.

160 fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epi

161 a and metabolic alterations, but only subtle alterations of renal urate excretion and ABCG2 abundance

162 was required for PPP2R2A deficiency-induced alterations of replication initiation/RS and sensitivity

163 ntestinal mucosae of infant macaques through alterations of resident innate immune cells giving rise

164 One commonality that we discovered is an alteration of resurgent current kinetics, although the m

165 mited knowledge is currently available about alterations of retinal blood flow (F), oxygen delivery (

166 NOVA2 downregulation in vitro and to rescue alterations of retinotectal axonal pathfinding induced b

167 We also discuss alterations of ribosome-associated proteins (RAPs), with

168 Moreover, we showed strong alteration of right ventricular cardiomyocyte excitabili

169 Alteration of RITMO1 expression levels and timing by ect

170 Alterations of S100A10 (p11) level are also implicated i

171 The results suggest alterations of seascapes by farming practices may have c

172 t is estimated that heating and hydrothermal alteration of sediments rich in organic matter and carbo

173 Here we show that seafloor alteration of serpentinites is a source of Si to the oce

174 Laboratory analysis showed alteration of serum creatine kinase and creatinine in th

175 , profiling of miRs from CAF exosomes showed alterations of several exosomal miRs in FAK-null CAFs, a

176 ts are higher in SAN vs atria; heterogeneous alterations of several isoforms, specifically nNav1.6, a

177 No detected alteration of SFPR1 gene and SFRP1 expression in ampulla

178 Alterations of SHH canonical signaling, causally linked

179 The alteration of sialylated N-glycan expressions is importa

180 Second, because the alteration of sialylation patterns has been previously i

181 ish a blueprint for better understanding the alteration of signaling compartments associated with dis

182 ardiomyopathy may reveal novel Lmna-mediated alterations of signaling pathways leading to dilated car

183 Sleep disturbances, alterations of sleep architecture, and the development o

184 oplastics were present, suggesting potential alterations of soil stability.

185 d ventricles); global delay with significant alteration of speech, language, and behavior; hypotonia;

186 these mutations were cryptic, either exonic alterations of splice enhancers or silencers or deeply i

187 lecular pathways through amino acid changes, alteration of splicing patterns or expression of genes,

188 scanning electron microscopy showed minimal alterations of starch, by SFE, in long-range crystalline

189 activities on physiology and transcriptional alterations of steroid-specific target genes at 96 and 1

190 ect to energy expenditure, which may involve alteration of strategies in response to changes in resou

191 sure (PME) suggest structural and functional alterations of striatal, frontal, parietal, and limbic r

192 rked by myolysis, glycogen accumulation, and alteration of structural proteins.

193 dy provides definitive evidence that genetic alterations of SUGP1 genocopy SF3B1 mutations in lung ad

194 le on human dendritic cells (DC) through the alteration of surface markers, cytokine secretion, and t

195 Our studies demonstrate that chemical alteration of surface-exposed moieties can confer gain-o

196 in an AD-like mouse model, which induced an alteration of surveillance functions in endogenous micro

197 e in GABA/glutamate presynaptic activity and alteration of synaptic plasticity in the basolateral amy

198 ex vivo We found that mutant neurons exhibit alterations of synaptic input and GABAB/GIRK signaling,

199 t synapses, a phenotype that paralleled with alterations of synaptic morphology, transmission, and pl

200 These results suggest that alteration of temperature within realistic parameters su

201 n, and response severity was controllable by alteration of the amount of allergen used for challenge.

202 f a metal-organic framework through a domino alteration of the bond connectivity under mild condition

203 Alteration of the chemical constitution of abacavir gene

204 e and easily scalable strategy, which avoids alteration of the core sequence of the microprotein.

205 itoprotective properties of SS-31, including alteration of the distribution of ions and basic protein

206 his transient knockdown caused a genome-wide alteration of the DNA methylation remodeling that takes

207 e tested in vitro and in vivo, demonstrating alteration of the E2 antigenic profile in several cases,

208 h manipulation of maternally derived EGF and alteration of the earliest gut defenses, we have develop

209 thermore, the NMR results reveal the induced alteration of the FA to MA ratio due to deuteration caus

210 Here, we propose that alteration of the Fe-S protein function by LCO is a mole

211 l model, we show that upstream ESCRT-induced alteration of the Gaussian bending rigidity and their cr

212 itis and rectal prolapse, is associated with alteration of the gut microbiota.

213 ical excitability, which in turn suggests an alteration of the homeostatic plasticity range.

214 Our results reveal that global alteration of the host lysosomal system is a defining fe

215 e insect was primarily zeolitized during the alteration of the host rocks and later sealed in opal de

216 ucocorticoid exposure resulted in persistent alteration of the hypothalamic-pituitary-adrenal (HPA) a

217 t depletion following vitrectomy suggests an alteration of the intraocular oxidant-antioxidant balanc

218 ammonium-free droplets is attributed to the alteration of the ion distribution in the presence of am

219 t of UBCH7/UBE2L3 on p27(Kip1) is not due to alteration of the levels of any of the ubiquitin ligases

220 Alteration of the microbiome alters TLR7-MyD88 signaling

221 eonatal period is associated with persistent alteration of the microbiome and innate immune response

222 ease risk; and the prospects for therapeutic alteration of the microbiota in children with JIA.

223 NAA10 activity inhibition through structural alteration of the NAA10 substrate-binding site.

224 but is inhibited by HYPK through structural alteration of the NatE substrate-binding site.

225 specific changes in INM due to a significant alteration of the nuclear apical movement dynamics with

226 Cs and peripheral nerves reverses functional alteration of the peripheral nerves and restores the hom

227 ended in culture media when prepared without alteration of the pH of the suspending media and imaged

228 of flowering under long-day conditions, and alteration of the phase of circadian leaf movements.

229 cancer types, GSECA correctly identified the alteration of the PI3K/AKT signaling pathway driven by t

230 (i.e., activities) and/or low pH led to the alteration of the pigment lead white (hydrocerussite, 2P

231 approaches often rely on the target-specific alteration of the point spread function to encode the mu

232 Alteration of the redox state of FAD4 or PRXQ through si

233 ragmatic dysfunction related to a structural alteration of the ryanodine complex that is reversed wit

234 Furthermore, reciprocal alteration of the same residue in inducible costimulator

235 documentation of the widespread hydrothermal alteration of the shallow crust caused by the intrusion

236 g the recruitment of inflammatory cells, the alteration of the skin microbiome, and the decrease in t

237 of lipid compartmentalization, as well as an alteration of the structure of the protein bodies and of

238 This is reflected by the strong alteration of the SubPz electronic properties produced b

239 low portion of the frame with no significant alteration of the valve housing.

240 fication" of the Arctic Ocean with potential alterations of the Arctic marine food web and biogeochem

241 s lacunar stroke or more subtle pathological alterations of the brain parenchyma, which may eventuall

242 autistic spectrum might be characterized by alterations of the brain's inference about the causes of

243 ay be a synergistic result of ageing-related alterations of the cell cycle, cytoskeleton, and mitocho

244 llergen-specific blocking IgG antibodies and alterations of the cellular immune response so that the

245 Structural and biomechanical alterations of the cornea were screened.

246 We reveal somatic or germline alterations of the CYLD gene in 15/15 cylindromas and 5/

247 x resulted in diminished HIV-1 infection and alterations of the cytokine profile produced by brain pe

248 ed important functions related to epigenetic alterations of the EBV and KSHV genomes that mediate onc

249 evidence now clearly demonstrates that these alterations of the ECM not only affect the structural pr

250 as transient blurred vision and with subtle alterations of the fundus.

251 Alterations of the genome and epigenome were correlated

252 The ability to create targeted alterations of the genome through this easy to design sy

253 rRNA gene amplicon sequencing indicated that alterations of the gut microbiome contributed to the obs

254 Alterations of the gut microbiome in Parkinson disease (

255 E are associated with specific morphological alterations of the hippocampus, which could help stratif

256 Age-associated alterations of the hormone-secreting endocrine system ca

257 Dietary habits have been associated with alterations of the human gut resident microorganisms con

258 nsulin signaling presumably mediated through alterations of the integrin beta1 signaling pathway and

259 Furthermore, alterations of the large and small cerebral vasculature,

260 , the clinical expression matches functional alterations of the mitochondria.

261 Particularly, we found that alterations of the mitogen-activated protein kinase path

262 Concomitantly, specific alterations of the niches, which support haematopoietic

263 ant applications given ongoing anthropogenic alterations of the nutrient and organic matter inputs to

264 Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss

265 -implant marginal mucosa defects (PMMDs) are alterations of the peri-implant soft tissue architecture

266 ounding hospital-acquired pneumonia, discuss alterations of the respiratory microbiome and of the muc

267 atin remodeling complex, are the most common alterations of the SWI/SNF complex in estrogen-receptor-

268 ell-type proportions and consequently marked alterations of the transcriptome.

269 lytic rates in cancer cells despite constant alterations of the tumour tissue.

270 Age-related pathological alterations of the vasculature have a critical role in m

271 The alterations of the viscoelastic properties caused by glu

272 aim of this study is to investigate possible alterations of the vitamin D(3) activity in hPDLCs under

273 uired to treat prostate cancers that exhibit alterations of the WNT pathway.

274 itizer molecules, resulting in a significant alteration of their singlet oxygen ((1)O(2)) production.

275 Males are at unique risk from alterations of their single copies of these genes.

276 dium complexes can be controlled through the alteration of thermodynamic processes and provides a roa

277 isms of social affiliative behaviors and the alteration of these behaviors in many neuropsychiatric a

278 ion, only Diclofenac exposure shows a marked alteration of these intracellular parameters, leading to

279 Alterations of these amino acids abolish DNA-binding abi

280 and consequent over-activity of GDH through alteration of this allosteric communication network.

281 sphate homeostasis via the efflux route, and alteration of this interplay likely contributes to PFBC.

282 The alterations of those properties were dependent upon epig

283 tential to manipulate it clinically, because alterations of thymus development or function can result

284 scence signature that is associated with the alteration of tissue structure and biochemical profile.

285 e cellular defects that can be attributed to alterations of TNF-alpha-dependent signalling pathways a

286 forms of the tau protein without significant alterations of total tau or other forms.

287 High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of AT

288 ng of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI

289 d species-specific colonization patterns and alterations of ultracellular structures.

290 s and nectar during peak secretion; however, alteration of vascular nitrate supply had no impact on A

291 s work provides insight into ethanol-induced alterations of vHipp-NAc synapses and suggests that, sim

292 Gag involves inhibition of nuclear entry and alteration of viral integration sites.

293 ntified TP receptor R295(7.40), which showed alteration of voltage sensitivity of TP receptor upon mu

294 n impacts from flooding and leading to major alterations of water quality, biogeochemistry, and ecolo

295 sed frequency of forest fires and subsequent alteration of watershed carbon and nutrient dynamics.

296 Through alteration of wave-generating atmospheric systems, globa

297 the splicing networks of lineage commitment, alteration of which may be involved in early embryonic l

298 vibrissae available to a rat resulted in an alteration of whisking strategy consistent with the rat

299 Molecular alterations of YES1, a member of the SRC (proto-oncogene

300 Alterations of Young's modulus (YM) and Poisson's ratio