ライフサイエンスコーパス: alternate splicing

1 result from differential promoter usage and alternate splicing.

2 nucleosome destabilization and modulation of alternate splicing.

3 coding sequence diversity, where insects use alternate splicing.

4 t least three protein isoforms that arise by alternate splicing.

5 nylation and other Flt1/sFlt1 transcripts by alternate splicing.

6 to the 5' portion of intron 11 also promoted alternate splicing.

7 nus and in the active site for ATPase due to alternate splicing.

8 through the use of alternative promoters and alternate splicing.

9 NAs that vary via alternate promoter use and alternate splicing.

10 by the FANTOM2 clones revealed a pattern of alternate splicing.

11 es, MACROH2A1.1 and MACROH2A1.2, produced by alternate splicing.

12 ll-length and truncated sAC are generated by alternate splicing.

13 sm in the cyclin D1 gene enhances the gene's alternate splicing.

14 and betaII-PKC, isotypes that are derived by alternate splicing.

15 er-molecular-weight forms of Bin1 protein by alternate splicing.

16 RNase protection experiments reveal no such alternate splicing.

17 RET alternate splicing affects the strength of interaction w

18 of IMPDH1 in human retina are the result of alternate splicing and alternate start sites of translat

19 The evolution of the alternate splicing and an additional exon in these GKs,

20 eterogeneity of human sFlt1 that arises from alternate splicing and from alternative polyadenylation

21 tial mass differences such as polymorphisms, alternate splicing and post-translational modifications

22 As a result of alternate splicing and subsequent frameshift, the report

23 quences in retinal photoreceptors because of alternate splicing and/or promoter usage.

24 r in the form of tissue-specific expression, alternate splicing, and 5' end mRNA heterogeneity, as we

25 These findings reveal autoinhibition and alternate splicing as regulators of atlastin-mediated ER

26 We also show that alternate splicing at another site (Z site) dramatically

27 It also results in alternate splicing at multiple sites, some of which have

28 y of GBSS pre-mRNA processing and results in alternate splicing at three cryptic sites.

29 *) isoforms of E6, which originate by way of alternate splicing, can modulate procaspase 8 stability.

30 d a protein product of a potentially related alternate splicing event (cyclin D1b) may influence canc

31 t abundant mRNA isoforms are derived from an alternate splicing event that inserts an evolutionarily

32 sibility that the breast cancer risk and the alternate splicing event were due to the same causal SNP

33 h the biological functions of EWS leading to alternate splicing events and defects in DNA-damage repa

34 Alternate splicing events can create isoforms that alter

35 The boundaries of exons 6-8 and the alternate splicing events in this region are identical t

36 ases the diversity of protein functions, and alternate splicing events occur in tumors.

37 is transcriptionally complex, with multiple alternate splicing events, antisense transcription, and

38 LUL1, not detected in canine CLUL1, suggests alternate splicing events.

39 rst study showing tumor overexpression of an alternate splicing factor resulting in drug resistance.

40 ein binds to p32, a component of the ASF/SF2 alternate splicing factors; in cells infected with a rec

41 An early feature of their activation is alternate splicing followed by complete transcriptional

42 Alternate splicing generates the complex proteosome in e

43 Alternate splicing generates two variants coding for a m

44 odents that are characterized by significant alternate splicing generating isoforms capable of negati

45 Alternate splicing gives rise to a low abundance mRNA en

46 m from the exon 11 splice donor site promote alternate splicing in both wild-type and HGPS fibroblast

47 nces 5' to the alternate splice site reduced alternate splicing in HGPS cells and modestly lowered pr

48 Exons 1B and 1C, generated by alternate splicing in intron 1, and exon 1A, which is 5'

49 has been predicted that TN-X should undergo alternate splicing in its fibronectin-like domains.

50 Alternate splicing in the exon-8 of vascular endothelial

51 Alternate splicing in the exon-8 of VEGF-A results in th

52 A differential pattern of expression and alternate splicing indicate several levels of RIN1 regul

53 ediatric t(8;21) AMLs, likely resulting from alternate splicing, internal deletions and/or breakpoint

54 However, VEGF-A is generated by alternate splicing into two families, the proangiogenic

55 Abundant alternate splicing involving the 1.5-kb LAT splice accep

56 Our findings argue that alternate splicing is an important determinant of the fu

57 Furthermore, we present evidence that alternate splicing is the mechanism that governs the pro

58 me, and the more recent identification of an alternate splicing isoform of the gene product.

59 Galectin-9 had an alternate splicing isoform, exclusively expressed in the

60 se from the same transcription unit but from alternate splicing isoforms.

61 Alternate splicing, leading to the insertion of the trip

62 ase mRNA seen in other tissues suggests that alternate splicing may occur in this organ.

63 -terminal extension (CTE) and the associated alternate splicing mechanism, which splices the RCA-alph

64 Both glucagon and GLP-1 are derived from alternate splicing of a common precursor, proglucagon by

65 Alternate splicing of agrin mRNA results in a family of

66 volving the RNA processing apparatus and the alternate splicing of apoptosis regulatory proteins.

67 rom effects of SPF45 on the transcription or alternate splicing of ERbeta-regulated genes.

68 FGFR1 isoforms are formed from alternate splicing of exon 3 and of exon 8 or 9 in Ir-li

69 ranscriptional control of the hTERT gene and alternate splicing of hTERT transcripts.

70 Alternate splicing of human plasma membrane calcium pump

71 protected KSPG25 mRNA fragments, suggesting alternate splicing of KSPG25 transcripts.

72 ay and secretion of the same protein through alternate splicing of pre-mRNA.

73 Alternate splicing of PRKG1 transcripts confers distinct

74 The AcPb isoform is resultant from alternate splicing of the AcP transcript.

75 We found no evidence of alternate splicing of the BEST1 transcript in ADVIRC iPS

76 oduct has also been described because of the alternate splicing of the gene.

77 gion that is not generated by a mechanism of alternate splicing of the iPLA(2)beta transcript.

78 two different serpin proteins, generated by alternate splicing of the last coding exon.

79 effect through GPCRs that are generated via alternate splicing of the Oprm1 transcript.

80 Alternate splicing of the Pit-1 message produces the Pit

81 Alternate splicing of the primary brk transcript generat

82 ifference is reflected in the expression and alternate splicing of the protein subunit of the telomer

83 ducts from related genes; from differential, alternate splicing of the same gene product; from the us

84 The two cDNAs were predicted to arise from alternate splicing of the same gene to yield different m

85 d with GGN1 and GGN3, two proteins formed by alternate splicing of the same gene, gametogenetin (Ggn)

86 A-2beta and PTP-NP-2 are isoforms arising by alternate splicing of the same gene.

87 Alternate splicing of the VEGF gene in mice results in v

88 ssor produced by complete P elements through alternate splicing of their RNA.

89 s are characterized in terms of copy number, alternate splicing of their transcripts, and the proport

90 erent proteins derived from the same gene by alternate splicing of two different first exons.

91 tation/artifacts in vivo (cryptic promoters, alternate splicing) or in vitro (nuclease degradation).

92 new avenue to target cancer by intercepting alternate splicing pathways.

93 that SR1 pre-mRNA could be committed to two alternate splicing pathways.

94 We conclude that alternate splicing plays a key role in regulating cellul

95 Alternate splicing produces one or two smaller variants

96 , thereby determining the mechanism by which alternate splicing produces the two mRNA species.

97 butions to the heterogeneity of SMGC include alternate splicing, proteolysis and N-glycosylation.

98 The alternate splicing reduces transcripts for wild-type pre

99 esults suggest that the insertion creates an alternate splicing site, which eliminates not only the i

100 These observations suggest that, through alternate splicing, the H(hsp/CP) transgene produces a r

101 Along with alternate splicing, the predicted protein of the 5B copy

102 MEF2 gene transcripts are subject to alternate splicing to generate protein isoforms with div

103 single zinc-finger gene can be used, through alternate splicing, to fulfill different functions in th

104 lational modifications, amino acid variants, alternate splicing variants and protein cleavage pattern

105 Alternate splicing was observed in 31% of D. melanogaste

106 ducts of the same alpha-TM gene produced via alternate splicing, whereas ATmC-1 and ATmS-1 are the id

107 in the interdomain linker and resulted from alternate splicing within intron 4 of the transcript.

108 Alternate splicing within the receptor extracellular dom

109 encoding the PIK-like protein ATR undergoes alternate splicing within the region of the mRNA encodin

110 Alternate splicing yields two distinct isoforms of the f