ライフサイエンスコーパス: alternative pathway

1 esults in phosphorylation on Tyr-323 (pY323, alternative pathway).

2 the third complement component (C3) via the alternative pathway.

3 e of overactivity of the complement system's alternative pathway.

4 t inhibitor of complement deposition via the alternative pathway.

5 e classical and lectin pathways, but not the alternative pathway.

6 human CFH regulates activation of the mouse alternative pathway.

7 next cell-cycle, and gain insight into this alternative pathway.

8 ugh C3 cleavage and its amplification by the alternative pathway.

9 ctivity leading to loss of regulation of the alternative pathway.

10 t on factor B, indicating involvement of the alternative pathway.

11 ic mutations of components of the complement alternative pathway.

12 C3c and potently inhibits C3 cleavage by the alternative pathway.

13 malian factor H, a negative regulator of the alternative pathway.

14 uggesting that PLP is being produced by some alternative pathway.

15 ates the hydroxylation of cholesterol in the alternative pathway.

16 G1, and anaphylaxis that was mediated by the alternative pathway.

17 ) are the major regulators of the complement alternative pathway.

18 e-dependent activation of complement via the alternative pathway.

19 ic reaction of the amplification loop of the alternative pathway.

20 equently occurs via subsequent activation of alternative pathways.

21 e II (Pol II) transcripts occurs through two alternative pathways.

22 t that is inefficiently membrane-targeted by alternative pathways.

23 chanisms known as the classical, lectin, and alternative pathways.

24 ipid absorption, suggesting the existence of alternative pathways.

25 in aberrant activation of both canonical and alternative pathways.

26 rects internalization into keratinocytes via alternative pathways.

27 se-1 phosphate by ketohexokinase (KHK) or by alternative pathways.

28 cription factors that can also be induced by alternative pathways.

29 oenzyme, can be incorporated into COX by two alternative pathways.

30 acLDL is mediated via both the classical and alternative pathways.

31 a (PDAC), underscoring the need to co-target alternative pathways.

32 Placental complement deposition and maternal alternative pathway 50 (AP50) values were higher in PE p

33 However, genetic and acquired alternative pathway abnormalities are also observed in I

34 nd a high prevalence of genetic and acquired alternative pathway abnormalities from patients with sol

35 although Cd46(-/-) mice have normal systemic alternative pathway activating ability, lack of CD46 lea

36 Alternative pathway activation (Ba) and endothelial acti

37 factor H and efficiently blocked LPS-induced alternative pathway activation and hemolysis induced by

38 SCR-2-3-4 inhibited both lectin and alternative pathway activation by nanoparticles.

39 s with the most effective ways to manipulate alternative pathway activation in complex systems.

40 , the prevalence of anti-C3b/anti-FB Abs and alternative pathway activation is similar in Ig-MPGN and

41 The indiscriminate nature of alternative pathway activation necessitates the regulato

42 at decreased DosR expression may result from alternative pathway activation of macrophages, with cons

43 ering the critical role of CFH in inhibiting alternative pathway activation on MDA-modified surfaces,

44 apoE molecules via domains 5-7 and regulates alternative pathway activation on plasma HDL particles.

45 aced FH from the bacterial surface, enhanced alternative pathway activation, and reduced bacterial bl

46 vel treatments, specifically those targeting alternative pathway activation, are highly desirable.

47 a variety of diseases that involve increased alternative pathway activation, but no therapeutic facto

48 FXIII-A) was reported to be a good marker of alternative pathway activation.

49 regulatory activity, resulting in excessive alternative pathway activation.

50 Alternative pathway activity is inhibited by complement

51 roperdin, a positive regulator of complement alternative pathway activity, increases PGA formation wh

52 at FH levels determine a delicate balance of alternative pathway activity, thus affecting the resista

53 ice contains pro-FD and has markedly reduced alternative pathway activity.

54 at can both initiate and positively regulate alternative pathway activity.

55 athway is the predominant signaling cascade, alternative pathways also affect ethylene responses.

56 and lectin pathways is amplified through the alternative pathway amplification loop.

57 mplement pathway activation to C1q-dependent alternative pathway amplification.

58 g assembly of a C3 convertase and downstream alternative pathway amplification.

59 nction is downregulated and replaced with an alternative pathway, an essential first step in the crea

60 In an alternative pathway, an O-bound enolate-iron(III) comple

61 The article then reviews alternative pathway analysis approaches that aim to redu

62 nt in muscle regeneration is mediated by the alternative pathway and C3a receptor (C3aR) signaling, a

63 tive responses were dependent on complement (alternative pathway and component 5), and immunoglobulin

64 its, including properdin and factor H in the alternative pathway and mannan-binding lectin, mannan-bi

65 (genes encoding components of the complement alternative pathway and other genes associated with the

66 However, C1-INH spares the alternative pathway and the membrane attack complex (C5-

67 dy represents a potent inhibitor of both the alternative pathway and the terminal pathway, with possi

68 The combination of these alternative pathways and canonical autophagy blockade, r

69 e by activating resistance mechanisms and/or alternative pathways and escape mechanisms.

70 The definition of genes contributing to alternative pathways and their expression profiles corro

71 specimens, suggesting an abnormality in the alternative pathway, and it was positive in seven (54%)

72 of complement-the classic pathway (CP), the alternative pathway, and the lectin pathway (LP)- conver

73 nding of ethylene signaling, including these alternative pathways, and discusses how ethylene signali

74 These results indicate a key role of alternative pathway androgen biosynthesis in the prenata

75 riod of sexual differentiation and show that alternative pathway androgen biosynthesis is active in t

76 idoreductase mutations predominantly support alternative pathway androgen biosynthesis.

77 ion product C3b, which autoamplifies via the alternative pathway (AP) amplification loop.

78 ibitor ACH-4471, which blocks the complement alternative pathway (AP) and is in phase 2 development f

79 tor B (cfB) is an essential component of the alternative pathway (AP) and plays an important role in

80 or acquired dysregulation of the complement alternative pathway (AP) are traditionally classified on

81 The alternative pathway (AP) is critical for the efficient a

82 The alternative pathway (AP) of complement activation is the

83 ing of CCPs 1-7) are major regulators of the alternative pathway (AP) of complement activation.

84 Inhibition of the alternative pathway (AP) of complement by saliva from An

85 regarded as the first-acting protease of the alternative pathway (AP) of complement.

86 ing protein that regulates activation of the alternative pathway (AP) of complement.

87 The alternative pathway (AP) of the complement system is a k

88 of acquired or genetic abnormalities in the alternative pathway (AP) of the complement system.

89 role in the amplification of the complement alternative pathway (AP) of the innate immune system.

90 hat in cTTP, complement is activated via the alternative pathway (AP) on the cell surface.

91 sential positive regulator of the complement alternative pathway (AP) providing stabilization of the

92 Alternative pathway (AP) regulatory factors were quantif

93 that prevents complement activation via the alternative pathway (AP) was described previously in a S

94 athway (CP), the lectin pathway (LP), or the alternative pathway (AP), and it plays a critical role i

95 ritical regulatory protein of the complement alternative pathway (AP), are typically associated with

96 malities in the regulation of the complement alternative pathway (AP).

97 glomerulopathy (C3G) is characterized by the alternative-pathway (AP) hyperactivation induced by neph

98 that the convertases from the classical and alternative pathways are likely to share their overall a

99 factor B (FB), an important component of the alternative pathway, are upregulated and could predict o

100 ed MAC deposition via both the classical and alternative pathway at the pneumococcal surface.

101 beyond 100-fold were not observed because an alternative pathway becomes dominant, with nonnative P5a

102 g to a differentiation pathway means leaving alternative pathways behind.

103 NET induction, whereas ionophores require an alternative pathway but that NETs produced by all stimul

104 lysis minimize the simultaneous operation of alternative pathways, but by introducing flux-weighting

105 ane potential and mitochondrial Ca(2+) is an alternative pathway by which IL-6 regulates effector fun

106 individual simulations and, thus, to explore alternative pathways by averaging thousands of simulatio

107 ngly similar to the crystal structure of the alternative pathway C3 convertase C3bBb, which is in acc

108 odies targeting factor B (a component of the alternative pathway C3 convertase) were found in a signi

109 at this occurs through the inhibition of the alternative pathway C3 convertase.

110 (for C3b and C4b) and DAA (for classical and alternative pathway C3 convertases), named decay cofacto

111 -3 and SCR-4 are critical for binding to the alternative pathway C3bBb convertase, whereas SCR-1 is d

112 particular, to establish the extent to which alternative pathways can contribute to achieving specifi

113 is an important complement regulator of the alternative pathway commonly recruited by pathogens to a

114 re sequence and structural homology with the alternative pathway complement inhibitor FH.

115 igated the role of properdin (P), a positive alternative pathway complement regulator, in allergen-in

116 ative GN (MPGN) was recently reclassified as alternative pathway complement-mediated C3 glomerulopath

117 (C3aR) signaling, as deletion of Cfb, a key alternative pathway component, or C3aR leads to impaired

118 is due to acquired or genetically defective alternative pathway control and is generally associated

119 trated that anti-factor B antibodies enhance alternative pathway convertase activity in vitro, confir

120 Because of the indispensable role of alternative pathway convertase in amplifying complement

121 dget and that installing an energy-efficient alternative pathway could substantially increase crop yi

122 We identified alternative pathways critical for Nrf2-dependent growth

123 ors, suggesting that initiation through this alternative pathway determines how aggressive the CRC be

124 esidual visual function that must rely on an alternative pathway directly to extrastriate occipital r

125 eat exposure, suggesting the existence of an alternative pathway during nonstressed conditions.

126 Severe alternative pathway dysregulation can be triggered by au

127 glomerulopathy is associated with complement alternative pathway dysregulation, which includes functi

128 pe CD4(+) T cells, but not those lacking the alternative pathway, enhanced tumor growth in T cell-def

129 We show that, even though a large number of alternative pathways exist, the alternatives carry lower

130 ing pathway, although evidence suggests that alternative pathways exist.

131 A second, alternative pathway exists, however: stimulation of the

132 malized ADE levels of classical pathway C4b, alternative pathway factor D and Bb, lectin pathway mann

133 th its low expression and the presence of an alternative pathway for Ca(2+) uptake into photoreceptor

134 Kountz et al have discovered an alternative pathway for carnitine metabolism in the gut

135 ation of lipid bilayer membranes presents an alternative pathway for cellular delivery of nanoparticl

136 otube connections have been identified as an alternative pathway for cellular spreading of certain vi

137 l and mechanical design not only provides an alternative pathway for extending lifetime of lithium me

138 er in energy than the CSS, it may provide an alternative pathway for fast decay from the LES to the g

139 The work highlights an alternative pathway for forming a new transition metal d

140 Our results identify both an alternative pathway for inducible PGE(2) synthesis and a

141 In this study, we describe an alternative pathway for intercellular transmission of PR

142 of the JCI, Saito and colleagues identify an alternative pathway for mitophagy that utilizes the seri

143 arative transcriptomics analysis revealed an alternative pathway for NH(4)(+) oxidation with electrod

144 We have identified an alternative pathway for PARPi-mediated growth control in

145 This work demonstrates an alternative pathway for SARS-CoV-2 diagnostics that does

146 Our study thus describes an alternative pathway for Th9 cell differentiation and pro

147 dressing by donor DCs serves as an efficient alternative pathway for the acquisition of recipient all

148 human and murine IL-23R was identified as an alternative pathway for the generation of sIL-23R.

149 This form of virus transport represents an alternative pathway for virus spread, which is resistant

150 ntified a number of proteins associated with alternative pathways for acetate production that are enc

151 sistent with the effects of retinoic acid on alternative pathways for ceramide generation.

152 link between autophagy block, activation of alternative pathways for degradation, and excretion of c

153 Our results demonstrated that two alternative pathways for DHA biosynthesis exist in teleo

154 It includes alternative pathways for excited-state decay and provide

155 e course of this study we explored plausible alternative pathways for H(2) activation, namely direct

156 brane glycerolipids and also how to engineer alternative pathways for lipid production in non-seeds.

157 of nitric oxide synthase (NOS1 and NOS2), or alternative pathways for polyamine biosynthesis via argi

158 genetic deletion, suggesting that there are alternative pathways for promoting eosinophilia.

159 Each did fit well to a model for two alternative pathways for proton transfer, each involving

160 on complex IV, revealing the co-existence of alternative pathways for the biogenesis of "supercomplex

161 d policy makers of the costs and benefits of alternative pathways for the future of global biodiversi

162 An alternative pathway from arginine to agmatine to putresc

163 complement system via classical, lectin, or alternative pathways generates anaphylatoxins (C3a and C

164 Activation of complement through the alternative pathway has a key role in the pathogenesis o

165 IL)-6 of the classic pathway and IL-4 of the alternative pathway have been studied widely.

166 he classical ipso, and the mechanism of this alternative pathway, have been investigated.

167 100/p52) are the downstream mediators of the alternative pathway; however, the B cell-intrinsic funct

168 The alternative pathway (i.e., introduction via leaf fall) a

169 mediated by lipocalin-2 and calprotectin via alternative pathways, IL-22 boosted its colonization of

170 ssociated with its M1 Fab that activates the alternative pathway in an Fc-independent manner.

171 s cross-reactive and inhibits the lectin and alternative pathway in murine serum.

172 y confirms the deregulation of the NF-kappaB alternative pathway in NSCLC and also demonstrates the i

173 t not of acLDL suggesting involvement of the alternative pathway in the binding of acLDL to CR1.

174 Finally, the absence of the two alternative pathways in a double mutant pgrl1 hydrogenas

175 ophages may be activated by both classic and alternative pathways in health and in periodontal diseas

176 fically probe whether tumors are able to use alternative pathways in its absence, we created a xenogr

177 at the Notch1 signaling axis synergizes with alternative pathways in promoting metastatic CRPC and ma

178 tivity of the reactants involved may provide alternative pathways in their aggregation.

179 adaptor protein LAT, it also stimulates an "alternative" pathway in which p38 is activated by the ki

180 oxidation product of thymine, occurs via two alternative pathways, in one of which, polymerases kappa

181 usters 1 and 2 had massive activation of the alternative pathway, including activation of the termina

182 heric slow-wave propagation that may rely on alternative pathways, including cortico-subcortico-corti

183 n treatment of MS patients may occur through alternative pathways, independent of Nrf2.

184 ssical and lectin pathways while leaving the alternative pathway intact.

185 ed and inherited mtDNA normally, pointing to alternative pathways involved in these processes.

186 als for Lewis acid-mediated cyclizations, an alternative pathway involving a domino sequence of Prins

187 ing LKB1, NUAK1 activity is maintained by an alternative pathway involving calcium-dependent activati

188 g dual C-Cl bond formation and contradict an alternative pathway involving electrochemical evolution

189 More recently, an alternative pathway involving the change of the magnetic

190 The complement alternative pathway is a powerful arm of the innate immu

191 A competitive alternative pathway is also found where the decarboxylat

192 Dysregulation of the complement alternative pathway is fundamental to the manifestations

193 Key to the effects of the alternative pathway is properdin, a serum glycoprotein t

194 However, the biological relevance of this alternative pathway is under debate.

195 g KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visc

196 mpete with factor H in the regulation of the alternative pathway, it has been hypothesized that the a

197 As ARGX-117 does not inhibit the alternative pathway, it is expected not to affect the an

198 esult from a dysregulation of the complement alternative pathway, leading to glomerular endothelial c

199 This alternative pathway may help flies silence newly acquire

200 ck ER-PM contacts grow well, indicating that alternative pathways may be compensating for the loss of

201 eactions, titanium offers new approaches and alternative pathways/mechanisms that are complementary t

202 been less well described in association with alternative pathway-mediated glomerulopathies (GP).

203 ribe the interplay between properdin and the alternative pathway negative regulator, Factor H, and ho

204 WT) and IDO1(-/-) macrophages, suggesting an alternative pathway of AhR activation.

205 characterized by excessive activation of the alternative pathway of complement (APC).

206 ut not the N protein, directly activates the alternative pathway of complement (APC).

207 The alternative pathway of complement activation is strongly

208 ement factor H (CFH), thereby inhibiting the alternative pathway of complement activation.

209 mplement factor H, the main regulator of the alternative pathway of complement activation.

210 nd factor H (FH), the major regulator of the alternative pathway of complement activation.

211 outer membrane protein P5 in evasion of the alternative pathway of complement activation.

212 s suggest that Stx-induced activation of the alternative pathway of complement and generation of C3a

213 thy caused by uncontrolled activation of the alternative pathway of complement at the cell surface le

214 This led to activation of the alternative pathway of complement exclusively via associ

215 e describe albicin, a novel inhibitor of the alternative pathway of complement from the salivary glan

216 In functional experiments, activation of the alternative pathway of complement in the carriers of rs8

217 Furthermore, CipA directly inhibited the alternative pathway of complement in vitro, irrespective

218 The alternative pathway of complement is an important part o

219 In C3 glomerulopathy (C3G), the alternative pathway of complement is frequently overacti

220 and indicate a novel mechanism by which the alternative pathway of complement may be triggered direc

221 commonly caused by inherited defects of the alternative pathway of complement, or the proteins that

222 function that allows it to downregulate the alternative pathway of complement.

223 e (aHUS) patients cause dysregulation in the alternative pathway of complement.

224 Ig; the C3 is derived from activation of the alternative pathway of complement.

225 to mutations that lead to activation of the alternative pathway of complement.

226 As an alternative pathway of controlled cell death, necroptosi

227 This study identified an alternative pathway of CS-induced EC permeability.

228 istent with this activity, LigIII acts in an alternative pathway of DNA double strand break repair th

229 r function of CD1c(+) DCs and demonstrate an alternative pathway of LC differentiation that may have

230 Thus, AdExos are both an alternative pathway of local lipid release and a mechani

231 Herein we identify an alternative pathway of NK-cell development driven by the

232 ording to our results, the activation of the alternative pathway of the complement system strongly co

233 H) is an important regulatory protein in the alternative pathway of the complement system, and CFH po

234 actor protein (CD46), a key regulator of the alternative pathway of the complement system, is only ex

235 ) is strongly linked to dysregulation of the alternative pathway of the complement system.

236 most important fluid-phase regulator of the alternative pathway of the complement system.

237 cute postinfectious GN had activation of the alternative pathway of the complement system.

238 tight regulation of the classical/lectin and alternative pathways of complement activation, respectiv

239 Alternative pathways of epitope production have been ide

240 Transcript levels of genes involved in alternative pathways of respiration and amino acid catab

241 which control subsequent stimulus-dependent alternative pathways of T cell differentiation.

242 assembly of the complement components of the alternative pathway on the nanoworm surface.

243 complement activation via the classical and alternative pathways on surfaces such as the extracellul

244 From this approach, it is evident that three alternative pathways operate to introduce the PS module

245 ith agents that target downstream signaling, alternative pathways, or components of the host immune s

246 This alternative pathway participates in thermogenesis in sel

247 Here we provide evidence for an alternative pathway previously undescribed for orthomyxo

248 se as compared with that established for the alternative pathway proconvertase C3bB.

249 s a unique C2 conformation compared with the alternative pathway proconvertase.

250 utations in genes that encode the complement alternative pathway proteins or the molecules that regul

251 Older studies indicated that the complement alternative pathway regulator factor H (FH) competes wit

252 Factor H (FH) is a key alternative pathway regulator that controls complement a

253 function of the transcription factors of the alternative pathway, RELB and NF-kappaB2, in late B-cell

254 C and diacylglycerol lipase alpha is known, alternative pathways remain unsettled.

255 overwhelming activation of complement via an alternative pathway results in atypical hemolytic uremic

256 H, demonstrating that this inhibition of the alternative pathway significantly contributes to the vir

257 In an alternative pathway structures can also be removed from

258 Considering the overall picture, alternative pathways such as vinylacetylene-mediated rea

259 e biodiversity; the remainder arises through alternative pathways, such as ecological speciation and

260 e derivatives apparently are synthesized via alternative pathways, such as the degradation of indole

261 C-SIGN-mediated endocytosis provided a minor alternative pathway that depended on SH and/or G and thu

262 he lipid kinase PIKfyve as a regulator of an alternative pathway that distributes engulfed contents i

263 ovide experimental evidence that suggests an alternative pathway that does not involve electron trans

264 We investigated an alternative pathway that involves activating the airway

265 to ATP synthesis, plant mitochondria have an alternative pathway that involves type II NAD(P)H dehydr

266 target DNA, whereas PAM mutations elicit an alternative pathway that recruits a nuclease-inactive Ca

267 ols also may help to identify organisms with alternative pathways that are involved in maintaining th

268 bon away from mitochondrial respiration into alternative pathways that avoid producing reactive oxyge

269 ly used topoisomerase II poisons and defines alternative pathways that could be therapeutically explo

270 rt because nascent RNAs become directed into alternative pathways that lead to circular RNA productio

271 lar neurons that can differentiate along two alternative pathways, thereby leading to major neural ci

272 that MIA-dependent precursor proteins use an alternative pathway to cross the outer mitochondrial mem

273 on after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation.

274 We conclude that Leishmania uses an alternative pathway to induce host autophagy while simul

275 se findings indicate that Leishmania uses an alternative pathway to mTOR to induce autophagy in host

276 An alternative pathway to plasticity was not restored by an

277 Here we show how an alternative pathway to predicting synthesizability emerg

278 ity adaptation, and furthermore, provides an alternative pathway to refine PC output.SIGNIFICANCE STA

279 ated and specific miRNAs are generated by an alternative pathway to regulate genes involved in cellul

280 We report an alternative pathway to the Wacker oxidation of internal

281 serendipitously uncovers the existence of an alternative pathway to the well-described POMT (protein

282 decades, a substantial number of supposedly alternative pathways to altruism have been published, le

283 Or do historical contingencies impose alternative pathways to answer the same challenge?

284 pels the quest for new compounds that target alternative pathways to current drugs.

285 hat prenucleation clusters (PNCs) can lie on alternative pathways to phase separation, where the very

286 Thus, Mtb uses alternative pathways to produce PG, each with its own bi

287 sults indicate that POP exposure may enhance alternative pathways to the glutathione detoxification r

288 wever, they could be valuable in identifying alternative pathways to the traits under investigation.

289 An alternative pathway utilizes Thi5, a novel enzyme that u

290 pyruvate intermediate in model microbes, the alternative pathway via arogenate is predominant in plan

291 ficolin-3, and C4, whereas inhibition of the alternative pathway was caused by degradation of C5.

292 of natural and CPM conditions show that the alternative pathway was significant, but its presence wa

293 cance of major effectors of the NF-kappaBeta alternative pathway, we investigated the relationship be

294 In search of alternative pathways, we tested the mRNA export complex

295 Genetic mutations of the complement alternative pathway were confirmed in half of our patien

296 ncy, with complement activated mainly by the alternative pathway, whereas the lectin pathway is also

297 evented activation of both the classical and alternative pathways, whereas pneumolysin inhibited only

298 d synthesis pathway but induced those in the alternative pathway, which is consistent with decreased

299 ed by force; instead, higher forces favor an alternative pathway, which seeks to release the vinculin

300 ysis of rabbit erythrocytes in assays of the alternative pathway while having no inhibitory effect on