ライフサイエンスコーパス: alveolar cell

1 ma, lung/airway epithelial lining fluid, and alveolar cells.

2 a putative mechanism used for viral entry in alveolar cells.

3 mainly near the basal surface of the mammary alveolar cells.

4 deficiency of adherence to the human type II alveolar cells.

5 ter after TNFalpha stimulation of A549 human alveolar cells.

6 he small distal airways and no expression in alveolar cells.

7 ay secretory cells and subsequently generate alveolar cells.

8 d promotes the tumorigenic potential of aged alveolar cells.

9 ant viruses, suppress interferon in infected alveolar cells.

10 ng/airway epithelial lining fluid (ELF), and alveolar cells.

11 l cell polarity and functional maturation of alveolar cells.

12 e to attach to human tracheal epithelial and alveolar cells.

13 es molecular and cellular differentiation of alveolar cells.

14 eas and bronchi, with limited replication in alveolar cells.

15 critical survival factor for milk-producing alveolar cells.

16 erminal differentiation of type 1 and type 2 alveolar cells.

17 at 0.16% EtOH increased ENaC activity in rat alveolar cells.

18 nd is required for proper differentiation of alveolar cells.

19 xamined telomere length in leukocytes and in alveolar cells.

20 he retargeting of AAV-DJ vectors to distinct alveolar cells.

21 differentiated surfactant-secreting type II alveolar cells.

22 al, secretory, ciliated, neuroendocrine, and alveolar cells.

23 sis of its phagosome and to replicate within alveolar cells.

24 RK activity was evident in airway lining and alveolar cells.

25 , cells which show characteristics of type 2 alveolar cells.

26 uli of DNA synthesis in cultured rat type II alveolar cells; addition of neutralizing antibodies to H

27 nock-in allele to follow the fate of Type II alveolar cells (AEC2) in vivo.

28 AAV vector transduction occurred in alveolar cells, airway epithelial cells, and smooth musc

29 Ethambutol concentrations were highest in alveolar cells (alveolar cell-plasma ratio, 15.0; 95% CI

30 Ethambutol concentrations were highest in alveolar cells (alveolar cells:plasma ratio 15.0, 95% CI

31 Alveolar cells and areas of atypical adenomatous hyperpl

32 lation systems are co-expressed with ACE2 in alveolar cells and associated with their differentiation

33 tiation arrest results in the lack of type I alveolar cells and differentiated surfactant-secreting t

34 CD209L is expressed in human lung in type II alveolar cells and endothelial cells, both potential tar

35 ymphocytes and the highest Rps27l in mammary alveolar cells and hepatocytes.

36 tant-secreting lamellar bodies within type 2 alveolar cells and increased intracellular phospholipid

37 s transgene expression to mammary ductal and alveolar cells and is nonresponsive to estrogen manipula

38 gulated host response, followed by damage to alveolar cells and lung fibrosis.

39 lanted into injured lungs differentiate into alveolar cells and rescue lung function.

40 heir role as progenitors to both airways and alveolar cells and the requirement of this transitional

41 cCRE linked to SLC6A20, a gene expressed in alveolar cells and with known functional association wit

42 critical survival factor for milk-producing alveolar cells and, together with population models, rev

43 e was detected in pulmonary airway cells, in alveolar cells, and in small pulmonary arteries.

44 resses Elf5, a master regulatory TF gene for alveolar cells, and regulates mature luminal TF/co-facto

45 mice failed to show significant reduction in alveolar cell apoptosis and alveolar destruction after t

46 onic blockade of VEGF receptors could induce alveolar cell apoptosis and emphysema.

47 ndings suggest that inhibition of structural alveolar cell apoptosis by alpha1-antitrypsin represents

48 plasia with fibrosis, accompanied CS-induced alveolar cell apoptosis caused by enhanced TGF-beta sign

49 Alveolar cell apoptosis is involved in the pathogenesis

50 There is growing evidence that alveolar cell apoptosis plays an important role in emphy

51 significantly reduced lung oxidative stress, alveolar cell apoptosis, alveolar destruction, and pulmo

52 associated with increased RUNX3 expression, alveolar cell apoptosis, and the antiangiogenic factor G

53 ing antibodies to EMAPII resulted in reduced alveolar cell apoptosis, inflammation, and emphysema-ass

54 rolling de novo ceramide synthesis prevented alveolar cell apoptosis, oxidative stress and emphysema

55 lso protected CS-exposed mice from pulmonary alveolar cell apoptosis.

56 ma in gp130(F/F) mice by preventing elevated alveolar cell apoptosis.

57 P nick end labeling assay was used to assess alveolar cell apoptosis.

58 efenses and decreasing lung inflammation and alveolar cell apoptosis.

59 , preventing emphysema through inhibition of alveolar cells apoptosis.

60 rproliferation and lack of maturation of the alveolar cells are at least in part caused by attenuatio

61 Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of

62 after T cell-target interaction, the type II alveolar cells are stimulated to produce the chemokine m

63 +) T cells, the transgene expressing type II alveolar cells, are not immediately destroyed by the eff

64 ntified bronchial ciliated cells and type II alveolar cells as a major local source of IL-33 during v

65 tol, in plasma, epithelial lining fluid, and alveolar cells as covariates in the bacillary eliminatio

66 donor-derived patches comprising AT1 and AT2 alveolar cells, as well as donor-derived mesenchymal and

67 ifts in abundance and distribution of type 2 alveolar cells at sites of fibrogenesis.

68 Type II alveolar cells (AT2s) are critical for basic respiratory

69 lactation, a large portion of mammary gland alveolar cells become polyploid, but how these cells bal

70 for the proliferation and differentiation of alveolar cells but also for their maintenance during lac

71 type vectors gave high transduction rates in alveolar cells but much lower rates in the airway epithe

72 large lipid droplets enclosed in the mammary alveolar cells, but milk analysis showed that these larg

73 genic IGF-I and IGFBP-3 were seen in lobular-alveolar cells by in situ hybridization.

74 Thanks to the small pore size, lung alveolar cells can be cultured on its apical surface for

75 fer of MDSC from naive sash mice into line 1 alveolar cell carcinoma tumor-bearing wild-type litterma

76 e, accelerated growth of transplanted line 1 alveolar cell carcinoma tumors is a mast cell-independen

77 se gaps in knowledge in a model of pulmonary alveolar cell-cell communication.

78 ung-on-chip (LoC) and mouse models, cords in alveolar cells contribute to suppression of innate immun

79 inflammatory response characterized by acute alveolar cell death and hyaline membrane formation, sust

80 ay play an important role in inhibiting lung alveolar cell death thereby preserving the lung architec

81 g antibody normalized TGF-beta signaling and alveolar cell death, conferring improved lung architectu

82 ands were, in part, the result of programmed alveolar cell death.

83 nts, followed by seeding these matrices with alveolar cells derived from human iPSCs.

84 nt with the phenotype, genes associated with alveolar cell differentiation and survival were differen

85 Normal fetal lung development and alveolar cell differentiation is regulated by a network

86 ure at birth due to an arrest in the type II alveolar cell differentiation program.

87 Current protocols to derive and culture alveolar cells do not faithfully recapitulate the archit

88 Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours

89 PNECs can be colabeled with alveolar cells during lung development, and following lu

90 , and dermal absorption, ultimately reaching alveolar cells either directly via the lungs or indirect

91 letion of the ARE restricted to lung type II alveolar cells exhibited an essentially identical lethal

92 From E15.5 to PN20, type II alveolar cells expressed both prosurfactant protein C an

93 n genetics, provides an epigenetic basis for alveolar cell fate and potential, and introduces an expe

94 te pregnancy-induced mammary cell expansion, alveolar cell fate commitment, and lactogenesis.

95 m, and subsequent Notch blockade promotes an alveolar cell fate.

96 ble for the production of NO) was induced in alveolar cells from L. pneumophila-infected immunocompet

97 Apoptosis was increased in alveolar cells from transgenic mammary glands at midpreg

98 Recently, excessive apoptosis of structural alveolar cells has emerged as a major mechanism in the d

99 n 1 pathway is critical for maintaining lung alveolar cell homeostasis and that loss of its expressio

100 ogenitors are intrinsically programmed or if alveolar cell identity is determined by environmental fa

101 f S. pneumoniae in A549 and isolated primary alveolar cells in a temperature-dependent manner.

102 d the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy.

103 pecific localization of the receptor mRNA to alveolar cells in the lung and to cardiac myocytes in th

104 AAV6 vector transduced airway epithelial and alveolar cells in the lung at rates that were at least a

105 CD8(+) T cell recognition of alveolar cells in vitro triggered monocyte chemoattracta

106 Newly weaned ferrets had little alveolar cell infection.

107 d-product (sRAGE) levels, a marker of type I alveolar cell injury and BOS.

108 respiratory epithelial cells, reprogramming alveolar cells into epithelial cells with characteristic

109 The human lung alveolar cell line A549 was found to produce PGE(2) but

110 The A549 human type II alveolar cell line was cultured to confluence in RPMI 16

111 n factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of

112 ore, at the time that the bacteria encounter alveolar cells (macrophages and epithelial cells) in the

113 nded by lung mesenchyme and cells expressing alveolar-cell markers.

114 limp1 regulates proliferation, apoptosis and alveolar cell maturation during puberty and pregnancy.

115 progression by degrading the stemness of the alveolar cell of origin.

116 C10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung.

117 at maintains the bronchiolar Clara cells and alveolar cells of the distal lung and that their transfo

118 Alveolar cells of the lung are injured and killed when e

119 Unexpectedly, our data also establish that alveolar cells other than lipofibroblasts, specifically

120 ncentrations were highest in alveolar cells (alveolar cell-plasma ratio, 15.0; 95% CI, 11.4-18.6).

121 ncentrations were highest in alveolar cells (alveolar cells:plasma ratio 15.0, 95% CI 11.4-18.6).

122 However, the mechanisms governing alveolar cell plasticity during lung repair remain elusi

123 ed role of the PCLAF-DREAM axis in promoting alveolar cell plasticity, beyond cell proliferation cont

124 gest that PABCs arise preferentially from an alveolar cell population that expands during pregnancy a

125 show that small NPs (~120nm) access specific alveolar cell populations and hematopoietic stem and pro

126 tic analyses to identify roles for different alveolar cell populations involved in mediating these re

127 Importantly, though, alveolar cells possess cellular repair and remodeling me

128 ht index (LWI), lung volume index (LVI), and alveolar cell proliferation index (CPI) were measured in

129 ted decreased adherence to the human type II alveolar cells, reduced nasopharyngeal colonization in i

130 APSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

131 ot inhibit Psa-mediated bacterial binding to alveolar cells, suggesting that both surfactant and cell

132 ed in a negative selection of differentiated alveolar cells, suggesting that Jak2 is required not onl

133 pendent, LPHA-positive vesicles in mink lung alveolar cells, suggesting that the coarse vesicles in t

134 r RLIM to exert its biological functions, as alveolar cell survival activity is inhibited in cells ex

135 dinates cellular compartments during mammary alveolar cell survival.

136 Of particular interest is a subset of alveolar cells termed basal-luminal (BL) cells, which ex

137 ol achieved higher concentrations in ELF and alveolar cells than plasma.

138 oncentrations in epithelial lining fluid and alveolar cells than plasma.

139 ineage tracing system, we show that bipotent alveolar cells that give rise to AT1 and AT2 cells are a

140 ion and milk production upon pregnancy, with alveolar cells that lack RLIM undergoing apoptosis as th

141 n that coexpresses SPC, a marker for type II alveolar cells that promotes alveolar regeneration follo

142 d C, and electron microscopic examination of alveolar cells, there was no evidence of abnormal pulmon

143 This mimicked the increased alveolar cell thickening in calves experimentally infect

144 contrast to the majority of fully committed alveolar cells, this epithelial population does not unde

145 expression, which is recapitulated in young alveolar cells through DNA methylation inhibition.

146 PR1-lipocalin-2 axis is detrimental to young alveolar cells through ferroptosis induction.

147 mes in type II cell hyperplasia and atypical alveolar cells, together with the high frequency of thes

148 scriptomics reveal a third, chicken-specific alveolar cell type expressing KRT14, hereby named lumina

149 ung cells (WI26 and A549), representative of alveolar cell type-I and type-II, respectively.

150 und in macrophages, bronchial and epithelial alveolar cells type 2, leading to pulmonary emphysema.

151 genitors along distinct lineages into mature alveolar cell types are still incompletely known, in par

152 vo counterparts and generate both airway and alveolar cell types in vitro.

153 ere directed to differentiate into airway or alveolar cell types using well-established methods, they

154 sexpression prevented the differentiation of alveolar cell types.

155 HIV] coinfected), drug exposure in plasma or alveolar cells was not associated with sputum bacillary

156 MYC overexpression targeted to pulmonary alveolar cells was sufficient to induce lung adenomas an

157 ssion of ErbB2 selectively in WAP(+) mammary alveolar cells, we found that tumors had similar morphol

158 intenance of PRL-responsive, differentiating alveolar cells, we utilized a transgenic strain that exp

159 No type I alveolar cells were evident.

160 he barrier with greater efficiency when A549 alveolar cells were infected with M. tuberculosis than w

161 Alveolar cells were obtained by BAL, and BE were obtaine

162 Furthermore, MSCs enhanced Ki67 staining in alveolar cells, which may indicate regeneration of the d

163 M. tuberculosis invaded A549 type II alveolar cells with an efficiency of 2 to 3% of the init

164 c labeling and ablation of airway (club) and alveolar cells with exposure to environmental noxious an