ライフサイエンスコーパス: amblyopic

1 n), and of these, 211 (27%) were bilaterally amblyopic.

2 visual cortex, and the deprived eye becomes amblyopic.

3 ction (27.7 +/- 14.7) and for those who were amblyopic (24.3 +/- 6.6) or strabismic (34.0 +/- 9.8).

4 < 0.001) and higher percentage of them were amblyopic (37.2% versus 10.4%, P=0.005).

5 mounted display in a sample of anisometropic amblyopic adults and to evaluate the potential usefulnes

6 ophthalmic follow-up until they are past the amblyopic age range, even after resolution of nystagmus.

7 al acuity was tested twice in each eye of 32 amblyopic and 11 normal children.

8 Of the 63 eyes evaluated, 13 (21%) were amblyopic and 50 (79%) were control eyes.

9 between amblyopic and fellow eyes or between amblyopic and control eyes in both hyperopic and myopic

10 13 (39%) and 27 of 46 (54%) patients in the amblyopic and control groups, respectively, were identif

11 ifferences were observed in visual acuity of amblyopic and fellow eyes at 15 years of age (P = .44 an

12 es showed no significant differences between amblyopic and fellow eyes in both groups.

13 VI showed no significant differences between amblyopic and fellow eyes or between amblyopic and contr

14 rence in macular thickness was found between amblyopic and fellow eyes, with amblyopic eyes having gr

15 Treatment Diabetic Retinopathy Study test in amblyopic and fellow eyes.

16 s were found in the foveal structure between amblyopic and fellow eyes.

17 ination thresholds were elevated in both the amblyopic and fellow fixing eyes but were within the nor

18 lyopia and compared the projections from the amblyopic and fellow normal eye in the visual cortex.

19 ar changes in ocular biometric components in amblyopic and non-amblyopic eyes.

20 The mean axial elongation in amblyopic and non-amblyopic groups over three years was

21 um to 101.10 +/- 9.98 mum (p = 0.008), while amblyopic and normal eyes showed no significant changes

22 rly impairs object perception in peripheral, amblyopic and possibly developing vision.

23 We tested the responses of ten amblyopic and six normal observers to illusions of perce

24 and grating acuity were identified as normal/amblyopic based on age-matched norms.

25 These results show that the mature amblyopic brain is surprisingly malleable, and point to

26 f a range of spatial visual functions in the amblyopic brain.

27 play also alters temporal processing in the amblyopic brain.

28 ale macaque monkeys (Macaca nemestrina) made amblyopic by artificial strabismus or anisometropia in e

29 Parents pity their amblyopic child when they think that they suffer from oc

30 gratings (0.5-4 cyc/deg) were measured in 24 amblyopic children (<7 years of age) before eye patching

31 Sixty-five amblyopic children (3-7 years; 20/32-125) were randomly

32 ell tolerated and noninferior to patching in amblyopic children 4 to < 9 years of age.

33 Parents of amblyopic children also experience lower quality of life

34 BIN scores of amblyopic children and controls were measured, and 21 ch

35 ch questionnaire domain and compared between amblyopic children and controls.

36 f the degree of optical treatment success in amblyopic children are visual acuity of the amblyopic ey

37 e binocular vision training to anisometropic amblyopic children by complementing the concepts of perc

38 ter outcomes from optical treatment alone in amblyopic children from 3 up to 7 years.

39 Only 3 of the 27 amblyopic children had previous diagnoses or treatments

40 Overall, 81% of amblyopic children had worse dichoptic than monocular AE

41 onal cartoon that explains without words why amblyopic children should wear their eye patch improves

42 ence in repeatability between the normal and amblyopic children tested.

43 Prior to the study, amblyopic children were hypothesized to less frequently

44 Forty amblyopic children who had fixation eye movement recordi

45 Fifty amblyopic children with a mean age of 5.6+/-1.3 years we

46 Amblyopic children with unilateral high myopia tend to h

47 mic changes may be present in the retinas of amblyopic children with unilateral high myopia.

48 levodopa/carbidopa can improve the vision of amblyopic children, but the effect was small (0.17-0.3 l

49 ors influencing optical treatment outcome in amblyopic children, clinicians will be unable to predict

50 um angle of resolution) acuity in normal and amblyopic children, while adequately controlling for opt

51 l learning can improve visual performance in amblyopic children.

52 ar by conventional patching in anisometropic amblyopic children.

53 The amblyopic cohort will receive both treatments in a rando

54 g the eyes dichoptically, we showed that, in amblyopic cortex, the binocular combination of signals i

55 correspondence between the magnitude of the amblyopic deficits and the reduction in retinal image co

56 ptotype acuity and sweep VEP acuity revealed amblyopic deficits in both pseudophakic and aphakic eyes

57 binocular summation of contrast and that the amblyopic deficits of binocularity can be simulated with

58 Amblyopic deficits using the 0.5 degrees radius 8 RF pat

59 ity, assessments of optotype acuity revealed amblyopic deficits; contrast sensitivity was impaired as

60 o evaluate patients diagnosed and treated as amblyopic despite not meeting traditional VA criteria fo

61 opic amblyopes, strabismic amblyopes and non-amblyopic esotropes.

62 thout anomalous BSV, in exotropes and in non-amblyopic esotropes.

63 al visual experience during development, the amblyopic eye (AE) loses visual sensitivity whereas the

64 found that reduced excitatory input from the amblyopic eye (AE) revealed a form of balanced binocular

65 .0001) in the mean visual acuity (VA) of the amblyopic eye (AE) was demonstrated, from 0.51 +/- 0.27

66 Fourteen anisometropic amblyopes (VA amblyopic eye 6/12 or lower; better eye greater than 6/7

67 After patching, amplitudes increased in the amblyopic eye across all spatial frequencies (ANCOVA; P

68 hed a suppressive action of the fovea of the amblyopic eye acting on the companion, non-amblyopic eye

69 The amblyopic eye acuity at the 7- to 12-month visit in the

70 The amblyopic eye acuity on the 3- to 6-month visit in the c

71 Improved function of the amblyopic eye after visual loss in the non-amblyopic eye

72 ncluding loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision.

73 ic visual training, aimed at stimulating the amblyopic eye and eliminating the interocular supression

74 e amblyopic eye acting on the companion, non-amblyopic eye and indicate that correction of ocular mis

75 isk of serious vision loss affecting the non-amblyopic eye and its results are greater than that prev

76 gned to provide different stimulation to the amblyopic eye and the fellow eye.

77 tifying T2 200 ms after T1) seen through the amblyopic eye and this improvement in performance transf

78 Thus, connections serving the amblyopic eye are capable of substantial plasticity beyo

79 course of perceived contrast found increased amblyopic eye attenuation, and reduced contrast normaliz

80 at-home, binocular movie treatment improved amblyopic eye BCVA after 2 weeks (similar to patching),

81 At baseline, the mean (SD) amblyopic eye BCVA was 0.48 (0.14) logMAR (approximately

82 At the 2-week visit, improvement in amblyopic eye BCVA was greater with the binocular game c

83 r children with amblyopia includes measuring amblyopic eye best-corrected visual acuity (AE BCVA) wit

84 Measures: The primary outcome was change in amblyopic eye best-corrected visual acuity (BCVA) at the

85 y impaired after loss of vision in their non-amblyopic eye but had no other disorder affecting their

86 pia), patching improved visual acuity of the amblyopic eye by a mean of less than 1 line on a standar

87 ea and thinner inner and outer macula in the amblyopic eye compared to the normal fellow eye.

88 amblyopic patients had AMD diagnosed on the amblyopic eye compared with the nonamblyopic eye.

89 e amblyopic eye after visual loss in the non-amblyopic eye could be a model for residual neural plast

90 h initial visual acuity >= 0.6 logMAR in the amblyopic eye experienced little trouble with games duri

91 ehavioral performance; neurons driven by the amblyopic eye had even shorter integration times than th

92 in modulation is altered so that the weaker, amblyopic eye has little effect while the stronger fello

93 Mean BCVA in amblyopic eye improved significantly from a logMAR value

94 ren and adults without amblyopia than in the amblyopic eye in children with amblyopia.

95 es were reduced for stimuli presented to the amblyopic eye in higher-order visual areas and in pariet

96 ed an expanded foveal representation for the amblyopic eye in one early-onset strabismic subject with

97 they primarily feature requisite use of the amblyopic eye in the face of fellow-eye masking, integra

98 In anisometropes, the amblyopic eye influenced a relatively small proportion o

99 Indeed, LRx restricted to the amblyopic eye is sufficient to induce robust MMP2/9 acti

100 useful should they lose vision in their non-amblyopic eye later in life.

101 In Group I, amblyopic eye LogMAR VA improved from 0.23 +/- 0.10 to 0

102 Mean visual acuity in the amblyopic eye measured in 147 participants at 15 years o

103 ning with high-attention demand tasks in the amblyopic eye might be an effective way to treat amblyop

104 luation the principal visual deficits in the amblyopic eye of each subject were identified using the

105 A greater decrease in amblyopic eye refractive error was associated with bette

106 Fixation stability was elevated in the amblyopic eye relative to controls across all motion sti

107 petitive practice of a visual task using the amblyopic eye results in improved performance in both ch

108 Before patching, the amblyopic eye showed decreasing amplitude with increasin

109 he pooled responses of neurons driven by the amblyopic eye showed reduced sensitivity to coherent mot

110 mechanism amblyopia, there is a decrease in amblyopic eye spherical equivalent refractive error to l

111 , stereoacuity, treatment compliance and the amblyopic eye spherical-equivalent refractive error.

112 riod, and achieve a level of vision in their amblyopic eye that would be useful should they lose visi

113 ex that enable the weak connections from the amblyopic eye to gain strength, in which case the recove

114 We conclude that a weakened ability of the amblyopic eye to modulate cortical response gain creates

115 rmed to compare the macular thickness of the amblyopic eye to that of the fellow eye.

116 to the relative strength of the input of the amblyopic eye to the cortex only for the more seriously

117 The main outcome measure was change in amblyopic eye VA from baseline to 16 weeks.

118 1 year there was a partial reduction in the amblyopic eye VA gain of 0.085+/-0.1 logMAR compared to

119 Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in

120 At 12 weeks, amblyopic eye VA improved by 1.8 lines (95% confidence i

121 Mean amblyopic eye VA improved from baseline by 3.5 letters (

122 Median amblyopic eye VA improved similarly between the simultan

123 Median amblyopic eye VA improved similarly between the simultan

124 When amblyopic eye VA stops improving with 2 hours of daily p

125 At 12-week post-treatment, improvement in amblyopic eye VA was maintained vs baseline (0.27 +/- 0.

126 enagers aged 13 to <17 years, improvement in amblyopic eye VA with the binocular iPad game used in th

127 uman study on the therapeutic, we found that amblyopic eye vision improved significantly after 12 wee

128 The primary efficacy outcome was change in amblyopic eye visual acuity (VA) from baseline at 12 wee

129 me was the mean improvement from baseline in amblyopic eye visual acuity (VA) to week 16 in both stud

130 e primary outcome was the improvement in the amblyopic eye visual acuity (VA), modeled with a repeate

131 ults in clinically meaningful improvement in amblyopic eye visual acuity for most 3- to <7-year-old c

132 Mean amblyopic eye visual acuity improved 1.8 lines for child

133 Overall, amblyopic eye visual acuity improved a mean of 2.6 lines

134 Average (+/- SD) LogMAR VA in the amblyopic eye was 0.96 +/- 0.31.

135 mpared with one in which the contrast in the amblyopic eye was adjusted (normalized) to equate monocu

136 The projection from the amblyopic eye was found to have a normal cortical magnif

137 ial length and vitreous chamber depth in the amblyopic eye was greater than in the non-amblyopic eyes

138 resolution of cortical neurons driven by the amblyopic eye were substantially and significantly lower

139 not amplified further by attenuation of the amblyopic eye's projections from V1 to V2.

140 ia, binocular vision status, fixation of the amblyopic eye, and the age of the subject at the start o

141 s full recovery of visual acuity (VA) in the amblyopic eye, but there has been no systematic study on

142 represent more parafoveal locations for the amblyopic eye, compared with the fellow eye, in some sub

143 ably, children with low visual acuity in the amblyopic eye, had little difficulty playing games.

144 trast normalization of the fellow eye by the amblyopic eye, in amblyopic participants compared to con

145 esponded preferentially to the fellow versus amblyopic eye, in anisometropic compared with strabismic

146 ed with improvements in visual acuity in the amblyopic eye, inter-ocular visual acuity difference and

147 amblyopic children are visual acuity of the amblyopic eye, interocular visual acuity difference, ste

148 training-related and -unrelated tasks in the amblyopic eye, relative to the fellow eye.

149 ho had newly acquired vision loss in the non-amblyopic eye, resulting in acuity of worse than 6/12 or

150 Using the amblyopic eye, strabismic amblyopes counted inaccurately

151 on to the benefits of improved vision in the amblyopic eye, treatment of amblyopia during childhood i

152 ring binocular viewing, the FI of fellow and amblyopic eye, vergence instability, and inter-ocular FI

153 al and temporal cortex when viewing with the amblyopic eye.

154 -dependent (BOLD) signal was reduced for the amblyopic eye.

155 4 people had improved visual acuity in their amblyopic eye.

156 nt attributable to loss of vision in the non-amblyopic eye.

157 ye but had no other disorder affecting their amblyopic eye.

158 The primary outcome is visual acuity in the amblyopic eye.

159 ine that are aimed at forcing the use of the amblyopic eye.

160 l loss is due to active suppression of their amblyopic eye.

161 However, the pRF sizes are enlarged for the amblyopic eye.

162 al disarray within the representation of the amblyopic eye.

163 nd often only method of treating a 'lazy' or amblyopic eye.

164 the 2 eyes: right eye/left eye for controls, amblyopic eye/fellow eye for amblyopes.

165 tive error from hyperopia to less hyperopia (amblyopic eye: -0.65 diopter, 95% CI -0.85, -0.46; fello

166 70 (Snellen equivalent, 20/29), 0.50 (20/40 [amblyopic eye]), and 1.20 (20/17).

167 Main Outcomes and Measures: Change in amblyopic-eye VA from baseline to 16 weeks.

168 At 16 weeks, mean amblyopic-eye VA improved 1.05 lines (2-sided 95% CI, 0.

169 <7 years) without prior amblyopia treatment, amblyopic-eye VA improved by a mean (SD) of 2.5 (1.5) li

170 At 18 weeks, amblyopic-eye VA improved from randomization by an avera

171 In children aged 5 to younger than 13 years, amblyopic-eye VA improved with binocular game play and w

172 At 4 weeks, mean amblyopic-eye VA letter score improved from baseline by

173 s if needed or demonstrate no improvement in amblyopic-eye visual acuity (VA) for at least 8 weeks pr

174 The 95% LOA of the AR was greatest in the amblyopic eyes (-1.25 diopters [D], 1.62 D) of children

175 ups, with a greater increase observed in the amblyopic eyes (0.36 vs. 0.28 mm) (p < 0.001).

176 p < 0.001) was greater than that observed in amblyopic eyes (21.71+/-0.80 mm to 21.82 +/- 0.86 mm, p

177 amblyopia had significantly larger BCEAs for amblyopic eyes (mean = 0.56 log deg(2)) than fellow eyes

178 steep keratometry increased significantly in amblyopic eyes (p < 0.001), while it was constant in non

179 yes showed greater axial elongation than non-amblyopic eyes (p < 0.001).

180 he amblyopic eye was greater than in the non-amblyopic eyes (p < 0.001).

181 ience in making Vernier judgments with their amblyopic eyes (with the lines at a different orientatio

182 ing BFT highlight its potential use in adult amblyopic eyes after the surgical alignment of the strab

183 Structural retinal changes were observed in amblyopic eyes and in fellow eyes after patching, with n

184 in amblyopic eyes while it decreased in non-amblyopic eyes by 0.13 mm.

185 Fixation was unstable in amblyopic eyes compared to control eyes (p < 0.001).

186 altered microperimetric average threshold in amblyopic eyes compared to fellow eyes (p = 0.024) and c

187 BFT was applied monocularly to four amblyopic eyes either on the spontaneous preferential re

188 Myopic amblyopic eyes had higher inferior peripapillary VD than

189 Hyperopic amblyopic eyes had significantly wider LCAs than fellow

190 0.14 logMAR (approximately 20/25); 59.9% of amblyopic eyes had visual acuity of 20/25 or better and

191 ound between amblyopic and fellow eyes, with amblyopic eyes having greater foveal thickness but reduc

192 th strabismic amblyopia due to esotropia, 12 amblyopic eyes of 12 patients with deprivation amblyopia

193 th hypermetropic anisometropic amblyopia, 15 amblyopic eyes of 15 patients with strabismic amblyopia

194 ith hypermetropic ametropic amblyopia and 21 amblyopic eyes of 21 patients with hypermetropic anisome

195 The AR between the fellow and amblyopic eyes of children with amblyopia and eye 1 and

196 Fixation instability in amblyopic eyes of children with strabismus and/or anisom

197 Amblyopic eyes showed greater axial elongation than non-

198 The 31 treated amblyopic eyes showed: logMAR HOTV = 0.97(logMAR E-ETDRS

199 macular thickness was less in deprivational amblyopic eyes than in age-matched normal eyes, but ther

200 t multiple measures of the AR be obtained in amblyopic eyes to improve the precision of measures.

201 Mean spherical equivalent for the amblyopic eyes was +3.57 diopters, with a mean VA of 20/

202 Mean spherical equivalent in amblyopic eyes was -10.79 +/- 3.40 diopters.

203 Anterior chamber depth was constant in amblyopic eyes while it decreased in non-amblyopic eyes

204 n making psychophysical judgments with their amblyopic eyes, and experienced observers (n = 5), who h

205 esholds were significantly correlated in the amblyopic eyes, as were sVEP and optotype interocular th

206 ared before and after amblyopia treatment in amblyopic eyes, fellow eyes, and the right eyes of healt

207 al thickness decreased significantly only in amblyopic eyes, from 216.20 +/- 19.36 mum to 210.76 +/-

208 ficant improvements in BCVA were observed in amblyopic eyes, improving from 0.21 +/- 0.15 logMAR at b

209 xation accuracy was significantly reduced in amblyopic eyes.

210 ce in repeatability among normal, fellow, or amblyopic eyes.

211 es (p < 0.001), while it was constant in non-amblyopic eyes.

212 ar biometric components in amblyopic and non-amblyopic eyes.

213 uperficial capillary plexus was lower in the amblyopic group than in the control group in both 3 x 3-

214 e mean axial elongation in amblyopic and non-amblyopic groups over three years was 0.37 (95% CI: 0.34

215 those tested second in either the normal or amblyopic groups.

216 Children with non-amblyopic horizontal strabismus were enrolled and comple

217 Overall, non-amblyopic horizontally strabismic children demonstrated

218 Although the vision of amblyopic humans is often described as being noisy by pe

219 nsible for a range of perceptual deficits in amblyopic humans, the neural basis for the elevated perc

220 elated quality of life was mildly reduced in amblyopic individuals compared to non-visually impaired

221 ction in primary visual cortex and V2 of six amblyopic macaque monkeys (Macaca nemestrina) and two vi

222 e properties of visual cortex neurons in six amblyopic macaques; three monkeys were anisometropic, an

223 along the horizontal axis of the ellipse for amblyopic (mean = 3.53 degrees ) than fellow (mean = 1.9

224 Here we show that LRx to adult amblyopic mice induces perisynaptic MMP2/9 activity and

225 pd6 overexpression restores visual acuity in amblyopic mice that underwent early long-term monocular

226 ty in the adult restores binocular vision in amblyopic mice.

227 nteractions in visual cortex of anesthetized amblyopic monkeys (female Macaca nemestrina), using 96-c

228 eurons and the perceptual performance of our amblyopic monkeys.

229 The CV(2) was pronounced in amblyopic neurons for high-contrast stimuli and the m-FF

230 stimuli and the m-FF was abnormally high in amblyopic neurons for low-contrast gratings.

231 In amblyopic neurons, the contrast versus response function

232 f spontaneous activity were also elevated in amblyopic neurons.

233 We found that some amblyopic observers show markedly abnormal templates for

234 Two groups of amblyopic observers were tested: novice observers (n = 6

235 ate with perceptual visibility in normal and amblyopic observers.

236 cal and sVEP vernier acuity were measured in amblyopic observers.

237 ater AL growth in the fellow eye compared to amblyopic or normal eyes.

238 not the fast speed stimuli, using either the amblyopic or the fellow eye.

239 Sixteen amblyopic participants (eight females) plus eight indivi

240 n of the fellow eye by the amblyopic eye, in amblyopic participants compared to controls.

241 Compared to controls, the OD response in amblyopic participants formed larger fused patches that

242 The difference between foveal structure in amblyopic participants relative to structure in subjects

243 stical analysis of the visually impaired and amblyopic participants was performed, and associations w

244 hreshold by DE enables visual input from the amblyopic pathway to trigger robust perisynaptic proteol

245 ffects of BFT on fixation stability in adult amblyopic patients after surgical intervention to treat

246 se tools reliably detected acuity in treated amblyopic patients and Bangerter blurred normal subjects

247 netoencephalography (MEG) from anisometropic amblyopic patients and control participants during two v

248 ately reproduce self-reported perceptions of amblyopic patients and decrease drawing-percept differen

249 Visual fixation may be affected in amblyopic patients and, moreover, its stability may be a

250 Less amblyopic patients had AMD diagnosed on the amblyopic ey

251 Amblyopic patients performed critical line, then thresho

252 ed evidence of generalized learning, several amblyopic patients showed evidence for improvement that

253 Residual amblyopia is seen in 40% of amblyopic patients treated with part-time patching.

254 Amblyopic patients with infantile onset strabismus or an

255 sful treatment restored normal BIN scores in amblyopic patients without strabismus.

256 ts consisted of eight normal adults and five amblyopic patients, with the amblyopic subjects added to

257 ith standard treatments to improve vision in amblyopic patients.

258 or the first time, a dynamic retuning of the amblyopic perceptual decision template and a substantial

259 Amblyopic performance could be simulated in normal obser

260 l basis for the elevated perceptual noise in amblyopic primates is not known.

261 rea V2 could limit the visual performance of amblyopic primates.

262 The mean CISS score of 31.6 +/- 9.0 for non-amblyopic/strabismic students having near vision poorer

263 ary students (9935 eyes), including 4931 non-amblyopic students (9893 eyes) and 37 students with ambl

264 ontrols (15.3 +/- 12.2 years of age) and 104 amblyopic subjects (13.3 +/- 11.2 years of age) during b

265 Twenty-six amblyopic subjects (mean age, 39 +/-12 years) were train

266 adults and five amblyopic patients, with the amblyopic subjects added to gauge whether the outcome wa

267 All amblyopic subjects demonstrated a functional loss in eac

268 We classified amblyopic subjects per the fixational eye movements char

269 n, against which the learned improvements in amblyopic subjects was compared.

270 primary deficit in visual function, and when amblyopic subjects were divided according to their prima

271 as held constant and when data from the five amblyopic subjects were included to expand the range of

272 t for improving the restoration of vision in amblyopic subjects whose occlusion is removed in adultho

273 Of the amblyopic subjects, 77% were unilateral.

274 Here we compare FI between normal and amblyopic subjects, and evaluate the relationship betwee

275 tern of learned visual improvements in adult amblyopic subjects.

276 n plasticity after action video game play by amblyopic subjects.

277 nship between selective visual attention and amblyopic suppression and its role in the success of amb

278 is significant transfer of learning from the amblyopic to the dominant eye, suggesting that the learn

279 c suppression and its role in the success of amblyopic training, we used EEG source-imaging to show t

280 ted from two studies with similar protocols, Amblyopic Treatment Studies 5 (n = 152) and 13 (n = 128)

281 bility may be associated with the effects of amblyopic treatments on visual performance in patients w

282 ective visual attention bias between eyes in amblyopic vision, and that dichoptic training with high-

283 cortical hierarchy of humans with normal and amblyopic vision, using source-imaged SSVEP and frequenc

284 of binocular interactions between normal and amblyopic vision.

285 sults suggest that neural connections in the amblyopic visual cortex, at least in V1, may have profou

286 anced experience-dependent plasticity in the amblyopic visual cortex, by promoting response potentiat

287 Excitatory drive from the FE dominated amblyopic visual cortex, especially in more severe ambly

288 Using the amblyopic visual system as a model, we discuss genetic,

289 vel limitation in the number of features the amblyopic visual system can individuate.

290 Reduced efficiency in the amblyopic visual system may reflect a poorly matched tem

291 that blur is veridically represented in the amblyopic visual system.

292 ost of the variability in performance of the amblyopic visual system.

293 al frequency information is available to the amblyopic visual system?