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1 integration of next generation data fails to ameliorate.
2 ed areas once harsh environmental conditions ameliorated.
6 highly potent, selective inhibitor, GNF362, ameliorated acute GVHD without impairing GVL against 2 a
7 using genetic and pharmacological approaches ameliorates acute and chronic forms of neurotoxicity.
10 esent an additional therapeutic strategy for ameliorating adverse cardiovascular and CNS outcomes.
11 dence shows that transient reprogramming can ameliorate age-associated hallmarks and extend lifespan
12 the role of alphaKG in rejuvenating MSCs and ameliorating age-related osteoporosis, with a promising
13 erged as a potential therapeutic approach to ameliorate ageing-related disease, and extend the human
15 op a human PD-1 agonist and show that it can ameliorate AHR and suppresses lung inflammation in a hum
23 d and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis.
24 ement (NREM) slow-wave oscillations offer an ameliorating, anxiolytic benefit on these brain networks
26 au-P301L), the hTau S199 phosphorylation was ameliorated as GSK3beta phosphorylation was regained.
28 l insufflation delivery of CDPL-GW nanoprobe ameliorated asthma pathologies including allergen-specif
30 se and complex sphingolipid accumulation and ameliorated autophagic defects in both NPC1 mutant and N
32 use models, and in vivo silencing of miR-210 ameliorated BA-induced liver pathology and decreased hyd
33 supporting three assertions underpinning the ameliorating benefits of Se: (1) dietary Se reduces MeHg
35 ral transduction with wild-type NDUFAF8-cDNA ameliorated both the assembly defect and the biochemical
36 pothesis that pharmacologic IL-13 inhibition ameliorates both inflammatory and remodeling pathways an
37 by KU55933 in cisplatin-treated mice did not ameliorate, but instead exacerbated cisplatin-induced DN
38 inal manifestation - prominent tics - may be ameliorated by a peripheral, sensory intervention compel
39 ion of midbrain dopamine neurons, and can be ameliorated by activating PV interneurons and by a TAAR1
46 ic suppression of PV GPe neuron activity was ameliorated by optogenetic inhibition of coincident D2-S
48 d via UUO or ischemia/reperfusion injury was ameliorated by systemic genetic knockout of OASIS, accom
52 of erythroid progenitor populations, defects ameliorated by TGFbeta-receptor and IL-6 inhibition, res
53 scriptome-wide RNA off-target editing can be ameliorated by the introduction of an additional mutatio
56 he FDA-approved kinase inhibitor, nilotinib, ameliorates cancer cachexia, representing a potential th
60 , pharmacological (JZL184) inhibition of MGL ameliorated cholestatic injury in DDC-fed WT mice and pr
61 liver and involved in cholesterol transport, ameliorated cholesterol accumulation in Npc1 mutant cell
62 ne effectiveness of inhibiting IL-6/IL-6R to ameliorate chronic allograft rejection and coronary allo
67 tion or via intracranial transplantation can ameliorate cognitive deficits following 9 Gy head-only i
69 ed intestine, monocyte ablation was shown to ameliorate colitis scores in preclinical animal models.
70 how that although the TLR2 peptide treatment ameliorated colitis, it allowed recruited monocytes to g
72 gous regulatory B cells (B(regs)) is able to ameliorate, cure, and sustain the durable remission of t
73 ry requires multipronged strategies aimed at ameliorating current and fire-induced threats, including
74 n (IL)-22, a cytokine with multiple targets, ameliorated CXCL1/HFD-induced NASH or methionine-choline
75 riginally developed for cancer have shown to ameliorate cyst formation and disease progression in ani
76 ion, and intervention with ART did not fully ameliorate damage to the DRG, specifically to peptidergi
77 upporting neuroprotective therapies aimed at ameliorating defects in antioxidant response pathways in
78 second (pps) reduced pathologic circling and ameliorated deficits in forelimb stepping similarly to e
79 tific commentary refers to 'Gene replacement ameliorates deficits in mouse and human models of cyclin
80 ualized therapeutic strategies to prevent or ameliorate depression and other psychiatric disorders in
82 duced TRPV1 interaction at the TRPV1 TRP box ameliorated diabetes-induced endothelial dysfunction and
87 to CDAs, with reduced time to diagnosis, and ameliorated differential diagnosis in terms of identific
88 3 channel blocker or a glutaminase inhibitor ameliorated disability in experimental neuroinflammation
89 vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small anim
90 y, but neither approach alone can completely ameliorate disease phenotype in high-fat diet-fed mice.
92 lycoprotein peptide (MOG(35-55)) revealed an ameliorated disease course in cortactin gene-deficient f
93 NAD(+) repletion via nicotinamide riboside ameliorated disease phenotypes in SCA7 mice and patient
96 that therapeutic administration of activin-A ameliorates disease severity and alleviates CNS immunopa
97 igates mHTT accumulation and neuronal death, ameliorating disease-associated phenotypes and lifespan.
99 immune responses, and may hold potential for ameliorating diseases mediated by pathogenic T cells.
102 drocytes attenuated EAE disease severity and ameliorated EAE-induced oligodendrocyte loss, demyelinat
103 we tested if blocking CRHR1 in young adults ameliorates early-life adversity-provoked memory deficit
105 ing plasma kallikrein activity might have an ameliorating effect on early disease caused by COVID-19
106 estyle and diet, e.g. fruit-vegetable intake ameliorating effects of alcohol-smoking-fatty food.
107 evolve, we grew populations of microalgae in ameliorated environments for several hundred generations
108 R stress inhibitor tauroursodeoxycholic acid ameliorates ER stress and fibrosis in Grp78 KO mouse and
110 ules involved in adipose tissue browning and ameliorated expression of thermogenic genes in adipose t
111 wed a healthier metabolic profile, including ameliorated fibrosis and inflammation, as well as improv
112 ablation of Myc in tubular epithelial cells ameliorated fibrosis and restored renal parenchymal func
113 sis for the development of DBS strategies to ameliorate gait impairments.SIGNIFICANCE STATEMENT We te
114 f the BCL11A enhancer prevented sickling and ameliorated globin chain imbalance in erythroid progeny
116 antly, DR3 engagement on ILC2s significantly ameliorates glucose tolerance, protects against insulin-
118 70) studies indicate that biotic factors can ameliorate harsh climatic conditions along high-latitude
121 l segregation, we can develop strategies for ameliorating hearing loss and improving speech recogniti
122 m handling while CM-specific deletion of D1R ameliorates heart failure-associated ventricular arrhyth
123 itor reduced active MMP-9 expression by 97%, ameliorated histologic evidence of injury, and reduced A
124 s colonic RORgamma(+ )T(reg) cell counts and ameliorates host susceptibility to inflammatory colitis
127 troller can adapt and control ventilation to ameliorate hypoventilation and restore normocapnia regar
129 roaches are superior to single treatments in ameliorating IE and anemia in beta-thalassemia and could
130 hat thermal adaptation may therefore have an ameliorating impact on the efficiency of phytoplankton a
135 pathic pulmonary fibrosis, has been shown to ameliorate inflammation in several animal models includi
137 Ralpha with genetic or pharmacological tools ameliorates inflammation, vascular leakage, neurodegener
138 hibition of this protein/protein interaction ameliorated inflammatory symptoms in mouse models of mul
140 eight gain, increased energy expenditure and ameliorated insulin resistance, associated with a smalle
144 results showed that BPF99 resolves NASH and ameliorates key histological and pathophysiological feat
145 xidant-activating sulforaphane significantly ameliorated kidney injury in Gstm1 knockout, but not wil
150 l approach that could be used to effectively ameliorate LID and improve the quality of life for PD pa
151 n promoting reduced chromatin accessibility, ameliorated light damage in our mouse model, supporting
152 tivation rescued FXR signaling and partially ameliorated liver injury and sinusoidal ischemia in SCD
153 f liver macrophage VDRs by vitamin D ligands ameliorates liver inflammation, steatosis and insulin re
154 lentiviral delivery of Wnt6 to the amygdala ameliorates locomotor impairment and social behavioral d
156 or cytokine-signaling pathways to reduce or ameliorate lung inflammation during respiratory viral in
157 eatment with Lip-1 inhibited ferroptosis and ameliorated lung IR-induced injury in animal and cell mo
159 which dietary approaches are already used to ameliorate metabolic and nutritional complications.
160 tion of Na/Ca(mito) may be a new approach to ameliorate metabolic dysregulation in heart failure.
164 ty of a specific cortico-striatal circuit to ameliorate motor symptoms and recover synaptic plasticit
169 ell-specific Tlr9 overexpression resulted in ameliorated nephritis, opposite of the effect of deletin
170 s and microglia to neurotoxic phenotypes and ameliorated neuropathology in an animal model of MS.
171 d for human use limited ZIKV replication and ameliorated newborn microcephaly in a murine model.
173 observed with brain-penetrant CB1R blockers, ameliorate obesity and its multiple metabolic complicati
176 ncept for therapeutic interventions aimed at ameliorating OMCDi dysfunction and pyelonephritis-induce
178 to genistein, which we previously showed to ameliorate other lysosomal abnormalities of cystinotic c
180 ence, targeting signaling lipid pathways may ameliorate oxaliplatin-induced acute peripheral pain and
182 nd 50% of PKC level in the heart, as well as ameliorating oxidative stress and cell apoptosis activit
183 High-rate optogenetic STN DBS can indeed ameliorate parkinsonian motor symptoms through reduction
184 dulate IRE1, ATF6, or PERK signaling to both ameliorate pathologic imbalances in UPR signaling implic
186 pigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse model of periodontitis.
187 health agencies; defining health policies to ameliorate patients' access to appropriate therapy and t
188 , an orally available SCD inhibitor potently ameliorates PD phenotypes, positioning this approach to
189 rexpression of Yap in Llgl1-depleted embryos ameliorated pericardial effusion and restored blood flow
191 nosensitive ion channel PIEZO1 were shown to ameliorate Plasmodium parasite growth, blood-brain barri
192 nse (SVR) to interferon (IFN)-free therapies ameliorates portal hypertension (PH); however, it remain
196 Of note, currently used antipsychotic drugs ameliorate psychosis, but they are not very effective in
197 sitol 1,4,5-trisphosphate (IP(3)) levels and ameliorates Purkinje cell degeneration in SCA17 knock-in
198 ctive genetic deletion of CNS complement C1q ameliorates radiation-induced cognitive impairments, syn
199 ived MSC therapy delivered at 3 h or 30 h in ameliorating radiation-induced hematopoietic syndrome an
200 wever, PERK ablation in S63del Schwann cells ameliorated, rather than worsened, S63del neuropathy des
201 arch could identify strategies to prevent or ameliorate residual DSPN after initiating cART in RLSs.
202 revented Mfn2 and Mlh1 hypermethylation, and ameliorated retinal dysfunction and diabetic retinopathy
203 xpression of miR-124 in the irradiated brain ameliorated RICD and reduced microglial activation.
204 ibiting UA and IL-1beta during RSV infection ameliorates RSV immunopathology, reduces the consequence
207 Because current treatments for TBI merely ameliorate secondary effects of the initial injury like
208 able to reduce the levels of toxic proteins, ameliorate signs of disease, and delay disease progressi
210 t frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous
211 the proteomic profile of circulating HDL and ameliorated some of the potentially harmful changes to t
212 orting postpartum women living in low SES by ameliorating some of the early maternal burdens associat
214 lished the increase in DRv TPH2+ neurons and ameliorated stress-induced anhedonia in susceptible rats
216 ion process, and, conversely, social support ameliorates stress responses, a phenomenon referred to a
217 ic and liver-directed locoregional therapies ameliorated survival, highlighting the potential for imp
220 letion impairs Th17 cell differentiation and ameliorates symptoms of EAE by decreasing Th17 cell-medi
221 lation enzymes to adjust gene expression and ameliorate synaptic defects could be a potential therape
222 atergic transmission, together with BIN1, to ameliorate synaptic dysfunction and disease progression.
225 ng convenient browser-based selection tools, ameliorating tedious steps involved in defining ranges t
228 nd tools like the Aristotle Classifier could ameliorate the ambiguities associated with challenging b
229 e PEG prophylaxis as a potential strategy to ameliorate the APA response to sensitizing PEGylated the
231 of different proton dose rates and drugs to ameliorate the cognitive sequelae of proton radiotherapy
233 temic lifespan-extending interventions could ameliorate the declining performance of the ejaculate as
237 hamphetamine, suggesting a novel approach to ameliorate the effects of HIV- and methamphetamine-assoc
241 production of IL-17a during inflammation can ameliorate the expression of social behaviour deficits b
245 e 3 years, possibly providing new avenues to ameliorate the long-term respiratory outcomes of infants
246 ts and that activation of these pathways can ameliorate the metabolic deficit in these cells and cons
247 ensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TR
248 s and cartilage structural parameters, which ameliorate the musculoskeletal phenotype of the disease.
251 se evoked by whisker stimulation but did not ameliorate the response to the endothelium-dependent vas
253 density of synaptic puncta, while isoform 2 ameliorated the calcium signalling defect compared to gr
258 ike endoplasmic reticulum kinase (PERK) also ameliorated the S63del neuropathy, despite reduced level
259 Inhibition of CYP1A1 enzymatic activity ameliorated the skin immunopathology by restoring benefi
261 argeting STAT3-mediated astrocyte reactivity ameliorates the cerebrovascular dysfunction associated w
262 vating therapeutic approach that effectively ameliorates the consequences of IRI in solid organ trans
263 deletion in a Gas1 null background partially ameliorates the craniofacial defects observed in Gas1 si
264 eta inhibition in corticolimbic interneurons ameliorates the deficits in spatial working memory and P
265 eduction or ablation of calpain-1 expression ameliorates the disease-associated phenotype in MJD cell
266 PTPRJ deletion in addition to Chk and Csk ameliorates the extent of thrombocytopenia, suggesting t
267 nted LAP receptor, heat shock protein 60 and ameliorates the Lm-induced intestinal barrier dysfunctio
268 ver, environmental enrichment (EE) similarly ameliorates the locomotor and social behavioral deficits
270 show that the absence of hematopoietic CXCL4 ameliorates the MPN phenotype, reduces stromal cell acti
272 senescent cells from damaged tissues in mice ameliorates the symptoms of these pathologies and even p
273 Treatment with recombinant acid ceramidase ameliorates the two pivotal features of cystic fibrosis
276 e from premature mortality and significantly ameliorates their underlying systemic inflammation and a
277 discovery because stereoselective drugs can ameliorate therapeutic difficulties including adverse to
279 HbF) comprising alpha- and gamma-globins may ameliorate these manifestations by mitigating sickle hem
281 By restoring ROS metabolism, BET inhibition ameliorates these hallmarks of the dystrophic muscle, tr
291 avenous IgG (IVIg) therapy, as being able to ameliorate various autoimmune diseases, researchers have
295 ut infection prevalence is smallest, and are ameliorated when coverage of the intervention is poor.
297 and haemolysis of the progenitor peptide is ameliorated with AA139, and the 'no observable adverse e