ライフサイエンスコーパス: amelioration

1 feron-gamma and TNF, which lagged behind the amelioration.

2 n of either IL-17A or IL-22 leads to disease amelioration.

3 ness of RYGB for weight loss and comorbidity amelioration.

4 r oceanic reorganization with global climate amelioration.

5 ifepristone prevented stress-induced disease amelioration.

6 nd suggest non-pharmacological means for its amelioration.

7 se and propose potential solutions for their amelioration.

8 of mitochondria in energy supply and stress amelioration.

9 nostic and therapeutic strategies in disease amelioration.

10 n impacts both cell types leading to disease amelioration.

11 icroglial cells, and cholinergic dysfunction amelioration after controlled donepezil release.

12 before dysfunction occurs and to monitor its amelioration after diagnosis and treatment.

13 B allows to obtain an effective GERD symptom amelioration and a reduction in acid exposure.

14 h precipitation are synonymous with climatic amelioration and cold and wet conditions are combined in

15 gnificant biochemical impact with phenotypic amelioration and extension in lifespan.

16 merges has far-reaching implications for the amelioration and/or prevention of developmental language

17 umatic brain injury (TBI) is the prevention, amelioration, and treatment of secondary neuronal dysfun

18 Multiple transcripts associated with stress amelioration are preferentially translated through uORF-

19 Temporary environmental amelioration arising from such fluctuations could either

20 T cells was necessary for DHEA-mediated EAE amelioration, as well as for direct downregulation of Th

21 The clinical response was correlated with amelioration biologic markers such as cytokine productio

22 emia-reperfusion and the impact of ER stress amelioration by a small molecule chaperon 4-phenylbutyri

23 nduction of depressive-like behavior and its amelioration by environmental enrichment in mice.

24 in development may also allow for subsequent amelioration by positive experiences.

25 The extent of neglect amelioration correlated with activation gain in the righ

26 The paquinimod-induced amelioration correlated with reduced priming of antigen-

27 nities in Antarctica will respond to climate amelioration directly and indirectly through changes in

28 months (P < 0.001); 36 months (P < 0.001)], amelioration for life quality [QoL scores improvement (P

29 m of garden bird food, coupled with climatic amelioration, has enabled a successful new wintering pop

30 PG-CAT treated mice showed amelioration in airway obstruction, reduction in neutrop

31 sothelial to fibroblastic transition and its amelioration in caspase-1 knockout mice.

32 These changes facilitate amelioration in cognitive function.

33 ore represent a promising avenue for disease amelioration in HD.

34 The polyphenolic reduction and clarity amelioration in mixed juice of berry and pomegranate was

35 This finding helps understand better the amelioration in selectivity that temperature modulation

36 No significant amelioration in symptoms was observed after sham stimula

37 n the upper limbs and trunk with more-modest amelioration in the lower limbs was observed in all pati

38 Dramatic and significant neurological amelioration in the upper limbs and trunk with more-mode

39 er suggest a cell-based strategy for disease amelioration in this disorder.

40 utoimmune regulator, displayed a significant amelioration in thymic epithelial compartment and an imp

41 onstitute an effective stimulus to induce an amelioration in vascular function, arterial stiffness an

42 on of Arntl partially reversed the steatosis amelioration induced by FLRL2 overexpression.

43 However, whether disease amelioration is due to nonspecific immunomodulation or m

44 Climate amelioration is likely to allow a greater influx of non-

45 CX3CL1 in regulating the microglia-mediated amelioration of Abeta pathology, as well as provide insi

46 This amelioration of Abeta toxicity is associated with a redu

47 te the M2 macrophage phenotype, resulting in amelioration of acid-induced lung injury.

48 novel techniques that promote the concurrent amelioration of acidic waste waters and selective recove

49 ing to cognitive enhancement and possibly to amelioration of AD pathologic findings.

50 both groups, the empagliflozin group showed amelioration of adverse remodeling at 2 months (lower le

51 its target gene expression, concurrent with amelioration of age-associated metabolic dysfunction at

52 The amelioration of age-associated phenotypes by epigenetic

53 The longevity phenotype is associated with amelioration of age-related gut pathology and functional

54 This included significant amelioration of all the ingenuity pathway analysis noted

55 ion by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic ins

56 ies TRPA1 as a bona fide drug target for the amelioration of alpha-DC stress, which represents a viab

57 ted to explore if BPOZ-2 participates in the amelioration of alpha-syn in vivo in basal ganglia.

58 z-2 gene delivery could have prospect in the amelioration of alpha-synucleinopathy in PD and other Le

59 e models via potentiation of BDNF levels and amelioration of alterations in neurotrophin signaling pa

60 EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).

61 h the substitutions evolved was explained by amelioration of antagonistic pleiotropy through epistasi

62 nophils, normalization of liver enzymes, and amelioration of any clinical symptoms.

63 t ventricular function, vascularization, and amelioration of apoptosis and hypertrophy.

64 ncluding reduced plasma triglyceride levels, amelioration of atherosclerosis and increased insulin se

65 lood glucose levels that correlated with the amelioration of atherosclerosis.

66 ce overexpressing VSMC-specific Aadac showed amelioration of atherosclerotic lesions.

67 died in the context of induced tolerance and amelioration of atherosclerotic symptoms.

68 gamma and its transactivator Tbx21/Tbet, and amelioration of autoimmune diabetes.

69 These data indicate that HSCT-mediated amelioration of autoimmune disease involves renewal of t

70 fficking poses an attractive opportunity for amelioration of autoimmune diseases such as multiple scl

71 atty acids candidates for the prevention and amelioration of autoimmune diseases.

72 xp3+ Treg-mediated suppression that leads to amelioration of autoimmune responses.

73 in an MCP-1-dependent manner and subsequent amelioration of autoimmunity.

74 orny bamboo is a successful practice for the amelioration of badland soils.

75 ase K-resistant fraction of alpha-synuclein, amelioration of behavioral aberrations and protection fr

76 tantly with a reduction in lesion volume and amelioration of behavioral deficits in aged transgenic m

77 These improvements did not correlate with amelioration of beta amyloid load or hippocampal adult n

78 s after a 7-d VLCD, was primarily due to the amelioration of beta cell function, whereas no contribut

79 l of Alzheimer's disease (AD) resulted in an amelioration of beta-amyloid (Abeta)-induced synaptic de

80 ); Cpeb1(-/-) double-knockout mice displayed amelioration of biochemical, morphological, electrophysi

81 sult in the development of approaches to the amelioration of blinding eye diseases associated with vi

82 rsodeoxycholic acid (TUDCA) causes long-term amelioration of body weight, food intake, glucose homeos

83 aculate performance, indicating simultaneous amelioration of both somatic and reproductive aging.

84 In conclusion, the amelioration of bradykinesia by dopaminergic medication

85 s a potential new therapy for prevention and amelioration of C. difficile disease.

86 also replenished the mucus layer, leading to amelioration of C. rodentium- and DBZ-induced colitis in

87 wild-type mice (p < 0.0001), and significant amelioration of cell loss by BDNF (p < 0.001).

88 ression of mRNAs, promotes a rapid and broad amelioration of cellular aging, including resetting of e

89 Amelioration of cerebrovascular reactivity or white matt

90 UDCA modulates ADAM17 activity, resulting in amelioration of cholestasis in a murine model of bile du

91 ensed disease-modifying treatment focuses on amelioration of cholestasis, with weight-dosed oral urso

92 2 in IL-10(-/-) mice resulted in significant amelioration of chronic colitis, indicating that NOD2 si

93 Sex-specific amelioration of chronic neuroinflammation rescues the br

94 reduction of the insulin pathway also led to amelioration of circadian and memory defects.

95 We show that reduction of FLAP leads to amelioration of cognition and memory along with the resc

96 induction of autophagy, was associated with amelioration of cognitive and motor deficits as well as

97 with significant amyloid pathology, a rapid amelioration of cognitive deficits was observed despite

98 tes reductions in AD pathology and resultant amelioration of cognitive deficits.

99 on of splenic and colonic GMPs, resulting in amelioration of colitis.

100 roach for long-term treatment of obesity and amelioration of comorbidities.

101 mance may lead to earlier identification and amelioration of complications and improve patient outcom

102 pollen SIT does not correlate well with the amelioration of concomitant food allergies.

103 A progressive amelioration of corneal sensitivity (baseline, 28 +/- 18

104 ecific to this site could provide short-term amelioration of corrosive conditions at certain times of

105 Amelioration of CRF with the three rhubarb extracts was

106 Administration of Val might lead to amelioration of CsA nephrotoxicity by probably diminishi

107 ed in CXCL10-deficient mice, resulting in an amelioration of cuprizone toxicity at later time points.

108 bitor, captopril, to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhib

109 dence that IL-3 has therapeutic potential in amelioration of degeneration of articular cartilage and

110 ng results in CD39 upregulation in vitro and amelioration of disease activity in a trinitro-benzene-s

111 utrophin, restoration of laminin binding and amelioration of disease in the mdx mouse model of DMD.

112 vation that knockout mice showed significant amelioration of disease indicates that AREG is pathogeni

113 Moreover, amelioration of disease manifestations was related to an

114 ion or treatment of osteomyelitis as well as amelioration of disease morbidity.

115 However, amelioration of disease severity has been shown to resul

116 ile current therapies for PAH do provide for amelioration of disease symptoms and acute survival bene

117 n vivo, leading to measurable phenotypes and amelioration of disease symptoms.

118 of ITF2357-treated animals, resulting in the amelioration of disease.

119 The striking amelioration of diverse deficits in animal AD models by

120 ate as a potential therapeutic agent for the amelioration of DKD.

121 latform for testing different strategies for amelioration of DMD pathogenesis.

122 ther DGKalpha is involved in the VtE-induced amelioration of DN in vivo remains unknown.

123 that DGKalpha is involved in the VtE-induced amelioration of DN in vivo, suggesting that DGKalpha is

124 Therefore, we investigated the VtE-induced amelioration of DN in wild-type (DGKalpha(+/+)) and DGKa

125 e mediated Nlrp3 inflammasome inhibition and amelioration of dNP are abolished in diabetic Nrf2(-/-)

126 with both therapies also yielded impressive amelioration of dystrophic pathology.

127 Amelioration of EAE via GlcNAc treatment suggests a nove

128 activity, and in turn, leading to the rapid amelioration of EAE.

129 In support of this view, amelioration of either OBSB or OBSD locks the system in

130 y GSK-3beta as a newly identified target for amelioration of empyema-related pleural fibrosis and pro

131 fects of MAPK inhibitors and agonists in the amelioration of endothelial function.

132 Prednisolone may lead to a prompt amelioration of eosinophilia and associated symptoms.

133 Br2 expression via the ER stress pathway and amelioration of ER stress in mice completely abolishes h

134 chemical chaperone PBA to ob/ob mice led to amelioration of ER stress, increased sortilin-1 expressi

135 tection against insulin resistance onset and amelioration of established insulin- resistance.

136 paBp65 activation, ultimately culminating in amelioration of excess collagen synthesis in cardiac hyp

137 g normalization of fasting hyperglycemia and amelioration of excessive postprandial glucose excursion

138 blood flow were associated with more robust amelioration of excited factor symptoms during active me

139 n of signaling through MyD88, and subsequent amelioration of experimental autoimmune arthritis was ob

140 yelin-specific Foxp3(+) Tregs in WT mice and amelioration of experimental autoimmune encephalomyeliti

141 uring myelin antigenic challenge resulted in amelioration of experimental autoimmune encephalomyeliti

142 suppression of autoantibody production, and amelioration of experimental autoimmune thyroiditis.

143 Moreover, the amelioration of experimental autoimmune uveitis in Il1r-

144 e, without prevention of seizure activity or amelioration of failure to thrive.

145 eight recovery associated with a significant amelioration of ferritin, fibrinogen, and alanine aminot

146 nsion, demonstrated clinical improvement and amelioration of fibrosis in the dy(2J) /dy(2J) mouse mod

147 mpressive improvement in muscle strength and amelioration of fibrosis.

148 wed significant increases in muscle mass and amelioration of fibrotic changes normally seen in 8-mont

149 ignificantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation.

150 Hence, the amelioration of HD and other neurodegenerative diseases

151 ted mitral regurgitation, thereby leading to amelioration of heart failure symptoms.

152 led to an increase in lipolysis and specific amelioration of hepatic insulin resistance.

153 c phenotype of DIO mice, which was linked to amelioration of hepatic steatosis and reduced inflammati

154 NAC administration resulted in amelioration of HFD-induced decidual vasculopathy indepe

155 We conclude that tadalafil amelioration of high glucose stimulation of synthesis of

156 s result in increased energy expenditure and amelioration of high-fat-diet-induced obesity and marked

157 K1 as a potential therapeutic target for the amelioration of hippocampal injury and cognitive deficit

158 01 prolongs survival after Tx, paralleled by amelioration of histologic signs of acute rejection.

159 pression in limb musculature and significant amelioration of histological and functional parameters.

160 replacement therapy (ERT) provides long-term amelioration of homocystinuria-associated phenotypes in

161 ul deployment of both MSCs and MAPCs for the amelioration of human autoimmunity and allograft rejecti

162 hway (that is, kynurenine pathway), leads to amelioration of Huntington's-disease-relevant phenotypes

163 We found that amelioration of hyperglycemia by different hypoglycemic

164 osclerotic vascular diseases, presumably via amelioration of hyperlipidemia-induced monocytosis, and

165 ed with restoration of renal vasculature and amelioration of hypoxia through increased renal tubular

166 According to this scenario, amelioration of immune-mediated chronic liver injury may

167 d lower erythropoietin levels, a significant amelioration of ineffective erythropoiesis (IE) and sple

168 icantly increased proliferation coupled with amelioration of infarction injury and increased hemodyna

169 Spontaneous amelioration of inflammation (often accompanied by fibro

170 e deficient for c-Jun in macrophages show an amelioration of inflammation and bone destruction in the

171 fer a wide array of host benefits, including amelioration of inflammation in IBDs.

172 Effect of AMH on mortality may be through amelioration of inflammation.

173 superior to lifestyle modification alone in amelioration of inflammation.

174 iarrhythmic therapies have limited efficacy, amelioration of inflow cannula contact with the endocard

175 d enhancement of recovery is associated with amelioration of injury-related hyperexcitability and res

176 ve stress and related protein modifications, amelioration of insulin resistance, and increased plasma

177 e model of colitis and enhanced LGG-mediated amelioration of intestinal inflammation in this model.

178 nodes which was accompanied with a distinct amelioration of intestinal inflammation.

179 ight the potential role of dietary fibers in amelioration of intestinal inflammation.

180 mmune-associated effects were accompanied by amelioration of IR and improved insulin signaling in liv

181 ing anemia is not a sufficient condition for amelioration of ITP but that the antibody's ability to p

182 g 2.5 g/kg IVIG in FcgammaRIIB(-/-) B6 mice, amelioration of ITP was as in wild-type in all animals.

183 senescence in synovial fibroblasts, enabling amelioration of joint inflammation.

184 e function compared with Prph2K/+ as well as amelioration of K153Del-associated defects in PRPH2/ROM1

185 ted in inhibition of cell-cycle progression, amelioration of kidney injury, and improved overall surv

186 The amelioration of lipid accumulation in TgCRND8 by removin

187 Inhibitor-treated mice show amelioration of lung function, decreased alveolar epithe

188 r 12 weeks of treatment, all patients showed amelioration of lymphoproliferation with lymph node size

189 jor actions of CYCLO on autophagy underlying amelioration of lysosomal pathology.

190 are obtained, highlighting the fact that the amelioration of metabolic function observed upon Policap

191 More importantly, the amelioration of mitochondrial dynamic deficits by mdivi-

192 nsumption Overall, the results indicate that amelioration of mitochondrial oxidative stress and infla

193 Significant amelioration of motor and cognitive functions was reveal

194 have reported promising findings in terms of amelioration of motor asymmetry in adult, 6-hydroxydopam

195 The reason for this sudden amelioration of motor control in REM sleep is unknown, h

196 lpha-synuclein, protection of SN neurons and amelioration of motor performance.

197 om wild-type littermates and demonstrated an amelioration of muscle disease as evidenced by an absenc

198 myotonia and potentially contributes to the amelioration of muscle paralysis.

199 We show that sarcospan-mediated amelioration of muscular dystrophy in DMD mice is depend

200 xic RNA, reversal of splicing biomarkers and amelioration of myotonia.

201 Mutants also hyperaccumulated TAG after the amelioration of N limitation.

202 highlight a pharmacogenetic approach for the amelioration of narcolepsy.

203 rable side effects, and provide only partial amelioration of negative and cognitive symptoms.

204 etwork connectivity with TMS corresponded to amelioration of negative symptoms, showing a statistical

205 Although HSF1 activation has been linked to amelioration of neurodegenerative disease, cancer cells

206 tiation, stress responses, and, potentially, amelioration of neurodegenerative diseases and aging.

207 resent a dietary route to the retardation or amelioration of neurodegenerative-related dysfunctions.

208 roved body weight gain and survival with the amelioration of neuronal histopathology in motor units s

209 Nf1(fl/fl);Mekk2(-/-);Dmp1-Cre mice show an amelioration of NF1-associated phenotypes.

210 ral, but not dorsal, hippocampus resulted in amelioration of nicotine withdrawal-induced anxiety-like

211 ith cirrhosis; in malnourished patients, the amelioration of nutritional status may be a goal to decr

212 Amelioration of ophthalmologic education in diabetic pro

213 rated by reduced autoantibody production and amelioration of organ pathologies.

214 t they may function in turgor buffering, the amelioration of osmotic stress, wounding-induced sieve t

215 Amelioration of outer nuclear layer thinning indicated t

216 ough preservation of membrane properties and amelioration of oxidative stress.

217 ophil depletion in infected mice resulted in amelioration of pathogenic responses, as evidenced by a

218 cal study demonstrating sildenafil-dependent amelioration of pathological remodeling, the cardioprote

219 Amelioration of pathology coincided with decreased trans

220 No amelioration of pathology was observed in the recombinas

221 offset costs of phenotypes through ontogeny, amelioration of phenotypic costs across environments, an

222 ct, LM-PLP infection resulted in significant amelioration of PLP178-191-induced EAE.

223 Altogether, our results suggest that amelioration of potassium leaks through potassium homeos

224 Amelioration of pre-rRNA imbalance is achieved through r

225 ry of miR-146a mimics into the skin leads to amelioration of psoriasiform skin inflammation, decrease

226 ified in humans as neurosurgical targets for amelioration of psychiatric disorders.

227 titis and may be useful in the prevention or amelioration of radiation changes in the skin.

228 Sustained amelioration of retinal vascular permeability (RVP) was

229 hages to anti-inflammatory M2 class underlie amelioration of RIII.

230 ustained improvement in locomotor skills and amelioration of secondary tissue damage.

231 the inhibition of NF-kappaB activity and the amelioration of SETD1-induced chromatin relaxation.

232 sequent treatment, notably radiotherapy, for amelioration of side effects.

233 features were independently associated with amelioration of significant MR after CRT by multivariabl

234 biotic intervention resulting in significant amelioration of skin inflammation and reductions in skin

235 pathway in vivo by Jnk3 knockout results in amelioration of SMA phenotype.

236 pression in SMADelta7 mice, correlating with amelioration of SMA-related defects in motor neurons and

237 ontrols, animals overexpressing VPS35 had an amelioration of spatial learning and working memory, whi

238 e insulin sensitivity in adipose tissue, and amelioration of spontaneous atherosclerosis.

239 sed rsFC in these circuits may contribute to amelioration of subjective withdrawal symptoms.

240 As in previous studies an amelioration of symptoms is seen immediately after surge

241 We show that the amelioration of symptoms was proportional to the extent

242 enerative diseases are limited mostly to the amelioration of symptoms, although promising new therape

243 se is limited to a few treatment options for amelioration of symptoms.

244 nt, rescue of their synaptic dysfunction and amelioration of synaptic integrity.

245 cell epitope peptide mixture demonstrated an amelioration of systemic allergic symptoms and a signifi

246 PERK branches of the UPR(ER) participate in amelioration of tauopathy by constitutively active XBP-1

247 ng that NKG2D is an important target for the amelioration of Th1- and Th17-mediated chronic inflammat

248 nceptually novel therapeutic targets for the amelioration of the affective, cognitive and systemic ma

249 Il17a lacking mutants exhibited amelioration of the aforementioned fibrosis, whereas Tnf

250 targeting without nucleases and demonstrate amelioration of the bleeding diathesis in haemophilia B

251 sruption in intracellular calcium levels, so amelioration of the calcium alteration could serve as an

252 Fasting is beneficial in the prevention and amelioration of the clinical manifestations of autoimmun

253 hepcidin is the subject of interest for the amelioration of the detrimental effects of either iron d

254 on the other hand, resulted in a significant amelioration of the different inflammatory parameters as

255 g the survival of the cancer patient through amelioration of the disease burden of gram-positive bact

256 eatment approach can lead to a more profound amelioration of the disease pathology.

257 gical assessment of colon sections confirmed amelioration of the disease phenotype.

258 of alphaLNNd in dy2J mice resulted in strong amelioration of the dystrophic phenotype, manifested by

259 netic or pharmacological means would lead to amelioration of the ectopic mineralization phenotype in

260 tion using 5-iodotubercidin, we demonstrated amelioration of the epigenetic effects of irradiation.

261 over 12 months, consistent with progressive amelioration of the HF syndrome.

262 apeutic approach (1) resulted in substantial amelioration of the low growth factor activity with sign

263 he antioxidant, oral N-acetylcysteine led to amelioration of the muscle atrophy and weakness in Gne m

264 and identify a novel therapeutic target for amelioration of the neurodegeneration and cognitive defi

265 tase 2 as a potential therapeutic target for amelioration of the neurologic sequelae caused by HSE.

266 of into the retina can achieve long-lasting amelioration of the pathologic findings of optic pit mac

267 The overall result was the amelioration of the pathological hallmarks and the cogni

268 with 4-phenylbutyrate resulted in remarkable amelioration of the pathological phenotypes in plectin-d

269 Targeting BATF expression resulted in amelioration of the pathophysiologic responses seen in c

270 deuteration goes beyond the pure and simple amelioration of the pharmacokinetic parameters of a drug

271 Amelioration of the phenotype by the alternative transcr

272 Amelioration of the sensory phenotypes caused by specifi

273 H4R(-/-) mice showed a clear amelioration of the skin lesions, with a diminished infl

274 E2 secretion by IL-1beta was associated with amelioration of their myofibroblast differentiation in v

275 ng components of these signalling responses, amelioration of their toxic effects and so the treatment

276 This study evaluated the amelioration of these poor soils by thorny bamboo, one o

277 tion of novel therapeutic strategies for the amelioration of these serious human conditions.

278 colon and a potential therapeutic target for amelioration of this disease.

279 clearance of necrotic tissue interferes with amelioration of tissue injury and induces abnormal tissu

280 r-triptolide achieved significantly improved amelioration of tumor burden compared to free triptolide

281 ons for overall health and the prevention or amelioration of various chronic diseases.

282 l health implications in both prevention and amelioration of various diseases involving oxidative str

283 gher plant diversity was associated with the amelioration of warming-induced environmental conditions

284 Significant amelioration of weight reduction was noted in treated mi

285 for, and potential molecular targets for the amelioration of, the hyperprolactinemia and sexual dysfu

286 platelet counts, and their levels indicated amelioration or exacerbation of the disease.

287 ards significant role for MusaSAP1 in stress amelioration pathways of banana.

288 orization, resulting in long-term functional amelioration persisting up to 60 d after ischemia.

289 o be dampened or reversed when environmental amelioration persists.

290 ds the equatorial edges the magnitude of the amelioration provided by shaded microhabitats is largely

291 Periodic environmental amelioration (short periods of reduced temperature) caus

292 rewetting rates affect the rate of resource amelioration, specifically water and nitrogen, altering

293 direction of interactions (i.e., from stress amelioration to exacerbation).

294 atorial pharmaceutical approaches to symptom amelioration upon FMRP attenuation.

295 Disease amelioration was associated with reduced IL-17 and IFN-g

296 ed experimental autoimmune encephalomyelitis amelioration was canceled in mice with ERbeta-deficient

297 nduction of ischemia, whereas no significant amelioration was observed when beta2AR knock out (KO) EP

298 nes that mostly associated with the clinical amelioration were Ccr7, its ligand, Ccl19, and dendritic

299 The authors also observed an amelioration with tDCS of other symptoms as measured by

300 tically ill patients, TAVI provides clinical amelioration, with early improvement in LVEF.