ライフサイエンスコーパス: amidate

1 umans, norUDCA is glucuronidated rather than amidated.

2 cases even aryl chlorides can be efficiently amidated.

3 s CTL epitopes when the carboxyl terminus is amidated.

4 90% of known or predicted neuropeptides are amidated.

5 erminal d-alpha-aminopimelyl carboxylic acid amidated.

6 lly and thermodynamically with electron-rich amidates.

7 e endogenous presence of a highly conserved, amidated, 14-aa neuropeptide called either spexin or NPQ

8 kappa2-amidate ligand to yield an Al(kappa2-amidate)2(kappa1-carboxamide)(NHR) complex, followed by

9 erms of initial hydrolysis of phosphodiester amidates 2a, 2b, 4a, 4b, and 6 catalyzed by intracellula

10 BMCs incubated with the AZT phosphomonoester amidates 3 and 4 was 2- and 3-fold less than that observ

11 In particular, the AZT phosphomonoester amidate 4 displayed comparable antiviral activity to the

12 t TFOs containing N3'-->P5' phosphoramidate (amidate), 5-(1-propynyl)-2'-deoxyuridine (pdU), 2'-O-met

13 acial partitioning of a family of 17-residue amidated-acetylated peptides into both neutral and anion

14 e human KiSS1 gene encodes a COOH-terminally amidated active peptide, and this peptide is the ligand

15 due that provides a substrate for endogenous amidating activity in the mammary gland.

16 show that PHM is required for peptide alpha-amidating activity throughout the life of Drosophila.

17 for maintaining appropriate levels of alpha-amidating activity under changing conditions in vivo.

18 chanism where the M(III) complex engages the amidating agent via oxidative coupling to form a M(V)-im

19 Novel amidating agents containing a 1,4,2-dioxazole moiety all

20 dation of thioamides with robust dioxazolone amidating agents via C(sp(3) )-H bond activation to gene

21 (-) units provides this; a C-terminal Glu to amidated Ala mutation results in a 5-fold retardation of

22 ts of (1) steady-state formation of a Pd(II)-amidate-alkene chelate with release of 1 equiv of pyridi

23 Chiral dimeric tridentate NHC-amidate-alkoxide palladium(II) complexes, 3a and 3b, eff

24 Clavanins are histidine-rich, amidated alpha-helical antimicrobial peptides that were

25 aryl iodides using 1,2-diamine ligated Cu(I) amidates also provide insights into the mechanism of ary

26 e that consists of a mixture of tris-(kappa2-amidate)aluminum(III) complexes.

27 For this purpose, low esterified amidated (AM), low (LM) and high (HM) methoxylated citru

28 esis of Glu-666 revealed that only acidic or amidated amino acids at this position preserved PilQ fun

29 ications, we show that the single-stranded 3'amidate and 5'amidate backbones are equally well solvate

30 ation to the P(OX) state, whereby a backbone amidate and an oxygenic residue (Ser or Tyr) ligate to t

31 iometric reactions implied that the isolated amidate and imidate complexes are intermediates in the r

32 These results show that amidate and pdU-modified TFOs can be used as reagents to

33 However, of these modified TFOs, only the amidate and pdU-modified TFOs mediate induced recombinat

34 The Pd-amidate and resulting Pd-alkyl species have been crystal

35 Consequently, a series of non-amidated and acetylated polyarginines was synthesized.

36 of such inhibitors using positional scanning amidated and acetylated synthetic l- and d-hexapeptide c

37 erminally acetylated and carboxyl-terminally amidated and consists entirely of D-amino acids.

38 y resolution of tryptic fragments containing amidated and deamidated forms using high pressure liquid

39 The tp10 variants examined include amidated and free peptides, and replacements of tyrosine

40 Approximately 20% of newly synthesized amidated and Gly-extended gastrins were secreted within

41 Our results show that both the amidated and non-amidated peptides had a disordered stru

42 Consistent with this trend, Cu(II)-amidates and Cu(II)-benzoates containing more electron-r

43 These amidates and imidates reacted much more slowly with chlo

44 3'-NHP(O)(O-)O-5'internucleoside linkages (3'amidate) and alternatively modified oligonucleotides con

45 with a series of copper-carboxylate, copper-amidate, and copper-imidate complexes were performed.

46 For comparison, the amidate anion 2, vinylamine 3, and a simulated dimer 4 w

47 olated styelin D, a 32-residue, C-terminally amidated antimicrobial peptide, from the blood cells (he

48 We isolated a novel 22-residue, C-terminally amidated antimicrobial peptide, moronecidin, from the sk

49 AZT phosphomonoester amidates are internalized by lymphocytes to the same ext

50 In contrast, FLT phosphomonoester amidates are rapidly converted to FLT-5'-monophosphate b

51 neuropeptides including those containing an amidated arginine(R)-phenylalanine(F) motif at their C-t

52 ses FLP-13 neuropeptides characterized by an amidated arginine-phenylalanine (RFamide) C-terminus mot

53 s best explained by reduced flux through the amidated arm of the NAD+ salvage pathway due to reduced

54 The inability of peptides amidated at their C termini to effect restoration of act

55 solvation calculations which show that the 3'amidate backbone is favored relative to the 5'amidate ba

56 ckbones are equally well solvated, but the 5'amidate backbone is not adequately solvated in an A-form

57 midate backbone is favored relative to the 5'amidate backbone.

58 how that the single-stranded 3'amidate and 5'amidate backbones are equally well solvated, but the 5'a

59 eaction of aryl- and benzylsulfanopyridinium amidates bearing a methyl group in position 6 with 2 equ

60 ase (PAM), an enzyme required for generating amidated bioactive signaling peptides, in Chlamydomonas

61 An efficient and selective bis(amidate)bis(amido) titanium precatalyst for the anti-Mar

62 yne substrates, a commercially available bis(amidate)bis(amido)Ti catalyst is utilized to yield a cyc

63 ontributes significantly in the cases of the amidate bridges and that this is more important for M =

64 arboxyl group of N-acetylneuraminic acid was amidated by taurine.

65 to Leu substitution, a free N terminus, and amidated C terminus readily forms amyloid.

66 an N-terminal stearic acid attachment and an amidated C terminus were designed, synthesized, and test

67 bridge between residues two and seven and an amidated C terminus.

68 a-carboxyglutamic acid (Gla) residues and an amidated C-terminal asparagine amide, was synthesized ch

69 peptide consisting of 37 amino acids with an amidated C-terminal residue.

70 The role of the amidated C-terminus in amyloid formation by IAPP and in

71 of a set of variants with a free and with an amidated C-terminus shows that disrupting the putative H

72 (O = 4-trans hydroxyproline; * indicates an amidated C-terminus).

73 l14a contains 25 amino acid residues with an amidated C-terminus, an elongated N-terminal tail (six r

74 ination product and regenerate the active Pt-amidate catalyst.

75 Both also make significant quantities of amidated CCK 22, a slightly larger form found in the gut

76 intestinal tumor, process pro-CCK mainly to amidated CCK 8.

77 C-terminus of CCK 8 were mutated to GAA, no amidated CCK was produced.

78 expression or the production of some form of amidated CCK.

79 The model invokes internal amidate chelation to control ester enolate geometry and

80 power ((m2 - m1)/ml) of 118,000 (C terminal amidated cholecystekinin fragment 26-33 (CCK-8), DY(PO3H

81 The resting states were found to be a 2:1 Pt-amidate complex (25, for N-acetamido) of the deprotonate

82 ay that includes photoexcitation of a copper-amidate complex, followed by electron transfer to form a

83 curs through a 1,2-diamine-ligated copper(I) amidate complex.

84 n also prevent the formation of the kappa(2)-amidate complexes and thereby generate more stable catal

85 Homoleptic uranium(IV) amidate complexes have been synthesized and applied as s

86 that suggests that the formation of kappa(2)-amidate complexes is deleterious to the effectiveness of

87 Copper(I) imidate and amidate complexes of chelating N,N-donor ligands, which

88 evealed that the incorporation of C-terminus amidated D-amino acids onto bacterial surfaces substanti

89 yielded a massive and toxic incorporation of amidated DAP into the peptidoglycan that ultimately led

90 with the amidotransferase SsfD produced the amidated decaketide backbone that is required for the fo

91 bacco hornworm, Manduca sexta, including the amidated decapeptide F10.

92 In contrast, 5'amidates do not form duplexes at all.

93 There is no steric reason that the 5'amidate duplex should not form.

94 oside linkages (5'amidate) have shown that 3'amidate duplexes, formed with DNA or RNA complementary s

95 eakdown of the alkoxide to form aldehyde and amidate (E1cB-like).

96 Bifunctional peptidylglycine alpha-amidating enzyme (alpha-AE) catalyzes the O2-dependent c

97 Bifunctional peptidylglycine alpha-amidating enzyme (alpha-AE) catalyzes the two-step conve

98 beta-hydroxylase and peptidyl glycine alpha-amidating enzyme also co-aggregated with granule content

99 The bifunctional peptidylglycine alpha-amidating enzyme catalyzes the C-terminal amidation of g

100 ses and other modifying enzymes, such as the amidating enzyme complex (PAM), in converting inactive o

101 omain was demonstrated with the bifunctional amidating enzyme of Xenopus laevis.

102 diverse amidated neuropeptides and with the amidating enzyme peptidylglycine alpha-hydroxylating mon

103 ystem to create mosaics for the neuropeptide amidating enzyme PHM; amidation is a highly specific and

104 bstrate specificity of peptidylglycine alpha-amidating enzyme was determined and compared against a c

105 The amidating enzyme, peptidyglycine alpha-amidating mono-ox

106 lopmentally regulated release of the peptide amidating enzyme, peptidylglycine alpha-amidating monoox

107 embrane domain and cytoplasmic domain of the amidating enzyme, peptidylglycine alpha-amidating monoox

108 PCs), carboxypeptidase E, and peptidyl alpha-amidating enzyme, to transform recombinant precursors in

109 ns, Dph1 to Dph5, and an as-yet-unidentified amidating enzyme.

110 oteins, Dph1 to -5, and a still unidentified amidating enzyme.

111 The peptidyl amidating enzymes have previously been identified in cel

112 l acid form of Tp1a compared with the native amidated form (IC50 2.1 nM), suggesting that the peptide

113 lso caused a 2-fold increase in the ratio of amidated forms of GLP-1 immunoreactivity to total glucag

114 zebrafish galanin gene encoded for a single amidated galanin peptide and a galanin message-associate

115 Amidated gastrin (G-17) attenuated the growth suppressin

116 Since mature, amidated gastrin (G-17) can induce cyclin D1, we determi

117 s assessed in transgenic mice overexpressing amidated gastrin (INS-GAS) and mice in which hypergastri

118 e overexpressing either progastrin (hGAS) or amidated gastrin (INS-GAS), compared with that in wild-t

119 labelling experiments, the conversion of the amidated gastrin G34 to G17 was inhibited by biogenic am

120 ithelia following injury, but the effects of amidated gastrin have not previously been assessed.

121 cleavage of G34 (the thirty-four amino acid amidated gastrin) at Lys-74-75 to give G17 (the seventee

122 -74-75 to give G17 (the seventeen amino acid amidated gastrin), and of G34-Gly to G17-Gly (G34 and G1

123 In colorectal cancer, FAK is activated by amidated gastrin, a protumorigenic hormone.

124 avage of 35S-labelled thirty-four amino acid amidated gastrin, i.e. [35S]G34, and of [35S]G34 with CO

125 cholecystokinin-2 receptor was treated with amidated gastrin-17.

126 imary receptor for cholecystokinin (CCK) and amidated gastrin.

127 ice similarly suggested a protective role of amidated gastrins against colon carcinogenesis, which su

128 epithelial differentiation; and C-terminally amidated gastrins stimulate colonic proliferation, gastr

129 y that loss of gastrin expression (and hence amidated gastrins) significantly increases susceptibilit

130 putative growth factors; their products, the amidated gastrins, regulate epithelial cell proliferatio

131 mice lacking normal physiological levels of amidated gastrins.

132 ng pathways initiated by biologically active amidated gastrins.

133 s and if the effects are similar to those of amidated gastrins.

134 xpressing high levels of progastrin, but not amidated gastrins.

135 islet alpha cells, leading to an increase in amidated GLP-1, which can then exert an insulinotropic e

136 terminal free carboxyl group, the C-terminal amidated group, or the N-terminal ammonium group of pept

137 ttributed to the meta disposition of the two amidate groups in 4,6-dioxypyrimidinate as compared to t

138 he copper complexes follows the trend Cu(II)-amidate > Cu(II)-imidate > Cu(II)-benzoate.

139 n organism in which the peptidoglycan is not amidated, has a strong preference for a terminal carboxy

140 3'-O(O-)(O)PNH-5'internucleoside linkages (5'amidate) have shown that 3'amidate duplexes, formed with

141 The 37-residue, C-terminally amidated human amylin peptide derives from a proprotein

142 rted expression system for the production of amidated IAPP.

143 This intermediate was esterified or amidated in solution phase.

144 into solution and the four carboxylates are amidated in the sequential order of e, d, b, and g for t

145 de acyl oxygen to form a high-energy O-alkyl amidate intermediate, (2) attack of the 2'-OH group on t

146 esterase(s) to give stable phosphomonoester amidate intermediates with a free carboxyl group.

147 After each round of catalysis the partially amidated intermediates are released into solution and th

148 that dinorCDCA, as norCDCA, is inefficiently amidated, is metabolized as a xenobiotic, and induces hy

149 mbyx mori, and Aedes aegypti: A C-terminally amidated ITP and a C-terminally unblocked ITP-like pepti

150 artially randomized with carboxylate b being amidated last.

151 utational investigations have implicated the amidate ligand in nickel superoxide dismutase (NiSOD) in

152 an intramolecular nucleophilic attack of the amidate ligand on the coordinated alkene.

153 to aluminum and proton transfer to a kappa2-amidate ligand to yield an Al(kappa2-amidate)2(kappa1-ca

154 so employed to construct a variant where the amidate ligand was converted to a secondary amine, H1*-N

155 A new family of tetra-anionic tetradentate amidate ligands, N1,N1'-(1,2-phenylene)bis(N2-methyloxal

156 The effects of oleamide, an amidated lipid isolated from the cerebrospinal fluid of

157 For this purpose, low esterified amidated, low and high methyl esterified citrus and appl

158 e of the peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain of peptidylglycine alpha-am

159 d lyase (peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL)) domains.

160 enzyme, peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5), has no known homologu

161 PHM, and peptidyl-alpha-hydroxyglycine alpha-amidating lyase or PAL) that in most eukaryotes are expr

162 eaturing an extended, pai-delocalized, tetra-amidate macrocyclic ligand (TAML) as water oxidation cat

163 introduction of a lipophilic phosphodiester amidate moiety on the HIV activity of inactive unsaturat

164 The amidating enzyme, peptidyglycine alpha-amidating mono-oxygenase (PAM), the prohormone convertas

165 nal enzyme called PAM (peptidylglycine alpha-amidating mono-oxygenase).

166 Peptidylglycine alpha-amidating monooxygenase (PAM) (EC 1.14.17.3) catalyzes p

167 al domains of membrane peptidylglycine alpha-amidating monooxygenase (PAM) are essential for peptide

168 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes a two-step react

169 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the amidation of

170 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the carboxyl-ter

171 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the COOH-termina

172 tide processing enzyme peptidylglycine alpha-amidating monooxygenase (PAM) contains signals that dire

173 g of integral membrane peptidylglycine alpha-amidating monooxygenase (PAM) in the neuroendocrine AtT-

174 Peptidylglycine alpha-amidating monooxygenase (PAM) is an enzyme expressed by

175 Peptidylglycine alpha-amidating monooxygenase (PAM) is an essential enzyme tha

176 Because peptidylglycine alpha-amidating monooxygenase (PAM) is one of the few membrane

177 Peptidylglycine alpha-amidating monooxygenase (PAM), a bifunctional enzyme, ca

178 ing P-type ATPase, and peptidylglycine alpha-amidating monooxygenase (PAM), a copper-dependent membra

179 amined the turnover of peptidylglycine alpha-amidating monooxygenase (PAM), a membrane enzyme involve

180 for full activation by peptidylglycine alpha-amidating monooxygenase (PAM), a transmembrane vesicular

181 o catalytic domains of peptidylglycine alpha-amidating monooxygenase (PAM), a type I integral membran

182 ical tools to identify peptidylglycine alpha-amidating monooxygenase (PAM), a type I secretory granul

183 in atrial granules is peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential for a

184 Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential for b

185 Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential for n

186 We recently identified peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme required for ge

187 sis and trafficking of peptidylglycine alpha-amidating monooxygenase (PAM), an essential cuproenzyme

188 Peptidylglycine alpha-amidating monooxygenase (PAM), an integral membrane prot

189 Peptidylglycine alpha-amidating monooxygenase (PAM), an integral membrane prot

190 uires a single enzyme, peptidylglycine alpha-amidating monooxygenase (PAM), and lack of amidation ren

191 tide amidating enzyme, peptidylglycine alpha-amidating monooxygenase (PAM), and the presence of pepti

192 zing esterase/lipase, peptidyl glycine alpha-amidating monooxygenase (PAM), peptidase cleavage, and g

193 ion, we find that both peptidylglycine alpha-amidating monooxygenase (PAM), the enzyme responsible fo

194 cyl-CoA synthetase and peptidylglycine alpha-amidating monooxygenase (PAM).

195 the amidating enzyme, peptidylglycine alpha-amidating monooxygenase (PAM).

196 es by the bifunctional enzyme peptidyl-alpha-amidating monooxygenase (PAM).

197 e bifunctional enzyme, peptidylglycine alpha-amidating monooxygenase (PAM).

198 he bifunctional enzyme peptidylglycine alpha-amidating monooxygenase (PAM).

199 outing determinants of peptidylglycine alpha-amidating monooxygenase (PAM).

200 essing is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM).

201 egral membrane protein peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) contains mul

202 he bifunctional enzyme peptidylglycine-alpha-amidating monooxygenase mediates the conversion of C-ter

203 s of a single protein (peptidylglycine alpha-amidating monooxygenase or PAM).

204 glycine (hippurate) by peptidylglycine alpha-amidating monooxygenase to again yield benzamide and gly

205 lyase (PAL) domain of peptidylglycine alpha-amidating monooxygenase was investigated with respect to

206 processing enzyme PAM (peptidylglycine alpha-amidating monooxygenase) as tools to study the peptiderg

207 y its interaction with peptidylglycine alpha-amidating monooxygenase, an enzyme essential for neurope

208 or to the mature form, peptidylglycine alpha-amidating monooxygenase, were upregulated by inositol de

209 h its interaction with peptidylglycine-alpha-amidating monooxygenase.

210 sed on PS-SCL screening results identified 3 amidated monosubstituted and disubstituted peptides that

211 The resulting amidated N-glycans can then be released from the protein

212 ty purification allowed the sequencing of an amidated neuronostatin peptide of 13 residues from porci

213 In Drosophila, the amidated neuropeptide pigment dispersing factor (PDF) is

214 DIMM is coexpressed with diverse amidated neuropeptides and with the amidating enzyme pep

215 levels and reproducibly altered patterns of amidated neuropeptides in the CNS.

216 ervous system confirms the important role of amidated neuropeptides in these parasitic flatworms.

217 Amidated neuropeptides of the FMRFamide class regulate n

218 ey also support the hypothesis that multiple amidated neuropeptides, acting upstream, downstream, or

219 or amidation and therefore activation of all amidated neuropeptides, and amidated PACAP are expressed

220 We investigated the role of amidated neuropeptides, and specifically pituitary adeny

221 eriments were conducted to determine whether amidated neuropeptides, such as PACAP38, might function

222 reening and characterization of C-terminally amidated neuropeptides.

223 eukaryotic NAD+ synthetases use glutamine to amidate nicotinic acid adenine dinucleotide while many p

224 Moreover, the amidated NPY CTFs protected human neuronal cultures from

225 ino acid carbomethoxy ester phosphomonoester amidate nucleotide prodrugs by PBMCs does not require pr

226 ino acid carbomethoxy ester phosphomonoester amidates of AZT are not significantly metabolized to eit

227 acid carbomethoxy ester aryl phosphodiester amidates of nucleotide prodrugs.

228 t zero binding density) for the +8-charged C-amidated oligopeptide KWK6 and short single-stranded DNA

229 erivatives (acetylated on the N-terminal and amidated on the C-terminal end) of [Ala2,D-Leu5]-Enk, [D

230 es is reflected in the nucleofugality of the amidate once the alkoxide is formed and not in the pKa o

231 ctivation of all amidated neuropeptides, and amidated PACAP are expressed in developing and adult olf

232 Amidated PACAP is highly expressed in proliferative basa

233 These mice had decreased amidated PACAP production and concomitant decreased numb

234 One identified amidated PAM product serves as a chemoattractant for mat

235 ough atrial natriuretic peptide (ANP) is not amidated, Pam expression in the atrium exceeds levels in

236 APP or Amylin) is a 37-residue, C-terminally amidated pancreatic hormone, cosecreted with insulin tha

237 del systems containing high methoxylated and amidated pectins, respectively.

238 6-8 PEG chains attached to the non-carboxyl-amidated PEG-rMETase.

239 The carboxyl-amidated PEGylated rMETase was hyper-PEGylated at a mola

240 ir breakdown to the corresponding C-terminal amidated peptide and glyoxylate as final products.

241 prohormones to the active, C-terminal alpha-amidated peptide and glyoxylate.

242 PAM catalyzes the final step in alpha-amidated peptide biosynthesis, and its proposed role in

243 monooxygenase (PAM), an enzyme essential for amidated peptide biosynthesis.

244 The N-acetylated, C-amidated peptide corresponds to the sequence comprising

245 rus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges.

246 Kisspeptin is a C-terminally amidated peptide encoded by the KiSS1 gene.

247 ics of binding and insertion of the free and amidated peptide groups.

248 rmations in catecholamine neurotransmitters, amidated peptide hormones, and collagen biosynthetic pat

249 Dissociation constants (Kd's) of the amidated peptide HPVHHYQ-NH2 to various A-site RNA const

250 ears, and the physiological function of this amidated peptide in regulating gastric acid secretion vi

251 this alpha-hydroxyglycine derivative to the amidated peptide plus glyoxylate.

252 sis behavior by secretion of an unidentified amidated peptide(s).

253 lycine-extended peptides to C-terminal alpha-amidated peptides and glyoxylate.

254 These data establish amidated peptides and specifically PACAP as having impor

255 Recently, a new class of small C-terminally amidated peptides comprising four to seven amino acid re

256 mally and express wildtype levels of several amidated peptides despite having one half the wildtype l

257 However, the non-amidated peptides FKRF, FLRF and nLRF and also WMDFamide

258 results show that both the amidated and non-amidated peptides had a disordered structure in aqueous

259 A number of amidated peptides play essential roles in each of these

260 FF), AF (NPAF), and SF (NPSF) are homologous amidated peptides that were originally identified on the

261 Despite the proposed contribution of amidated peptides to neuronal cell proliferation, no alt

262 n PHM mutants revealed specific disruptions: Amidated peptides were largely absent in strong hypomorp

263 am treatment, which depletes stores of alpha-amidated peptides, increased the specific activity of PH

264 l for the biosynthesis of catecholamines and amidated peptides, respectively.

265 ne protein essential for the biosynthesis of amidated peptides, was used to assess the role of cytoso

266 on may also prove useful in decreasing other amidated peptides.

267 ch toward the synthesis of an array of ortho-amidated phenylimidazo heterocycles without prior activa

268 Acetylated, amidated PHSCN (Ac-PHSCN-NH2) was 30-fold more potent; h

269 The potency of acetylated, amidated PHSRN (Ac-PHSRN-NH(2)) is significantly increas

270 The best compound, the (S)-FPMPA amidate prodrug, exerts anti-HIV-1 activity in TZM-bl an

271 rences displayed by these enzymes toward TFV amidate prodrugs are nearly identical to their preferenc

272 ide quinoline N-oxide and by converting this amidated product into functionalized quinolines.

273 ded peptide intermediate into a C-terminally amidated product.

274 )-H bond activation to generate the desired amidated products is reported.

275 ors, subtilisin-like prohormone convertases, amidated products, and receptors) in ciliary ectosomes f

276 e same site completely blocked production of amidated products, whereas serine substitution did not.

277 cine-extended peptides to their active alpha-amidated products.

278 ns that convert peptidyl-Gly substrates into amidated products.

279 rminated in lysine for one isoform and alpha-amidated proline for another isoform.

280 peptides ending in glycine, lysine, or alpha-amidated proline.

281 is(phenylsulfonyl)-imide) was explored as an amidating reagent for C8-amidation of quinoline N-oxide

282 of quinoline N-oxide using dioxazolone as an amidating reagent under mild conditions is disclosed.

283 xazolone, which is an environmentally benign amidating reagent.

284 ino acid carbomethoxy ester phosphomonoester amidates revealed that their decomposition pathway diffe

285 (NMN) and nicotinamide riboside (NR) in the amidated salvage pathway despite no increase in nicotina

286 We describe a method for the production of amidated sCT in the mammary gland of transgenic rabbits.

287 s the endocannabinoid anandamide and related amidated signaling lipids.

288 sly unappreciated route for the secretion of amidated signaling peptides.

289 sary to completely cyclize and aromatize the amidated tetracyclic aglycon.

290 The amidated tetracycline backbone is biosynthesized by the

291 late the misacylated tRNA substrate and then amidate the activated intermediate to form the cognate p

292 Removing the C-terminal alanine alone, or amidating the C terminus carboxyl group, also eliminated

293 nor brain natriuretic peptide (ANP, BNP) is amidated, the major membrane protein in atrial granules

294 ediate, (2) attack of the 2'-OH group on the amidate to form a 1',2'-acyloxonium species, (3) hydroly

295 The enzyme did not amidate tripeptide- and tetrapeptide-truncated versions

296 Protein acids are subsequently amidated under buffered conditions in DMSO using the cou

297 des were used to identify and quantitate the amidated versus deamidated forms of each tryptic fragmen

298 The synthetic, amidated white bass moronecidin exhibited broad spectrum

299 CDCA, in contrast, was efficiently amidated with taurine or glycine.

300 roups of polyamide nylon 6/6 to give (eta(2)-amidate)zirconium complexes in high yield.