ライフサイエンスコーパス: amide bond

1 attributed to the resonance stability of the amide bond.

2 eloped due to resonance stabilization of the amide bond.

3 ric contacts between the substituents on the amide bond.

4 nic acid analogue and holothin, linked by an amide bond.

5 e N-terminus of the acpcPNA probe through an amide bond.

6 FOA after 8 days due to the stability of the amide bond.

7 cyclization of amino alcohol to form the key amide bond.

8 ester carbonyl carbon, which favors a trans amide bond.

9 nal glycine of a protein via formation of an amide bond.

10 rogen atom to facilitate the cleavage of the amide bond.

11 matic increase in nonplanarity about the C-N amide bond.

12 NC overlayer to afford a biologically stable amide bond.

13 of which synthesizes a single intramolecular amide bond.

14 investigate the effect of locking a proline amide bond.

15 l or a carboxyl conjugated to glycine via an amide bond.

16 icantly more compact conformation with a cis amide bond.

17 converting the ring-closing ester bond to an amide bond.

18 e complexes that are linked through a stable amide bond.

19 through direct nucleophilic addition to the amide bond.

20 , a commercial antiemetic, directly from the amide bond.

21 lecule possessing the biologically important amide bond.

22 ng heterocycles via polarity reversal of the amide bond.

23 riven by ground-state destabilization of the amide bond.

24 stereocenter promotes a cis-alanine-proline amide bond.

25 opargylation and full recovery of the native amide bond.

26 ive metal insertion into the carbon-nitrogen amide bond.

27 synthetic chemistry for general formation of amide bonds.

28 s) residues using succinimidyl chemistry via amide bonds.

29 d the interaction of proteases with backbone amide bonds.

30 the formation of peptidyl and glycopeptidyl amide bonds.

31 to Pro-cis-Pro-aromatic and aromatic-cis-Pro amide bonds.

32 onation of nitrogens in the peptide backbone amide bonds.

33 nd thioacids with amines to form challenging amide bonds.

34 atural peptides and proteins are composed of amide bonds.

35 the cis-trans isomerization of pSer/pThr-Pro amide bonds.

36 n adjacent carbonyl groups of the main-chain amide bonds.

37 o acids, which are linked to one another via amide bonds.

38 shes a strong energetic preference for trans-amide bonds.

39 bic environment and a periphery of secondary amide bonds.

40 e helical structures featuring repeating cis-amide bonds.

41 h paratopes containing potential cis proline amide bonds.

42 alysts have been developed that bear Xaa-Pro amide bonds.

43 partner) approaches for the construction of amide bonds.

44 ond rather than at the Th=C(carbene) or Th-N(amide) bonds.

45 ble NP isomer residues via reversible ester (amide) bonds.

46 to Py/Py-COOH/MNP modified gold WEs through amide bonding.

47 dged lactams to directly access N-protonated amide bonds, (2) validates the use of the additive Winkl

48 idely occurring biaryl compounds through N-C amide bond activation is reported.

49 ologue, catalyses the formation of the first amide bond, an N-acyl-beta-peptide link, in andrimid bio

50 tability; this was overcome by reversing the amide bond and changing the heterocycle.

51 e second having glycine connected through an amide bond and displaying a terminal carboxylic acid (DB

52 hesized with a PEG group attached through an amide bond and examined for water solubility, antitumor

53 pon collisional activation, cleavages of the amide bond and of one ether bond were observed to procee

54 cess is a low barrier to rotation around the amide bond and the alpha-substituent Z.

55 sition, the length of the linker between the amide bond and the phenyl ring B, and the amino substitu

56 of the (D)P diastereomer to support a trans-amide bond and the proclivity of (L)P for a cis-amide bo

57 nternally directs activation of the backbone amide bond and thereby facilitates formation of a stable

58 tly bound with succinimidyl group on SAM via amide bond and unreacted active groups of LC-SPDP were b

59 Trans amide bonds and fast cis- trans isomerization of Xaa-Pro

60 ence of structural blocks (SBs) connected by amide bonds and not being limited to the natural amino a

61 is linked with structural changes at nearby amide bonds and that this perturbation is mediated by th

62 The effect of geometry on the reactivity of amide bonds and the amide bond distortion range that mar

63 Most importantly, some amide bonds and their similar groups and even benzene ri

64 rimides to achieve full twist of the acyclic amide bond, and results in the discovery of N-acyl-gluta

65 bone amides, significant nonplanarity of the amide bonds, and a unique "basket" arrangement of (S)-N(

66 h secondary and tertiary aminomethyl groups, amide bonds, and hydroxymethylene groups, respectively.

67 NA B domains of BcpA generate intramolecular amide bonds, and one of these contributes also to pilus

68 Amide bonds are ubiquitous in peptides, proteins, pharma

69 nvolving direct nucleophilic addition to the amide bond as a key step.

70 s of compounds and that the direction of the amide bonds (as in 1) is obligatory.

71 20 amino acids that link together through an amide bond at a rate approaching the diffusion limit.

72 avbeta3 integrin, and differs for a modified amide bond at the main protease cleavage site.

73 YFR is branched and contains glutamates with amide bonds at both their alpha- and gamma-carboxyl grou

74 ptide tags that are able to form spontaneous amide bonds, based on harnessing reactions of adhesion p

75 rolysis is utilized for the formation of the amide bond between actin subunits.

76 n O- to N-acyl transfer to form the hindered amide bond between N-methyl tubuvaline and isoleucine.

77 itor for the first time the formation of the amide bond between reactive SAM surfaces and the project

78 ine-containing protein fragments to form the amide bond between respective protein fragments signific

79 N motif as a nucleophile, sortase A forms an amide bond between the BcpA C-terminal carboxyl group of

80 of the major pilin, BcpA, sortase D forms an amide bond between the C-terminal threonine and the amin

81 RavZ hydrolyzed the amide bond between the carboxyl-terminal glycine residue

82 the synthesis include the installation of an amide bond between the indole-nitrogen of tryptophan and

83 The amidases cleave the amide bond between the lactyl group of muramic acid and

84 y an N-terminal poly-Gly sequence to form an amide bond between the Thr and N-terminal Gly.

85 nta-amino acid motif, LPXTG, and cleaves the amide bond between Thr and Gly to form a thioacyl-linked

86 sorting signal and catalyzes formation of an amide bond between threonine (T) of the sorting signal a

87 ation is an effective means to synthesize an amide bond between two groups of otherwise orthogonal re

88 We demonstrate the controlled formation of amide bonds between amino acids or peptides in the gas p

89 action of amide synthetases which construct amide bonds between aminocoumarins and various acyl moie

90 araldehyde (GA) and (ii) by formation of the amide bonds between carboxylic groups of rGO-Fc(COOH)(2)

91 Amide bonds between G1-NH2 and PA free carboxylic groups

92 cribe tetrazole analogs as suitable backbone amide bond bioisosteres for the parent pan PAD inhibitor

93 d intensity with ion type, the dependence of amide bond breakage on the residues surrounding the clea

94 the bridgehead nitrogen and twist about the amide bond, but the most puckered penem system still ret

95 nding indicates that the poor mimicry of the amide bond by many peptidomimetics stems from their inab

96 s of an existing "anchor" peptide to form an amide bond by protonating the anchor peptide's basic res

97 leasing and thus more delocalized across the amide bond by resonance.

98 that deprotonation and polarization of this amide bond by TbtD removes this barrier and provides a s

99 The data suggest that distortion of these amide bonds by approximately 50 degrees is sufficient fo

100 e, which appear to form by hydrolysis of the amide bonds (C(O)-N).

101 of amide bonds is a straightforward process: amide bonds can be synthesized with relative ease becaus

102 on, allowing differentiation of one of seven amide bonds central to the vancomycin core structure, th

103 hosphate acts as the nucleophilic species in amide bond cleavage and implications for Dop function ar

104 ide cross-coupling reactions with the N-C(O) amide bond cleavage as a key step.

105 seudoallylic strain to the enormous rates of amide bond cleavage in tertiary amide derivatives of Kem

106 ffect could not compensate for the extensive amide bond cleavage, resulting in declined rejection.

107 in the propargylation site resulted in rapid amide bond cleavage, which extends the applicability of

108 c groups, the latter produced as a result of amide bond cleavage.

109 tegy and suggests that cytotoxicity requires amide bond cleavage.

110 s obtained from modified SM lipid anions via amide bond cleavage.

111 Two vicinal J-couplings sensitive to amide bond conformation (cis and trans amide) were also

112 Here, we investigated the influence of the amide bond conformation on the stereoselectivity of H-Pr

113 The ratio of the cis and trans amide bond conformers was determined by NMR study, highl

114 specialized serine peptidase that cleaves an amide bond connecting the peptidyl or aminoacyl moieties

115 phore synthetase AsbB catalyzes formation of amide bonds crucial for petrobactin assembly through use

116 the most frequent cleavage sites for similar amide bonds, defined based on the similarity of the SB t

117 A fourth amide bond, derived from the Ig fold of CNA(1), is forme

118 lly suited to span the whole spectrum of the amide bond distortion energy surface.

119 try on the reactivity of amide bonds and the amide bond distortion range that marks the boundary of a

120 ning aromatic residues exhibiting 45-60% cis amide bonds, due to Pro-cis-Pro-aromatic and aromatic-ci

121 Through a combination of ester-amide bond exchange and ester bond hydrolysis, depsipept

122 significance of a trans conformation prolyl amide bond for the pi-clamp reactivity.

123 Amide bond formation and aromatic/heteroaromatic nitro-g

124 eactivity of aldehydes and amines to enforce amide bond formation between amino acid residues and pep

125 sing EDC/NHS chemistry, which results in the amide bond formation between amino groups of PANI and CO

126 in cytoskeleton by catalyzing intermolecular amide bond formation between E270 and K50 residues of ac

127 l]carbodiimide hydrochloride (EDC)-catalyzed amide bond formation between the carboxyl group of 5caC

128 s after the conserved threonine, followed by amide bond formation between threonine and the pentaglyc

129 This modality was found to be general in amide bond formation from a number of activated esters i

130 reaction scope, generating biocatalysts for amide bond formation from carboxylic acid and amine.

131 Chemoselective reactions for amide bond formation have transformed the ability to acc

132 The amide bond formation in FDM A biosynthesis is proposed t

133 n, as an amide synthetase that catalyzes the amide bond formation in FDM A biosynthesis.

134 ly from improved E2 recruitment and enhanced amide bond formation in the E2 active site.

135 In these ligations, amide bond formation is accelerated by transient enforce

136 Amide bond formation is one of the most important reacti

137 immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-ste

138 Surprisingly, amide bond formation occurred at a similar rate at 4 and

139 s been prepared involving an anion-templated amide bond formation reaction at the macrocyclization st

140 s and amines that strategically deviate from amide bond formation remains both a challenge and an opp

141 atible with commonly used esterification and amide bond formation techniques, including the Fmoc/tBu

142 In this way we have accessed reversible amide bond formation that allows crystalline order to de

143 enes, which usually undergoes intramolecular amide bond formation to impart mechanical and proteolyti

144 action uses the same activating principle as amide bond formation to replace a carboxylic acid moiety

145 of oxidative activation, thereby undergoing amide bond formation upon reaction with N-terminal pepti

146 Amide bond formation was accomplished via coupling of th

147 The amide bond formation was independent of redox state and

148 fact that minute levels of oxidation actuate amide bond formation with high turnover is offered.

149 lation of unprotected peptides, and on-resin amide bond formation with protected peptides.

150 arkably, SgcC5 is also capable of catalyzing amide bond formation, albeit with significantly reduced

151 It first catalyzes amide bond formation, and then the intramolecular cyclod

152 gcC5 is capable of catalyzing both ester and amide bond formation, providing an evolutionary link bet

153 Along with amide bond formation, Suzuki cross-coupling, and reducti

154 The most frequently used reactions were amide bond formation, Suzuki-Miyaura coupling, and SNAr

155 entral chemical step of peptide synthesis is amide bond formation, which is typically catalyzed by th

156 kinetic and thermodynamic driving force for amide bond formation.

157 ed to standard direct conjugation methods of amide bond formation.

158 ttachment of the various side chains through amide bond formation.

159 is enzyme cleaves ATP to ADP and P(i) during amide bond formation.

160 macrocyclization is efficiently achieved by amide bond formation.

161 lic acids and coupling agents widely used in amide bond formation.

162 ebiotically plausible mechanism for peptide (amide) bond formation that is enabled by alpha-hydroxy a

163 aightforward solid-phase approaches based on amide-bond formation or a Cu(I)-catalyzed azide-alkyne c

164 or the labeling of octreotide either through amide-bond formation or by CuAAC reaction.

165 t to be the sole enzyme responsible for this amide-bond formation.

166 at the biosynthesis involves two conspicuous amide bond formations accomplished by an amidotransferas

167 sonitriles to furnish secondary and tertiary amide bond formations have been applied to a novel total

168 y reported bias toward reaction classes like amide bond formations or Suzuki couplings.

169 o ligases acting sequentially in untemplated amide bond formations using attack of substrate carboxyl

170 nes, which are substrates for chemoselective amide-bond forming reactions with alpha-ketoacids.

171 he colibactin biosynthetic enzyme ClbL is an amide bond-forming enzyme that links aminoketone and bet

172 The scope of isonitrile-mediated amide bond-forming reactions is further explored in this

173 in backbone cleavages mainly occurred at the amide bonds from C-terminal to aspartic acid residues (e

174 ., c(5), ion series of c(29) and c(63)), and amide bonds from C-terminal to glutamic acid residues (e

175 nciples used for decades to make simple C-N (amide) bonds from carboxylic acids with loss of water ca

176 mide isomerization kinetics and isoenergetic amide bond geometries influenced by torsional strain and

177 s are accessible in peptoids featuring trans amide bond geometries.

178 herein explore the role of stereochemistry, amide bond geometry, transannular hydrogen bonding, and

179 e N-CO cleavage catalyzed by Pd(0) utilizing amide bond ground-state destabilization.

180 eplacing the ring-closing ester bond with an amide bond had little or no effect on activity.

181 boxylic acid derivatives with amines to form amide bonds has been the most widely used transformation

182 sts in an extended conformation with a trans amide bond; however, it binds to Hsp90 in a significantl

183 A phosphodiester linkages, but DNA-catalyzed amide bond hydrolysis has been elusive.

184 The mechanism of PBP 5 catalysis of amide bond hydrolysis is initial acylation of an active

185 m N40 or N100 random pools initially seeking amide bond hydrolysis, although they both cleave simple

186 effect of structure on the reversibility of amide bond hydrolysis, which we attributed to the transa

187 ases that use NAD(+)as a co-substrate during amide bond hydrolysis.

188 The catalytic hydrogenolysis of the titanium-amide bond in (eta(5)-C5Me4SiMe3)2Ti(Cl)NH2 to yield fre

189 rt mechanistically describes a new cleavable amide bond in 4-aminopyrazolyloxy acetamide peptide anal

190 dily achieve substantial nonplanarity of the amide bond in a bicyclic lactam framework.

191 ite catalyzes the hydrolytic cleavage of the amide bond in DMF.

192 to a single CPP were carried out through an amide bond in one case and through a triazole linkage ('

193 r linkage on the bead surface but through an amide bond in the bead interior.

194 tate NMR chemical shifts indicate the prolyl amide bond in the pi-clamp motif adopts a 1:1 ratio of t

195 gues have a cis-configuration at the Val-Dil amide bond in their functionally relevant tubulin bound

196 nd amines is highlighted in the synthesis of amide bonds in diverse drug-like molecules (ABNO=9-azabi

197 Remote amide bonds in simple N-acyl amino acid amide or peptide

198 Moreover, we found that the X-Pro amide bonds in the inter-cysteine loop are rigidly const

199 vestigate whether the polypeptide main chain amide bonds in the N-terminus of SDF-1alpha play a role

200 rnalization is dependent upon the main chain amide bonds in the N-terminus of SDF-1alpha.

201 ng a cyclic secondary amine to form the C-28 amide bond increased the metabolic stability of the deri

202 modification alters the conformation of the amide bond, interferes with hydrogen bond formation, and

203 ropose that a structural perturbation of the amide bond is driven by redox-linked electrostatic chang

204 As the NHS or sulfo-NHS group leaves, an amide bond is formed between a free, unprotonated, prima

205 e is cleaved following the threonine, and an amide bond is formed between the threonine and the penta

206 e broken in each of the reactants as the new amide bond is formed.

207 e energy barrier for rotation around the C-N amide bond is lowered by up to 3.6 kcal/mol upon encapsu

208 The amide bond is one of nature's most common functional and

209 de bond and the proclivity of (L)P for a cis-amide bond is sterically driven and can be reversed by s

210 f an amine with a carboxylic acid to form an amide bond is the most popular chemical reaction used fo

211 The formation of amide bonds is a straightforward process: amide bonds ca

212 tionalized graphene (graphene acid = GA) via amide bonds is reported.

213 steric environment surrounding the tertiary amide bonds is the key promoter of conformational prefer

214 Proline amide bond isomerization is the slow step in collagen fo

215 Substantial cis/trans amide bond isomerization, however, gives rise to conform

216 Current methods for constructing amide bonds join amines and carboxylic acids by dehydrat

217 n DNA and RNA templates is shown to catalyze amide bond ligation and controlled bPNA chain extension.

218 zed by an unprecedented alternated cis/trans amide bond linkage.

219 hey are the only enzymes known to cleave the amide bond linking the gamma-carboxylate of glutamate to

220 recently enabled the development of elusive amide bond N-C cross-coupling reactions with organometal

221 Nonetheless, amide bond N-methylations incorporated as post-translati

222 With the surfactants containing an amide bond near the headgroup, the MINPs had a layer of

223 the conventional acylation of amines when an amide bond needs to be formed without going through an a

224 enging due to the intrinsic stability of the amide bond; nevertheless, the ability to reduce highly s

225 proteolytic) cleavages on both disulfide and amide bond of iRGD peptide.

226 e enzyme hydrolytically processes the lactyl amide bond of the 1,6-anhydro-N-acetylmuramyl moiety.

227 the cis and trans isomers of the N-terminal amide bond of the amino acid proline.

228 rogen bonds between the hinge region and the amide bond of the core structure and a hydrogen bond bet

229 a, beta-lactamase enzymes that hydrolyze the amide bond of the four-membered beta-lactam ring are the

230 ase-type mechanism for the hydrolysis of the amide bond of the substrate, N-acetyl- l-aspartate.

231 cis and trans conformations of the backbone amide bonds of peptoids can be significantly populated.

232 addition of trypsin was found to cleave the amide bonds of protein, triggering the dissociation of p

233 pressed in Escherichia coli, form the tandem amide bonds of the dapdiamide scaffold at the expense of

234 ically stable bioisosteres to replace labile amide bonds of the peptide.

235 ndicate the cis conformation of the backbone amide bonds of the peptoids studied is more populated th

236 y to degrade these compounds by cleaving the amide bond or the lactone ring.

237 )-fluoroproline, which favors the native cis amide bond, or the stereoisomeric (2S,4R)-fluoroproline,

238 ls upon nucleophilic addition to the twisted amide bonds present in the lactam precursors.

239 show that the reduced amidicity of aziridine amide bonds provides an entry point for the site-specifi

240 -catalyzed chemistry, but the substrates are amide bonds rather than thioesters.

241 d a direct correlation between the trans/cis amide bond ratio and the enantio- and diastereoselectivi

242 e envisioned that control over the trans/cis amide bond ratio may provide a tool to optimize the cata

243 tumor uptake in vivo in comparison to a (all amide bond) reference compound.

244 t amyloid polypeptide with the Ser-19 Ser-20 amide bond replaced by an ester circumvents these proble

245 nted findings strongly support the classical amide bond resonance model in predicting the properties

246 experimental evidence that N-protonation of amide bonds results in a dramatic increase in nonplanari

247 ct of structural variations on the cis-trans amide bond rotamer equilibria in a selection of monomer

248 Isosteric replacement of amide bond(s) of peptides with surrogate groups is an im

249 ither C-chlorination in acidic conditions or amide bond scission in alkaline conditions.

250 chemical transformations (C-chlorination or amide bond scission) result in an irreversible increase

251 ependent cis/trans isomerization of backbone amide bonds, side chain stereochemistry, and flexibility

252 he ability to achieve full distortion of the amide bond significantly expands the range of reagents a

253 ous report, replacing the ester bond with an amide bond significantly reduces biological activity, an

254 orbital on a positive site to a disulfide or amide bond site and (ii) intermolecular transfer from an

255 the ability to direct the presence of trans-amide bonds specifically at N-aryl positions.

256 educes the rotational barrier about the aryl-amide bond, stabilizing the planar transition state for

257 ne bond strength while diminishing the metal-amide bond strength.

258 ,2,3-triazoles as metabolically stable trans-amide bond surrogates in radiolabeled peptides in order

259 ficient method has been developed for direct amide bond synthesis between carboxylic acids and amines

260 that draws from the same substrates used for amide bond synthesis: amines and carboxylic acids.

261 The activating principles used in amide-bond synthesis can therefore be used, with nickel-

262 genous and exogenous McC7 by hydrolyzing the amide bond that connects the peptide and nucleotide moie

263 bond more readily than the peptide backbone amide bonds that enabled the identification of disulfide

264 o the formation of intra- and intermolecular amide bonds that stabilize the protein structure and imp

265 hat bacillaene is a linear molecule with two amide bonds: the first links an alpha-hydroxy carboxylic

266 hesize a discrete sequence of intramolecular amide bonds, thereby conferring structural stability and

267 s as a tool to enforce the presence of trans-amide bonds, thereby engendering structural stability.

268 cleavage of albicidin at a peptide backbone amide bond, thus abolishing its antimicrobial activity.

269 gh cleavages of the enol double bond and the amide bond, thus furnishing fully substituted 5-isoxazol

270 ino acid peptide that spontaneously forms an amide bond to a protein partner, via reaction between ly

271 th a molecule of aryne by insertion into the amide bond to form a 2,3-dihydroquinolin-4-one, which su

272 dified ITO electrode was accomplished via an amide bond to further enhance red-light-driven, direct e

273 obtained a peptide (SpyTag) which formed an amide bond to its protein partner (SpyCatcher) in minute

274 nerally the case for the analogous secondary amide bond to proline residues in acyclic peptides.

275 re of peptoids, from the conformation of the amide bond to the formation of protein-like tertiary str

276 a nitrone spin trap, 4, that is tethered via amide bonds to a beta-cyclodextrin (beta-CD) and a dodec

277 (ACP) to covalently link fatty acids, via an amide bond, to specific internal lysine residues of the

278 lkylation activates the otherwise unreactive amide bond towards sigma N-C cleavage by switchable coor

279 C(gamma)-exo pucker typically display a high amide bond trans/cis (K(T/C)) ratio.

280 s metabolically stable bioisosteres of trans-amide bonds (triazole scan) was recently applied to the

281 The cleavage of amide bonds under mild acidic conditions is a rare chemi

282 Novel methodology for the formation of amide bonds under neutral conditions is described.

283 The construction of amide bonds using available methods relies principally o

284 e of their cylindrical shape and established amide bond vibrations.

285 the Phe(3) side chain flexibility, the final amide bond was N-methylated and Phe(3) was replaced by a

286 Further investigation revealed that the amide bond was the source for the poor blood stability o

287 Chemical bioisosteres of amide bonds were explored to improve cell-based potency.

288 The amide bonds were replaced with triazole rings, and alpha

289 yzes the phosphorylation of peptide backbone amide bonds, which leads to the formation of azolines an

290 function on a substrate with a multitude of amide bonds, which may be expected to inhibit a hydrogen

291 y occupied orbitals in multiple, consecutive amide bonds, which may by separated by one to three meth

292 e identified by modification of two or three amide bonds, which yielded both improved stability and i

293 Tag is a peptide that spontaneously forms an amide bond with its protein partner SpyCatcher.

294 SpyTag is a peptide that forms a spontaneous amide bond with its protein partner SpyCatcher.

295 Moreover, one-step construction of imide and amide bonds with a long-chain alkyl group is an attracti

296 An amine-containing PS forms amide bonds with peptidic cargo, a thiol derivative is d

297 The enzyme CapD generates amide bonds with peptidoglycan cross-bridges to anchor c

298 poly-gamma-D-glutamate capsule and generates amide bonds with peptidoglycan cross-bridges to deposit

299 dified with amines to give chemically stable amide bonds without installation of pH-dependent feature

300 proceeds in aqueous buffer to afford native amide bonds without the use of additives.