ライフサイエンスコーパス: amidine

1 ance stabilized iminoquinone (i.e., extended amidine).

2 cyclization to form the corresponding cyclic amidine.

3 ylamide are good alternatives for the second amidine.

4 f the second generation PAD inhibitor, BB-Cl-amidine.

5 sosteres for the parent pan PAD inhibitor Cl-amidine.

6 oduce five-, six-, and seven-membered cyclic amidines.

7 robic [3+2]-annulation reaction of N-alkenyl amidines.

8 ore the remarkable behavior of the residue 4 amidines.

9 pre-organized for a fit to the heterocyclic amidines.

10 e reduced binding to DNA relative to similar amidines.

11 ial relationship with the groove relative to amidines.

12 azoles in the preparation of polysubstituted amidines.

13 azole-biphenyl isomers with terminal charged amidines.

14 hesize 1,3,5-trizines from acetophenones and amidines.

15 d sulfonamide enables efficient synthesis of amidines.

16 For example, proline ester amidine 1 is converted to 2-arylpyrrolidine 3 in the pre

17 Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. r

18 le cycloaddition rates and efficiencies with amidines (1,2,3,5-tetrazine/amidine ligation).

19 % yields in two steps from the corresponding amidines 2.

20 Diamidine 1 and di( N-isopropyl)amidine 45, administered at 4 x 1 mg/kg, exhibited poten

21 Amidine 6 and guanidine 7 were comparably effective agai

22 nzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields.

23 Amidines (8, 13) had greatest selectivity for the kappa

24 ifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd(2)(dba)(3) and Xantphos, foll

25 2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a PAD4 inactivator with enhanced potency.

26 2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a recently described pan-PAD inhibitor, could

27 that inhibition of PAD enzyme activity by Cl-amidine, a pan-PAD inhibitor, blocks NLRP3 inflammasome

28 We recently found that Cl-amidine, a peptidylarginine deiminase (PAD) inhibitor, i

29 ted for 11 weeks with daily injections of Cl-amidine, a peptidylarginine deiminase inhibitor.

30 rted the synthesis and characterization of F-amidine, a potent and bioavailable irreversible inactiva

31 h increased concentrations (0-800 muM) of Cl-amidine, a specific PAD inhibitor.

32 In the case of the pyrrolidine-derived amidines, about 25% of the decomposition results in clea

33 transformation of the 5-cyano group into an amidine allows synthesis of 2,5-terpyrimidinylenes with

34 potent PAD4 inhibitors, we show here that Cl-amidine also exhibits a strong inhibitory effect against

35 Tertiary amidines also produce nitrosamines in minor, but signifi

36 ion in group 3 metal (Y and Sc) complexes of amidine-amidopyridinate ligands.

37 NZM mice were treated with Cl-amidine, an inhibitor of peptidylarginine deiminases (PA

38 f mechanistic studies of NOS inactivation by amidine analogues of l-arginine and other previous mecha

39 affinities for related amidine and reversed amidine analogues.

40 We confirmed survival-improving effect of Cl-amidine and are the first to explore the role of Cl-amid

41 investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus

42 ir assessment indicates that combined pocket amidine and CBP peripherally modified analogues exhibit

43 novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the go

44 In this respect, amidine and guanidine derived catalysts have been shown

45 of the literature on the N-arylation of the amidine and guanidine functionalities.

46 Importantly, PAD4 inhibitor Cl-amidine and HDAC inhibitor suberoylanilide hydroxamic ac

47 zed oxidative cyclization of 2-aminopyridine/amidine and isothiocyanate via N-S bond formation at amb

48 ICs = 0.06-0.005 and 0.5-0.06 mug/mL for the amidine and methylene analogues, respectively) and likel

49 phase behavior and microstructure of diC(14)-amidine and of the lipid/DNA (circular plasmid, 5.4 kb)

50 omplexes or Ti(NMe2)4, promotes formation of amidine and oxotitanium products.

51 cin stems from its unprecedented macrocyclic amidine and rare beta-methylated amino acid residues.

52 ifferences in binding affinities for related amidine and reversed amidine analogues.

53 etic compounds containing the core residue 4 amidine and thioamide modifications are reported.

54 m exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their pe

55 ssover reactivities (1,2,4,5-tetrazines with amidines and 1,2,3,5-tetrazines with strained dienophile

56 , mainly been exploited for the synthesis of amidines and amidine-containing heterocycles.

57 specific review covering the N-arylation of amidines and guanidines appeared.

58 Amidines and guanidines are considered as fundamental en

59 Amidines and guanidines are often only thought of as str

60 An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed.

61 to the formation of the corresponding cyclic amidines and guanidines, typically in good to excellent

62 he first time the development of phosphonate amidines and sulfonate amidines as isosteres of pArg and

63 riles (YMs) react with amines to form cyclic amidines and that the starting linear YMs are nonemissiv

64 gnificant difference in the positions of the amidines and their DNA interaction strength.

65 emonstrated by 33 examples with a variety of amidines and three different 4H-pyrido[1,3]oxazin-4-one

66 multicomponent synthesis of pyrimidines from amidines and up to three (different) alcohols.

67 ion with substituents between the vinylogous amidine, and hydrolytic properties that can be controlle

68 mall molecules and macromolecules containing amidine, and to a lesser extent, guanidine functional gr

69 vided by a benzimidazole (or indole) -NH and amidines, and (iii) appropriate curvature of the dimer c

70 d from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines.

71 ored with the synthesis of series of amides, amidines, and ureas.

72 al proteins observed in mice treated with Cl-amidine are consistent with the notion that Cl-amidine d

73 Direct synthetic routes to amidines are desired, as they are widely present in many

74 s are nonemissive in solution and the cyclic amidines are fluorescent.

75 Both amidines are positively charged under experimental condi

76 These diazeniumdiolated amidines are shown to be useful NO donor compounds which

77 These compounds, denoted F4- and Cl4-amidine, are the most potent PAD3 inhibitors ever descri

78 The amidine arylation method was found applicable for the sy

79 opment of phosphonate amidines and sulfonate amidines as isosteres of pArg and then use these mimics

80 The manifold uses amidines as the nitrogen source and activated skipped di

81 oxylation step during inactivation of NOS by amidines as well as the HO-catalyzed reaction, the essen

82 interaction of a key compound, which has the amidine at the phenyl shifted from the para position in

83 itively charged group such as an amine or an amidine at this position results in improved affinity fo

84 ensation of 4H-pyrido[1,3]oxazin-4-ones with amidines at room temperature or under microwave irradiat

85 rom PFAA-enamine cycloadditions rearrange to amidines at room temperature, while (3 + 2) cycloadditio

86 In contrast, Cl-amidine attenuated these CLP and lipopolysaccharide-indu

87 col substituted phthalocyanines utilizing an amidine-base-promoted phthalonitrile tetramerization rea

88 inal domain of apoE4 and identified a benzyl amidine based fragment binder.

89 The highly Lewis basic amidine-based catalyst DHIP promotes the rearrangement o

90 : enantioselective acyl transfer promoted by amidine-based catalysts (ABCs) and a racemic chain mecha

91 Amidine-based catalysts (ABCs), a new class of enantiose

92 Asymmetric N-acylation promoted by amidine-based catalysts, particularly Cl-PIQ 2 and BTM 3

93 r to the previously published structures for amidine-based inhibitors complexed with factor Xa.

94 to the discovery of a novel series of cyclic amidine-based inhibitors of beta-secretase (BACE-1).

95 and derived from a series of guanidine- and amidine-based inhibitors.

96 We report here a new class of amidine-based sphingosine analogues that are competitive

97 organo-catalyst compared with guanidine and amidine bases.

98 ed from (3 to 106) x 10(-5) s(-1), while the amidine basicity ranged over 5 pK(a) units.

99 Rate constants corrected for amidine basicity showed the pyrrolidine derived amidines

100 Compounds with linked, one or two amidine-benzimidazole-phenyl (ABP) motifs were designed,

101 Four crystal structures of diverse amidines binding in the active site are deposited and di

102 The next generation of flexible bis(amidine)/bis(amidinate) platforms with up to six N-donor

103 oroaryl ring, and a phenyl ring linked by an amidine bond, were efficiently synthesized by a straight

104 conformer relative to rotation about the P-C(amidine)() bond; however, DFT calculations indicate a lo

105 a new, practical, and direct route to N-acyl amidines but also represents a new type of C-N bond form

106 containing natural products are converted to amidines by a C-H amination-oxidation sequence or to hyd

107 constitutes a bioorthogonal approach toward amidines by avoiding the use of amines and transition-me

108 o radius of curvature from amidine carbon to amidine carbon but a significant dihedral twist across t

109 ives for targeting the minor groove have the amidine carbon linked to a central heterocyclic system,

110 mpounds have a zero radius of curvature from amidine carbon to amidine carbon but a significant dihed

111 bstrate by hydrogen atom abstraction from an amidine carbon, the 5'-deoxyadenosyl radical abstracts h

112 en atom that had migrated from the substrate amidine carbon.

113 is their ability to carry out methylation of amidine carbons of the adenosine substrate.

114 An amidine-carboxylic acid interface is observed for electr

115 orin associated to NI are consistent with an amidine-carboxylic acid interface, which is also verifie

116 n transfer (PCET) through well-characterized amidine-carboxylic acid interfaces.

117 oton to the carboxylate to form a nonionized amidine-carboxylic acid two-point hydrogen network, wher

118 e diphenyl ether core that is flanked by the amidine cations.

119 ne) (14), has been reported to give a cyclic amidine complex when treated with 2 equiv of 2,6-dimethy

120 compounds, biphenyl tetrazole tert-butyl Cl-amidine (compound 13), exhibits enhanced cell killing in

121 Many dicationic amidine compounds bind in the DNA minor groove and have

122 n 40 aglaroxin C analogues utilizing various amidine condensation partners.

123 ation of peptide sequence dependence of this amidine conjugation reveals a tripeptide tag CIS that al

124 , reflecting the extent of vinylogous amide (amidine) conjugation.

125 A number of novel amidine containing heterocycles were designed to reprodu

126 Amidines containing more than one replaceable hydrogen p

127 ly observed for iNOS inactivation by another amidine-containing compound, N5-(1-iminoethyl)-L-ornithi

128 exploited for the synthesis of amidines and amidine-containing heterocycles.

129 These cyclic amidines could be converted into mono-benzyl-protected v

130 d on the basis of the N'-(4-halopyrazol-5-yl)amidine cyclization under the conditions of copper-catal

131 Surprisingly, unlike the amidine derivative, the pyrrole -NH of DB884 formed an H

132 In all cases, six-membered amidine derivatives 1 showed higher barriers than the co

133 or the preparation of alpha,beta-unsaturated amidine derivatives appears to offer high yield, mild co

134 Amidine derivatives for targeting the minor groove have

135 For the direct synthesis of N-benzoyl amidine derivatives from aromatic dioxazolones, [Cu(OAc)

136 mechanisms of decomposition of guanidine and amidine derivatives in aqueous solution and the rate enh

137 ic guanidine, N-alkylguanidine, and reversed amidine derivatives of fused ring systems have been synt

138 d provides authentic residue 4 thioamide and amidine derivatives of the vancomycin aglycon that will

139 idine are consistent with the notion that Cl-amidine derives its efficacy from its ability to inhibit

140 would be transformed into superelectrophilic amidine dications.

141 Importantly, the amidines display effective dual, balanced binding affini

142 ional bonding overlaps in the HOMO, and this amidine effect predicts lower N-inversion barriers in an

143 l-N'-tetradecylamino-propionamidine (diC(14)-amidine), efficiently ports DNA into mammalian cells in

144 Compound 1 was the first non-amidine factor Xa inhibitor from our lab that had measur

145 h possesses the ethylene tether and extended amidine feature found in the pyrroloiminoquinone natural

146 we show the versatility of these vinylogous amidines for organic synthesis, including the following:

147 Hexadentate bis(amidines) form versatile networks of hydrogen bonds both

148 Competitive amidine formation and transamidation are observed with C

149 yield, presumably via novel Sn (IV)-mediated amidine formation from the initial aniline reduction pro

150 ary carboxamides exhibit different outcomes, amidine formation versus transamidation, depending on th

151 d with Cp*TiIV complexes, generally favoring amidine formation.

152 cules exist as zwitterions with a protonated amidine fragment of the eight-membered ring neutralizing

153 diamine tautomer of a variety of substituted amidine free bases reacts with nitric oxide (NO) to prod

154 ecarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides at

155 vestigation revealed that the in situ formed amidines from the coupling of benzylamines and nitriles

156 ystal, a solution of inhibitor containing an amidine functional group on a naphthalene ring was added

157 yclic rings to iminoquinones with vinylogous amidine functionality.

158 Acid-catalyzed loss of an amidine gave the final aromatic product.

159 y accessible 1,4,2-dioxazol-5-ones to N-acyl amidines, generating CO(2) as the only byproduct.

160 lation, which liberates the desired sulfonyl amidines, generating N2 and CO2 as the only reaction byp

161 ion of a hydroxyl group para to the proximal amidine group increases the potency vs fXa by 1-2 orders

162 ne nitroxides bearing an N',N'-disubstituted amidine group is reported.

163 te that substitution of the thiourea with an amidine group leads to greatly enhanced cytotoxicity in

164 Certain exogenous nucleobases that share the amidine group of adenine restored activity to abasic rib

165 ural and biochemical evidence implicated the amidine group of an active site adenosine, A38, in a pH-

166 The amidine group of PNAAN can be protonated into a hydrophi

167 f either carboxylic acid ligands through the amidine group or pyridine-type ligands through the Zn(II

168 interaction and a replacement for the distal amidine group that binds in the S3/S4 pocket of fXa.

169 terminal phenyl substituent on the reversed amidine groups as critical components in the strong bind

170 he new synthetic compounds have two aromatic-amidine groups for A/T recognition, and these are connec

171 The amidine groups in the dimer are oriented in the 5' direc

172 In the presence of dCO2, the amidine groups in the NAEAA block protonate and convert

173 ements indicate that the position of the two amidine groups on the carbazole ring influences signific

174 acrylamide), or P(DMA-co-NAEAA), containing amidine groups was synthesized.

175 as well as the nature of substituents on the amidine groups.

176 This tutorial review highlights the use of amidine, guanidine, and related isothiourea catalysts in

177 wis pair catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lew

178 l review is largely organized by the type of amidine/guanidine and transition metal used and covers l

179 ll nitrogen bases: nitriles, azoles, azines, amidines, guanidines, vinamidines, biguanides, and phosp

180 For cyclic amidines/guanidines only systems which possess an exocyc

181 BB-Cl-amidine had a pro-apoptotic effect on all Th subsets in

182 ns, but the linking group for the two phenyl amidines has a pK(a) of 6.3 that is susceptible to a pro

183 ethod for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aer

184 ne-pot domino reaction of 1,2-diketones with amidines has been identified that enables their transfor

185 Tethered tetradentate bis(amidines) have emerged in coordination chemistry, enanti

186 ies of benzimidazole-based derivatives of Cl-amidine, hypothesizing that this scaffold would allow ac

187 the enzyme-bound structure of ZK-816042, an amidine-imidazoline inhibitor of human factor Xa (FXa).

188 Following the same one-pot procedure, amidine imides react with the sulfur ylides to provide i

189 and are the first to explore the role of Cl-amidine in immune response.

190 ile MeCN was used in the formation of N-aryl amidines in moderate to high yield.

191 lts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free con

192 N-Acyl amidines in particular can be used as a starting materia

193 , a third mechanism is proposed in which the amidine inactivators of iNOS bind as does substrate L-ar

194 Moreover, Cl-amidine increased circulating monocytes.

195 Further, Cl-amidine increased the differentiation capacity of bone m

196 steric and leaving group requirements for F-amidine-induced PAD4 inactivation, the structure of the

197 boratory has developed a series of novel non-amidine inhibitors of factor Xa.

198 alogue 2 can be used when the product cyclic amidine is organic-soluble, thus producing water-soluble

199 bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr.SMe(2)/2,2'

200 reaction for the conversion of thioamides to amidines is disclosed.

201 most potent PAD4 inhibitors (i.e., F- and Cl-amidine) known to date.

202 The amidine labels also promote specific fragmentation pathw

203 echanisms of hydrogen exchange in amides and amidines led to the influence of hydrogen bonding and to

204 y a direct reaction between Ca metal and the amidine ligands in the presence of ammonia.

205 fficiencies with amidines (1,2,3,5-tetrazine/amidine ligation).

206 Proteolysis is the action of an amidine lyase (EC 4.3.2).

207 Cl-amidine may represent a novel class of disease-modifying

208 (2) abstraction of a hydrogen atom from the amidine methyl group followed by attachment to the heme

209 oes substrate L-arginine, but because of the amidine methyl group, the heme peroxy intermediate canno

210 etween the electronegative tip and guanidine-amidine moiety extends the conjugation and facilitates n

211 mical and structural analyses pinpointed the amidine moiety of base Ade38 as a key functional group i

212 the introduction of fluorine adjacent to the amidine moiety, resulting in in vivo brain reduction of

213 uent with the formally sp(2) nitrogen in the amidine moiety.

214 g at different sites of a (Zn)phthalocyanine-amidine molecule (Pc1), enables the dissociation of the

215 rd the Ala190 enzymes is observed due to the amidine N1 nitrogen of the bound inhibitor being deprive

216 0 or Ala190 enzymes, hydrogen bonds with the amidine N1 nitrogen of the inhibitor.

217 The conjugate containing an amidine-NH donor group cis to the chloride leaving group

218 stem, whereas in the reverse orientation, an amidine nitrogen provides the link.

219 Pseudo-first-order rate constants for amidine nitrosation in aqueous acetic acid with excess n

220 involved water-mediated H-bonds between one amidine of the compound and DNA bases at the floor of th

221 ran that, when amplified out to the terminal amidines of the benzimidazole compounds, yields a very s

222 ty by treating mice in the CIA model with Cl-amidine on days 0-35.

223 rvival, focusing on protective effects of Cl-amidine on immune response.

224 cooperative dimer to form but removal of one amidine or addition of an alkyl group to the amidine str

225 It was also demonstrated that the required amidine or iminocarbamate directing group fulfills two m

226 cribed here was the discovery of a novel bis(amidine) organocatalyst that provides high enantioselect

227 Two novel mono(amidine) organocatalysts (MAM) were discovered to provid

228 mpared with 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater r

229 Even at 25% of the initial dose of amidine-oxime (i.e., a dose of 36 mumol/kg, i.p.), 7b an

230 Amidine-oxime reactivation rates for OP-inactivated acet

231 A new class of amidine-oxime reactivators of organophosphate (OP)-inhib

232 hat caused lethality in 6/11 animals without amidine-oxime.

233 t (i.e., 5 min after OP exposure, i.p,) with amidine oximes 7a-c and 12a, 12c, 12e, 12f, and 15b (145

234 Amidine-oximes were tested in vitro, and reactivation ra

235 Amidine-oximes were tested in vivo for protection agains

236 istry of nine acyclic secondary and tertiary amidines (Ph-N=C(R(1))NR(2)R(3); R(1) = H, CH(3), Ph; R(

237 be lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 a

238 The nitro- or cyano-substituted guanidine/amidine planes of the neonicotinoids provide a unique el

239 Collectively, our results demonstrate Cl-amidine plays protective roles by significantly decreasi

240 iminium ion generated from alpha-(phenylthio)amidine precursor 16 by reaction with Cu(OTf)(2) undergo

241 conjugation of novel alpha,beta-unsaturated amidine precursors with proteins, methylarginine mimics

242 In the present study we investigated how Cl-amidine promotes survival, focusing on protective effect

243 g addition and intramolecular cyclization of amidine pronucleophiles on arylpropiolates.

244 ible region upon alteration of the amidinium/amidine protonation state; no such change is observed fo

245 yano group and replacement of guanidine with amidine, pyrimidine, pyridine, or the imidazole moieties

246 PAD4 inhibition by Cl-amidine reduced NETting neutrophils and rescued wound he

247 Treatment with the PAD inhibitor, Cl-amidine, reduced the abundance of deiminated-histone 3,

248 ycloaddition (C4/N1 vs C5/N2) as well as the amidine regioselectivity were unaffected by introduction

249 ve reaction pathway leading to an N-terminal amidine rendering the side chain thiol available for fur

250 The acyl amidine represented by the 4,5-dihydro-2(3H)-pyrazinone

251 at both the N-terminus and C-terminus of Cl-amidine result in >100-fold increases in PAD2 potency an

252 HCl to alkenylaldimines, -formamidines, and -amidines results in the protonation of the sp2-nitrogen

253 acts as a nucleophile to promote the cyclic amidine ring opening.

254 cant dihedral twist across the tricyclic and amidine-ring junctions.

255 Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated a

256 The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupl

257 Diverse heterocyclic amidines, several of which are known to be poorly reacti

258 Because of the large dihedral, the reversed amidines should have reduced binding to DNA relative to

259 ion revealed a novel rearrangement affording amidines, specifically compound 45, which was found to p

260 amidine or addition of an alkyl group to the amidine strongly inhibited dimer formation.

261 The amidine structural motif within each core forms a bident

262 was found to be modulated by the location of amidine substituents on the core phenyl-furan-phenyl rin

263 iplets, along with proper positioning of its amidine substituents to occupy the minor and the major-m

264 heterocyclic cations, a series of "reversed amidine" substituted heterocycles has been prepared.

265 A detailed study of amidine synthesis from N-allyl-N-sulfonyl ynamides is de

266 ) catalyzes the ring opening of the bicyclic amidine system of DBU (1,8-diazabicyclo[5.4.0]undec-7-en

267 ly one amino-pyrrole-carboxamide unit and an amidine tail is connected to either side of a central di

268 Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstit

269 benzimidazole-biphenyl system with terminal amidines that gives the compound a linear conformation w

270 benzimidazole-biphenyl system with terminal amidines that results in a linear conformation that does

271 of vancomycin aglycon residue 4 substituted amidines that were used to clarify their interaction wit

272 s from the arthritic mice treated with BB-Cl-amidine, there was a decrease in total cell numbers but

273 dine basicity showed the pyrrolidine derived amidines to be most reactive.

274 Conversion of the amidines to guanidinium groups does permit the cooperati

275 C3 deposition were significantly lower in Cl-amidine-treated mice compared with vehicle controls.

276 Cl-amidine treatment had no ameliorative effect on collagen

277 Moreover, BB-Cl-amidine treatment induced a shift from Th1 to Th2 cytoki

278 Cl-amidine treatment inhibited NZM NET formation in vivo an

279 In the pancreas, BB-Cl-amidine treatment preserved insulin production and was a

280 Cl-amidine treatment reduced total synovial and serum citru

281 ymes mediating citrullination, through BB-Cl-amidine treatment, prevents diabetes development in NOD

282 Cl-amidine treatments inhibited deimination in a dose-depen

283 These results demonstrated that Cl-amidine treatments slow down cornification and alter aut

284 The two most potent fragments exhibiting an amidine-type scaffold are not the most enthalpic binders

285 be excellent reagents for the preparation of amidines under mild reaction conditions.

286 roach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediat

287 -haloenones with 1,3-dicarbonyl compounds or amidines utilizing K2CO3/DMSO at ambient temperature tha

288 The reaction proceeds by dual acylation of amidines via oxidative C(CO)-C(CO) bond cleavage of 1,2-

289 At 800 muM , Cl-amidine was shown to reduce deimination by half, alter k

290 simple protocol, a diverse range of sulfonyl amidines was obtained in moderate to excellent yields.

291 d a highly functionalized and chiral primary amidine, which forms the pyrimidine cores and introduces

292 tion of the mechanism of NOS inactivation by amidines, which leads to heme degradation, also provides

293 de reaction of A(3)-coupling of heterocyclic amidine with aldehyde and alkyne, 5-exo-dig cycloisomeri

294 finity of compounds containing the residue 4 amidine with the model D-Ala-D-Ala ligand 2 was found to

295 -3-ones, available from cyclocondensation of amidines with dimethyl acetylenedicarboxylate (DMAD), un

296 Condensation of amidines with readily prepared alpha,beta-unsaturated al

297 D4 inactivation, the structure of the PAD4-F-amidine x calcium complex, and in vivo studies with N-al

298 he aforementioned dimer is assembled by dual amidine-Zn(II) coordination between neighboring Pc1 mole

299 and idazoxan produced monodiazeniumdiolated amidine zwitterions from which NO release was observed f

300 the preparation of the monodiazeniumdiolated amidine zwitterions.