ライフサイエンスコーパス: amination

1 or a nitrogen-based fragment (aziridination, amination).

2 ed through a sequential cyclopropanation/oxo-amination.

3 yridine inhibition effect on the rate of C-H amination.

4 eutical industry are performed via reductive amination.

5 excess azide, inhibiting any subsequent C-H amination.

6 ion and transition-metal-catalyzed arene C-H amination.

7 C-N bond forming dearomatization or aryl C-H amination.

8 d by an intramolecular Pd-catalyzed aromatic amination.

9 es C) and a similar reactor setup as for the amination.

10 nic acids, leading to chemoselective primary amination.

11 lysis rather than the expected deoxygenative amination.

12 ic process for enantioconvergent radical C-H amination.

13 o group at C-7 for conjugation via reductive amination.

14 id-phase peptide synthesis through reductive amination.

15 lled fashion between C-H oxygenation and C-H amination.

16 xidase catalyzing direct, intermolecular C-H amination.

17 ise radical pathway for the Co(II)-based C-H amination.

18 ohols via a silver-catalyzed propargylic C-H amination.

19 at their free reducing terminus by reductive amination.

20 beta-amines by enantioselective, radical C-H amination.

21 itosan by Schiff base reaction and reductive amination.

22 termolecular-intramolecular Buchwald-Hartwig amination.

23 to quantum tunneling during interstitial C-H amination.

24 substances that are synthesized by reductive amination.

25 fford diazatetracenes using Buchwald-Hartwig aminations.

26 e need for metal-catalysed abiotic reductive aminations.

27 o2 (mu-NH2 )(PMe3 )2 ](3+) (n=2, 3), and C-H amination [((3) PDI2 *-mu-NH)Co2 (PMe3 )2 ](3+) products

28 f tertiary alkylamines is carbonyl reductive amination(3), which comprises two elementary steps: the

29 l%) to form the branched products of allylic amination 4a-4l and 5a-5l, respectively, as single regio

30 y acetate ligand-assisted intramolecular C-H amination.a This reaction is high-yielding and straightf

31 ased variants with dramatically enhanced C-H amination activity acquired through disruption of the na

32 nce is applied to the enantioselective alpha-amination, aldol, and alpha-aminoxylation/alpha-hydroxya

33 Enantioselective C(sp(3))-H aminations allow an efficient access to nonracemic chira

34 s in carbon-nitrogen bond-forming reactions (amination, amidation, nitration and nitrosation) that in

35 for further functionalization via reductive amination, amidation, or other chemistry.

36 copper nitrene species competent for alkane amination and alkene aziridination, lending further cred

37 for visible-light-activated asymmetric alpha-amination and alpha-alkylation, respectively, of 2-acyl

38 and antidepressant sertraline by late-stage amination and azidation reactions.

39 reagent are supported by intermolecular C-H amination and aziridination reactivities.

40 reactivity was successfully explored by C-H amination and borylation reactions, although C-H fluorin

41 yurethane oligomers via sequential reductive amination and carbamation.

42 lly useful transformations, including olefin amination and directed carbon-hydrogen (C-H) bond functi

43 tifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl

44 Meta-C-H amination and meta-C-H alkynylation using a modified nor

45 substrates are compatible with both meta-C-H amination and meta-C-H alkynylation.

46 '-tetranitro-2H,2'H-3,3'-bipyrazole (4) by N-amination and N-azo coupling reactions is described.

47 been designed and synthesized using Buchwald amination and oxidative homocoupling as key steps.

48 rocarbazolone core via a palladium-catalyzed amination and oxidative indole formation.

49 through concurrent Pd(II)(SOX) catalyzed C-H amination and Pd(0)(SOX) catalyzed isomerization cycles.

50 file the conditions for the Buchwald-Hartwig amination and rapidly identify bespoke conditions for ch

51 ivatives using copper-catalyzed azidation or amination and reductive alkylation of benzylazide by a h

52 onalization, transimination, ortho-selective amination, and a cyclization sequence.

53 uoromethanesulfonate promoted intramolecular amination, and a diastereoselective epoxidation that sim

54 ene (NBE-CO2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized

55 ersion of alcohols to imidates, directed C-H amination, and hydrolysis to NH2).

56 f the heterotricyclic core, an electrophilic amination, and the stereoselective hydrogenation of a te

57 nitrenoids that participate in catalytic C-H amination, and we characterize these transient intermedi

58 functionalizations that lead to oxidations, aminations, and halogenations are also presented.

59 A unique alpha-amination approach using various anilines has been devel

60 The products from C-H amination are formed in up to 98% yield and approximatel

61 In general, reductive aminations are challenging processes, especially for the

62 g commercial medicines and by the late-stage amination-aromatization of natural products, steroids an

63 harnessed this novel radical strain-release amination as part of a multicomponent cascade compatible

64 lude a sterically demanding Buchwald-Hartwig amination as well as a unique C(sp(3) )-H amination/indo

65 NNRTI relies on two sequential Pd-catalyzed aminations as the key steps.

66 protonation at C6 followed by regioselective amination at C5 with a variety of primary and secondary

67 te initiates an intramolecular, benzylic C-H amination at room temperature, chemical reduction of ((t

68 uses a robustly diastereoselective reductive amination/aza-Michael reaction sequence to achieve rapid

69 e and sodium cyanoborohydride, the reductive amination-based method can be utilized to generate novel

70 mega-TA) is an ideal catalyst for asymmetric amination because of its excellent enantioselectivity an

71 Schwartz's reagent), followed by a reductive amination between the resulting hemiaminal and primary o

72 y ferrous hydroxides did not drive reductive amination but instead promoted pyruvate reduction to lac

73 Strain-release amination can diversify a range of substrates with a mul

74 diazonium salt with nitrile, which undergoes amination/cascade cyclization/aromatization, leading to

75 marily assimilated ammonia through reductive amination catalyzed by glutamate dehydrogenase (GDH); se

76 Reductive amination chemistry was used to synthesize all possible

77 The amination chemoselectivity was examined using substrates

78 The catalytic amination conditions are mild, requiring 0.1-2 mol% cata

79 Reductive aminations constitute an important class of reactions wi

80 family, was accessed through electrochemical amination, Cu-mediated aziridine opening, and a remarkab

81 The amination cyclization reaction mechanism was examined em

82 ted one-pot successive base-mediated allylic amination/cycloisomerization reaction strategy has been

83 The asymmetric ruthenium-catalyzed reductive amination employing ammonia and hydrogen to primary amin

84 we summarize the work published on reductive amination employing hydrogen as the reducing agent.

85 his multi-catalytic, asymmetric, radical C-H amination enabled broad access to chiral beta-amino alco

86 AC-assisted Ni-catalyzed amination, etherification, and esterification of aromati

87 ght across a wide range of substrates in the amination, etherification, and esterification of aryl br

88 te influence the site-selectivity of the C-H amination event.

89 hydrogen-atom transfer (HAT) during the C-H amination event.

90 bromoterephthalonitrile via Buchwald-Hartwig amination followed by an acid-mediated cyclization to fu

91 ouble functionalization via an electrophilic amination followed by nucleophilic trapping.

92 This catalytic amination follows an unprecedented metalloradical activa

93 e, we present a mild dirhodium-catalyzed C-H amination for conversion of structurally diverse monocyc

94 benzene (PIDA)-mediated direct oxidative C-H amination for the synthesis of 3-amino substituted imida

95 l-group compatibility of electrochemical C-H amination, for example, tolerating electron-rich aromati

96 mines based on a palladium-catalyzed allylic amination has been developed.

97 essful realization of a 'carbonyl alkylative amination' has not yet been achieved.

98 ng with one or the other aspect of reductive amination have appeared.

99 termediates that mediate Rh(2)-catalyzed C-H amination have eluded characterization for more than 40

100 n account of the development of the Chan-Lam amination, highlighting progress and notable examples of

101 sin II receptor) through copper-mediated C-H amination, hydroxylation, thiolation, arylation, and tri

102 n aldehyde-active solid support by reductive amination; (ii) stabilization of fragile sialic acids by

103 sm for hydroamination occurring by oxidative amination in concert with reduction of the resulting imi

104 odate, and conjugated to CRM197 by reductive amination in dimethyl sulfoxide.

105 hydrothermal systems, can undergo reductive amination in the presence of mixed-valence iron oxyhydro

106 mplexes are generally poor catalysts for C-H amination: in this catalyst, the enzyme's protein framew

107 In addition, mechanisms of reductive aminations including selective formation of desired amin

108 ig amination as well as a unique C(sp(3) )-H amination/indole formation.

109 Arene amination is achieved by site-selective C-H zincation fo

110 and selectivity of the Co(II)-catalyzed C-H amination is attributed to its underlying stepwise radic

111 Allylic C-H amination is currently accomplished with (sulfon)amides

112 first time, therefore, the Buchwald-Hartwig amination is described to occur inside the highly comple

113 The chemoselectivity for C-H bond amination is greater than 20:1 in all cases.

114 Dirhodium-catalyzed C-H amination is hypothesized to proceed via Rh2-nitrene int

115 The reductive amination is impressive with regard to the product scope

116 Reductive amination is one of the most important methods for the s

117 ctivity of this imine chaperone-mediated C-H amination is presented herein.

118 HAT is rate-limiting, whereas intramolecular amination is product- and stereo-determining.

119 ased on mechanistic studies, the present oxo-amination is proposed to proceed through an S(N)2-like n

120 A silver-catalyzed amination is reported that occurs at the aliphatic C3-su

121 Unlike in bacteria, where amination is the last step in RQ biosynthesis, in worms

122 o-4-methylpentyl)benzene, intramolecular C-H amination kinetically outcompetes formation of the corre

123 ediates support a dynamic kinetic asymmetric amination mechanism based on the labilization of the ste

124 In contrast to the previously reported C-H amination mediated by ((Ar)L)Co(NR) ((Ar)L = 5-mesityl-1

125 We report the catalytic C-H amination mediated by an isolable Co(III) imido complex

126 This Synopsis presents recent amination methods using nitrogen-heteroatom bonds as a p

127 bilized glycoproteins on resin via reductive amination, modified alpha2,6-linked sialic acids through

128 amine moieties, regio- and enantioselective amination occurs with complete site-selectivity to furni

129 or intramolecular denitrogenative C(sp(3))-H amination of 1,2,3,4-tetrazoles bearing unactivated prim

130 A detailed kinetic study for C(sp(3))-H amination of 1-azido-4-phenylbutane (S1) revealed zero o

131 An enantioselective ring-closing C(sp(3) )-H amination of 2-azidoacetamides is catalyzed by a chiral-

132 loride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported.

133 lowed by mixed copper-copper oxide-catalyzed amination of 4-bromophthalazin-1(2H)-ones 4 with primary

134 ronic state (GES), redox potentials, and C-H amination of [Rh2(II,III)(O2CCH3)4(L)n](+) (1_L) (L = no

135 ituted N-heterocycles via intramolecular C-H amination of a range of C-H bonds, including primary C-H

136 zed the challenging intramolecular sp(3) C-H amination of a series of alkyl azides to afford alpha-su

137 A radical-mediated strategy for beta C-H amination of alcohols has been developed.

138 catalyzed approaches for the directed remote amination of alcohols have been well established.

139 fically, the enantio- and regioselective C-H amination of alcohols to access medicinally valuable chi

140 as found to be uniquely suited to effect C-H amination of alcohols via an in situ generated hemiamina

141 ed as new powerful tools for directed remote amination of alcohols.

142 the development of a new metal-free allylic amination of alkenes that allows the introduction of a w

143 he wavelength filters used demonstrates that amination of all linkers of the MOF is not required to o

144 sfully demonstrated using the example of the amination of allyl alcohol.

145 etalloradical system features chemoselective amination of allylic C-H bonds and is compatible with he

146 Herein, we present a stereoselective alpha-amination of amides employing simple azides that proceed

147 Copper-mediated direct ortho-C-H amination of arenes has been accomplished with the aid o

148 The direct catalytic C-H amination of arenes is a powerful synthetic strategy wit

149 for the direct stoichiometric electrophilic amination of aromatic hydrocarbons and the Schmidt react

150 Attempted electrophilic amination of aromatics such as benzene and toluene with

151 e reaction conditions for the Chan-Evans-Lam amination of aryl BPin with alkyl and aryl amines.

152 successfully applied in the Buchwald-Hartwig amination of aryl chlorides, bromides, and iodides.

153 The amination of aryl halides has become one of the most com

154 amination, the Buchwald-Hartwig-Ullmann-type amination of aryl halides stands as one of the most empl

155 ly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium comple

156 catalysts can promote the intramolecular C-H amination of arylsulfonyl azides with over 10 000-14 000

157 and sustainable direct meta-selective H(2)N amination of benzylic and related aromatic picolinates u

158 ng chemoselective borylation, silylation and amination of benzylic C-H bonds, as well as hydrogenatio

159 r the highly enantioselective intermolecular amination of benzylic C-H bonds.

160 or copper-catalyzed, aminoquinoline-assisted amination of beta-C(sp(2))-H bonds of benzoic acid deriv

161 Direct amination of C(sp(3) )-H bonds is of broad interest in t

162 variety of amines and amides is reported via amination of C(sp(3))-H and C(sp(2))-H bonds.

163 ure enzymes that catalyze the direct primary amination of C(sp(3))-H bonds with excellent chemo-, reg

164 ne of several iron complexes observed in the amination of C-H bond substrates or styrene aziridinatio

165 been limited by low chemoselectivity for the amination of C-H bonds over competing reduction of the a

166 The intermolecular amination of C-H bonds represents a particularly desirab

167 CPF-5) is described that promotes the direct amination of C-H bonds with exceptional activity.

168 reactivity of the intermolecular radical C-H amination of carboxylic acid esters with organic azides

169 ve in promoting the intermolecular sp(3) C-H amination of cyclohexene using unprotected anilines to p

170 escribes the development of Buchwald-Hartwig amination of different bromoflavones with amino acid and

171 roup tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well a

172 report a photoredox-coupled ring-opening oxo-amination of electronically unbiased cyclopropanes, whic

173 asymmetric synthesis of 1,2-diamines through amination of enecarbamates has been proposed as a highly

174 iral phosphoric acid catalyzed electrophilic amination of enecarbamates with dibenzyl azodicarboxylat

175 lective tandem three-component electrophilic amination of enecarbamates.

176 e describe a metal-free regioselective alpha-amination of ethers mediated by N-chloroimides in ethere

177 d strategy for consecutive diazenylation and amination of indole moieties has been demonstrated.

178 gy is also applicable for the regioselective amination of indolizines.

179 eroxide to cyclohexanone, and the asymmetric amination of ketones with NH(3)/H(2).

180 rmations they require either an amine donor (amination of ketones) or an amine acceptor (deamination

181 Enantioselective amination of primary C(sp(3))-H bonds in substrates that

182 transfer mechanism for the enantioselective amination of primary, secondary and tertiary C(sp(3))-H

183 The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-

184 fectively catalyze the enantioconvergent 1,6-amination of racemic tertiary C(sp(3))-H bonds at the op

185 talytic system for enantioconvergent radical amination of racemic tertiary C(sp(3))-H bonds.

186 ough intramolecular oxidative C-H activation-amination of readily available 2-(het)aryl-3-(het)aryl/a

187 s practical reagents for the decarboxylative amination of simple and complex redox-active esters.

188 In this work, we have demonstrated selective amination of SiNx surface as compared to Si surface.

189 rimental observations validate that the ipso amination of substituted boronic acids involves the form

190 As showcased with asymmetric 1,5-C-H amination of sulfamoyl azides, the enantiocontrol of whi

191 by an enantioselective ring-closing 1,5-C-H amination of sulfamoyl azides.

192 The study of the oxidative amination of tetrahydroisoquinolines under chiral-anion

193 ely, the combination of a chemical reductive amination of the 4-carboxyindanone followed by a subsequ

194 n-atom transfer to form N-H bonds, or 3) C-H amination of the alkyl linker of the (n) PDI2 ligand.

195 Mechanistic studies involving amination of the enantiomerically enriched, deuterium-la

196 R)(SO2R')]2 promote the selective direct C-H-amination of the indole core of various tryptamines.

197 important features include 1) the direct C-H amination of the tetralone substrate in the synthesis of

198 Fe(NHAd), and can mediate intermolecular C-H amination of toluene [PhCH3/PhCD3 kH/kD: 15.5(3); PhCH2D

199 hod for catalytic intermolecular allylic C-H amination of trans-disubstituted olefins is reported.

200 The efficient and catalytic amination of unactivated alkenes with simple secondary a

201 challenging intramolecular direct C(sp(3))-H amination of unactivated organic azides to generate a ra

202 The Cdelta -H amination of unactivated, secondary C-H bonds to form a

203 r developments in transition metal-catalyzed aminations of aryl halides to form anilines, a common st

204 regio- and enantioselective Tsuji-Trost-type aminations of racemic branched alkyl-substituted allylic

205 Electrophilic amination often requires a disparate toolkit of reagents

206 these methods are limited to beta - or delta-amination only.

207 by either a new silver-promoted nucleophilic amination or a rhodium-catalyzed C-H amination protocol.

208 ted substrates undergo alternative oxidative amination or allylic amination pathways, and these react

209 development of a general catalytic Chan-Lam amination, overcoming long-standing and unsolved amine a

210 distinct conditions to give the products of amination, oxidation, and arylation.

211 process, which is proposed to proceed via an amination-oxidation sequence, selectively promotes the t

212 o alternative oxidative amination or allylic amination pathways, and these reactions will also be dis

213 Reductive amination plays a paramount role in pharmaceutical and m

214 fective for enantiodivergent radical 1,5-C-H amination, producing both enantiomers of the strained fi

215 ove the selectivity and scope of this direct amination protocol, aromatic carboxylic acids were addit

216 ophilic amination or a rhodium-catalyzed C-H amination protocol.

217 target compounds via reduction and reductive amination protocols.

218 The discovery of the Chan-Lam amination provided a C-N bond forming process that was m

219 Depending on the directing group, the amination provided orthogonally protected 1,4-diamine, e

220 tic pathways: (1) using a titanium-reductive amination reaction affording a 50/50 mixture of cis and

221 Extension of the method to the alpha-amination reaction by using azodicarboxylate esters as e

222 A method for enantioselective direct alpha-amination reaction catalyzed by a sterically "frustrated

223 Herein, we describe a late-stage aryl C-H amination reaction for the synthesis of complex primary

224 uential one-pot multicomponent carbonylation/amination reaction has been developed.

225 of an enantioselective Pd(II)-catalyzed C-H amination reaction is described.

226 An efficient aerobic linear allylic C-H amination reaction is reported under palladium(II)/bis-s

227 erimental and theoretical studies of the C-H amination reaction mediated by the iron dipyrrinato comp

228 The direct amination reaction of heterocyclic thiols has been devel

229 re we report a regioselective C-H activation/amination reaction of various unsymmetrical dialkyl-subs

230 The C-H amination reaction proceeded with high site- and enantio

231 diastereoselective rhodium(II)-catalyzed C-H amination reaction to set the configuration of the axial

232 We report an investigation of the Chan-Lam amination reaction.

233 , a ring-closing metathesis reaction, and an amination reaction.

234 of reactive side chains during the reductive amination reaction.

235 involves two rounds (cascades) of reduction/amination reactions (AA -> 6-ACA -> HMD).

236 The application of Rh- and Ir-catalyzed C-H amination reactions in complex settings were used to gai

237 CARs and TAs for several rounds of reduction/amination reactions in one-pot cascade systems and their

238 by palladium-catalyzed double-carbonylative amination reactions is discussed.

239 yze enantioselective intramolecular C-H bond amination reactions of sulfonyl azides.

240 Palladium-catalyzed amination reactions using soluble organic bases have pro

241 cant progress, copper-catalyzed/mediated C-H amination reactions with electron-rich anilines remain a

242 ioconjugations, as demonstrated in reductive amination reactions with Streptavidin.

243 engineered to catalyze abiological C-H bond amination reactions, but the yields of these reactions h

244 both in cellulo Suzuki and Buchwald-Hartwig amination reactions.

245 selectivity in Hull's Pd-catalyzed oxidative amination reactions.

246 e limitations of palladium(II)-catalyzed C-H amination reactions.

247 suitable enzymes to catalyze challenging C-H amination reactions.

248 road spectrum of enantioselective C(sp(3))-H amination reactions.

249 her, ((Ar)L)Co(NR)(py) displays enhanced C-H amination reactivity compared to that of the pyridine-fr

250 provide insights into the origin of the C-H amination reactivity enhancement and highlight the diver

251 d be engineered to further improve their C-H amination reactivity, which demonstrates their evolvabil

252 A sequence of oxidative cleavage/reductive amination/reductive cleavage enables the preparation of

253 addition to the alkene with subsequent beta-amination resulting in 1,2-carboamination.

254 A sequence of N,O-ketalization and reductive amination secured the chemoselectivity of N-methylation,

255 through a deprotection and double-reductive amination sequence to give 4,5,6,7-tetrahydropyrazolo[1,

256 highly enantioselective electrophilic alpha-amination step in the presence of europium triflate and

257 odium diphosphine complex, and the reductive amination step, which is conducted as a transfer hydroge

258 and the description is focused on reductive amination steps.

259 merization in the O-alkylation and reductive amination steps.

260 Starting from a general C2-amination strategy, subsequent transformations enable a

261 Here we show the first allylic amination that can directly afford alkyl allylamines, en

262 mation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type amination o

263 The reductive amination, the reaction of an aldehyde or a ketone with

264 arked on for the enantioselective C(sp(3))-H amination through the catalyst design.

265 displays productive intramolecular C-H bond amination to afford N-heterocyclic products using alipha

266 signed synthesis features a Buchwald-Hartwig amination to construct the core ester 23c in a convergen

267 lar 1,3-dipolar cycloaddition as well as C-H amination to furnish 1,2,3-dihydrotriazole and substitut

268 phyrins for enantioselective radical 1,5-C-H amination to stereoselectively construct 5-membered cycl

269 comprehensive review on catalytic reductive aminations to discuss the potential catalysts used and a

270 f catalysts capable of fast, robust C-H bond amination under mild conditions is an unrealized goal de

271 established substrates for ARC-based olefin amination under similar conditions.

272 Bronsted acid-catalyzed asymmetric reductive amination using a silane as the hydride source.

273 ch as Wittig olefination or Buchwald-Hartwig amination using an expert system.

274 n this review we discuss catalytic reductive aminations using molecular hydrogen and their applicatio

275 In particular, catalytic reductive aminations using molecular hydrogen are highly valued an

276 compounds such as aminopolyols, biocatalytic aminations using transaminase enzymes (TAms) have been i

277 ural requirements inherent to supporting C-H amination versus C-H monooxygenation reactivity within t

278 Asymmetric C-H amination via nitrene transfer is a powerful tool to pre

279 iating challenging C(sp(3))-H oxidations and aminations via high-valent iron oxos and nitrenes, C(sp(

280 rapid mono and diselective Buchwald-Hartwig aminations via microwave irradiation.

281 sing class of biocatalysts for mediating C-H aminations via nitrene transfer, a valuable transformati

282 The mechanism of C-H amination was probed via kinetic isotope effect experime

283 of amino acids (AAs) for the cross-coupling aminations was examined.

284 For the C-H amination, we observe that the temperature required for

285 zide adducts serve as viable species for C-H amination when the C-H bonds are (1) proximal to the azi

286 One such example is the Kochetkov amination, where reducing end amines exist solely as the

287 chemo- and enantioselective silver-catalyzed aminations which transform di- and trisubstituted homoal

288 e installation of a chiral amine through C-H amination, which is a challenging chemical transformatio

289 e and include enzymatic asymmetric reductive amination, which offers an efficient route to many of th

290 The Co(II)-catalyzed intermolecular C-H amination, which operates under mild conditions with the

291 ycans on a MALDI target through nonreductive amination, while simultaneously functioning as a matrix

292 c organosulfur compounds (OSCs) by reductive amination with (13)C, D2-formaldehyde, and developed an

293 Subsequent amination with a large variety of amines provided the fi

294 ple of a highly enantioselective C(sp(3) )-H amination with aliphatic azides.

295 s) for absolute quantification via reductive amination with isotopic formaldehydes.

296 This intermediate can be subjected to amination with nitriles under Ritter reaction conditions

297 ne and pyridine-type ligands in Ullmann-type aminations with aryl halides, the reactions of aryl hali

298 is able to catalyze stereoselective benzylic aminations with ee values of 97.5%.

299 also demonstrate preparative scale reductive aminations with wild-type and Q240A variant biocatalysts

300 R) displays enhanced yields and rates of C-H amination without the aid of a cocatalyst, and no cataly