ライフサイエンスコーパス: amine oxidase

1 idized by the copper-containing bovine serum amine oxidase.

2 ess it is oxidized to spermidine by the Fms1 amine oxidase.

3 ytochrome oxidase, superoxide dismutase, and amine oxidase.

4 equine plasma amine oxidase and human kidney amine oxidase.

5 nesis has been carried out on a yeast copper amine oxidase.

6 al peptide was identified for human placenta amine oxidase.

7 cquisition of Cu(I) by nascent H. polymorpha amine oxidase.

8 hich occurs in cofactor biogenesis in copper amine oxidases.

9 turally similar to aromatic hydroxylases and amine oxidases.

10 lective mechanism-based inhibitors of copper amine oxidases.

11 that is highly selective over LOX and other amine oxidases.

12 nhibitors of the mammalian copper-containing amine oxidases.

13 nucleus found in the plasma and other copper amine oxidases.

14 quinone (TPQ) cofactor in copper-containing amine oxidases.

15 erases and both flavin- and copper-dependent amine oxidases.

16 gn: (a) PTS selectivity and (b) stability to amine oxidases.

17 ies: monomeric globins and copper-containing amine oxidases.

18 The X-ray crystal structures of copper amine oxidase-1 from the yeast Hansenula polymorpha (HPA

19 g upregulated pro-oxidative enzymes, such as amine oxidase 3/vascular adhesion protein 1 (AOC3/VAP1)

20 Together, these results link the amine oxidase activity of VAP-1 with hepatic inflammatio

21 antibody only blocking the adhesion, not the amine oxidase activity of VAP-1.

22 Amine oxidase activity regulates the development of pulm

23 that circulating renalase lacks significant amine oxidase activity under basal conditions (prorenala

24 5C behave similarly with regard to aliphatic amine oxidase activity, showing 3-7-fold decreases in ki

25 nia despite the fact that this mutant has no amine oxidase activity.

26 ced Smad3 phosphorylation likely through its amine oxidase activity.

27 oxidase (KDAO), and Arthrobacter globiformis amine oxidase (AGAO) to examine the effect of different

28 f substrate-reduced Arthrobacter globiformis amine oxidase (AGAO) under a wide range of conditions.

29 ne oxidase (rhDAO), Arthrobacter globiformis amine oxidase (AGAO), and Pichia pastoris amine oxidase

30 ine oxidase (PSAO), Arthrobacter globiformis amine oxidase (AGAO), Escherichia coli amine oxidase (EC

31 site of the enzyme Arthrobacter globiformis amine oxidase (AGAO).

32 corresponding sections of other flavoprotein amine oxidases, although the overall identity of aligned

33 dopa decarboxylase and a membrane-associated amine oxidase, amiloride-binding protein 1.

34 ular adhesion protein-1 (VAP-1) is a primary amine oxidase and a drug target for inflammatory and vas

35 d tissue-specific expression of LOXL2, a new amine oxidase and a member of an emerging family of huma

36 The activities of plasma amine oxidase and diamine oxidase were only minimally re

37 Here, we demonstrate that Hp has both amine oxidase and ferroxidase activity in cultured cells

38 wo mammalian enzymes examined, equine plasma amine oxidase and human kidney amine oxidase.

39 in confirms that zinc binds to H. polymorpha amine oxidase and prevents reconstitution with copper.

40 lism of a branched primary amine by a copper amine oxidase and suggests a novel type of reversible me

41 onstituents, are the semicarbazide-sensitive amine oxidase and the scavenger lipoprotein receptor CD3

42 and may have influenced the distribution of amine oxidases and catalase in cells.

43 The homology of FMS1 to FAD-containing amine oxidases and its role in beta-alanine biosynthesis

44 This PTI exhibited decreased sensitivity to amine oxidases and low toxicity as well as high potency

45 semble the ortho-quinone cofactors in copper amine oxidases and mediate the efficient and selective a

46 actor in several wild-type copper-containing amine oxidases and mutants of the amine oxidase from Han

47 riplasmic topaquinone- and copper-containing amine oxidase, and FeaB is a cytosolic NAD-linked aldehy

48 Thus, IdaA is a secondary amine oxidase, and our findings improve understanding of

49 is an acute-phase protein with ferroxidase, amine oxidase, and pro- and antioxidant activities.

50 ongly influenced PTI potency, sensitivity to amine oxidases, and cytotoxicity.

51 such as topaquinone in the copper-containing amine oxidases, and lysine tyrosylquinone in lysyl oxida

52 us to conclude that the cofactor in A. niger amine oxidase AO-I has been misidentified.

53 en reported to exist in an Aspergillus niger amine oxidase AO-I.

54 esis of the covalently bound topa quinone in amine oxidase are discussed.

55 Copper amine oxidases are a family of enzymes with quinone cofa

56 e been identified as Cu(II) ligands in other amine oxidases are conserved in the human placenta amine

57 this study establishes the 97-kDa rat/human amine oxidase as the first integral membrane amine oxida

58 n-gel and spectrophotometric ferroxidase and amine oxidase assays demonstrated that Cp activity was e

59 tutes for tyrosine and the substrate used in amine oxidase assays.

60 from Arthrobacter globiformis, pea seedling amine oxidase at pH 7.1, and the E406Q mutant of HPAO.

61 l catalysts, (b) high-potential quinones and amine oxidase biomimetic quinones, and (c) Pd aerobic ox

62 ant, bacterial, and fungal copper-containing amine oxidases: bovine plasma amine oxidase (BPAO), equi

63 enantioselectively (S >> R) by bovine plasma amine oxidase (BPAO) both as a temporary inactivator and

64 Incubation of bovine plasma amine oxidase (BPAO) with benzylamine and various p-subs

65 per-containing amine oxidases: bovine plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO)

66 nt irreversible inactivator of bovine plasma amine oxidase (BPAO), exhibiting a 30 min IC(50) of 2.9

67 pastoris lysyl oxidase (PPLO), bovine plasma amine oxidase (BPAO), human kidney diamine oxidase (KDAO

68 novel fluorogenic substrate of bovine plasma amine oxidase (BPAO), namely, (2-(6-(aminomethyl)naphtha

69 the copper-containing proteins, bovine serum amine oxidase (BSAO) and human kidney diamine oxidase (D

70 Bovine serum amine oxidase (BSAO) catalyzes the oxidative deamination

71 Bovine serum amine oxidase (BSAO) exhibits a similar nu(C=O) mode at

72 e copper-containing quinone-dependent plasma amine oxidase but that the activity recovers over time,

73 imilation pathway: the replacement of copper amine oxidase by a flavin-dependent backup enzyme.

74 chanism of inactivation of quinone-dependent amine oxidases by normal substrates in vitro if the prod

75 during the reoxidation of substrate-reduced amine oxidases by O(2) has not yet been definitively est

76 The expression of a copper amine oxidase (CAO) from Hansenula polymorpha in Sacchar

77 Copper amine oxidase (CAO) is a dual-functioning enzyme that ca

78 of the topaquinone (TPQ) cofactor of copper amine oxidase (CAO) is self-catalyzed and requires coppe

79 Copper amine oxidases (CAOs) are responsible for the oxidative

80 The copper amine oxidases (CAOs) catalyze both the single-turnover

81 The copper amine oxidases (CAOs) catalyze the O(2)-dependent, two-e

82 Copper amine oxidases (CAOs) catalyze the two-electron oxidatio

83 Copper amine oxidases (CAOs) contain 2,4,5-trihydroxyphenylalan

84 All known copper amine oxidases (CAOs) contain 2,4,5-trihydroxyphenylalan

85 ificity are investigated in a pair of copper amine oxidases (CAOs) from Hansenula polymorpha (HPAO-1

86 The copper amine oxidases (CAOs) have evolved to catalyze oxidative

87 actor to O2 in the catalytic cycle of copper amine oxidases (CAOs) remains controversial.

88 ite sequences of all known copper-containing amine oxidases (CAOs).

89 (2HP) is an irreversible inhibitor of copper amine oxidases (CAOs).

90 The copper amine oxidases carry out two copper-dependent processes:

91 The copper amine oxidases catalyze the O(2)-dependent, two-electron

92 Among these, the copper amine oxidases catalyze the oxidative deamination of pri

93 Lysyl oxidase (LOX), an extracellular amine oxidase, catalyzes the cross-linking of collagen a

94 flavin adenine dinucleotide (FAD)-dependent amine oxidases, certain inhibitors of monoamine oxidases

95 Copper amine oxidases contain a buried protein-derived quinone

96 At their active sites, copper amine oxidases contain both a mononuclear copper ion and

97 Amine oxidase copper containing-3 (AOC3) is a cell-surfa

98 Amine oxidase copper-containing 1 (AOC1; formerly known

99 We now have identified AOC3 (amine oxidase, copper containing 3), a surface monoamine

100 Lysyl oxidase (LOX), an amine oxidase critical for the initiation of collagen an

101 alculated O(2) free energy maps using copper amine oxidase crystal structures in the absence of xenon

102 Copper-containing amine oxidases (CuAOs) are involved in the regulation of

103 Copper amine oxidases (CuAOs) catalyze the oxidative deaminatio

104 usly identified substrate analogue of copper amine oxidases (CuAOs) has been screened against six dif

105 Based on luciferase assays, the amine oxidase domain of LSD1 is important in suppressing

106 rated that the SNAG domain of Snail1 and the amine oxidase domain of LSD1 were required for their mut

107 The second enzyme, DMSP-amine oxidase (DOX), requires O(2) for activity, shows a

108 ethylmethionine decarboxylase (SDC) and DMSP-amine oxidase (DOX).

109 ormis amine oxidase (AGAO), Escherichia coli amine oxidase (ECAO), and Pichia pastoris lysyl oxidase

110 ctive site copper in Escherichia coli copper amine oxidase (ECAO), we initiated a metal-substitution

111 mately 430 nm (adduct I) in Escherichia coli amine oxidase (ECAO).

112 the four SPE genes and by the FAD-dependent amine oxidase encoded by FMS1.

113 e yeast Saccharomyces cerevisiae, a putative amine oxidase, encoded by FMS1, was found to be rate-lim

114 A copper amine oxidase encoding gene, atao1, has been isolated an

115 key step involves a stereoselective one-pot amine oxidase/ene imine reductase cascade to convert N-s

116 LSD1 belongs to the amine oxidase enzyme superfamily which utilize molecular

117 rs are (a) topa quinone in copper-containing amine oxidases, enzymes found in nearly all forms of lif

118 e plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO), pea seedling amine oxidase (PSAO),

119 ompounds were screened against equine plasma amine oxidase (EPAO), Pisum sativum amine oxidase (PSAO)

120 4g14940 (AtAO1) encodes an apoplastic copper amine oxidase expressed at the early stages of vascular

121 of compounds acting as an inactivator of one amine oxidase family and a pure substrate of another ami

122 s co-expressed with other members of the LOX amine oxidase family in most mammalian cells.

123 ible substrate activity in vitro for related amine oxidase family members, leading to metabolic stabi

124 idase family and a pure substrate of another amine oxidase family represents a unique lead to the dev

125 prising, as enzymes of the flavin-containing amine oxidase family were invariably thought to use O(2)

126 Pnao), both members of the flavin-containing amine oxidase family, catalyze the first two steps in th

127 e (NicA2), a member of the flavin-containing amine oxidase family, is of medical relevance as it show

128 Unlike other enzymes in the amine oxidase family, NicA2 reacts very slowly with O(2)

129 is the subject of controversy in the copper amine oxidase family.

130 eferring to members of the flavin-containing amine 'oxidase' family.

131 The flavin-dependent amine oxidase (FAO) superfamily consists of over 9000 no

132 Here we show that amine oxidase (flavin-containing) domain 1 (AOF1), a pro

133 eversibly inhibit the activity of the copper amine oxidase from Arthrobacter globiformis (AGAO), with

134 xchange was observed for wild-type HPAO, the amine oxidase from Arthrobacter globiformis, pea seedlin

135 n of the copper-containing quinone-dependent amine oxidase from bovine plasma (BPAO).

136 ange (t(1/2) < 30 min) were observed for the amine oxidase from Escherichia coli and the N404A mutant

137 action of the copper-containing quinoprotein amine oxidase from Escherichia coli have been determined

138 methyltryptophan oxidase, a flavin-dependent amine oxidase from Escherichia coli, was studied using a

139 n of a cobalt-substituted form of the copper amine oxidase from Hansenula polymorpha (HPAO).

140 containing amine oxidases and mutants of the amine oxidase from Hansenula polymorpha (HPAO).

141 In this study, the structure of an amine oxidase from Hansenula polymorpha has been solved

142 rved active site tyrosine Y305 in the copper amine oxidase from Hansenula polymorpha kinetically, spe

143 ray structure for the active form of a yeast amine oxidase from Hansenula polymorpha, a hydrophobic s

144 ype and mutant forms of a recombinant copper amine oxidase from Hansenula polymorpha, expressed in Sa

145 Previously, using the amine oxidase from the yeast Hansenula polymorpha (HPAO)

146 the aminotransferase mechanism of the copper amine oxidase from the yeast Hansenula polymorpha has be

147 n in enzymatic studies by using the purified amine oxidase from yeast.

148 The similar (18)O KIEs reported for copper amine oxidases from other sources raise the possibility

149 ypeptide (ATAO1) with 48% identity to copper amine oxidases from pea and lentil.

150 riable experimental observations with copper amine oxidases from plant versus other eukaryotic source

151 e that LSD1 (KIAA0601), a nuclear homolog of amine oxidases, functions as a histone demethylase and t

152 The Arabidopsis (Arabidopsis thaliana) amine oxidase gene At4g14940 (AtAO1) encodes an apoplast

153 The H. polymorpha amine oxidase gene was subsequently expressed in Escheri

154 Because amine oxidases generally produce aldehyde derivatives of

155 Copper-containing amine oxidases have peptidyl 2,4,5 tri(oxo)phenylalanine

156 They showed that LSD 1, a nuclear amine oxidase homolog, is a bona fide histone H3 lysine

157 In contrast to prokaryotic copper amine oxidases, however, it has not been possible to ini

158 factor formation in the Hansenula polymorpha amine oxidase (HPAO) provided evidence for the coordinat

159 eady state kinetic data of the second copper amine oxidase (HPAO-2) are presented for comparison to t

160 The related copper-containing amine oxidase human vascular adhesion protein-1 also exc

161 tosidase and subsequently observed in copper amine oxidase, hyaluronate lyase, chondroitinase, and ma

162 A crystal structure of H. polymorpha amine oxidase in complex with xenon gas, which serves as

163 in vivo assembly of heterologously expressed amine oxidases in S. cerevisiae and E. coli.

164 Lysyl oxidase differs from other copper amine oxidases in that its active quinone cofactor refle

165 aldehydes produced by polyamine oxidase and amine oxidases include the 2-alkenal acrolein, the aceto

166 emethylase 1 (LSD1) belongs to the family of amine oxidases including polyamine oxidase and monoamine

167 amino acid sequence of the 97-kDa rat/human amine oxidase indicates that the protein consists of a v

168 mportant to prevent confounding bovine serum amine oxidase-induced cytotoxicity in mechanistic studie

169 est that the development of highly selective amine oxidase inhibitors is feasible.

170 enylalanine quinone (TPQ) cofactor in copper amine oxidases involves a key water addition to the dopa

171 sses of enzymes, including the FAD-dependent amine oxidases KDM1A/B.

172 Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent cross-linki

173 exogenous copper to precursor H. polymorpha amine oxidase lacking copper.

174 ize putative E. coca polyamine synthase- and amine oxidase-like enzymes in vitro, in yeast, and in pl

175 A second gene encoding a putative copper amine oxidase of clade 1a (CuAOalpha1) was associated wi

176 iscovery of lysyl demethylases using flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactor

177 Copper amine oxidases oxidize the polyamine putrescine (Put), p

178 polyamines spermine and spermidine by plasma amine oxidase (PAO) was specified many years ago to occu

179 oxidoreductase (NicA2) and pseudooxynicotine amine oxidase (Pnao), both members of the flavin-contain

180 n to inactivate the quinone-dependent plasma amine oxidases, possibly through active-site modificatio

181 is amine oxidase (AGAO), and Pichia pastoris amine oxidase (PPLO) have been examined.

182 reactions that are catalyzed by bovine serum amine oxidase proceed through tunneling.

183 Copper-dependent amine oxidases produce their redox active cofactor, 2,4,

184 oxyacid dehydrogenase, and copper-containing amine oxidase protein families.

185 oxidases are conserved in the human placenta amine oxidase protein sequence.

186 we show that substrate-reduced pea seedling amine oxidase (PSAO) exists predominantly in the Cu(I),

187 ne plasma amine oxidase (EPAO), pea seedling amine oxidase (PSAO), Arthrobacter globiformis amine oxi

188 e plasma amine oxidase (EPAO), Pisum sativum amine oxidase (PSAO), Pichia pastoris lysyl oxidase (PPL

189 and oxidative half-reactions of pea seedling amine oxidase (PSAO), the recombinant human kidney diami

190 that the apoform of the Hansenula polymorpha amine oxidase readily binds Cu(I) under anaerobic condit

191 novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood

192 4q27 (rs2069763) and renalase, FAD-dependent amine oxidase (RNLS)/10q23.31 (rs10509540), were associa

193 Renalase, an amine oxidase secreted by the proximal tubule, degrades

194 al finding that the quinone-dependent copper amine oxidases specifically metabolize primary amines.

195 ecule that possesses semicarbazide-sensitive amine oxidase (SSAO) activity, is involved in leukocyte

196 Semicarbazide-sensitive amine oxidase (SSAO) catalyses oxidative deamination of

197 ect of inhibition of semicarbazide-sensitive amine oxidase (SSAO; EC 1.4.3.6, also known as VAP-1) as

198 essential for organic cofactor formation in amine oxidases such as lysyl oxidase.

199 cotine degrading enzymes of the flavoprotein amine oxidase superfamily.

200 oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in

201 copper- and lysine tyrosylquinone-dependent amine oxidase that has been proposed to function both ex

202 ht binding fluorogenic substrate of a copper amine oxidase that is able to respond directly to the en

203 rotein-1 (VAP-1) is an adhesion molecule and amine oxidase that is expressed at high levels in the hu

204 (LOXL) protein is a novel copper-containing amine oxidase that is required for the cross-linking of

205 scriptional repressor and a flavin-dependent amine oxidase that is responsible for the removal of met

206 fy renalase as what we believe to be a novel amine oxidase that is secreted by the kidney, circulates

207 oth spermidine synthase and the FMS1-encoded amine oxidase that oxidizes spermine to spermidine.

208 hesion protein-1 (VAP-1) is a membrane-bound amine oxidase that promotes leukocyte recruitment to the

209 iously identified renalase, a secreted novel amine oxidase that specifically degrades circulating cat

210 gh degree of similarity to flavin containing amine oxidases that use dioxygen directly, both enzymes

211 LOX is a hypoxia-inducible amine oxidase, the activity of which enhances breast can

212 Unrelated to other amine oxidases, this enzyme contains haem, flavin mononu

213 amine oxidase as the first integral membrane amine oxidase to be cloned.

214 lyoxal, generated by semicarbazide-sensitive amine oxidase, to cause the metabolic phenotype of MDSCs

215 onversion of prorenalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholam

216 from those of other topa quinone-containing amine oxidases under similar conditions.

217 Copper and topaquinone (TPQ) containing amine oxidases utilize O2 for the metabolism of biogenic

218 The membrane amine oxidase was more abundant in the plasma membranes

219 f the available crystal structures of copper amine oxidases, we propose that a histidine residue in t

220 ctions of 1,4-diamino-2-butyne with selected amine oxidases were also examined.

221 to the copper, D630N in Hansenula polymorpha amine oxidase, which greatly increases the concentration

222 he corresponding region of a human placental amine oxidase, which was cloned simultaneously and propo

223 oxidase (LOX) is a secreted copper-dependent amine oxidase whose primary function is to drive collage

224 MTOX is one of several flavin-dependent amine oxidases whose chemical mechanism is still debated

225 Comparison of the human placenta amine oxidase with DNA sequences found in GenBank sugges

226 ofactor of wild-type Escherichia coli copper amine oxidase (WT-ECAO) is stable at neutral pH, 25 degr