ライフサイエンスコーパス: amino acid

1 tural relationships (e.g. distances ligand - amino acid).

2 o that of other genera, but much longer (418 amino acids).

3 curement for quantification of this critical amino acid.

4 ve measurement of the excluded volume of the amino acid.

5 ntry were observed upon mutation of a single amino acid.

6 zyme are largely unaffected by the unnatural amino acid.

7 strain was already inhibited by 1 mM of the amino acid.

8 eased urinary concentrations of the cationic amino acids.

9 puree resulted in high levels of total free amino acids.

10 e complex, bioactive metabolites from simple amino acids.

11 encoding a putative membrane protein of 127 amino acids.

12 ls of nutrients such as glucose, lipids, and amino acids.

13 s intracellular, but not circulating, N-acyl amino acids.

14 rotein (CP) comprising ~260 rather than ~180 amino acids.

15 a handful of the most reactive proteinogenic amino acids.

16 vity with IA derived from L-Glu and aromatic amino acids.

17 nts with (1)O(2) comparable to those of free amino acids.

18 oved by enriching the linker with functional amino acids.

19 cing industrially important C3-C5 diols from amino acids.

20 alogues were synthesized by conjugating with amino acids.

21 orporation of acetate into organic acids and amino acids.

22 id profiling showed good amount of essential amino acids.

23 ubtle molecular differences among all twenty amino acids.

24 mechanisms towards cysteine thiols and other amino acids.

25 ble of modifying almost all of the canonical amino acids.

26 Amino acid 159 of the envelope (E) protein is reportedly

27 These results show that amino acids 93-111 in SNAP25 act as a flexible molecular

28 -amino-acid-long fragment is located between amino acids 961-971.

29 ar growth and not just a suggested source of amino acids; a role driven by albumin engagement with it

30 The composition of beer wort in terms of amino acid (AA) content affects the final product qualit

31 tivation to support T cell growth even under amino acid (AA) replete conditions.

32 fast' proteins, respectively, based on their amino acid absorption rate.

33 s, which are tags of minimal size (ca. 15-20 amino acids) affording high-affinity lanthanide ion bind

34 Rather, amino acids alanine, phenylalanine, glutamic acid, valin

35 clinical features of epilepsy identified two amino acid-altering mutations in KPNA7.

36 of viral genome representation: nucleotide, amino acid, amino acid properties and protein domains.

37 port the first application of the system for amino acid analysis coupled to an extraction unit in ord

38 Our data support the model that the amino acid and growth factor signaling pathways converge

39 l amino acids, and a conditionally essential amino acid and its precursor.

40 e that allowed us to assemble their complete amino acid and nucleotide sequences.

41 t is, the predominance of "left-handed" or l-amino acids and "right-handed" or d-sugars, is a unique

42 et al and Frohner et al report that flanking amino acids and an underappreciated posttranslational mo

43 nt in metabolic pathways (eg, branched chain amino acids and arginine biosynthesis) and virulence gen

44 orphology of the subpopulations, and 20 free amino acids and glucose in EV subpopulations were identi

45 indings indicate that sequential inputs from amino acids and growth factors trigger PA production req

46 lipins, and the metabolism of carbohydrates, amino acids and indol- and alkaloid-derivatives.

47 -to-tail cyclized, composed of proteinogenic amino acids and lack disulfide bonds; they are also know

48 sent entities of the protein-ligand complex (amino acids and ligands) and the edges represent structu

49 During this process, most amino acids and monosaccharides kept increasing, and acc

50 ment of dopegal in the reaction with several amino acids and neuropeptides.

51 ameters and fluorescence spectra of aromatic amino acids and nucleic acids (AAA + NA), tryptophan res

52 the generation of unnatural gamma-quaternary amino acids and other valuable synthetic targets.

53 tional modifications (PTMs) affecting single amino acids and peptides.

54 ation, which results in the truncation of 45 amino acids and shifts the localization of ClVST1(97) to

55 Isolated aromatic amino acids and short peptides provide benchmark cases t

56 olines, phosphatidylcholines, acylcarnitine, amino acids and sphingomyelins; Lyso.PC.a.C18.0, PC.ae.C

57 he diastereoselective synthesis of unnatural amino acids and the late-stage derivatization of a tripe

58 res seemed dependent on both their number of amino acids and their proximity with the supported lipid

59 including monosaccharides, disaccharides, an amino acid, and a steroid.

60 ethanolamines, 5 ceramides, 3 branched chain amino acids, and 9 neurotransmitters).

61 ridoxine/vitamin B6, taurine, some essential amino acids, and a conditionally essential amino acid an

62 vels of very low-density lipoprotein (VLDL), amino acids, and citrate.

63 linking studies with site-specific unnatural amino acids, and species-specific activity of AimB.

64 The N-acyl amino acids are a family of bioactive lipids with pleiot

65 s gateways, seven different diol-convertible amino acids are converted to diols including 1,3-propane

66 Eighteen of the 20 amino acids are each encoded by more than one synonymous

67 In comparison, all of the other 17 amino acids are encoded by either 4, 3, 2, or 1 codon.

68 Reduced amounts of amino acids are found in the guts of conventionally rais

69 Peptides and free amino acids are naturally generated in dry-cured ham as

70 hich depend critically on the details of how amino acids are packed.

71 study focused on understanding the specific amino acids around the receptor binding site (RBS) that

72 lved in the biosynthesis of nonproteinogenic amino acids as building blocks of natural products and a

73 potential of end-to-end learning for single amino acids, as compared to more classical manually-cura

74 in of type P(N) SadP adhesin showed that the amino acid asparagine 285, which is replaced by an aspar

75 le fermentation product (isocaproate) and an amino acid associated with tissue damage (taurine), whic

76 nique cross-linked position pair for every 7 amino acids at a 1% false discovery rate.

77 Two splice variants of MPST, differing by 20 amino acids at the N terminus, give rise to the cytosoli

78 lycan residue of APOE and positively charged amino acids at the receptor-binding area suggested that

79 ation of growth and metabolite release in an amino-acid auxotroph community demonstrates that the int

80 A biosynthesis genes, and a gene controlling amino acid availability.

81 les (e.g. proteins, dyes, drugs, biomarkers, amino acids) based on application of the alternating ele

82 ; P = 0.04; eta2p = 0.31] and branched-chain amino acids (BCAAs) [between-group difference (95% CI):

83 mydial response mechanisms acting when other amino acids become limiting, we tested the efficacy of p

84 0.046-0.002), including five gamma-glutamyl amino acids, beta-citryl-glutamate, N-acetyl-aspartyl-gl

85 we demonstrate that increasing extracellular amino acids beyond the nutritional need of HLCs and HepG

86 n developed to identify regions with LCRs or amino acid bias, but most of them as stand-alone applica

87 We identify an amino-acid-binding pocket that is formed by transmembran

88 s essential for biological processes such as amino acid biogenesis, iron-sulfur cluster formation, an

89 ynthase (DAH7PS), at the gateway to aromatic amino acid biosynthesis in Mycobacterium tuberculosis, w

90 xylic acid cycle, balancing anaplerosis from amino acid breakdown.

91 We first validate that amino acids buried within the structural core are networ

92 and avian H3N2 influenza viruses encoded 61 amino acids but were truncated after introduction into d

93 reveals that necrocytosis provides not only amino acids, but sugars, fatty acids and nucleotides for

94 ein-deprived diet enriched in free essential amino acids can 1) promote the brown fat thermogenic pro

95 on remains uncertain but does not involve an amino acid change in FAN1.

96 s carrying the parC mutation conferring S83I amino acid change.

97 The highest-affinity variant contained seven amino acid changes and bound to the RBD 170-fold more ti

98 Amino acid changes in the hypervariable part of G protei

99 he domain provides a binding platform for 21 amino acid CIF peptide ligands, which are tyrosine sulfa

100 Here we investigate amino acid code for fuzzy binding in terms of the entrop

101 vian ANP32A proteins harbor an additional 33 amino acids compared to human ANP32A proteins, which are

102 gap dipeptide composition (g-gap DC), pseudo-amino acid composition (PseAAC), auto-correlation functi

103 equences are characterized by a less diverse amino acid composition compared to typically observed se

104 ictions to gain insights on the interplay of amino acid composition, structure, self-association, and

105 prion protein (PrP(C)) molecules varying in amino acid composition.

106 i-synthetic organism creation, and unnatural-amino-acid-containing protein synthesis.

107 2-targeted pTyr residues exist in a specific amino acid context that allows selective binding.

108 gSPY-MYC(3), 2) its functional dependence on amino acids critical for OGT activity, and 3) its abilit

109 imulations and state-dependent non-canonical amino acid cross-linking.

110 C have impaired growth in the absence of the amino acid cysteine and that gigC regulates the expressi

111 ted by metabolites that are derived from the amino acid cysteine.

112 omatis, has a limited capacity to synthesize amino acids de novo and therefore must obtain oligopepti

113 lite 3-MOB along with related branched-chain amino acids demonstrated strong predictability for famil

114 is interaction is promoted during oxygen and amino acid depletion and protects LRS from degradation.

115 lation, the reduced charging of tRNA(Gln) in amino-acid-deprived cells also leads to specific depleti

116 ar to non-polar molecule, while for the VP4, amino acid differences at position D195G was radical in

117 ng penicillin G (pcbAB, pcbC and penDE) show amino acid divergence between the Fleming strain and bot

118 sequence enables the formation of sulfonated amino acids during embryo development in the egg at no c

119 ly and metabolism of nutritional glucose and amino acids (e.g., arginine) to drive the synthesis of c

120 AF contained all the essential amino acids (EAA) except lysine and threonine, as requir

121 ed with MODL and higher content of essential amino acids (EAAs) (488.6-402.9 mg/g of protein respecti

122 to confirm the central role of GLR3.3 in the amino acid-elicited cytosolic Ca(2+) increase in Arabido

123 this method, including enantiomerically pure amino acids, enabling us to explore structural diversity

124 Amino acid exporters were identified in MAGs identified

125 The first amino acid-Fmoc-O-TIPS-beta-tyrosine-was prepared in 78%

126 Amino acid fragments from such hydrated protein films ar

127 talytically active hexamers to generate free amino acids from human hemoglobin and are drug targets f

128 sis revealed changes in pathways involved in amino acid, glucose, and TCA cycle metabolism.

129 ts potentially toxic ammonia to the valuable amino acid, glutamine.

130 between structural water and strain-specific amino acid groups is fundamental to the stabilisation of

131 al pathogen Candida albicans, utilization of amino acids has been shown to be critical for survival,

132 l as the interfacial adhesive roles of other amino acids have been understudied.

133 angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome.

134 is where glucagon is a critical regulator of amino acid homeostasis.

135 ectars contain nitrogenous compounds such as amino acids; however, little is known about the role(s)

136 hin the ATP binding site highlights a single amino acid (I960 -> V) responsible for the potency shift

137 hr518Met mutation altered a highly conserved amino acid in the MYRF protein and three of four algorit

138 other tRNAs retain charging of their cognate amino acids in a manner that is dependent upon intact ly

139 stry with pulsed stable isotope labelling of amino acids in cell culture to quantify the host proteom

140 beling approach using stable isotope-labeled amino acids in cells (pSILAC), phosphoproteomics, and a

141 Investigations of plasma amino acids in early psychosis and their unaffected sibl

142 eater changes in the reducing sugar and free amino acids in fermented cocoa beans.

143 probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are dis

144 vity toward indole, phenyl, or hydroxyphenyl amino acids in plant AAADs.

145 years, suggesting that the low abundances of amino acids in Tagish Lake cannot be ascribed to fluid c

146 xons 7 and 8 is predicted to delete critical amino acids in the ATP-binding site.

147 nds, organic acids, water soluble sugars and amino acids in three onion varieties ('Shallot', 'Chata'

148 theless, the lower TID of sulphur-containing amino acids in tofu than in soya milk induced a signific

149 Gbetagamma directly binds to a domain of 10 amino acids in TRPM3 and solve a cocrystal structure of

150 ranslation, but the effect of other pairs of amino acids, in the context of all 400 possible pairs, h

151 eity in GCK using a combination of unnatural amino acid incorporation, time-resolved fluorescence, an

152 ; secreted glutamine and other nitrogen-rich amino acids, indicating active protein breakdown, at a r

153 to predicted self-regulatory intramolecular amino acid interactions between the SnoaL_2 domain and t

154 ketoimine rather than an alpha,beta-dehydro-amino acid intermediate during C(alpha)-thioether bridge

155 to enable incorporation of the rare cognate amino acids into the growing peptide chain at a rate of

156 led by demonstrating that for ABCG2 a single amino acid is essential for engaging and initiating tran

157 x dynamic allostery: three distinct aromatic amino acids jointly communicate occupancy to the active

158 ant heme proteins that degrade the essential amino acid, l-tryptophan (Trp), along the kynurenine pat

159 , we demonstrate that the mammalian Expi293F amino acid labelling kit is suitable for preparation of

160 s the decoding of some triplets of these two amino acids, leading to reduced translation efficiency.

161 Each ingredient affected plasma amino acid levels in a singular manner when fed individu

162 ary administration of high protein increases amino acid levels in the gut and promotes pathogen colon

163 Correspondingly, amino acid levels were increased 2 weeks after tendon re

164 Three models (baseline plus amino acids, lipid metabolites, or all combined metaboli

165 ar signaling?', or 'Is a variant changing an amino acid located at the protein core or part of a clus

166 Specific glycan sites and amino acids located at the tip of the HA molecule enhanc

167 We found that the cleavage site in this 1192-amino-acid-long fragment is located between amino acids

168 The alteration of modified amino acid (MAA) profiles in biological samples is relat

169 in skeletal muscle may contribute to reduced amino acid metabolism and insulin resistance in MHD pati

170 is might impair glucagon's action on hepatic amino acid metabolism and lead to hyperaminoacidemia and

171 Amino acid metabolism in different cells and their cross

172 Protein rebalancing and amino acid metabolism were focal points of the metabolic

173 uxes (Krebs cycle, fatty acid, carbohydrate, amino acid metabolism).

174 oid and phytol metabolism, a limited role in amino acid metabolism, and dual sets of the SUF pathway

175 ty of m-Tyr may result from interfering with amino acid metabolism, destabalizing a large number of p

176 uding AOX, TCA cycle, fatty acid metabolism, amino acid metabolism, organic acid metabolism, and ethy

177 whole-body protein turnover, and splanchnic amino acid metabolism.

178 transcriptional activation and that this 90-amino acid mini-protein is cell permeable and can inhibi

179 has recently emerged as a mild approach for amino acid modification, generating a sizable toolbox of

180 The amino acid moiety was included on the grounds that it ma

181 24 bp in length with an ORF that encodes 434 amino acids (molecular mass of 46.9 kDa).

182 an open reading frame (ORF) that encodes 539 amino acids (molecular mass of 62.7 kDa); dsRNA2 dsRNA i

183 Each of the identified single amino acid mutations result in impaired shRNA-mediated s

184 Neuregulin protein 1 (NRG1) is a large (> 60-amino-acid) natural peptide ligand for the ErbB protein

185 (GCE) technologies incorporate non-canonical amino acids (ncAAs) into proteins at amber stop codons.

186 d bacteriocytes, where it produces essential amino acids needed by hosts.

187 We demonstrate that the 33 amino acids of chicken ANP32A and the PB2 627 domain of

188 r becomes unstable when fused to the last 10 amino acids of SpxA2 but remained stable when fused to t

189 nhanced over 10-fold by deleting the last 19 amino acids of the cytoplasmic tail.

190 erated by the brain, D-serine, an endogenous amino acid, offers new hope as a therapeutic agent for r

191 The inhibitory effects of amino acids on Pro- and Ala-stimulated R(N) were mitigat

192 data, e.g. words or n-grams in language, or amino acids or nucleotides in bioinformatics, are genera

193 ite (imidazolide) and can covalently bind to amino acids other than cysteine on target proteins such

194 Amino acid positions in the HA protein that may be invol

195 pth structural analyses to identify key ACE2 amino acid positions including 30, 83, 90, 322, and 354

196 The kinase-specific positional amino acid preferences are learned using a bidirectional

197 genotypes, most likely because of chelating amino acids present in the murine nutrient solution.

198 t-chain fatty acids, nitrogen recycling, and amino acid production.

199 rial encapsulation affected the volatile and amino acid profile of the wines, while the biogenic amin

200 contained 55.7% of proteins with a balanced amino acid profile when compared with MODL and higher co

201 Amino acid profiling showed good amount of essential ami

202 Amino acid propensities at a site change in the course o

203 nome representation: nucleotide, amino acid, amino acid properties and protein domains.

204 This study describes the use of amino acid quantitation and amino-acid-specific isotope

205 olates of the same emm type had an identical amino acid replacement.

206 Virtually all analyzed strains had single amino acid replacements in penicillin-binding protein 2X

207 L-Tryptophan is an essential amino acid required for protein synthesis.

208 inase K (PK), an N-terminal truncation up to amino acid residue 209 altered the conformation of the S

209 Here, we focused on the amino acid residue at position 8 (P8) of the proteolytic

210 Here, we show that a single amino acid residue in CD28 drove T cell exhaustion and h

211 sequences annotated to indicate whether the amino acid residue is located within a hinge-bending reg

212 eolytic cleavage site of MuV F, because this amino acid residue shows a striking variability dependin

213 ighly reactive and footprint broadly several amino acid residue side chains on the time scale of subm

214 m was characterized and named ToPI1, with 33 amino acid residues and three disulfide bonds.

215 y activity, we propose that those C-terminal amino acid residues are a potentially targetable motif o

216 When these amino acid residues are individually mutated, the necros

217 g entire genes, and orthologs for which most amino acid residues are polymorphic.

218 e designed a systematic approach to identify amino acid residues crucial for the expression and stabi

219 d light on this issue, we exchanged selected amino acid residues in a highly conserved stretch within

220 enthalpy of unfolding provides the number of amino acid residues nu participating in the unfolding re

221 the structure of apo-hGGT reveal movement of amino acid residues within the active site as the substr

222 nvolved in degrading oligopeptides with 4-12 amino acid residues.

223 ys79 showed that changing Lys79 to any other amino acid resulted in an inactive enzyme.

224 Site-specific replacement of active-site amino acids revealed the presence of a water-coordinatin

225 s, to calculate the digestible indispensable amino acid score (DIAAS).

226 (TFs) regulated by the Ssy1-Ptr3-Ssy5 (SPS) amino acid sensing system and have been proposed to have

227 tated peptide peaks with their corresponding amino acid sequence by database search and subsequent MA

228 11 teleost Sws2 photopigments for which both amino acid sequence information and experimentally measu

229 ted how natural interstrain variation in the amino acid sequence of gO influences the biology of HCMV

230 oop of approximately 20 residues in the ExoU amino acid sequence.

231 3a, respectively, and translated these into amino acid sequences and used for genotype variation ana

232 sequences and protein information, including amino acid sequences, are included.

233 existing tools can not perform alignment of amino acid sequences, which could prove useful in variou

234 map-guided structure modeling starting from amino acid sequences.

235 determined that p.D50A changed locations of amino acid side chains altering RNA binding sites in the

236 gions (IDRs), are modulated by the nature of amino acid side chains as well as by local solvent expos

237 vestigated the stability of the conventional amino acid side-chain-protecting groups, t-Bu, Boc, Trt,

238 ain a conserved helicase core domain and key amino acid sites affecting helicase function, which shar

239 pended on extracellular macromolecules as an amino acid source by activating endocytosis to sustain c

240 ribes the use of amino acid quantitation and amino-acid-specific isotope ratio analysis of scalp hair

241 HPF1, an accessory factor that switches the amino acid specificity of PARP1 and PARP2 from aspartate

242 This structural feature means that each amino acid spends sufficient time in the pore for sensit

243 Th17 cells that led to the induction of the amino acid starvation response and altered cellular fatt

244 f Gln4p inhibited growth, and induced a GCN4 amino acid starvation response, indicative of uncharged

245 ex, and prevents Rag dimer activation during amino acid starvation.

246 is associated with reorganization of further amino acids structurally transforming a loop adjacent to

247 Here, we identify a single amino acid substitution (M159I) that fundamentally alter

248 e, virtually all emm12 isolates had a single amino acid substitution in penicillin-binding protein PB

249 escribe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA

250 her SSB folds and creation of truncation and amino acid substitution mutants, we provide the first ev

251 n S. discolor and S. vitellina, including an amino acid substitution that is unique to warblers but o

252 Clinical trial data revealed that PA amino acid substitutions at residue 38 (I38T/F/M) reduce

253 plasticity in PR with resistance-associated amino acid substitutions by formation of optimal sulfur

254 e methods provides insight into how specific amino acid substitutions distant from the active site in

255 The location of a number of encoded amino acid substitutions in hemagglutinin-esterase fusio

256 g and requires a particular investigation of amino acid substitutions in the context of protein struc

257 cell viability assays, we report that point amino acid substitutions in the trigger loop, a flexible

258 For VP7 neutralization epitopes, amino acid substitutions observed at positions T91A/V, S

259 able increase in stability with as few as 18 amino acid substitutions suggests that this bovinization

260 Three GmVTL1a amino acid substitutions that block nitrogen fixation in

261 nd a derivative homology model containing 61 amino acid substitutions unique to the indirect flight m

262 ng with interspecies chimeras and individual amino acid substitutions, to identify regions required f

263 's hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its act

264 t linear sequence, LLS) from the constituent amino acid subunits with kinetically controlled diastere

265 be associated with oil synthesis (27 genes), amino acid synthesis (four genes) and the tricarboxylic

266 sis, the tricarboxylic acid (TCA) cycle, and amino acid synthesis/catabolism.

267 Here, we apply bioorthogonal non-canonical amino acid tagging (BONCAT) to visualize and quantify ba

268 tidine produces a vibrational-probe-equipped amino acid that can readily be incorporated into any pep

269 orrelation is at play between a small number amino acids that either favour or disfavour hinge-bendin

270 Together with other hydrophobic amino acids, the phenylalanines act as the channel's gat

271 der Mer (vdM)-that maps the backbone of each amino acid to statistically preferred positions of inter

272 mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and auto

273 In this study, we used a set of unnatural amino acids to fully map the substrate preferences of Gr

274 ng-range interaction patterns between k-mers amino acids to predict protein crystallizability.

275 omic distances, and positioning of catalytic amino acids to rationalize the underlying electronic rea

276 ing a minimal motif consisting of thirty-six amino acids to spCas9.

277 nsporter-mediated histidine uptake, system L amino acid transporter activity and Na(+) K(+) -ATPase a

278 orter-mediated histidine uptake and system L amino acid transporter activity were similar in sarcolem

279 y 7 member 5 (SLC7A5) gene, which encodes an amino acid transporter cause microcephaly and seizures,

280 Amino acid transporter-mediated histidine uptake and sys

281 clude a glycine-proline-hydroxyproline (GPO) amino acid triad are biomimetic analogs of the collagen

282 86%), and liver (47%) is predominantly a 129-amino acid truncated mature frataxin (79-207) in which t

283 om gut bacterial metabolism of the essential amino acid tryptophan, in regulating intestinal barrier

284 oadly considering LCRs as regions with fewer amino acid types compared to an average composition.

285 Targeting LAT1-mediated amino acid uptake is a potentially useful immunosuppress

286 distinct, if uncertain, roles in protein and amino acid utilization.

287 /MLL4 human sequences, we mapped a short ~80-amino-acid UTX stabilization domain (USD) that promotes

288 gin of life there were only seven primordial amino acids: Valine (coded by GUX [X = U, C, A or G]), a

289 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and quantified growth effec

290 (DMS) datasets probing the effects of single amino acid variation on enzyme activity and steady-state

291 The true ileal digestibility (TID) of their amino acids was determined in minipigs, to calculate the

292 Among amino acids, we find that cysteine is most toxic for mit

293 ing intermediates separated by as few as two amino acids were detected using focused-ion-beam-modifie

294 uctures of inactive MCR lacking the modified amino acids were indistinguishable from the fully modifi

295 signal intensity for polar molecules such as amino acids, which has important implications for SIMS i

296 m combines the natural catabolism of charged amino acids with a catalytically efficient and thermodyn

297 ship for binding using a series of unnatural amino acids with different lengths of hydrophobic side c

298 esis of previously identified phosphorylated amino acids within CHT7.

299 rch over a template database of fixed-length amino acid words to determine estimated class-membership

300 y of ZikV-NS5 appears to be dispensable, the amino acids Y25, K28, and K29 that are involved in NS5 o