ライフサイエンスコーパス: amino acid substitution

1 tif in IRF3 is changed to NPHK with a D -> N amino acid substitution.

2 This was subsequently blocked by a bulky amino acid substitution.

3 elic TUBB2B mutation, resulting in a p.R390Q amino acid substitution.

4 rs were observed in domestic pigs with the 2 amino acid substitution.

5 n silent mutations, with five conferring the amino acid substitutions.

6 ts of InDels compared to point mutations and amino acid substitutions.

7 the Galpha:RGS protein pair based on single amino acid substitutions.

8 es between the codons result in conservative amino acid substitutions.

9 proaches exist for predicting the effects of amino acid substitutions.

10 nal ophthalmoplegia generate T251I and P587L amino acid substitutions.

11 an be genetically separated through targeted amino acid substitutions.

12 enicillin-binding proteins (PBPs), with many amino acid substitutions.

13 a mechanism supported by the effects of Nun amino acid substitutions.

14 ere synthesised with strategic sequences and amino acid substitutions.

15 mutations have focused almost exclusively on amino acid substitutions.

16 Therefore, amino acid substitution A117V in ZIKV NS2A could be used

17 activation because trimming the Phe by small amino acid substitutions abolished alphaLbeta2 binding w

18 XP substrates confirming that the introduced amino acid substitution abolishes ClpXP activity.

19 The C181S second-site amino acid substitution abrogated myeloid transformation

20 s landscapes that survey the impact of every amino acid substitution across the entire protein-protei

21 The results suggest that this single amino acid substitution acts as a thermal and regulatory

22 igate, at atomic-level resolution, how these amino acid substitutions affect the collagen III-integri

23 These amino acid substitutions affect well-conserved residues

24 r of repair, we unexpectedly discovered that amino acid substitutions affecting alpha-helix-6 within

25 resulted in immune escape viruses containing amino acid substitutions alanine to threonine at residue

26 redox properties of CcP Y191 by non-natural amino acid substitution, altering the ET driving force a

27 We conducted a series of amino acid substitution analyses and identified S1777, i

28 facile method to predict the severity of an amino acid substitution and may help accelerate the iden

29 This effort yielded a P450 variant with 11 amino acid substitutions and a large deletion of the non

30 re, showed maximum variability comprising 22 amino acid substitutions and absence of two peptides and

31 head subdomain, which is highly tolerant of amino acid substitutions and continual addition of glyco

32 fD variants comprising between one and three amino acid substitutions and distinguished several that

33 tness effect of ~12,000 pairs of consecutive amino acid substitutions and used our previous study of

34 -art performance in predicting the impact of amino acid substitutions, and can easily and rapidly be

35 A Leu to Ala amino acid substitution approximately 10 A from the Cd(2

36 Like others, we find that convergent amino acid substitutions are not more abundant in echolo

37 tions and estimate that approximately 50% of amino acid substitutions are positively selected but tha

38 tected in the gnomAD control cohort, and the amino acid substitutions are predicted to be damaging.

39 nked glycosylation site is mutated by single-amino-acid substitution are highly attenuated and nonlet

40 o the hypervariable region, including single-amino acid substitutions, are sufficient to eliminate se

41 on, bnAbs acquire an abundance of improbable amino acid substitutions as a result of nucleotide mutat

42 uired U2AF2 mutations, namely N196K or G301D amino acid substitutions associated with leukemia or sol

43 ntiation by CMPI, but not by NS9283, whereas amino acid substitution at alpha4His-116, a known determ

44 monstrated that the positively charged basic amino acid substitution at E367 enhanced the viral bindi

45 ings provide the first evidence that a basic amino acid substitution at E367 strongly impacts the in

46 rresponding to a glutamine (Q) to lysine (K) amino acid substitution at position 223 of the lectin do

47 AATD is most often caused by a single amino acid substitution at position 342 in the mature pr

48 A single amino acid substitution at position 61 in the SNH domain

49 13025 strain because of an alanine-to-valine amino acid substitution at residue 188 in NS1.

50 ly neutralizing antibody, AC10, exhibited an amino acid substitution at residue S368 in the lateral r

51 Conventionally, most amino acid substitutions at "important" protein position

52 is, i.e. the scanning of all possible single amino acid substitutions at all sequence positions to es

53 surface glycoprotein hemagglutinin (HA), and amino acid substitutions at exposed epitope sites in HA

54 A key finding is that rates of amino acid substitutions at exposed sites in the capsid

55 Class I variants designed with amino acid substitutions at key positions within the con

56 Amino acid substitutions at peptide position 1 predicted

57 at the pathology in these patients is due to amino acid substitutions at positions 206, 281, and 284

58 Clinical trial data revealed that PA amino acid substitutions at residue 38 (I38T/F/M) reduce

59 We also show that amino acid substitutions at residues known to interact w

60 ominant-negative mechanism for the action of amino acid substitutions at this highly conserved glutam

61 -1,6-BP coupling were again fully tunable by amino acid substitutions at this limited set of distant

62 follows: experimentally evaluated effects of amino acid substitutions at toggle positions are binary,

63 Mutational analyses disclosed that amino acids substitutions at the 246 and 256 residue pos

64 A single amino acid substitution-based adaptive coevolution of th

65 quence analysis of Rf4 revealed four encoded amino acid substitutions between restoring and non-resto

66 A systematic comparison identified 380 amino acid substitutions between these coronaviruses, wh

67 derive from a rich mutational 'landscape' of amino acid substitutions broadly distributed throughout

68 plasticity in PR with resistance-associated amino acid substitutions by formation of optimal sulfur

69 a 3-fold decrease occurs in the case of the amino acid substitution C592G.

70 Thus, a single amino acid substitution can significantly alter the AAV

71 ine transmembrane proteins containing single amino acid substitutions can activate the platelet-deriv

72 Finally, we show that antibiotics and single amino acid substitutions can be used to target specific

73 This revealed that single amino acid substitutions can silence the extended networ

74 The resulting amino acid substitutions cause local disorder and misfol

75 cripts, the mechanisms by which these single amino acid substitutions change gene expression remain c

76 Disease-associated amino acid substitutions cluster in regions adjacent to

77 s phenotype-genotype database, we identified amino acid substitutions consistent with abnormal hair b

78 aceted protein engineering, far beyond a few amino acid substitutions, could significantly improve rF

79 riant IA-2 molecule (IA-2var) that has three amino acid substitutions (Cys(27), Gly(608), and Pro(671

80 nfectivity of B virus isolates with a single amino acid substitution (D122N) in the IgV-core of the g

81 The resulting amino acid substitutions destabilize SOD1's protein stru

82 e methods provides insight into how specific amino acid substitutions distant from the active site in

83 Whereas the single amino acid substitutions do not affect the function of t

84 m aggregation in vitro However, how a single amino acid substitution enhances the rate of aggregation

85 es cerevisiae was identified that encodes an amino acid substitution equivalent to the human variant

86 A single amino acid substitution evolved together with this regul

87 of ADH enzyme activity in vivo, we find that amino acid substitutions explain only a minority (0 to 2

88 scovered in a patient with epilepsy, causing amino acid substitution F302L at helix S4, in the K(V) 1

89 This conspicuous phenotype is caused by amino acid substitutions F37I and F37R in beta strand S2

90 We found that a single amino acid substitution, F548S, in the Ebola virus polym

91 In this paper, we generated a single amino acid substitution FMDV variant with a high-fidelit

92 Natural amino acid substitutions found in Aglaia eIF4As changed

93 Although an amino acid substitution from aspartic acid to alanine at

94 including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M

95 ost mammals, humans differ at two functional amino acid substitutions from chimpanzees, bonobos and g

96 populations possessed mutations that caused amino acid substitutions from ClO2-labile to ClO2-stable

97 ns carried hly mutations leading to a single amino acid substitution (G299V) or a premature stop codo

98 f the missense polymorphism resulting in the amino acid substitution Glu326Lys.

99 sequence with sets of specific nucleoprotein amino acid substitutions greatly impairs the viral genom

100 tructural assessment predicted that the five amino acid substitutions have damaging effects on DNA bi

101 However, K550 amino acid substitutions have no effect on Poliota's abi

102 ariables, including taxon and site sampling, amino acid substitution heterogeneity and saturation, no

103 Two amino acid substitutions I138M and I139M retard the form

104 the mutations found in ChAc patients causes amino acids substitution I2771R which affects the locali

105 Amino acid substitutions identified by the screen map to

106 We propose that combining specific SIRT6 amino acid substitutions identified in enzymology studie

107 r understanding of the functional effects of amino acid substitutions implicated in antigenic drift a

108 Li1 short fiber mutant as a single Gly65Val amino acid substitution in a polymerization domain of an

109 n autosomal recessive mutation leading to an amino acid substitution in a WD40 domain of the highly c

110 The authors demonstrated that this single amino acid substitution in CD28-based mesothelin CAR-T c

111 an engineered mouse model harboring a single-amino acid substitution in FAAH (S268D) that selectively

112 The single amino acid substitution in FMDV polymerase resulted in a

113 related to Neanderthals, on the basis of an amino acid substitution in its collagen.

114 onal scanning to measure the effect of every amino acid substitution in M1 on viral replication in ce

115 inant mutation (ref4-3) that causes a single amino acid substitution in MED5b functions as a strong s

116 ci revealed causal roles of one AGS-specific amino acid substitution in mediating cytoprotection by A

117 e, virtually all emm12 isolates had a single amino acid substitution in penicillin-binding protein PB

118 Such ability was restored by a single amino acid substitution in position 186 (K186E) that res

119 A single amino acid substitution in the binding pocket can dramat

120 This mutation causes an amino acid substitution in the calcium-binding motif of

121 ific domain-domain interactions via targeted amino acid substitution in the catalytic site of the C-t

122 escribe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA

123 he coding region resulted in a nonsynonymous amino acid substitution in the CsSGR protein, and thus d

124 o evolution also revealed that just a single amino acid substitution in the envelope can confer subst

125 This same amino acid substitution in the homologous but distinct m

126 gineered in both TRPV1 orthologs by a single amino acid substitution in the N-terminal ankyrin-repeat

127 Thus, a single amino acid substitution in the regulatory domain (the te

128 V A isolates, while all RSV B isolates had 2-amino acid substitution in the suptavumab epitope that l

129 An amino acid substitution in the WD40 repeats of RFWD3 (I6

130 ZIKV infectivity was enhanced by this amino acid substitution in the ZIKV FSS13025 strain in m

131 d a nuclear localization signal in NAMPT and amino acid substitution in this sequence ((424)RSKK to A

132 An amino acid substitution in VgpA (VgpA(L10A) ) did not al

133 Indeed, just one amino acid substitution in VSIV can govern sensitivity/r

134 genic reactivity, confirming that individual amino acid substitutions in A/H2N2 viruses can confer ma

135 recruitment, by different effects of single amino acid substitutions in ACKR3 on arrestin in respons

136 rus replication and the high fitness cost of amino acid substitutions in capsids to HIV-1 infectivity

137 We use single amino acid substitutions in DAXX that abrogate formation

138 s and characterized the genetic lineages and amino acid substitutions in each gene segment identified

139 le acid-dependent activation was enhanced by amino acid substitutions in ENaC that depress open proba

140 These results identify amino acid substitutions in Env that confer broad escape

141 Together, these findings demonstrate that amino acid substitutions in Fn-binding repeat-9 can sign

142 Amino acid substitutions in Fn-binding repeats (FnBRs) h

143 The location of a number of encoded amino acid substitutions in hemagglutinin-esterase fusio

144 and growth selection approach, we identified amino acid substitutions in human and mouse Ctr2 protein

145 dine (Q148H) and glycine-140->serine (G140S) amino acid substitutions in integrase that result in cli

146 Moreover, we found that seven specific amino acid substitutions in NP impair the function of RN

147 At least three human-specific amino acid substitutions in PA-X dramatically enhanced t

148 The locations of many of the amino acid substitutions in Pol delta resemble those of

149 nvestigate antimutator mutations that encode amino acid substitutions in Pol delta that suppress this

150 This allowed amino acid substitutions in rabbit PrP and accurate anal

151 ing lipid II in solution and that individual amino acid substitutions in ring A have little effect on

152 Amino acid substitutions in Rpb9 or Rpb1 that disrupt pr

153 n, but binding affinities were influenced by amino acid substitutions in the adjacent SH3 domain.

154 Many of these insects evolved parallel amino acid substitutions in the alpha-subunit (ATPalpha)

155 Single amino acid substitutions in the C-terminal membrane loca

156 All RV-A strains show high rates of amino acid substitutions in the capsid proteins at expos

157 mangabeys (SIVsm) clone SIVsmE543-3 acquired amino acid substitutions in the capsid that overcame TRI

158 g and requires a particular investigation of amino acid substitutions in the context of protein struc

159 focal leukoencephalopathy (PML) carry single amino acid substitutions in the domain of the VP1 capsid

160 These data revealed that specific amino acid substitutions in the EBOV GP have increased t

161 Both the SSPE and the MIBE viruses had amino acid substitutions in the ectodomain of the F prot

162 Importantly, single amino acid substitutions in the EF-hand domain of SEPN1

163 Indeed, we found that recently evolved amino acid substitutions in the GDH2 allosteric domain c

164 t generated using this MAb showed that three amino acid substitutions in the HA head domain contribut

165 ing approach to evaluate all possible single amino acid substitutions in the human TpoR TMD for their

166 promised due to antigenic drift arising from amino acid substitutions in the major influenza virus an

167 (ad) of BoNT/C1 through rationally designed amino acid substitutions in the metalloprotease domain o

168 A variety of amino acid substitutions in the NS3-4A protease of the h

169 We found that five amino acid substitutions in the NS5 protein reduced vira

170 PBP5 of HOU503 exhibited amino acid substitutions in the penicillin-binding domai

171 Amino acid substitutions in the repeat-region of FnBPA i

172 Amino acid substitutions in the RNAP interaction domain

173 Our studies show that single amino acid substitutions in the selectivity filters of A

174 Amino acid substitutions in the thumb subdomain of the R

175 sensitivity phenotype could be suppressed by amino acid substitutions in the transglycosylase domain

176 cell viability assays, we report that point amino acid substitutions in the trigger loop, a flexible

177 lC-Ka, we created mutations that resulted in amino acid substitutions in these residues.

178 ls transfected with PKAc variants containing amino acid substitutions in these three sites.

179 LDL) receptor (LDLR) mRNA did not reveal any amino acid substitutions in this cell line, HPAF-II cell

180 Amino acid substitutions in this region produce a hypera

181 The two amino acid substitutions in XylR enhance xylose utilizat

182 Here we identified a two-amino-acid substitution in RORgammat (RORgammat(M)) that

183 inst a majority of NS3 resistance-associated amino acid substitutions, including the highly prevalent

184 ssociation of gp120 with the virion and that amino acid substitution increased the amount of dissocia

185 rotein homology modelling suggests that four amino acid substitutions inferred to be under positive s

186 tions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions lead

187 uPA(-/-)) or uPAR (uPAR(-/-)) or with a four-amino acid substitution into the growth factor domain of

188 Here, by introducing two amino acid substitutions into the beta scorpion toxin Ts

189 Upon introducing these amino acid substitutions into the E. coli D-lactate prod

190 pocket generated by the insertion of the six amino acid substitutions, into which the pro-(S) carboxy

191 predicting changes in protein stability upon amino acid substitution is a much sought after goal.

192 by vEDS-associated mutations and by specific amino acid substitutions is unclear.

193 , but this activity was restored by a single amino acid substitution (K186E), which was responsible f

194 Amino acid substitutions K599E and T601M conferred no ga

195 the S. suis NrtR naturally contains a single amino acid substitution (K92E) in the catalytic site of

196 both ALA1 and ALA2 was abolished by a single amino acid substitution known to inactivate the flippase

197 The single amino acid substitution l-Leu47Lys results in 340-fold e

198 HR1 mutants encode an FHR-1 protein with two amino acid substitutions, L290S and A296V, converting th

199 Altering region II with two conservative amino acid substitutions (L92A/I94A) had the profound ef

200 The amino acid substitutions lie in two highly conserved loo

201 An amino acid substitution, lysine to glutamine, at positio

202 Here, we identify a single amino acid substitution (M159I) that fundamentally alter

203 anderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) rela

204 cid plasticity in vitro, tolerating multiple amino acid substitutions, many of which have not yet bee

205 te the power of our method, we construct two amino acid substitution matrices from the prediction sta

206 ic prediction method relies on the choice of amino acids substitution matrices.

207 DeMaSk first infers a directional amino acid substitution matrix from DMS datasets and the

208 her SSB folds and creation of truncation and amino acid substitution mutants, we provide the first ev

209 Amino acid substitution mutations within a PMS2 C-termin

210 Amino acid substitution mutations within the correspondi

211 the hemagglutinin (HA) of the H3N2 IAVs, the amino acid substitution N 145 K causes significant antig

212 r understanding of the functional effects of amino acid substitutions near the RBS and the interplay

213 For VP7 neutralization epitopes, amino acid substitutions observed at positions T91A/V, S

214 We find that unique amino acid substitutions occur at sites under positive s

215 ed novel transgenic mice harbouring a single amino acid substitution of arginine 124 with cysteine in

216 ted cell growth in the presence of drug, but amino acid substitutions of conserved NTD residues compr

217 The amino acid substitutions of MCR-3.5 have not altered its

218 mpared with planktonic-derived PG, including amino acid substitutions of the stem peptide and modific

219 Based on these predictions, we selected the amino acid substitution on Glu324, or on Asn408 to Lys t

220 provided in-depth insights on the effects of amino acid substitutions on IL-8 protein structure, func

221 Effects of identified amino acid substitutions on in vitro susceptibility to p

222 We investigated the effect of amino acid substitutions on propensity of the completely

223 Amino acid substitutions on the exterior surface of the

224 one (D137L) or two (D137L/G126R) stabilizing amino acid substitutions on the mechanical behavior of r

225 simulations that model the effect of several amino acid substitutions on the thermodynamic (DeltaG de

226 the effect of the shaker-1 mutation, a R502P amino acid substitution, on the motor function is unclea

227 VACV mutants with amino acid substitutions or duplications near the N term

228 ealed that some escape mutants possessing an amino acid substitution other than K166Q showed superior

229 closed active site, we observed that subtle amino acid substitutions outside the active site in the

230 at improves the prioritization of pathogenic amino acid substitutions over existing methods, generate

231 nonsense variant or c.164G>A that encodes an amino acid substitution p.Arg55His, but also affects spl

232 ely a c.526C > T substitution leading to the amino acid substitution p.L176F in the guanylate cyclase

233 = 1.3 x 10(-15); odds ratio [OR] = 9.4) with amino acid substitution p.V95A on the risk haplotype har

234 d a novel variant in KCNJ5 which leads to an amino acid substitution (p.Trp101Cys) in the first trans

235 x syndrome, associated with distinct de novo amino acid substitutions (p.Glu117Val and p.Glu117Gly) a

236 -3 that had been engineered to contain the 4 amino acid substitutions present in gp41 of SIVsm804E.

237 on/function produced by readthrough-mediated amino acid substitutions prevented a significant functio

238 rely autistic male patient carrying a single amino acid substitution (R101Q) in the NLGN4 gene.

239 the same missense mutation, which led to an amino acid substitution (R171W) in the MSN four-point-on

240 We find that the blue trait maps to a single amino acid substitution (R644W) in an uncharacterized po

241 We detected comparable accelerated amino acid substitution rates in FIS2 and MEA but not in

242 onally, there is a tight correlation between amino acid substitution rates inclpP1 and the nuclear-en

243 We found that these amino acid substitutions reduce the apparent Na(+) affin

244 This SNP produces a nonsynonymous amino acid substitution, replacing asparagine (N40) with

245 A single amino acid substitution responsible for SSS (W1570C) mar

246 The HA amino acid substitutions responsible for switching the a

247 volution of A/H2N2 viruses over time and the amino acid substitutions responsible for this antigenic

248 arrier protein and even conservative peptide amino acid substitutions resulted in a complete loss of

249 6-P-specific enzyme was started by a single amino acid substitution resulting in negative selection

250 lysis of the two iNK TCR types with a single amino acid substitution revealed that the staining inten

251 t prepared cyanobacterial ChlB variants with amino acid substitution(s) to mimic ChlB translated from

252 , secondary structure identity, tolerance to amino acid substitutions, solvent accessibility, and sid

253 We used an unbiased D-amino acid substitution strategy to determine structure-

254 The p.Tyr553Cys amino acid substitution strongly slowed ClC-6 gating and

255 of charge neutralization via acetylation or amino-acid substitutions such as K->Q.

256 able increase in stability with as few as 18 amino acid substitutions suggests that this bovinization

257 Two amino acid substitutions, T128D and N139K, located in th

258 We have updated the environment-specific amino-acid substitution tables based on the current expa

259 utants were designed to contain every single amino acid substitution that distinguishes rabbit recomb

260 tant allele produces a protein with a single amino acid substitution that is stable but assembles les

261 n S. discolor and S. vitellina, including an amino acid substitution that is unique to warblers but o

262 lation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 t

263 bitor 1A (SERPINA1) gene leading to a single amino acid substitution that results in an unfolded prot

264 It was shown that the same amino acid substitutions that abrogated the E2-DCTN6 int

265 The HA gradually accumulates amino acid substitutions that allow IAV to escape immuni

266 ed, the daughter gene (RNASE1B) has multiple amino acid substitutions that are parallel to those foun

267 Three GmVTL1a amino acid substitutions that block nitrogen fixation in

268 te binding cavity predisposes them to single amino acid substitutions that enable a switch between lo

269 at hPAH is more dynamic, which is related to amino acid substitutions that enhance the flexibility of

270 ted species enabled the identification of 11 amino acid substitutions that improved its thermostabili

271 n, to express the RSV F glycoprotein bearing amino acid substitutions that increase its stability in

272 While amino acid substitutions that result in escape from CD8(

273 To evaluate the contribution of each amino acid substitution to shaping the dynamic conformat

274 Single amino acid substitutions to benenodin-1 generate peptide

275 vious study of the fitness effects of single amino acid substitutions to calculate epistasis for over

276 in a protein family and prioritize interface amino acid substitutions to reprogram specific protein-p

277 We tested 7800 of 7828 possible single amino acid substitutions to the beta-2 adrenergic recept

278 ng with interspecies chimeras and individual amino acid substitutions, to identify regions required f

279 nd a derivative homology model containing 61 amino acid substitutions unique to the indirect flight m

280 We generated a knock-in model carrying an amino acid substitution (V154M) in mouse STING, correspo

281 We found that a single amino acid substitution (V6A) in a motif associated with

282 A Glu-217-Gln amino acid substitution was found to confer high Rca act

283 Using structure-guided amino acid substitutions, we increased the neutralizatio

284 Six amino acid substitutions were detected in 5 patients.

285 Amino acid substitutions were found in unique groups of

286 Fourteen amino acid substitutions were introduced into the NA of

287 Out of 86 variants of p145, seven amino acid substitutions were selected and made the basi

288 finding indicates that some of the numerous amino acid substitutions were selected to restore a viab

289 Resistance to C1 was conferred by a single amino acid substitution within the compound-binding site

290 Critically, a single destabilising amino acid substitution within the hCCS interface reduce

291 ceptor specificity, accumulation of multiple amino acid substitutions within a single hemagglutinin d

292 Specifically, we engineered alanine amino acid substitutions within each of the 5 VP1 region

293 kably, one copy, designated LeuRS-I, had key amino acid substitutions within its editing domain that

294 xpression or protein level but did have four amino acid substitutions within NCED3.

295 common human MLKL polymorphisms that encode amino acid substitutions within or adjacent to the brace

296 We identified 37 amino acid substitutions within the NA gene, 16 of which

297 tagenesis and functional studies to identify amino acid substitutions within the ubiquitin-binding su

298 repression of DNMT3A activity is blocked by amino acid substitutions within this interface, but surp

299 ation analysis of FeLV Env demonstrated that amino acid substitutions within variable region A altere

300 ncy virus type-1 (HIV-1) with HBV-associated amino acid substitutions Y115F/F116Y/Q151M in its RT (HI