ライフサイエンスコーパス: amino alcohol

1 on ligands bearing a chiral binaphthyl-based amino alcohol.

2 rac-1 to be used to determine the ee of the amino alcohol.

3 dily hydrolyzed to an oxazolidin-2-one or an amino alcohol.

4 the synthesis of anti-1,2-diols and anti-1,2-amino alcohols.

5 tereoselective reduction to syn- or anti-1,3-amino alcohols.

6 htforward approach to prepare chiral vicinal amino alcohols.

7 d total concentration of a variety of chiral amino alcohols.

8 pulated to yield highly enantioenriched free amino alcohols.

9 2-iodo-1-naphthoic acid and enantiopure beta-amino alcohols.

10 vailable two- and three-carbon Cbz-protected amino alcohols.

11 used for enantioselective sensing of chiral amino alcohols.

12 lled convergent elaboration of protected 1,5-amino alcohols.

13 n be used to prepare enantiopure N-aryl beta-amino alcohols.

14 ore conveniently, from the corresponding 1,2-amino alcohols.

15 in synthesizing pharmaceutical compounds and amino alcohols.

16 ymmetric synthesis of both syn- and anti-1,3-amino alcohols.

17 pha- and beta-amino acids, beta-lactams, and amino alcohols.

18 ghtforward access to either syn- or anti-1,2-amino alcohols.

19 ighly practical reagent for preparing chiral amino alcohols.

20 in a modular fashion, from readily available amino alcohols.

21 paration of anti-alpha-(difluoromethyl)-beta-amino alcohols.

22 the highly enantioselective synthesis of 1,2-amino alcohols.

23 can be enantioselectively quenched by chiral amino alcohols.

24 synthesized from K(2)PtCl(4) and appropriate amino alcohols.

25 efficiently and enantioselectively by chiral amino alcohols.

26 or protonated amino acid esters, amines, and amino alcohols.

27 e of phosphocholine and other phosphorylated amino alcohols.

28 ines has been developed to afford valuable B-amino alcohols.

29 ansformations of podophyllotoxin and several amino alcohols.

30 tereocenter-containing motifs, including 1,2-amino alcohols.

31 - and trans-N-Boc-monoprotected diamines and amino alcohols.

32 PHOX ligands as well as diversely protected amino alcohols.

33 iothiols, aliphatic, and aromatic amines and amino alcohols.

34 esis of a family of bicyclic fluorinated 1,3-amino alcohols.

35 lyzed heterocyclization reactions of allenic amino alcohols.

36 osynthetic strategy for the synthesis of 1,2-amino alcohols.

37 zolines, which are precursors of unsaturated amino alcohols.

38 ces between the two single hydrocarbon chain amino-alcohols.

39 c propargylation provides homopropargyl beta-amino alcohol 1 with high regio- and diastereoselectivit

40 This route was used to prepare amino alcohol 1, the core portion of the HIV protease in

41 catalyst systems derived from a multidentate amino alcohol (1).

42 ng causes of the selectivity for three gamma-amino alcohols, 1, 2, and 3.

43 The cis-decalin based gamma-amino alcohols, 1-5, were synthesized, resolved, and emp

44 the salicaldimine complex 11 and the derived amino alcohol 12 with 94% ee overall.

45 and allylation at the alpha-carbon to yield amino alcohol 17, which is similar to a hydride migratio

46 Amino alcohol 2-MAP was prepared from its trans isomer 2

47 Two-dimensional NMR was used to characterize amino alcohol 2-MAP, and NOE was used to confirm its rel

48 Amino alcohols 2-MAP and 3-MAP were also found to be use

49 Regioisomeric amino alcohols 2-MAP and 3-MAP, even though they were pr

50 The protected amino-alcohol ((2R,3R,4R,5R)-5-amino-2,3:4,6-diisopropyl

51 Amino alcohol 3-MAP was synthesized by converting (+)-no

52 nene, was converted to the two regioisomeric amino alcohols 3-MAP and 2-MAP in very good yield and ex

53 involving regioisomeric, pseudo-enantiomeric amino alcohols 3-MAP and 2-MAP.

54 )allyliridium-aldehyde pairs to form vicinal amino alcohols 3a-3z, 3a'-3c' with high levels of regio-

55 dditions to aldehydes promoted by the chiral amino alcohol 415, but this process was not catalytic ye

56 1,3-Anti amino alcohols 5(a)-18(a) are obtained with high diaster

57 Polymer-supported amino alcohols 5a-c have been evaluated as catalytic lig

58 A series of gamma- and beta-amino alcohols 6 and 15 was designed to restrict the cor

59 bromide to ester 4 and converted to pyrrolyl amino alcohol 7 by olefin oxidation and Paal-Knorr conde

60 O-N acyl migration to install the C-terminal amino alcohol, a different strategy was required to acce

61 nit Pol32 of DNA polymerase delta and for T2-amino alcohol, a small-molecule inhibitor of human PCNA.

62 a mild one-pot oxidative lactamization of an amino alcohol, a two-step Z-selective olefination of a s

63 A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs)

64 to isocyanate formation and primary amine or amino alcohol accelerated skeletal rearrangement to synt

65 selective formation of the corresponding syn-amino alcohol adduct 3.

66 s to the formation of the corresponding anti-amino alcohol adduct 4 with high stereoselectivity.

67 The reaction affords a range of beta-amino alcohols, after reduction of the aldehyde in situ,

68 The strategy employs a variety of amino alcohols/amines and proceeds with 6 + 4/6 + 5 and

69 l aziridine building blocks with an array of amino alcohols/amines in a modular one-pot, sequential p

70 eric composition of chiral amines, diamines, amino alcohols, amino acids, and alpha-hydroxy carboxyli

71 ctionalization of aliphatic C-H bonds within amino alcohols, an important class of small molecule.

72 molecular hydrogen bonding between the bound amino alcohol and the proximate N-oxide group.

73 e amide is reduced to the corresponding beta-amino alcohol and the substrate is then bis-nosylated to

74 This was reduced to the primary amino alcohol and was converted to the morpholino group

75 Oxazaborolidines made from chiral amino alcohols and 6-tosyl-1-hexenylboronic acid were tr

76 ations of this catalyst for the synthesis of amino alcohols and a one-pot procedure for indole synthe

77 activity is exploited to convert alkyls into amino alcohols and allylic amines.

78 s to produce chiral alpha-hydroxy acids, 1,2-amino alcohols and alpha-amino acids, respectively.

79 uantitative ee and concentration analysis of amino alcohols and alpha-hydroxy acids.

80 nd concentration of unprotected amino acids, amino alcohols and amines.

81 mino group, stereospecific oxidation to beta-amino alcohols and C-C bond transformations of the secon

82 pplied to more challenging compounds, namely amino alcohols and diastereomers possessing more than on

83 ides and cyclic nitrones derived from chiral amino alcohols and glyoxylic acid is reported.

84 backbone substituted N,N-bisubstituted beta-amino alcohols and isolated via flash column chromatogra

85 ore undergoes rapid condensation with chiral amino alcohols and subsequent asymmetric transformation

86 enamides toward the synthesis of cis vicinal amino alcohols and tetrasubstituted alpha-borylamido com

87 n of the nitro alcohols to the corresponding amino alcohols and their subsequent conversion to enanti

88 igh for pyridines, diamines, polyamines, and amino alcohols) and precise filtering conditions for mix

89 -fluoroacetoxylated products, 1,3-diols, 1,3-amino alcohols, and 1,3-diamines.

90 pid determination of the ee value of amines, amino alcohols, and amino acid esters.

91 quinones react smoothly with chiral amines, amino alcohols, and amino acids toward push-pull conjuga

92 iomers of 1,2- and 1,3-diols, chiral amines, amino alcohols, and amino-acid esters.

93 ant motifs including beta-amino acids, gamma-amino alcohols, and azetidines.

94 analysis of unprotected amino acids, amines, amino alcohols, and carboxylic acids in aqueous solution

95 e configurations of erythro and threo diols, amino alcohols, and diamines is reported.

96 Access to substituted amines, amino alcohols, and diamines is thereby made possible in

97 cids, amino phosphonic acids, hydroxy acids, amino alcohols, and diamines with an auxiliary-free coba

98 (3E)-2,5-anti-2,6-syn-substituted enediols, amino alcohols, and homoallylic alcohols in modest to hi

99 by their conversion to gamma-lactams, delta-amino alcohols, and hydrolysis products in high yields w

100 al functionalities present in carbohydrates, amino alcohols, and hydroxylated acyclic compounds in go

101 t motifs, including gamma-amino acids, delta-amino alcohols, and pyrrolidines.

102 0 alcohols, diols, hydroxy acids, amines and amino alcohols, and the accuracy of the stereochemical a

103 A series of amino alcohol- and diamino-cis-decalins were synthesized

104 Besides anti-beta-amino alcohols, anti-2-amino-1,3-diols and anti-3-amino-

105 These amino alcohols are based on serine (seramox) or isoserin

106 Enantiopure beta-amino alcohols are converted into N-hydroxyethylamides,

107 The amino alcohols are efficiently transformed to protected

108 Amino alcohols are not only functionally diverse but are

109 As a proof of concept, beta- and gamma-amino alcohols are prepared from the corresponding polye

110 Chiral 1,3-amino alcohols are ubiquitous structural motifs in natur

111 Chiral amino alcohols are valuable building blocks in the synth

112 Amino alcohols are vital in natural products, pharmaceut

113 Chiral 1,2-amino alcohols are widely represented in biologically ac

114 xample that species generated from the (beta-amino alcohol)(arene)RuCl (II) catalytic precursor can s

115 was used to study the reactivity of a (beta-amino alcohol)(arene)RuCl transfer hydrogenation catalyt

116 dependent upon the structure of reacting 1,2-amino alcohol as well as the unique properties of ethyle

117 By using natural and non-natural amino alcohols as "side chains" for the proline derivati

118 The usefulness of norephedrine-derived beta-amino alcohols as catalysts for the enantioselective alk

119 Employment of tethered optically active amino alcohols as pronucleophiles allowed for efficient

120 n indirect methanation method that harnesses amino alcohols as relay molecules in combination with a

121 mount and the enantiomeric excess of several amino alcohols at micromolar concentrations is reported.

122 emistry of a variety of chiral 1,2-diols and amino alcohols at room temperature with no chemical deri

123 As a result, from a single amino alcohol auxiliary, both enantiomers of key P-stere

124 eproducibility of GCC-IRMS determinations of amino alcohols averaged SD(613C) = 0.25 +/- 0.19%.

125 of compounds with 2, 3, or 4 carbon diol or amino alcohol backbones and oleoyl or palmitoleoyl acyl

126 These findings suggest that such secondary amino alcohol based linkers might be suitable tools for

127 curate concentration, er, and dr analysis of amino alcohols based on a simple mix-and-measure workflo

128 In the presence of enantioenriched amino alcohol-based catalysts, ArZnBu adds to aldehydes

129 (CaR) resulted in the identification of the amino alcohol-based hit 2 (IC(50) = 11 microM).

130 ly available amino acids or their respective amino alcohols (both antipodes), we obtained a complete

131 Amino alcohol calcilytics have been assessed as ADH1 the

132 ATF936 and AXT914, as well as the amino alcohol calcilytics, NPS 2143 and NPSP795, were sh

133 We have identified an amino-alcohol carbazole (N-CBZ) as a PfHsp90-selective i

134 carbonyls has been accomplished using a new amino alcohol catalyst in the presence of electron-rich

135 pM, third-generation) contains an open-chain amino alcohol cation with two asymmetric carbons.

136 ase method for the preparation of C-terminal amino-alcohol-containing peptides using activated Wang r

137 Opening of representative epoxides with 1,2-amino alcohols delivered the amino diols.

138 nonpolar amino acids to their corresponding amino alcohols, demonstrate a GC strategy to produce acc

139 ransformation to convert a relatively simple amino alcohol derivative to the functionalized core of t

140 furnished medicinally important N-aryl beta-amino alcohol derivatives in moderate to good yields.

141 ediated amidation of unactivated esters with amino alcohol derivatives is reported.

142 n efficient sequence of reactions, the above amino alcohol derivatives were subsequently transformed

143 nt C-C bond-forming step, furnishing syn 1,2-amino alcohol derivatives with excellent levels of diast

144 It can also provide amino alcohol derivatives with regio- and stereochemical

145 beta-amino acids and their corresponding 1,3-amino alcohol derivatives.

146 wide range of amino lactones as well as 1,2-amino alcohol derivatives.

147 dines in this reaction afforded N-aryl gamma-amino alcohol derivatives.

148 This circumvents the necessity to synthesize amino alcohols derived from (-)-nopinone, which in turn

149 we have been able to employ enantiopure 1,2-amino alcohols derived from abundant amino acids in C-C

150 diastereomers accessed by ring-opening of an amino alcohol-derived cyclic sulfamidate.

151 lectively to produce either the syn- or anti-amino alcohol diastereomer.

152 pure epoxides (ee, 99%) and N-protected beta-amino alcohols (ee, 99%) with quantitative yield in 16 h

153 for Cinchonine and Cinchonidine epimers and amino alcohol enantiomers, from which the quantitative d

154 esulted exclusively in C-O coupling when the amino alcohols featured primary alcohols and more hinder

155 vels of enantioselection, as constrained 1,3-amino alcohols featuring a chiral tertiary alcohol carbo

156 -methyl-2-imidazolecarboxaldehyde and chiral amino alcohols followed by reduction is key to the desig

157 e synthesis of five- or six-membered lactone amino alcohols, followed by incorporation of the require

158 llenge, we report linkers based on secondary amino alcohols for the release of peptides after capture

159 ocycles from commercially available chiral B-amino alcohols, formal inert C-H functionalization throu

160 he basicity of the hydroxyl group of the CF3 amino alcohol formed.

161 mination enabled broad access to chiral beta-amino alcohols from a variety of alcohols containing alk

162 dual purpose of installing the necessary 1,2-amino alcohol functionality as well as providing an effi

163 o-Mannich reaction to introduce the syn-beta-amino alcohol functionality of conduramine E and ring-cl

164 doxorubicin, reacts with formaldehyde at its amino alcohol functionality to produce a conjugate, Epid

165 well as the linker chain containing the beta-amino alcohol functionality.

166 Reduction of the resulting N-Boc amino alcohols furnished hygrolines and pseudohygrolines

167 t in the fluorous phase when treated with an amino alcohol generated from the asymmetric reaction of

168 ethyl (Dde) in place of Z protection on the amino alcohol has allowed us to introduce cationic amino

169 e Ts group, and subsequent formation of beta-amino alcohols have also been developed.

170 A commercially available collection of beta-amino alcohols have been converted to their correspondin

171 a range of cyclic allylic amines and vicinal amino alcohols have been prepared stereoselectively and,

172 The amino alcohol head group of the sphingosine backbone is

173 es an unusual four-electron oxidation of the amino alcohol histidinol via the histidinaldehyde interm

174 viding fast access to enantioenriched chiral amino alcohols, important building blocks for medicinal

175 atalyzed reaction of 4 and 5 to give the syn-amino alcohol in excellent yield and very high diastereo

176 on a surface and spraying a solution of beta-amino alcohol in methanol, two unique transient intermed

177 ility study of the activated alpha-aryl-beta-amino alcohol in this system.

178 These compounds can be prepared from beta-amino alcohols in enantiomerically pure form through a t

179 yl aldimines provides 1,2-disubstituted beta-amino alcohols in good yields (73-98%) and with high dia

180 ymmetric synthesis of highly substituted 1,2-amino alcohols in high yield and diastereoselectivity is

181 ver Pd/C furnished syn-1,2-disubstituted-1,3-amino alcohols in high yields (82-90%) with moderate to

182 precursors in the synthesis of protected 1,2-amino alcohols in high yields and diastereoselectivities

183 condensation of secondary alcohols and beta-amino alcohols in one pot to the pyrrole derivatives.

184 ersion of catalytically incompatible primary amino alcohols into hindered secondary amines that are c

185 vised, and the enantiopurity of the starting amino alcohol is retained in the aziridine product.

186 The formation of chiral poly 1,3-amino alcohols is also demonstrated.

187 y enamines to generate 1,2-disubstituted-1,3-amino alcohols is also outlined.

188 reparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic sys

189 tuted morpholines from enantiomerically pure amino alcohols is described.

190 ic amines, aromatic amines, amino acids, and amino alcohols is described.

191 hesis of complex aminocyclopentitols and 1,2-amino alcohols is discussed.

192 c alcohols for the synthesis of chiral gamma-amino alcohols is presented.

193 en-bond complexes between the dendrimers and amino alcohols is proposed to account for the fluorescen

194 ated NH(2) group in sphingosine, which is an amino-alcohol, is required for sphingosine's bactericida

195 igand does not require optically pure biaryl amino alcohols, its synthesis is significantly shorter a

196 tions in the presence of chiral diamines and amino alcohols led to the enantioselective allylation of

197 a dichloromethane solution of ( S)- or ( R)-amino alcohols led to the formation of polymer films at

198 Aminolysis of the latter entity with an amino alcohol liberates a thiol that reacts with an acry

199 t-hand side aromatic moieties as well as the amino alcohol linker region.

200 by an elemental analyzer coupled to IRMS and amino alcohols measured by GCC-IRMS was delta613C = 0.14

201 dihydropyran-2-one to the C-2, C-3 trans-1,2-amino alcohol moiety as present in ezoaminuroic acid.

202 e organocatalyst featuring a chiral diphenyl amino alcohol moiety instead derived its preferred (R)-a

203 f a catalyst derived from an enantioenriched amino alcohol (morpholino isoborneol, MIB).

204 s bulky quinone oxidant, the kinetic syn-1,3 amino alcohol motif can be accessed in comparable yields

205 establish the stereochemistry of the vicinal amino alcohol motif embedded within the targets.

206 hat enables unprecedented access to anti-1,3 amino alcohol motifs in good yields (33 substrates, avg.

207 c C-H amination reaction en route to syn-1,3-amino alcohol motifs is reported.

208 e highly selective synthesis of anti-vicinal amino alcohol natural products.

209 Due to the great value of amino alcohols, new methods for their synthesis are in h

210 ated with a mixture of the enantiomers of an amino alcohol, no fluorescence enhancement was observed

211 phosphine ligand, Pd(II) and a chiral amine, amino alcohol or amino acid gen-erates characteristic UV

212 d acceptorless dehydrogenative annulation of amino alcohols or 2-hydroxybenzyl alcohols has been prov

213 ,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids.

214 amic probes designed to rapidly bind amines, amino alcohols, or amino acids and to translate this bin

215 Building on peptidic amino alcohols originating from a phenotypic screening h

216 -epi-hyacinthacine B3 from a common anti-1,2-amino alcohol precursor is described.

217 he preparation of several functionalized 1,3-amino alcohol precursors.

218 zation-oxidation reaction of a Boc-protected amino alcohol, prepared from 3-butynol, which led to the

219 However, in some instances, the yield of an amino alcohol product and the regioselectivity could be

220 Either syn- or anti-amino alcohol products can be obtained by the appropriat

221 on oxidation reaction, to afford substituted amino alcohol products.

222 establishing a route to enantioenriched 1,3-amino alcohol products.

223 Specifically, we synthesized these amino-alcohol products using sequential, copper-hydride-

224 a route to all possible stereoisomers of the amino-alcohol products, which contain up to three contig

225 alysts generated the desired library of beta-amino alcohols rapidly and efficiently.

226 h hydrogen), simultaneously regenerating the amino alcohol relay molecule.

227 n of alkenes to unprotected, enantioenriched amino alcohols remains a challenge.

228 s to access medicinally valuable chiral beta-amino alcohols remains elusive.

229 hons where N-benzyloxycarbonyl (Z) protected amino alcohols replace the cyanoethyl group.

230 The amino alcohol residue of the coupling product 4 was oxid

231 neumococci appears to be the role that these amino alcohol residues play in a pneumococcal immune eva

232 transformation to optically active diol and amino alcohol scaffolds.

233 The systematic variation of the 4-position amino alcohol side chain led to analogues that maintaine

234 re a subgroup of glycolipids that contain an amino alcohol sphingoid base linked to sugars.

235 ved using biphasic conditions for a range of amino alcohol starting materials.

236 in, we report the synthesis of protected 1,2-amino alcohols starting from carbonyl compounds and alph

237 TC undergo stoichiometric reactions with the amino alcohol substrates to afford ureas and cyclic carb

238 ngle conformation upon condensation with two amino alcohol substrates.

239 emoselectively N- and O-arylate a variety of amino alcohol substrates.

240 their preparation most often focus first on amino alcohol synthesis and then reaction with phosgene

241 on-peptide small molecule PCNA inhibitor, T2 amino alcohol (T2AA), a T3 derivative that lacks thyroid

242 ein box (PIP-Box) interactions, including T2 amino alcohol (T2AA), inhibit translesion DNA synthesis.

243 of a carboxylic acid functionality into the amino alcohol template led to the identification of 12 w

244 Ring-opening of the isoxazolidines gives amino alcohols that can be converted to 1,3-oxazines, re

245 ic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes

246 des can be reduced to beta-substituted-gamma-amino alcohols, the major diastereomer of which can be i

247 N-heterocycles by using 1,3-dicarbonyls and amino alcohols through a domino sequential enamine forma

248 ]-catalyzed oxidative N-heterocyclization of amino alcohol to form the key amide bond.

249 environmentally friendly method to transform amino alcohols to amino acid salts using just basic wate

250 ysis for amino acids and their corresponding amino alcohols to evaluate any possible isotopic fractio

251 e deoxofluoro-arylsulfinylation of diols and amino alcohols to give fluoroalkyl arylsulfinates and ar

252 The catalyst efficiently transforms amino alcohols to oxazolidinones (upon reaction with CO(

253 ereospecific conversion of syn- and anti-1,2-amino alcohols to their respective syn- and anti-1,2-imi

254 [reaction: see text] Amino alcohols undergo W(CO)(6)-catalyzed oxidative carb

255 e case of adequately substituted enantiopure amino alcohols, up to 95:5 of diastereoisomeric excess w

256 -5,6-dihydro-1,3-oxazines, precursors of 1,3-amino alcohols, using the palladium-catalyzed cyclizatio

257 rescence of 1 can be effectively quenched by amino alcohols via H-bonding with the binaphthol moietie

258 e seen in the synthesis of anti- and syn-1,3 amino alcohol vitamin D3 analogue intermediates in half

259 The resulting amino alcohol was alkylated and then deoxygenated using

260 This amino alcohol was formed faster, but its subsequent dehy

261 substituted anti-alpha-(difluoromethyl)-beta-amino alcohol was further elaborated to form (2S,3R)-dif

262 GC separation of a mixture of the six amino alcohols was achieved using a thick stationary-pha

263 d dynamic covalent chemistry with amines and amino alcohols was developed and applied to quantitative

264 direct amidation of unactivated esters with amino alcohols was developed without the use of transiti

265 highly enantioenriched N-(2-ethylamino)-beta-amino alcohols was developed.

266 n of fluorinated alpha-bromoenones with beta-amino alcohols was elaborated.

267 ral information from small readily available amino alcohols was employed to control relative and abso

268 (fluorenylmethoxy)carbonyl (Fmoc) protected amino alcohols was found to load rapidly and efficiently

269 reaction with ambident nucleophiles such as amino alcohols was highly selective and took place exclu

270 lel to the reaction paths for simple amines, amino alcohols were converted into hydroxy sulfinyl amid

271 lected examples of 1,2-, 1,3-, 1,4-, and 1,5-amino alcohols were converted to the ureas in good to ex

272 sessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent h

273 The requisite amino alcohols were either commercially available (DBFOX

274 These amino alcohols were employed as chiral auxiliaries in th

275 A range of 1-allenyl-2-amino alcohols were obtained with excellent regioselecti

276 Enantioenriched beta-functionalized-gamma-amino alcohols were produced from simple achiral enals i

277 Enantiomerically pure anti-beta-amino alcohols were synthesized from optically pure alph

278 studies was derived from chiral, nonracemic amino alcohols which, themselves, were prepared from ami

279 (13)CN yielded the corresponding diprotected amino alcohol, which was readily converted to 32.

280 ino ketone product with Zn(BH4)2 gives a 1,3-amino alcohol with modest diastereoselectivity.

281 ning was used to etherify an alpha-aryl-beta-amino alcohol with stereochemical retention.

282 PE as the supporting ligand, generating anti-amino alcohols with >98% (Z)-selectivity under mild cond

283 unknown chemoselective O- and N-arylation of amino alcohols with (hetero)aryl chloride electrophiles,

284 mides, which furnished chiral amines or beta-amino alcohols with 94-->99% ee.

285 rding enantiomerically enriched chiral gamma-amino alcohols with broad substrate scope and excellent

286 es affords epoxy-diols and N-protected epoxy-amino alcohols with excellent enantio- and diastereosele

287 the reaction provided racemic Fmoc-protected amino alcohols with excellent regioselectivity but in lo

288 process readily affords synthetically useful amino alcohols with excellent selectivity (dr up to > 20

289 ducts from reaction of simpler vicinal trans-amino alcohols with formaldehyde.

290 nes provided the corresponding (2S,3R)-alpha-amino alcohols with good-to-excellent diastereoselectivi

291 F, leading to a remarkable chiral sensor for amino alcohols with greatly enhanced sensitivity and ena

292 chrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500

293 approach for the expeditious construction of amino alcohols with high levels of chemo-, regio-, diast

294 e 3-hydroxyimines can be reduced to give 1,3-amino alcohols with high syn selectivity.

295 reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78 deg

296 no ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5 degrees

297 1 was quenched by four chiral amino alcohols with unprecedentedly high Stern-Volmer co

298 cyclic amines via efficient chlorination of amino alcohols with use of SOCl(2) has been developed.

299 ane and LiBHEt(3) provides syn- and anti-1,3-amino alcohols with very high diastereomeric ratios.

300 es, readily available from the corresponding amino alcohols, yield enantioenriched keto-polyheterocyc