ライフサイエンスコーパス: aminopeptidase

1 lated aminopeptidase (IRAP), a transmembrane aminopeptidase.

2 trometry identified the protease as aspartyl aminopeptidase.

3 manganese as co-factor, including the BB0366 aminopeptidase.

4 1, but lacked the canalicular marker leucine aminopeptidase.

5 n with the structural core of the methionine aminopeptidase.

6 se as selective inhibitors for this group of aminopeptidases.

7 anic chemistry of DNPEP and other M18 family aminopeptidases.

8 f preferred amino acid cleavage by cytosolic aminopeptidases.

9 ding over 200 cleavages of blood proteins by aminopeptidases.

10 n of the substrate specificity of individual aminopeptidases.

11 ral characterization of several archaeal M42 aminopeptidases.

12 Endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 critically shape the

13 cursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event

14 ER aminopeptidase 1 (ERAP1) is an intracellular enzyme that

15 Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that

16 ide peptidase and endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is required for processing of t

17 Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims antigenic peptide precurs

18 Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides for MHC class I

19 Here, we identify endoplasmic reticulum aminopeptidase 1 (ERAP1), a key regulator of innate and

20 mily of M1 aminopeptidases, consisting of ER aminopeptidase 1 (ERAP1), ER aminopeptidase 2 (ERAP2), a

21 ow-activity variant of endoplasmic reticulum aminopeptidase 1 (ERAP1), Hap10, is associated with the

22 hin the aminopeptidase endoplasmic reticulum aminopeptidase 1 (ERAP1), which is essential for trimmin

23 rocessing peptidase and then by octapeptidyl aminopeptidase 1 (Oct1).

24 ses the aggregation of the premature form of aminopeptidase 1 (prApe1) in cytosol and its sequestrati

25 of the subtilase family and meiotic prophase aminopeptidase 1 using mass spectrometry-based proteomic

26 association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), whic

27 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) cooperate to t

28 llular aminopeptidases endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2), and as well a

29 ast to cytosolic peptidases, silencing of ER aminopeptidases 1 and 2 strongly impaired pp65(495-503)-

30 Endoplasmic reticulum-associated aminopeptidase-1 (ERAP1) plays a critical role in the pr

31 ates, we determined crystal structures of ER aminopeptidase 2 (ERAP2) in complex with a substrate ana

32 onsisting of ER aminopeptidase 1 (ERAP1), ER aminopeptidase 2 (ERAP2), and insulin-regulated aminopep

33 n the present study we found that methionine aminopeptidase 2 (MetAP2), a critical component of the t

34 459P mirrored those of endoplasmic reticulum aminopeptidase 2, a human enzyme with proline in the var

35 activity due to binding to human methionine aminopeptidase 2.

36 enic activity by binding to human methionine aminopeptidase 2.

37 Inhibition of methionine aminopeptidase-2 (MetAP2) represents a novel approach to

38 ite mutations, respectively, in the X-prolyl aminopeptidase 3 (XPNPEP3) gene.

39 al and cytosolic splice variants of X-prolyl aminopeptidase 3, can cause nephronophthisis-like ciliop

40 Aminopeptidase A (APA) is expressed in glomerular podocy

41 ral renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by sp

42 tamylcyclotransferase (gamma-GCT) as well as aminopeptidase A (APA), which are overexpressed in renal

43 Leucine aminopeptidase A (LapA) is a late wound-response gene of

44 y and safety of firibastat, a first-in-class aminopeptidase A inhibitor preventing conversion of brai

45 to chemical biology, with a platform for Zn-aminopeptidase A inhibitors being constructed here.

46 0)], and 6C3 [ENPEP glutamyl aminopeptidase (aminopeptidase A)].

47 e II/III of development, while inhibitors of aminopeptidase A, dopamine beta-hydroxylase, and the int

48 studies support the existence of protective aminopeptidase A-Ang III-Ang II type 2 receptor and ACE2

49 an MxaD homolog, an ABC-type transporter, an aminopeptidase, a putative homospermidine synthase, and

50 ng gamma-glutamyl transferase (GGT), alanine aminopeptidase (AAP), and N-acetyl-beta-d-glucosaminidas

51 teases, acid proteases, metalloproteases, or aminopeptidases abolished the effects of MET-1.

52 These data suggest a mechanism by which aminopeptidase access is determined and offer an explana

53 ates the omega-end of LTA4, distant from the aminopeptidase active site, thus providing a molecular b

54 HIV PIs altered not only proteasome but also aminopeptidase activities in PBMCs.

55 bifunctional enzyme with epoxy hydrolase and aminopeptidase activities.

56 hough sparing the enzyme's anti-inflammatory aminopeptidase activity (i.e., degradation and inactivat

57 We hypothesize that the LTA4H aminopeptidase activity alleviates neutrophilic inflamma

58 ne product possesses previously unrecognized aminopeptidase activity but no carboxy- or endopeptidase

59 The attenuation of CtsH aminopeptidase activity by a specific inhibitor or siRNA

60 potent leukocyte activating agent, while the aminopeptidase activity cleaves and inactivates the chem

61 ated for their ability to detect beta-alanyl aminopeptidase activity in bacteria known to hydrolyze b

62 all yield and were selective for beta-alanyl aminopeptidase activity in bacteria, producing a lighter

63 acological inhibition of puromycin-sensitive aminopeptidase activity in cell lines permissive for IBD

64 e biological contributions made by the LTA4H aminopeptidase activity in CS-induced emphysema, we expo

65 To analyze aminopeptidase activity in vitro (including high-through

66 Acrolein modifies LTA4H and inhibits aminopeptidase activity to the same extent as cigarette

67 When the LTA4H aminopeptidase activity was selectively augmented by 4MD

68 PGP/AcPGP and LTA4H aminopeptidase activity were detected by mass spectrosco

69 ease inhibitors and chosen metal ions on the aminopeptidase activity were determined.

70 However, restoring the leukotriene A4 aminopeptidase activity with a pharmaceutical agent prot

71 LTA(4)H also possesses aminopeptidase activity with unknown substrate and physi

72 pment of COPD, selectively inhibited LTA(4)H aminopeptidase activity, which led to the accumulation o

73 mation through selective inhibition of LTA4H aminopeptidase activity.

74 GP in the airspaces by suppressing the LTA4H aminopeptidase activity.

75 a lysosomal cysteine protease with a strong aminopeptidase activity.

76 trate a detailed catalytic mechanism for its aminopeptidase activity.

77 yl)urea) are competitive inhibitors of ERAP1 aminopeptidase activity.

78 significantly lower as compared with Xaa-Pro aminopeptidase activity.

79 rminated winter rape seeds were screened for aminopeptidase activity.

80 comparable to that of unlabeled Cry11Ba and aminopeptidase AgAPN2(t1) peptide.

81 ifferentiation 90)], and 6C3 [ENPEP glutamyl aminopeptidase (aminopeptidase A)].

82 hanges that occur along with inactivation in aminopeptidase, an abundant class of extracellular enzym

83 we report the structure of insulin-regulated aminopeptidase, an enzyme that prepares antigenic epitop

84 Both ERAP2 and leucine aminopeptidase, an enzyme unrelated to antigen processin

85 In particular, for dipeptidyl aminopeptidase, an SP that is recognized by the SRP for

86 rengthen a biochemical model that interlinks aminopeptidase and DPP4 activities.

87 Both Xaa-Pro aminopeptidase and mitochondrial processing activities o

88 (495-503) epitope presentation after leucine aminopeptidase and tripeptidyl peptidase II knockdown.

89 degraded by the cytosolic peptidases leucine aminopeptidase and tripeptidyl peptidase II, as evidence

90 ses (mainly, tri- and di-peptidylpeptidases, aminopeptidases and carboxypeptidases).

91 l secreted proteolytic activities, including aminopeptidases and carboxypeptidases.

92 ses, mainly, tri- and di-peptidylpeptidases, aminopeptidases and carboxypeptidases.

93 erwent endosomal and cytosomal processing by aminopeptidases and proteases.

94 in-class peptide-drug conjugate that targets aminopeptidases and rapidly and selectively releases alk

95 c cleavage events associated with methionine aminopeptidases and signal peptide peptidases, as well a

96 DUF4424 domain and individual domains of M1 aminopeptidases and tricorn proteases, which form massiv

97 t dynamic equilibrium may apply to other M17 aminopeptidases and underpin the moonlighting capabiliti

98 r trypsin, 14.8% for chymotrypsin, 93.4% for aminopeptidase, and 19.7% for pepsin.

99 kin (IL)-6, insulin (INS), alanyl (membrane) aminopeptidase (ANPEP), and IL-10 were observed in the P

100 of the leukotriene A(4) hydrolase (LTA(4)H) aminopeptidase (AP) activity with 4-methoxydiphenylmetha

101 The M42 aminopeptidases are dinuclear aminopeptidases displaying

102 Aminopeptidases are key enzymes involved in the regulati

103 Tetrahedral (TET) aminopeptidases are large polypeptide destruction machin

104 M17 leucyl aminopeptidases are metal-dependent exopeptidases that r

105 roteins such as GLUT4 and insulin-responsive aminopeptidase, as well as six proteins not previously r

106 ading complex, and the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP) are

107 es in mice lacking the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP).

108 in the absence of the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP).

109 s, TAP, and endoplasmic reticulum-associated aminopeptidase associated with Ag processing, but not ta

110 The endoplasmic reticulum aminopeptidase associated with Ag processing, ERAAP, pla

111 Additionally, with prolyl oligopeptidase and aminopeptidase B we identified two new Ag processing mac

112 ming of N-extended peptides into epitopes by aminopeptidases before loading onto MHC class I molecule

113 of an evolutionary highly conserved aspartyl aminopeptidase called DNPEP.

114 derived from the Escherichia coli methionine aminopeptidase can disrupt secondary and tertiary struct

115 Aminopeptidases catalyze N-terminal peptide bond hydroly

116 Each N-terminal modification prevented aminopeptidase cleavage but surprisingly differed in its

117 In this study, we identified cytosolic aminopeptidases cleavage preferences in primary cells an

118 The oxytocinase subfamily of M1 aminopeptidases, consisting of ER aminopeptidase 1 (ERAP

119 The M42 aminopeptidases are dinuclear aminopeptidases displaying a peculiar tetrahedron-shaped

120 Aspartyl aminopeptidase (DNPEP) has been implicated in the contro

121 n ABC transporter with a periplasmic metallo-aminopeptidase domain forms a sensory complex with UzcRS

122 The aminopeptidase DPP9 removes dipeptides from N-termini of

123 m of molecular piracy by a broadly conserved aminopeptidase during disease pathogenesis.

124 ctive inhibitor HFI-419 on insulin-regulated aminopeptidase (EC 3.4.11.3) in the rat neocortex.

125 Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminopeptidase 1 (E

126 Intracellular aminopeptidases endoplasmic reticulum aminopeptidases 1

127 e pp65(495-503) epitope, whereas ER-resident aminopeptidases enhance such generation.

128 A counter screen against glutamyl aminopeptidase (ENPEP), an enzyme with substrate specifi

129 The aminopeptidase ERAAP is essential for trimming peptides

130 The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role i

131 trimming process overall and of the major ER aminopeptidase ERAP1 in particular is not well understoo

132 The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immun

133 sion of the peptide transporter Tap1 and the aminopeptidase Erap1, which are required for MHC-I traff

134 he strong selectivity compared to homologous aminopeptidases ERAP1 and ERAP2.

135 Members of the oxytocinase subfamily of M1 aminopeptidases (ERAP1, ERAP2, and IRAP) play important

136 xpert trimming done by endoplasmic reticulum aminopeptidases (ERAPs), the final peptidases in the ant

137 together, these results indicate that the M1 aminopeptidase family is a divergent family with three s

138 The members of the M1 aminopeptidase family share conserved domains, yet show

139 Removal of N-terminal Met by Met-aminopeptidases frequently leads to Nt-acetylation of th

140 We applied this concept to methionine aminopeptidase from Mycobacterium tuberculosis and showe

141 Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiologi

142 PepX aminopeptidase from Streptococcus thermophilus ACA DC 00

143 pable of potent inhibition of the M1 and M17 aminopeptidases from both P. falciparum ( Pf-M1 and Pf-M

144 The M17 aminopeptidases from Plasmodium falciparum (PfA-M17) and

145 M1 family metallo-aminopeptidases fulfill a wide range of critical and in

146 eady-state kinetic studies revealed that the aminopeptidase has broad activity, with a preference for

147 Aminopeptidases have been linked to the editing of pepti

148 the variable residue in the S1 subsite of M1-aminopeptidases have facilitated the evolution of new sp

149 To perform this function, ER aminopeptidases have to recognize and process a vast var

150 (IEF) suggest the presence of more than one aminopeptidase, having similar molecular mass.

151 gest a new name for this enzyme: human ileal aminopeptidase (HILAP).

152 essing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and

153 ure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: a new strategy to

154 de-ranging importance of the host methionine aminopeptidase in phage replication.

155 ates with the absence of puromycin-sensitive aminopeptidase in these cells.

156 activation, indicating the importance of ER aminopeptidases in pp65(495-503) generation.

157 hese peptides can subsequently be trimmed by aminopeptidases in the cytosol and/or the endoplasmic re

158 Aminopeptidases in the endoplasmic reticulum (ER) can cl

159 is the degradative processing of peptides by aminopeptidases in the endoplasmic reticulum.

160 cell line in the presence and absence of the aminopeptidase inhibitor Tosedostat (CHR-2797).

161 Tosedostat is a novel oral aminopeptidase inhibitor with clinical activity in a pre

162 te-selective delivery of a potent dipeptidyl aminopeptidase inhibitor.

163 inhibitors (e.g., for Polo-like kinase 1 and aminopeptidase), inhibitors of mutated isocitrate dehydr

164 RAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA c

165 o required, including the insulin-responsive aminopeptidase IRAP and its binding partner, the scaffol

166 Here, we investigated the role of the aminopeptidase IRAP in GLUT4 trafficking.

167 In the absence of the aminopeptidase IRAP, the trafficking of CpG and TLR9 to

168 vesicles that contain the insulin responsive aminopeptidase (IRAP) and the SNARE protein Syntaxin 6.

169 Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) enhance fear avoidance and spatial

170 Insulin-regulated aminopeptidase (IRAP) is an enzyme with several importan

171 The insulin-regulated aminopeptidase (IRAP) is involved in vesicular trafficki

172 and ERAP2), and as well as insulin-regulated aminopeptidase (IRAP) process antigenic epitope precurso

173 The insulin-responsive aminopeptidase (IRAP) was recently identified as an S-ac

174 a glucose transporter, and insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase.

175 oss-presented peptides by insulin-responsive aminopeptidase (IRAP), an enzyme localized in a regulate

176 n of GSV cargos, GLUT4 and insulin-regulated aminopeptidase (IRAP), and ACBD3 was required for intrac

177 s nonpeptide inhibitors of insulin-regulated aminopeptidase (IRAP), have previously been shown to enh

178 nopeptidase 2 (ERAP2), and insulin-regulated aminopeptidase (IRAP), plays critical roles in the gener

179 gen was transported across insulin-regulated aminopeptidase (IRAP)-positive early and late endosomes;

180 aled the engagement of the insulin-regulated aminopeptidase (IRAP).

181 Insulin-regulated aminopeptidase is found in a semiclosed conformation wit

182 Puromycin-sensitive aminopeptidase is responsible for the peptidase activity

183 The specificity of M1-aminopeptidases is dominated by the interaction of the w

184 The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expresse

185 from P. menziesii, whereas potential leucine aminopeptidase (LA) activity was significantly lower for

186 sequencing, conventional methods for leucine aminopeptidase (LAP) and pyrrolidonyl arylamidase (PYR)

187 Leucine aminopeptidase (LAP) is an essential proteolytic enzyme

188 ne and human APNs, and the reference leucine aminopeptidase (LAP).

189 l-Leucine aminopeptidases (LAPs) are implicated in the progress of

190 Leucine aminopeptidases (LAPs) are present in animals, plants, a

191 Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identifie

192 Human leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional enzyme that con

193 Leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenz

194 Aminopeptidase M1 (APM1) is essential for embryonic, veg

195 Aminopeptidase M1 (APM1), a single copy gene in Arabidop

196 Aminopeptidase M1 (PfAM1), a zinc metalloprotease, has b

197 y enhancing cleavage of alpha1 by methionine aminopeptidase (MAP), resulting in acetylation of the N-

198 es, peptide deformylase (PDF) and methionine aminopeptidase (MAP).

199 genetically essential P. falciparum metallo-aminopeptidases (MAPs), PfA-M1 and Pf-LAP.

200 These studies show that a bestatin-sensitive aminopeptidase may be critical for the hydrolysis of exo

201 Methionine aminopeptidase (MetAP) carries out an important cotransl

202 Methionine aminopeptidase (MetAP) catalyzes the hydrolytic cleavage

203 The methionine aminopeptidase (MetAP) family is responsible for the cle

204 how that a host gene coding for a methionine aminopeptidase (metAP) is necessary for phage DT1 to com

205 N-terminal-modifying enzymes like Methionine aminopeptidase (MetAP), and the signal recognition parti

206 N-terminal methionine removed by methionine aminopeptidases (MetAP1 and MetAP2) prior to action.

207 Methionine aminopeptidases (MetAPs) are essential enzymes that make

208 erative activity and target human methionine aminopeptidases (MetAPs) for their cellular effects.

209 Methionine aminopeptidases (MetAPs), which remove the initiator met

210 The midgut-specific anopheline alanyl aminopeptidase N (AnAPN1) is highly conserved across Ano

211 t Phe(3) is a key residue for neprilysin and aminopeptidase N (AP-N) ectoenkephalinase inhibition.

212 ced the levels of the AngIV-degrading enzyme aminopeptidase N (AP-N).

213 angiotensin-I-converting enzyme (ACE I) and aminopeptidase N (AP-N).

214 Tumor cell surface aminopeptidase N (APN or CD13) has two puzzling function

215 Here we identify membrane alanyl aminopeptidase N (APN) as a receptor for pea enation mos

216 Mammalian aminopeptidase N (APN) plays multifunctional roles in ma

217 ctase-phlorizin hydrolase (LPH), and neutral Aminopeptidase N (ApN) were analyzed in duodenal and col

218 of this family that has been well studied is aminopeptidase N (APN), a multifunctional protease known

219 A 106-kDa aminopeptidase N (APN), called AgAPN2, was previously id

220 A nonspecific exopeptidase, aminopeptidase N (APN), is inhibited sequence-specifical

221 Aminopeptidase N (APN, CD13) is a transmembrane ectopept

222 ptidases, neprilysin (NEP, EC 3.4.24.11) and aminopeptidase N (APN, EC 3.4.11.2).

223 Aminopeptidase N (APN/CD13) is a zinc-dependent M1 amino

224 The metalloprotease aminopeptidase N (APN; CD13) is often overexpressed in t

225 cificity of human, pig, and rat orthologs of aminopeptidase N (CD13), a highly conserved cell surface

226 t viral entry factors ACE2 (for SARS-CoV-2), aminopeptidase N (for 229E), and glycosaminoglycans (for

227 es of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomic

228 Human aminopeptidase N (hAPN/hCD13) is a dimeric membrane prot

229 In this work, aminopeptidase N (TcAPN-I), E-cadherin (TcCad1), and sod

230 ide GNGRAHA, a ligand of the surface protein aminopeptidase N and of integrin alphavbeta3.

231 to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect hos

232 The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells,

233 PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor

234 EMV binds to a heavily glycosylated receptor aminopeptidase N in the pea aphid gut and is transcytose

235 CD13/aminopeptidase N is a negative regulator of mast cell ac

236 r with the lack of receptor functionality of aminopeptidase N proteins might account for some of the

237 d hydrophobic character for the S1 pocket of aminopeptidase N that is conserved with aminopeptidase N

238 s residue methionine 260 in Escherichia coli aminopeptidase N were characterized.

239 We have recently demonstrated that CD13 (aminopeptidase N) expressed by nonmalignant host cells o

240 ular adhesion molecule 1 (ICAM-1), anti-LG3, aminopeptidase N, CXCL9, endothelin-1, and gelsolin.

241 eprilysin, angiotensin-converting enzyme, or aminopeptidase N, respectively.

242 f a receptor protein in the aphid gut called aminopeptidase N, which is responsible for entry of the

243 Lepidopteran midgut aminopeptidases N (APNs) are phylogenetically divided in

244 d with differential alteration of two midgut aminopeptidases N, APN1 and APN6, conferred by a trans-r

245 ta-glucosidase (carbon-cycling) and l-leucin aminopeptidase (nitrogen-cycling), was reduced following

246 t of aminopeptidase N that is conserved with aminopeptidase Ns.

247 k and conclude that DPP9 is a novel integral aminopeptidase of the N-end rule pathway.

248 of catalytically inactive insulin-responsive aminopeptidase/oxytocinase only rescued apm1-2.

249 Overexpression of human insulin-responsive aminopeptidase/oxytocinase rescued all apm1 phenotypes,

250 dase, angiotensin-I-converting enzyme (ACE), aminopeptidase P (APP), and carboxypeptidase N/M (CPN)]

251 P. falciparum aminopeptidase P (PfAPP) shares with mammalian cytosolic

252 se P (PfAPP) shares with mammalian cytosolic aminopeptidase P a three-domain, homodimeric organizatio

253 The metalloenzyme aminopeptidase P catalyzes the hydrolysis of amino acids

254 Plasmodium falciparum expresses a homolog of aminopeptidase P during its asexual intraerythrocytic cy

255 Finally, through this approach Aminopeptidase P was identified as a new regulator of be

256 endopeptidase, dipeptidyl peptidase IV, and aminopeptidase P.

257 ed by this system is an exoprotease, leucine aminopeptidase (PA-LAP), which is coexpressed with sever

258 oduct of a putative cell membrane-associated aminopeptidase (PepN).

259 hia coli was nearly entirely dependent on an aminopeptidase, PepN, expression of PepN in periplasm al

260 idue valine 459 in the Plasmodium falciparum aminopeptidase PfA-M1 and of three substitutions of the

261 e malarial parasite Plasmodium falciparum M1 aminopeptidase (PfA-M1).

262 Here we present evidence that an M1-family aminopeptidase, PfA-M1, has been recruited to specialize

263 Two Plasmodium falciparum aminopeptidases, PfA-M1 and PfA-M17, play crucial roles

264 te Plasmodium falciparum employs two metallo-aminopeptidases, PfA-M1 and PfA-M17, which are essential

265 ed one of the extracellular enzymes (leucine aminopeptidase), pointing to a specific nanoparticle eff

266 ction of residues that are less cleavable by aminopeptidases predominantly at N-flanking sites, leadi

267 The partially purified enzyme as well as the aminopeptidases present in crude extract cleaved prefere

268 Endoplasmic reticulum (ER) aminopeptidases process antigenic peptide precursors to

269 Aminopeptidases process the N-terminal amino acids of ta

270 r-fold increase in vasopressinase, a cystine aminopeptidase produced by placental trophoblasts, which

271 Puromycin-sensitive aminopeptidase (PSA) is the only cytosolic enzyme able t

272 Puromycin-sensitive aminopeptidase (PSA/NPEPPS) is a novel modifier of TAU-i

273 by a host protease, the puromycin-sensitive aminopeptidase (PurSA).

274 variation in domestic cats as Transmembrane aminopeptidase Q (Taqpep), which encodes a membrane-boun

275 e active fractions, and recombinant aspartyl aminopeptidase recapitulated the cleavage pattern observ

276 nflammation is established, changes to LTA4H aminopeptidase remain, even in the absence of ongoing ci

277 nts of beta-casein with elastase and leucine aminopeptidase revealed the release of BCM-7 by competit

278 Aminopeptidase showed second-order inactivation rate con

279 Pro-Gly-Pro was identified as an endogenous aminopeptidase substrate for LTA4 hydrolase.

280 Aminopeptidases, such as dipeptidyl peptidase-4 (DPP-4,

281 ins participating in chitin utilization, two aminopeptidases, TagA-related protein, cytolysin, RbmC,

282 Since aminopeptidases take part in many physiological processe

283 termination of the 468 kDa large dodecameric aminopeptidase TET2 to a precision and accuracy below 1

284 Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptidase that activates most of tissue-degrading e

285 Dipeptidyl peptidase I (DPPI) is a cysteine aminopeptidase that can activate several serine protease

286 eptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by

287 ll surface-anchored and seahorse-shaped zinc-aminopeptidase that forms head-to-head dimers.

288 P1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immun

289 pam-1 encodes a puromycin sensitive aminopeptidase that regulates centrosome positioning in

290 Aminopeptidases that generate antigenic peptides influen

291 present the first dimer structure of an M42 aminopeptidase, TmPep1050 of Thermotoga maritima, along

292 To characterize this activity, the aminopeptidase was cloned, overexpressed, and purified.

293 The activity of leucine aminopeptidase was positively correlated with ECM fungal

294 lammation, and selective inhibition of LTA4H aminopeptidase, which ordinarily degrades PGP.

295 found that these enzymes are genuine Xaa-Pro aminopeptidases, which hydrolyze peptides with proline a

296 a membrane, detected using insulin-regulated aminopeptidase with a pH-sensitive GFP tag (pHluorin), p

297 ymes is a self-compartmentalizing tetrameric aminopeptidase with a preference for cysteine and hydrop

298 t (4MDM) that selectively augments the LTA4H aminopeptidase without affecting the bioproduction of le

299 The human aminopeptidase XPNPEP3 is associated with cystic kidney

300 ch, which can be applied in principle to all aminopeptidases, yields useful information for the desig