ライフサイエンスコーパス: amphiregulin

1 ed by administration of the lung ILC product amphiregulin.

2 n the shedding rate of any ligand, including amphiregulin.

3 f Ras in response to constitutively produced amphiregulin.

4 n of 2 crucial growth factors, TGF-alpha and amphiregulin.

5 ILC2 subset is enriched in cells expressing amphiregulin.

6 oter and thereby suppressed the induction of amphiregulin.

7 f the growth factors regenerating gene I and amphiregulin.

8 perplasia by the cAMP-dependent induction of amphiregulin.

9 he SCID mouse is mediated, in large part, by amphiregulin.

10 th proximal tubule cell-specific knockout of amphiregulin.

11 the mechanism by which tobacco smoke induces amphiregulin.

12 e H55a#1 contained a library insert encoding amphiregulin.

13 with a >/= 3 h delay relative to HB-EGF and amphiregulin.

14 and their tumorigenic potential by secreting amphiregulin.

15 n recipient Foxp3(+) cells were deficient in amphiregulin.

16 AFs through an autocrine process mediated by amphiregulin.

17 sue repair, including IL-7, Ccl2, Ptgs2, and Amphiregulin.

18 , and AREG, which codes for the EGFR ligand, amphiregulin.

19 2 expression of IL-5 and IL-13 and increased amphiregulin.

20 avage of TGF-alpha, heparin-binding EGF, and amphiregulin.

21 HT of human stroke are described, including amphiregulin, a growth factor that regulates matrix meta

22 roteinase (ADAM) 17) to cleave transmembrane amphiregulin, a ligand for the epidermal growth factor r

23 Recently, elevated levels of amphiregulin, a ligand of the EGFR, were found in the or

24 To determine in vivo the role of amphiregulin, a low-affinity EGFR ligand that is highly

25 (H)2), but not other T cell subsets, express amphiregulin, a member of the epidermal growth factor (E

26 The major target of WT1 was amphiregulin, a member of the epidermal growth factor fa

27 models of lung tumors in mice, we found that amphiregulin, a member of the epidermal growth factor fa

28 Interestingly, the expression of amphiregulin, a potent mammary epithelial cell growth fa

29 Levels of amphiregulin, a protein that induces mucin production, w

30 yrosine kinase or a neutralizing antibody to amphiregulin abrogated the increase in DNA synthesis med

31 c hyperplasia and suggest that inhibition of amphiregulin activity could be an efficacious therapeuti

32 strogen growth factor receptor (EGFR) ligand amphiregulin acts as an important stage-specific effecto

33 in ADAM17 hypomorphic mice; injected soluble amphiregulin also reversed the corresponding protective

34 lling and is inhibited by antibodies against amphiregulin, an EGFR ligand concentrated on these vesic

35 ralizing antibody to EGFR, or an antibody to amphiregulin, an EGFR ligand, also blocked tobacco smoke

36 Amphiregulin, an EGFR ligand, was induced in a TLR4, Cox

37 ed EGFR signaling by inducing the release of amphiregulin, an EGFR ligand.

38 gnaling, in part, by inducing the release of amphiregulin, an EGFR ligand.

39 , and enhances WT1-mediated transcription of Amphiregulin, an endogenous target gene.

40 vealed that PTH stimulates the expression of amphiregulin, an epidermal growth factor (EGF)-like liga

41 ed transmembrane molecule: the precursor for amphiregulin, an epidermal growth factor-related molecul

42 fter stimulation with heparin-binding EGF or amphiregulin and alters the rate of recruitment of the a

43 dermal growth factor receptor (Egfr) ligands amphiregulin and beta-cellulin, as well as Egfr and phos

44 aplasia (MUCIN5AC and MUCIN6), and increased amphiregulin and Egfr activity.

45 a, and Wnt10b, as well as Egf family ligands amphiregulin and epigen.

46 ription of HB-EGF (epidermal growth factor), amphiregulin and epiregulin, resulting in autocrine acti

47 bited with neutralization antibodies against amphiregulin and HB-EGF, the heparin-binding growth fact

48 NA levels of two other EGF receptor ligands, amphiregulin and heparin binding-EGF, however, in the sk

49 CE-deficient cells increased the shedding of amphiregulin and heparin-binding EGF (HB-EGF) proteins.

50 Amphiregulin and heparin-binding EGF-like growth factor

51 show that during infection, the EGFR ligands amphiregulin and heparin-binding EGF-like growth factor

52 in FOXP3(+) T cells expressing PD-1, IFN-y, Amphiregulin and IL-10.

53 The binding of amphiregulin and its homolog, heparin-binding epidermal

54 igh gene expression levels of epiregulin and amphiregulin and patients with wild-type K-ras are more

55 ss both transforming growth factor alpha and amphiregulin and require autocrine signaling through the

56 The ability of tobacco smoke to induce amphiregulin and thereby enhance DNA synthesis is likely

57 Interestingly, unlike amphiregulin and TNFRI, full-length intercellular adhesi

58 endent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR.

59 m by which TS activated EGFR, the release of amphiregulin and transforming growth factor alpha, two l

60 markedly induced the expression of mRNAs for amphiregulin and transforming growth factor alpha.

61 Serial serum samples were measured for amphiregulin and transforming growth factor-alpha (TGFal

62 the epidermal growth factor receptor ligand amphiregulin and tumor necrosis factor receptor I (TNFRI

63 release of the endogenous ADAM17 substrates, amphiregulin and tumor necrosis factor-alpha, metallopro

64 pigen, TGFalpha), which also require soluble amphiregulin and YAP1 to induce sustained EGFR activatio

65 evels of two ectopic EGFR ligands (HBEGF and amphiregulin) and the FGFR2(IIIb) receptor ligand KGF, f

66 dermal growth factor family members, epigen, amphiregulin, and betacellulin.

67 recognized HB-EGF as well as the EGFR ligand amphiregulin, and bound specifically to human HB-EGF, bu

68 owth factors TGF-alpha, heparin binding-EGF, amphiregulin, and EGF receptor tyrosine phosphorylation

69 l into two major groups as follows: (i) EGF, amphiregulin, and EPR; and (ii) betacellulin, TGFalpha,

70 ression of transforming growth factor-alpha, amphiregulin, and gastrin; and activation of extracellul

71 h factor vascular endothelial growth factor, amphiregulin, and glucose metabolism-involved gene insul

72 tor (EGF), transforming growth factor alpha, amphiregulin, and heparin-binding EGF in regenerating li

73 piregulin, transforming growth factor alpha, amphiregulin, and heparin-binding EGF-like growth factor

74 r, Wnt, Hh, transforming growth factor beta, amphiregulin, and hepatocyte growth factor) to their res

75 sulting in increased secretion of TGF-alpha, amphiregulin, and heregulin.

76 tor receptors (eg, hepatocyte growth factor, amphiregulin, and insulin-like growth factor 1 receptor)

77 genes revealed that caveolin 1, caveolin 2, amphiregulin, and melanoma growth stimulatory activity a

78 s effect allows plasma components, including amphiregulin, and other mitogens to enter the CSF and pr

79 These results define an amphiregulin- and ErbB1-dependent mechanism by which aut

80 B1 [transforming growth factor-beta1], AREG [amphiregulin], and HGF [hepatocyte growth factor]) coupl

81 tor, AG1478, 2) neutralizing HB-EGF, but not amphiregulin, antibodies, heparin, or CM197, and 3) phar

82 The anti-amphiregulin antibody reduced epidermal thickness of tra

83 nd we also demonstrated enhanced shedding of amphiregulin (AR) and heparin-binding (HB)-EGF upon rest

84 ic polypeptide-expressing metaplasia (SPEM), amphiregulin (AR) and transforming growth factor-alpha-d

85 Amphiregulin (AR) autocrine loops have been associated w

86 Dysregulated amphiregulin (AR) expression and EGR receptor (EGFR) act

87 in the ectodomain to release several soluble amphiregulin (AR) forms.

88 Overexpression of amphiregulin (AR) has been linked to psoriasis in mouse

89 Biosynthesis and processing of amphiregulin (AR) have been investigated in human colore

90 embryonic lungs synthesized and responded to amphiregulin (AR) in a different fashion.

91 ha synergistically induces the expression of amphiregulin (AR) in colon cancer cells.

92 Amphiregulin (AR) involvement in liver fibrogenesis and

93 Amphiregulin (AR) is a heparin-binding, heparin-inhibite

94 pidermal growth factor (EGF) receptor ligand amphiregulin (AR) is reported to be an 84-amino acid res

95 We previously determined that loss of amphiregulin (AR) promotes SPEM induced by acute oxyntic

96 a saline extract of tobacco smoke stimulated amphiregulin (AR) transcription resulting in increased a

97 Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-

98 We hypothesized that amphiregulin (AR), a keratinocyte autocrine growth facto

99 This study investigated whether amphiregulin (AR), a ligand of the epidermal growth fact

100 Here we report that the expression of amphiregulin (AR), a member of the epidermal growth fact

101 e A pathway, which induced the expression of amphiregulin (AR), an epidermal growth factor family mem

102 in-binding epidermal growth factor (EGF) and amphiregulin (AR), and activation of the EGF receptor an

103 protein, and mRNA transcripts for TGFalpha, amphiregulin (AR), and heparin-binding EGF-like growth f

104 es EGFR ligands heparin-binding (HB)-EGF and amphiregulin (AR), and reduces betacellulin mRNA levels.

105 ting hormone (FSH) and the EGF-like peptide, amphiregulin (AR), are potent inducers of maturation in

106 ming growth factor (TGF)-alpha, but not with amphiregulin (AR), betacellulin (BTC) or epiregulin (EPR

107 actor (TGF)-alpha, heprin-ding (HB)-EGF, and amphiregulin (AR), have been shown to stimulate events a

108 pidermal growth factor (EGF) family hormones amphiregulin (AR), transforming growth factor-alpha (TGF

109 epidermal growth factor-like growth factor, amphiregulin (AR), which was not expressed by untreated

110 RTs in EGFR recycling after stimulation with amphiregulin (AR).

111 ficking and signaling after stimulation with amphiregulin (AR).

112 tors, and by neutralizing antibodies against amphiregulin (AR).

113 at include epidermal growth factor (EGF) and amphiregulin (AR).

114 cascades in response to the ligands EGF and amphiregulin (AR).

115 sforming growth factor alpha (TGF alpha) and amphiregulin are delivered to the basolateral surface of

116 gh levels of the EGFR ligands epiregulin and amphiregulin are more likely to have disease control wit

117 sine kinase (DDR1) and the ErbB1 receptor of amphiregulin are, for example, required for ductal branc

118 genes repressed by BRCA1, we have identified amphiregulin (AREG) and early growth response-1 (EGR1).

119 dermal growth factor receptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG), and systemic

120 dermal growth factor receptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG).

121 idermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial cells for e

122 ving ectodomain shedding of the EGFR ligands amphiregulin (AREG) and TGF-alpha, which rely upon the c

123 is study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker

124 ve identified the EGF receptor (EGFR) ligand amphiregulin (AREG) as an important mediator of inflamma

125 idermal growth factor receptor (EGFR) ligand Amphiregulin (AREG) by co-activating the transcription f

126 ermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in d

127 GPR174 deficiency upregulates amphiregulin (AREG) expression in Tregs, thereby enhanci

128 Here, we demonstrated that amphiregulin (AREG) from bone marrow (BM) leptin recepto

129 se fragment complementation imaging studies, amphiregulin (AREG) functioned as a partial agonist, ind

130 The EGFR ligand amphiregulin (AREG) has been implicated as an important

131 here is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focu

132 with IL-33, expression of the growth factor amphiregulin (AREG) is a dominant functional signature o

133 Amphiregulin (AREG) is an important regulator of cellula

134 everal ligands, and we provide evidence that amphiregulin (AREG) is important for activating this sig

135 rian and lung cancer patients and found that amphiregulin (AREG) is the most abundant and generalized

136 how that silencing of the EGF-related factor amphiregulin (AREG) markedly inhibits the expansion of h

137 ession of EGFR ligands epiregulin (EREG) and amphiregulin (AREG) may correlate with EGFR-targeted the

138 epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of typ

139 tissue-protective ILC2 responses, defective amphiregulin (AREG) production and increased susceptibil

140 Amphiregulin (AREG) was by far the most abundant EGFR li

141 e epidermal growth factor (EGF)-like protein amphiregulin (AREG) was highly expressed in ExeR cells b

142 owth factor 7, hepatocyte growth factor, and amphiregulin (AREG) were elevated in the extracellular e

143 es(8,9) and the release of tissue-protective amphiregulin (AREG)(10-12).

144 Amphiregulin (Areg), a growth factor produced by regulat

145 study shows that AGR2 induces expression of amphiregulin (AREG), a growth promoting EGFR ligand.

146 Amphiregulin (AREG), an epidermal growth factor receptor

147 K by derepressing miR-200 targets, including amphiregulin (AREG), betacellulin (BTC), and the transcr

148 We evaluated the role of the EGFR ligand, amphiregulin (AREG), during cholestatic liver injury and

149 th factor receptor (EGFR) pathway, including amphiregulin (AREG), epiregulin (EREG), and ectodomain c

150 ubstrates TNF-alpha, TNFR1-alpha, TGF-alpha, amphiregulin (AREG), HB-EGF and IL-6Ralpha, from IGROV1-

151 factor (EGF)-like growth factors, including Amphiregulin (AREG), heparin-binding EGF (HB-EGF), and t

152 ligands including EGF, TGF-alpha (TGFalpha), amphiregulin (AREG), heparin-binding EGF-like growth fac

153 -mediated silencing of one of these ligands, amphiregulin (AREG), results in keratinocyte growth arre

154 alpha to regulate directly the expression of amphiregulin (Areg), the progesterone receptor (Pgr) and

155 evealed that the ADAM17 proteolytic targets, amphiregulin (AREG), transforming growth factor alpha (T

156 ratinocytes (KCs) is strongly dependent upon amphiregulin (AREG), whereas blockade of heparin-binding

157 growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved fro

158 dermal growth factor receptor (EGFR) ligand, amphiregulin (AREG).

159 axis leads to production of the EGFR ligand amphiregulin (AREG).

160 in AD, and we found dendritic cell (CLEC7A, amphiregulin/AREG, EREG) and macrophage products (CCL13)

161 Our findings implicate amphiregulin as a critical mediator of the estrogen resp

162 Our results identify amphiregulin as a key player in injury-induced kidney fi

163 elated evidence led to the identification of amphiregulin as a major autocrine factor for keratinocyt

164 HER2 induced the EGFR ligands TGF-alpha and amphiregulin at the mRNA and protein levels.

165 s a cause of sustained expression of uterine amphiregulin before the initiation of implantation.

166 Moreover, blockade of amphiregulin bioactivity using a neutralizing polyclonal

167 n addition to TGF-alpha release, GRP induced amphiregulin, but not EGF, secretion into HNSCC cell cul

168 We also demonstrate that amphiregulin, but not epiregulin, partially compensates

169 in blood and multiple tissue types produced amphiregulin, but this was neither a unique feature of T

170 tissue repair by producing the growth factor amphiregulin, but whether similar tissue-reparative Treg

171 )] markedly inhibited elaboration of soluble amphiregulin by NHKs.

172 Amphiregulin cleavage by pervanadate occurred in the abs

173 fter injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown

174 combination of F115 and Y123 determined the amphiregulin cross-reactivity and that F115 accounted fo

175 that the addition of recombinant epiregulin, amphiregulin, CX3CL1, and interleukin-11 significantly e

176 inflammation (interleukin-6), lung stretch (amphiregulin), damage to epithelial (surfactant protein

177 Amphiregulin declined in COVID-19 subjects as a function

178 Furthermore, T cell-restricted amphiregulin deficiency resulted in markedly delayed lun

179 e epithelial cell proliferation, and lack of amphiregulin delayed expulsion of the nematode Trichuris

180 am as well as downstream of ErbB1 to promote amphiregulin-dependent autocrine stimulation of NHKs and

181 pressor gene, a transcriptional activator of amphiregulin, did not parallel amphiregulin transcript l

182 Amphiregulin does not interact with NKD2 and retains its

183 ding of transforming growth factor alpha and amphiregulin does not require ADAM17, even though ADAM17

184 iated proteins appear to act as cofactors in amphiregulin-driven mitogenesis mediated by the epiderma

185 The in vivo expression profile of amphiregulin during fetal kidney development mirrors the

186 monstrated that specific proteins, including amphiregulin, effectively predict COVID-19 severity from

187 Results link HDM, IL-17A, amphiregulin, EGFR and GM-CSF in a mechanistic pathway i

188 signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, t

189 Amphiregulin enhances CL31 mesothelial clearance, a prer

190 factors and immune modulation-especially via amphiregulin-epidermal growth factor receptor (EGFR) sig

191 epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin.

192 bFGF, IL-8, and ANGPTL-2), as well as ErbB (amphiregulin, epiregulin, and neuregulins) and TGF-ss, w

193 pha, heparin-binding EGF-like growth factor, amphiregulin, epiregulin, betacellulin, or heregulin bet

194 exhibited TCR-independent, IL-33-stimulated amphiregulin expression and a heightened ability to indu

195 echanisms: protection from fatal immunity by amphiregulin expression and augmentation of antileukemic

196 ting mucin production, through regulation of amphiregulin expression and collagen deposition.

197 g miR-149, epidermal growth factor (EGF) and amphiregulin expression levels were strongly reduced, re

198 naling via IL-33 induces type 2 cytokine and amphiregulin expression, and increases ILC2 migration.

199 or-beta signaling, the extracellular matrix, amphiregulin expression, and the growth hormone/insulin-

200 ceptor-deficient mice is driven by decreased amphiregulin expression, which IFN signaling can up-regu

201 n transforming growth factor (TGF)-alpha and amphiregulin expression.

202 Amphiregulin, follistatin, and inhibin-beta-A and epireg

203 lar smooth muscle cells, particularly COX-2, amphiregulin, follistatin, inhibin-beta-A, and CYR61.

204 mutant mice suggests a compensatory role of amphiregulin for uterine loss of HB-EGF, preventing comp

205 th factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex b

206 emonstrate that PTH increases the release of amphiregulin from osteoblastic cells, which acts on the

207 Here we show that Amphiregulin functioned by releasing bioactive transform

208 -binding EGF-like growth factor (HB-EGF) and amphiregulin genes.

209 nes, the connective tissue growth factor and amphiregulin genes.

210 nscripts encoding epithelial growth factors (amphiregulin, Gro-1, Gro-2).

211 The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restorati

212 Overexpression of amphiregulin has been shown to induce psoriasiform chang

213 Therefore, amphiregulin has been suggested as a target for anti-pso

214 nds including epidermal growth factor (EGF), amphiregulin, heparin-binding EGF and beta-cellulin.

215 as well as transforming growth factor-alpha, amphiregulin, heparin-binding epidermal growth factor-li

216 In addition, three ErbB1 ligand transcripts (amphiregulin, heparin-binding epidermal growth factor-li

217 ) ligands (transforming growth factor-alpha, amphiregulin, heregulin, heparin binding EGF-like ligand

218 stromal lymphopoietin, and the growth factor amphiregulin in a human bronchial epithelial cell line.

219 increased expression of EGFR and its ligand amphiregulin in ATMs.

220 In this study, we investigated the role of amphiregulin in breast cancer cell proliferation using h

221 tating cleavage and release of TGF-alpha and amphiregulin in HNSCC.

222 ional psoriatic epidermis, the importance of amphiregulin in hyperproliferative skin diseases has bee

223 peutic or diagnostic applications of soluble amphiregulin in kidney disease.

224 ll RNA sequencing identifies upregulation of amphiregulin in leukocyte populations during sepsis, whi

225 binding EGF-like growth factor (HB-EGF); and amphiregulin in NHBECs, and when administered exogenousl

226 or gradient 2, yes-associated protein 1, and amphiregulin in OPA tumor cells, indicating a role for t

227 r, these data indicate an important role for amphiregulin in psoriatic hyperplasia and suggest that i

228 ls, suggesting that another factor regulates amphiregulin in SUM-149PT.

229 Our data confirm the importance of amphiregulin in the etiology of breast cancer.

230 Deletion of amphiregulin in these Treg cells impaired regeneration i

231 py induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-ex

232 Amphiregulin, in contrast, enables normal ductal develop

233 not transforming growth factor (TGF)alpha or amphiregulin, in young adult mouse colon cells and ADAM1

234 e secretion of EGF family ligands, including amphiregulin, independent of metalloprotease a disintegr

235 on on mesenchymal stromal cells (pericytes), Amphiregulin induced their differentiation into myofibro

236 In vivo, soluble amphiregulin injection sufficed to reverse protection fr

237 We also injected soluble amphiregulin into knockout mice with proximal tubule cel

238 terminal differentiation in adult breast and amphiregulin is critical to normal embryonic breast deve

239 Following from the observation that amphiregulin is overexpressed in lesional psoriatic epid

240 Amphiregulin is the most abundantly expressed EGFR ligan

241 e finding that proximal tubule cell-specific amphiregulin knockout mice were protected from fibrosis

242 trate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decre

243 Furthermore, amphiregulin levels were suppressed in patients treated

244 tion, resulting in impaired IL-5, IL-13, and amphiregulin levels, despite undiminished numbers of Th2

245 er EGFR ligands EGF, heparin-binding EGF, or amphiregulin, mediates SP-induced EGFR transactivation.

246 actor, transforming growth factor-alpha, and amphiregulin mRNA and protein in lesional psoriasis comp

247 nscription resulting in increased amounts of amphiregulin mRNA and protein.

248 9, an EP2-specific agonist, strongly induced amphiregulin mRNA levels in a protein kinase A-dependent

249 ly, TCN enhanced the expression of c-fos and amphiregulin mRNA.

250 genomic responses, since both calcitonin and amphiregulin mRNAs were increased after progesterone tre

251 hat release of activated HB-EGF (but neither amphiregulin nor EGF) occured after wounding.

252 Mice deficient in either amphiregulin or epiregulin, two EGFR ligands, display de

253 induces expression of either the EGFR ligand amphiregulin or the transcription factor CDX2, only the

254 ncentration that neutralized the function of amphiregulin, or antibodies against TGFalpha or HB-EGF a

255 tivity, high levels of ERBB2 (P = 0.036) and amphiregulin (P = 0.026) predicted sensitivity to lapati

256 GM-CSF production also required amphiregulin, p38 MAPK signalling and protease/TACE acti

257 t the cytoplasmic carboxy-terminal domain of amphiregulin plays an important role in regulating autoc

258 In this study, the role of the amphiregulin precursor (pro-AR) cytoplasmic domain in th

259 The finding that amphiregulin-producing Tregs have a noneffector phenotyp

260 h factor receptor (EGFR) phosphorylation and amphiregulin production were examined by Western blot an

261 s showed that IGF-1 transactivation required amphiregulin production, whereas LPA was dependent on mu

262 inhibited NHK proliferation, migration, and amphiregulin production.

263 The WT1(-KTS) isoform binds directly to the amphiregulin promoter, resulting in potent transcription

264 -dependent transcriptional activation of the amphiregulin promoter.

265 Through the YAP1 target, Amphiregulin, Ras activates the endogenous EGFR pathway,

266 dermal growth factor and 10-fold increase in amphiregulin, respectively) in HELUs compared with TDLUs

267 entified macrophages as a critical source of Amphiregulin, revealing a direct effector mechanism by w

268 Pharmacologic regulation of amphiregulin's expression and receptor signaling may eve

269 by the epidermal growth factor receptor, but amphiregulin's immunolocalization to keratinocyte nuclei

270 th proximal tubule cell-specific deletion of amphiregulin's releasing enzyme, the transmembrane cell-

271 TGF-alpha and amphiregulin secretion by GRP stimulation also was inhib

272 defect in tTreg cells caused by the lack of amphiregulin secretion, which could contribute to the ma

273 0 and ADAM17, reduces in vitro HER-2/neu and amphiregulin shedding, confirming that it interferes wit

274 mphiregulin transcript and protein amplifies amphiregulin signaling in a positive feedback loop.

275 ve androgen deprivation through an autocrine amphiregulin signaling pathway.

276 Two transgenic mouse models (amphiregulin, STAT-3) were reported that have features o

277 -Leuk1 cells with tobacco smoke or exogenous amphiregulin stimulated DNA synthesis.

278 cific pattern of WT1 itself, and recombinant Amphiregulin stimulates epithelial branching in organ cu

279 e observation of normal induction of uterine amphiregulin surrounding the blastocyst at the time of a

280 had a lower percentage of ILCs that produced amphiregulin than did controls.

281 ytes secrete soluble EGFR ligands (including amphiregulin) that are processed from membrane-bound pro

282 The binding of amphiregulin to EGFR then stimulates proliferation of lu

283 ne encoding keratin 14 promoter-driven human amphiregulin to the basal epidermis of mice.

284 d protein 1 (YAP1)-dependent upregulation of amphiregulin transcript and protein amplifies amphiregul

285 activator of amphiregulin, did not parallel amphiregulin transcript levels, suggesting that another

286 SUM-149PT and H55a#1 cells overexpressed amphiregulin transcripts, and secreted moderate EGF-like

287 PRIP-deficient glands expressed increased amphiregulin, transforming growth factor-alpha, and beta

288 on that regulates release of the EGFR ligand amphiregulin upon GRP treatment.

289 Amphiregulin was enriched in ERalpha-positive human brea

290 lonal antibody capable of neutralizing human amphiregulin was examined for anti-proliferative effects

291 ntrols, the percentage of ILCs that produced amphiregulin was higher in females than in males, and pe

292 teral ureteral obstruction demonstrates that amphiregulin was necessary for the development of fibros

293 nsforming growth factor-alpha (TGFalpha), or amphiregulin we have shown that only the anti-TGFalpha a

294 GF-alpha), heparin binding-EGF (HB-EGF), and amphiregulin were analyzed for their ability to mediate

295 itogenic on 32D.E4 cells, whereas HB-EGF and amphiregulin were inactive.

296 IL-10 and amphiregulin were upregulated.

297 (EGF), transforming growth factor alpha, and amphiregulin were used to identify roles for these EGF r

298 uscle Treg cells expressed the growth factor Amphiregulin, which acted directly on muscle satellite c

299 EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriati

300 xtures is dependent on transient exposure to amphiregulin, which is exclusively secreted by non-tumor