ライフサイエンスコーパス: an evolutionarily conserved

1 An evolutionarily conserved 12-bp cis-regulatory motif t

2 An evolutionarily conserved 3-hydroxy butyrate dehydroge

3 ene 3) is an imprinted gene localized within an evolutionarily conserved 500-kb domain in human chrom

4 article (cpSRP) is a heterodimer composed of an evolutionarily conserved 54-kDa GTPase (cpSRP54) and

5 of lagging chromatin between dividing cells, an evolutionarily conserved abscission/NoCut checkpoint

6 Our findings highlight an evolutionarily conserved activation mechanism of GPHR

7 erating neuromuscular junctions, mediated by an evolutionarily conserved activity of presynaptic ENaC

8 -binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum a

9 The unfolded protein response (UPR) is an evolutionarily conserved adaptive reaction to environ

10 We discovered an evolutionarily conserved allosteric restraint mechani

11 a methyl group to adenosine N(6) (m(6)A) is an evolutionarily conserved and common RNA modification

12 alyze these modifications, which are part of an evolutionarily conserved and complex tubulin code tha

13 humans, mice and zebrafish that Netrin-1 has an evolutionarily conserved and essential requirement fo

14 at cytoplasmic and organelle transport plays an evolutionarily conserved and functionally important r

15 One 9-aa-TAD sequence includes an evolutionarily conserved and functionally required EP

16 ORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regul

17 xtends the lifespan of the worms, confirming an evolutionarily conserved and unexpected role for retr

18 Thus, our studies reveal an evolutionarily conserved archaic embryonic program in

19 vation of these host DNA sensing pathways is an evolutionarily conserved bacterial adaptation.

20 Sleep is an evolutionarily conserved behavioral state whose regul

21 activity of soluble adenylyl cyclase (sAC), an evolutionarily conserved bicarbonate sensor.

22 h processing in the human auditory cortex-as an evolutionarily conserved biological process.

23 The hypothalamus is an evolutionarily conserved brain structure that regulat

24 Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes w

25 Here we describe an evolutionarily conserved C. elegans protein, VPS-50,

26 cological tools to demonstrate that TMEM16A, an evolutionarily conserved calcium-activated chloride c

27 tric forms, indexed by fractal dimension, is an evolutionarily conserved capacity, and tested this ca

28 Endoplasmic reticulum stress is an evolutionarily conserved cell stress response associa

29 DEPTOR is an evolutionarily conserved cell-intrinsic binding partn

30 Autophagy, an evolutionarily conserved cellular process by which cy

31 Autophagy is an evolutionarily conserved cellular process controlled

32 ty in epithelial stem cells is maintained by an evolutionarily conserved cellular response pathway, t

33 Taken together, our results show an evolutionarily conserved cerebral distribution of 5hm

34 be an exception and suggests the presence of an evolutionarily conserved chemosensory cue within the

35 Cohesin is an evolutionarily conserved chromosome-associated protei

36 Mediator is an evolutionarily conserved coactivator complex essentia

37 Our study identifies an evolutionarily conserved cold receptor, revealing tha

38 The INO80 chromatin remodeling complex is an evolutionarily conserved complex involved in diverse

39 ticulum (ER)-membrane protein complex (EMC), an evolutionarily conserved complex that has been propos

40 derlying aggression generation, highlighting an evolutionarily conserved 'core aggression circuit' co

41 infection with multiple PV types, suggesting an evolutionarily conserved critical step in infectious

42 The formation of WNK bodies requires an evolutionarily conserved cysteine-rich hydrophobic mo

43 Thus, we propose that an evolutionarily conserved, dedicated molecular network

44 cuitry underlying the execution of freezing, an evolutionarily conserved defensive behaviour, which i

45 Our study reveals an evolutionarily conserved deficiency of the Sec61/SecY

46 crystallographic and biochemical analyses of an evolutionarily conserved deubiquitinase, USP12, which

47 nterdigitated growth of neighboring cells is an evolutionarily conserved developmental strategy.

48 he T-box family of transcription factors and an evolutionarily conserved dosage-sensitive regulator o

49 Macroautophagy is an evolutionarily conserved dynamic pathway that functio

50 Here, we show that CRL4Mahj, an evolutionarily conserved E3 ubiquitin ligase, is esse

51 includes suppression of immune responses via an evolutionarily conserved effector target, but by reco

52 The COP9 signalosome (CSN) is an evolutionarily conserved eight-subunit (CSN1-8) prote

53 her, our data demonstrate that NDK-1/NME1 is an evolutionarily conserved element of successful phagoc

54 VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-a

55 We conclude that HERV-K ENV dictates an evolutionarily conserved entry pathway and that the r

56 etabolite for DNMT-catalyzed methylation, is an evolutionarily conserved epigenetic stress response,

57 ur results open a line of investigation into an evolutionarily conserved essential cellular process o

58 Novelty preference (NP) is an evolutionarily conserved, essential survival mechanis

59 We show that this interaction is mediated by an evolutionarily conserved ETGE motif on CDK20.

60 Exonuclease 1 (Exo1) is an evolutionarily conserved eukaryotic nuclease that pla

61 entous fungi, which are communicated through an evolutionarily conserved eukaryotic stress response p

62 (TIR) motif-containing protein 1 (SARM1) is an evolutionarily conserved executioner of this degenera

63 Consistent with an evolutionarily conserved extra-mitochondrial function

64 Here we identify an evolutionarily conserved factor, BRWD2/PHIP, which co

65 -2)-associated athanogene (BAG) proteins are an evolutionarily conserved family of co-chaperones that

66 d multivesicular body proteins (Chmp1-7) are an evolutionarily conserved family of cytosolic proteins

67 Galectins, an evolutionarily conserved family of glycan-binding pro

68 Here, we report that ascarosides, an evolutionarily conserved family of nematode pheromone

69 produce small molecules called ascarosides, an evolutionarily conserved family of nematode pheromone

70 The aurora kinases (AURKs) comprise an evolutionarily conserved family of serine/threonine k

71 APP belongs to an evolutionarily conserved family of transmembrane prot

72 one H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromati

73 ronal death, indicating these activities are an evolutionarily conserved feature of SARM1 function.

74 Recent evidence has implicated cryptochrome, an evolutionarily conserved flavoprotein receptor, in ma

75 Although sharing an evolutionarily conserved fold and related catalytic m

76 Presynaptic homeostatic plasticity (PHP) is an evolutionarily conserved form of adaptive neuromodula

77 Oga lines exhibited deficits in habituation, an evolutionarily conserved form of learning, highlighti

78 iated regulation of endocytic trafficking is an evolutionarily conserved function of caspases that ca

79 A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repress

80 D. melanogaster Toll signalling, suggesting an evolutionarily conserved function of Toll in defense

81 in the mammalian brain, our findings suggest an evolutionarily conserved function of vitamin A in ani

82 resents a positive FTi regulator that shares an evolutionarily conserved function with SOC1 and may n

83 RB control of cell polarity may be an evolutionarily conserved function, with important imp

84 omosome segregation during the cell cycle is an evolutionarily conserved, fundamental biological proc

85 Our experiments reveal an evolutionarily conserved GABA synthesis pathway media

86 An evolutionarily conserved Galpha-GPR-1/2(Pins/LGN)-LIN

87 Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functi

88 Thus, calcium wave is an evolutionarily conserved, general regulatory mechanis

89 a second PD-associated gene, RAB7L1, within an evolutionarily conserved genetic module in diverse ce

90 Bcl-2-associated athanogene (BAG) family is an evolutionarily conserved group of cochaperones that m

91 We show that mutants lacking hira-1, an evolutionarily conserved H3.3-deposition factor, have

92 ns unveil an unprecedented regulatory use of an evolutionarily conserved heat shock protein and prese

93 FACT (facilitates chromatin transcription), an evolutionarily conserved histone chaperone involved i

94 ed epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which di

95 The target of rapamycin (TOR) kinase is an evolutionarily conserved hub of nutrient sensing and

96 n(IV) oxochloride-derived cluster that binds an evolutionarily conserved IDR within the metazoan TFII

97 poptosis-stimulating protein of p53 (iASPP), an evolutionarily conserved inhibitor of p53, caused by

98 ER membrane protein complex (EMC) implicates an evolutionarily conserved insertion mechanism for dive

99 Our study underscores an evolutionarily conserved interaction between lentivir

100 We identify an evolutionarily conserved interaction surface formed b

101 ct with the yeast heptameric Sec complex via an evolutionarily conserved interface due to occupation

102 Autophagy, an evolutionarily conserved intracellular catabolic proc

103 Autophagy is an evolutionarily conserved intracellular degradation/re

104 Autophagy is an evolutionarily conserved intracellular lysosomal degr

105 Our results demonstrate an evolutionarily conserved, intricate network of transc

106 Our work revealed that Shh signaling is an evolutionarily conserved key target in CIA pathobiolo

107 The Hippo pathway is an evolutionarily conserved kinase cascade that is funda

108 Macropinocytosis is an evolutionarily-conserved, large-scale, fluid-phase fo

109 Our analysis uncovered an evolutionarily conserved let-7-5p-binding site within

110 These studies identify LAHLAs as an evolutionarily conserved lipid with anti-inflammatory

111 We further show that lnc-NR2F1 is an evolutionarily conserved lncRNA functionally enhances

112 Our results mark the first example of an evolutionarily conserved lncRNA in pathogenesis of UF

113 arrel proteins into membranes is mediated by an evolutionarily conserved machine.

114 Mre11 and Rad50 (M/R) proteins are part of an evolutionarily conserved macromolecular apparatus tha

115 PARs are present at the hair cell synapse in an evolutionarily conserved manner.

116 d associates with LINC complex components in an evolutionarily conserved manner.

117 Our observations identified an evolutionarily conserved marker of aging that is easi

118 n ETS transcription factor Etv2 functions as an evolutionarily conserved master regulator of vasculog

119 The target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integr

120 t complementary, functions and may represent an evolutionarily conserved means to ensure proper progr

121 Here we uncover an evolutionarily conserved mechanism by which CDK7 prom

122 results suggest that photooligomerization is an evolutionarily conserved mechanism determining the ph

123 gether, these data suggest that -2/-1 PRF is an evolutionarily conserved mechanism employed in non-EA

124 chondria via autophagy, termed mitophagy, is an evolutionarily conserved mechanism for mitochondrial

125 ociation of distinct protein clusters may be an evolutionarily conserved mechanism for the assembly o

126 nd differentiation homeostasis, and could be an evolutionarily conserved mechanism for the developmen

127 lla suggest that TAG breakdown may represent an evolutionarily conserved mechanism in light-induced s

128 We propose integrin-mediated anchorage as an evolutionarily conserved mechanism of general relevan

129 Our results establish rosette-based CE as an evolutionarily conserved mechanism of nerve cord morp

130 (2020) identify an evolutionarily conserved mechanism of presynaptic hom

131 Our results highlight an evolutionarily conserved mechanism of regulated prote

132 and Ca(V)2.2 by protein kinase A, revealing an evolutionarily conserved mechanism that confers adren

133 This may represent an evolutionarily conserved mechanism that not only redu

134 Nucleotide excision repair (NER) is an evolutionarily conserved mechanism that processes hel

135 pic heterogeneity within cell populations is an evolutionarily conserved mechanism that underlies pop

136 Nociception is an evolutionarily conserved mechanism to encode and proc

137 Together, we identified an evolutionarily conserved mechanism to specify neurona

138 Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by prokaryote

139 , the fetal mammalian brain is equipped with an evolutionarily conserved mechanism well-suited to sup

140 ulation of Yang cycle MTN proteins is likely an evolutionarily conserved mechanism whereby HopAF1 ort

141 We also reveal an evolutionarily conserved mechanism whereby the cell r

142 reported for other TRP channels, suggesting an evolutionarily conserved mechanism.

143 1 regulates hepcidin gene expression through an evolutionarily conserved mechanism.

144 Our data reveal that Piezo2 is an evolutionarily conserved mediator of thermal-tactile

145 MicroRNA390 (miR390) is an evolutionarily conserved microRNA that targets the Tr

146 nthetic lethality screen revealed a role for an evolutionarily conserved mitochondrial matrix protein

147 The 5' m7G cap is an evolutionarily conserved modification of eukaryotic m

148 ate that XIST RNA-protein complex folds into an evolutionarily conserved modular architecture.

149 Altogether our findings demonstrate an evolutionarily conserved modulation of immunity by sp

150 Heat shock protein 90 (Hsp90) is an evolutionarily conserved molecular chaperone that is

151 lates adipokine secretion and have uncovered an evolutionarily conserved molecular link between intra

152 his demonstrates that the LHX:LDB complex is an evolutionarily conserved molecular regulatory device

153 Here, we describe an evolutionarily conserved morphogenetic mechanism for

154 icient conditions; these promoters contained an evolutionarily conserved motif that we named the low

155 eading to the active site that is blocked by an evolutionarily conserved motif which we term the "DK

156 Here, we demonstrate that m6Am is an evolutionarily conserved mRNA modification mediated b

157 The Mediator is an evolutionarily conserved, multi-subunit complex that

158 Retromer is an evolutionarily conserved multiprotein complex that or

159 Condensin, an evolutionarily conserved multisubunit protein complex

160 In summary, the SC may be a key node in an evolutionarily conserved network for controlling choi

161 -bridging phenotype arises from mutations in an evolutionarily conserved network of coevolving amino

162 mononucleotide adenylyltransferase (NMNAT), an evolutionarily conserved nicotinamide adenine dinucle

163 or Nkx6.1 interacts with a cis-element (CR2, an evolutionarily conserved non-coding fragment in the s

164 The histone locus body (HLB) is an evolutionarily conserved nuclear body that regulates

165 ones are basic nuclear proteins that possess an evolutionarily conserved nucleosome-binding globular

166 We identified an evolutionarily conserved octameric sequence, CCCAGCAG

167 est arthropod and vertebrate brains may have an evolutionarily conserved organization.

168 monkeys to Hominoidea species, demonstrating an evolutionarily conserved organizational principle.

169 by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in

170 Collectively, this study reveals an evolutionarily conserved paradigm in which the sensor

171 itochondrial fatty acid synthesis (mtFAS) is an evolutionarily conserved pathway essential for the fu

172 la, the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals; however,

173 hagy (hereafter referred to as autophagy) is an evolutionarily conserved pathway in which proteins an

174 An evolutionarily conserved pathway readout is not estab

175 An evolutionarily conserved "Pavlovian" learning mechani

176 his beneficial effect of H2O2 is mediated by an evolutionarily conserved peroxiredoxin-p38/MAPK signa

177 Because PCP is an evolutionarily conserved phenomenon, our study is lik

178 Here, we show that photooligomerization is an evolutionarily conserved photoreaction characteristic

179 centromere translocation can be inhibited by an evolutionarily conserved pole-localized protein that

180 In summary, we identify an evolutionarily conserved population of RAS neurons, w

181 derstanding of this regulation by describing an evolutionarily conserved post-translational mechanism

182 These RBPs suppress an evolutionarily conserved posttranscriptional regulon

183 Autophagy is an evolutionarily conserved process across eukaryotes th

184 We propose that epiblast partial MET is an evolutionarily conserved process among all amniotic v

185 redoxin (Prx) proteins by Oct1 appears to be an evolutionarily conserved process because yeast Oct1 c

186 Autophagy is an evolutionarily conserved process by which long-lived

187 The DNA damage response (DDR) is an evolutionarily conserved process essential for cell s

188 totic cell (AC) clearance (efferocytosis) is an evolutionarily conserved process essential for immune

189 Macroautophagy (hereafter autophagy) is an evolutionarily conserved process in which portions of

190 Mitophagy is an evolutionarily conserved process involving the autoph

191 rnover of the 26S proteasome by autophagy is an evolutionarily conserved process that governs cellula

192 Autophagy is an evolutionarily conserved process that plays a key rol

193 Epithelial wound healing is an evolutionarily conserved process that requires coordi

194 n of HSV-1 infection.IMPORTANCE Autophagy is an evolutionarily conserved process that restricts certa

195 These additional factors suggest PRF is an evolutionarily conserved process whose function and r

196 f sphingolipid synthesis by seipin is likely an evolutionarily conserved process.

197 Myogenesis is an evolutionarily conserved process.

198 ponse to physiologically relevant stimuli is an evolutionarily conserved process.

199 ous research in rodents and humans points to an evolutionarily conserved profile of blunted threat ex

200 oop and disrupts steroid binding, suggesting an evolutionarily conserved property of CBGs.

201 g barbed ends of fascin-bundled filaments is an evolutionarily conserved property of Ena/VASP homolog

202 -transcribed genes with nucleoli seems to be an evolutionarily conserved property of the spatial orga

203 itosis and meiosis is triggered by separase, an evolutionarily conserved protease.

204 Retromer is an evolutionarily conserved protein complex, which sorts

205 Our results demonstrate how an evolutionarily conserved protein involved in the regu

206 S domain containing protein kinase (Pask) is an evolutionarily conserved protein kinase implicated in

207 Arginine methylation is an evolutionarily conserved protein modification catalyz

208 ight into their functions, we studied EFHC1, an evolutionarily conserved protein required for motile

209 coil and C2 domain containing 1A (CC2D1A) is an evolutionarily conserved protein, originally identifi

210 rophage migration-inhibitory factor (MIF) is an evolutionarily-conserved protein that has both extrac

211 The general stress response (GSR) is an evolutionarily conserved rapid and transient transcri

212 via a signalling pathway that has recruited an evolutionarily conserved receptor (Gpr1) and transcri

213 ein-coupled A2a adenosine receptor (A2aR) is an evolutionarily conserved receptor that limits and red

214 Our study uncovered an evolutionarily conserved recruitment of bHLH subfamil

215 Deletion or insertional duplication of an evolutionarily conserved region (ECR) downstream of H

216 to function effectively in yeast, and define an evolutionarily conserved region of the N domain invol

217 te-inducible RNA-associated protein-like) is an evolutionarily conserved regulator of cellular proteo

218 SREBP is an evolutionarily conserved regulator of lipid biosynthe

219 Dachsous (Dchs), an atypical cadherin, is an evolutionarily conserved regulator of planar cell pol

220 Together, these results argue that AdoMet is an evolutionarily conserved regulator of SG composition

221 These results suggest that SCYL-1/SCYL1 is an evolutionarily conserved regulator of Slo2 channels.

222 Finally, we identify TEs that may perform an evolutionarily conserved regulatory function, providi

223 Thus, calmodulin-mediated gating modulation, an evolutionarily conserved regulatory mechanism, endows

224 e also present in human heart, indicative of an evolutionarily conserved regulatory mechanism.

225 erved putative enhancer of Dmrt5, suggesting an evolutionarily conserved regulatory relationship betw

226 in both Drosophila and zebrafish, indicating an evolutionarily conserved requirement for PERK in slee

227 Finally, we show that an evolutionarily conserved residue in the PLL domain is

228 r provide evidence suggesting that Exo1 uses an evolutionarily conserved residue, Lys(185) This resid

229 Fever is an evolutionarily conserved response that confers surviv

230 onclusion, down-regulation of translation is an evolutionarily conserved response to reduced IIS, but

231 In this study, we demonstrated that an evolutionarily conserved ribosomal frameshifting mech

232 Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved RNA decay mechanism that has

233 n, C6orf203, that contains an S4-like domain-an evolutionarily conserved RNA-binding domain previousl

234 Lin28 is an evolutionarily conserved RNA-binding protein that inh

235 zygous CSF1R mutant human brain, identifying an evolutionarily conserved role for CSF1R signaling in

236 Our results elucidate an evolutionarily conserved role for Lhx9 in Hcrt neuron

237 in expression in the two species, suggesting an evolutionarily conserved role for lncRNAs during CD8(

238 down experiments in Xenopus laevis confirmed an evolutionarily conserved role for NRIP1 in renal deve

239 Our studies reveal an evolutionarily conserved role for substrate sequences

240 tion zone formation and function, suggesting an evolutionarily conserved role for Tmem231.

241 nd implicate that O-glycosylation might play an evolutionarily conserved role in modulating the circa

242 zone ribbons of cpx3 knockout mice supports an evolutionarily conserved role of Cpx upstream of SNAR

243 ckdown decreases differentiation, suggesting an evolutionarily conserved role of MUNC lncRNA in myoge

244 These findings highlight an evolutionarily conserved role of TOR signaling in SC

245 , SMARCD2 and SMARCD3 paralog family) reveal an evolutionarily conserved role specifically for the SM

246 This activity of Zhp3 suggests an evolutionarily conserved SC-independent strategy for

247 We report here that DLG5 functions as an evolutionarily conserved scaffold and negative regula

248 Many functional RNAs have an evolutionarily conserved secondary structure.

249 An evolutionarily conserved sequence at the 5' terminus

250 the master IFN-I inducer IRF3 by binding to an evolutionarily conserved sequence in the IFNB1 enhanc

251 Here, we investigate an evolutionarily conserved serine phosphorylation that

252 trate that phosphorylation of Dazl by MK2 on an evolutionarily conserved serine residue inhibits its

253 osphorylation and its autophosphorylation at an evolutionarily conserved serine residue near the carb

254 Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, is

255 NIP30 acts by binding to REGgamma via an evolutionarily-conserved serine-rich domain with 4-se

256 ular elements underlying behavior and reveal an evolutionarily conserved set of diverse neuromodulato

257 The central extended amygdala is an evolutionarily conserved set of interconnected brain

258 is cerana (Ac) and Apis mellifera (Am) share an evolutionarily conserved set of QMP compounds: (E)-9-

259 The Wnt/beta-catenin pathway is an evolutionarily conserved set of signals with critical

260 The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm

261 Notch signaling is an evolutionarily conserved signal transduction pathway

262 It is an evolutionarily conserved signaling cascade regulating

263 for phagolysosomal degradation in activating an evolutionarily conserved signaling cascade, which ens

264 The Hippo pathway is an evolutionarily conserved signaling pathway that plays

265 Hedgehog (Hh) is an evolutionarily conserved signaling protein that has e

266 reticulum (ER) stress sensor that activates an evolutionarily conserved signalling cascade in respon

267 The Hippo pathway is an evolutionarily conserved signalling pathway with key

268 ccupancy genome wide, reduced periodicity is an evolutionarily conserved signature of nucleosome-depl

269 lation, rhythmically phosphorylates BMAL1 at an evolutionarily conserved site.

270 nism that controls the activity of retromer, an evolutionarily conserved sorting device that orchestr

271 istone 3 lysine 9 dimethylation (H3K9me2) is an evolutionarily conserved, specific mark of nuclear pe

272 il domain (MyoV-GTD) interacts directly with an evolutionarily conserved Spir sequence motif.

273 Draper signals through an evolutionarily conserved Src family kinase cascade to

274 ults suggest that translation reprogramming, an evolutionarily conserved starvation response, has bee

275 These studies unmask an evolutionarily conserved structural role for the SMAR

276 The blood-brain barrier (BBB) is an evolutionarily conserved, structural, and functional

277 The centriole is an evolutionarily conserved structure built from highly

278 The superior colliculus (SC) is an evolutionarily conserved, subcortical (midbrain) stru

279 was taken as a representative candidate from an evolutionarily conserved subgroup that possesses high

280 inc finger HIT-type containing 1 (Znhit1) is an evolutionarily conserved subunit of the SRCAP chromos

281 droxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarat

282 ," that links adjacent SSB tetramers through an evolutionarily conserved surface near the ssDNA-bindi

283 e similar to those observed in aestivation - an evolutionarily conserved survival strategy that enabl

284 ems on the basis of their numerousness using an evolutionarily conserved system for approximating num

285 nt cross-talk modulates Wnt3a expression via an evolutionarily-conserved TCF/LEF site within the WNT3

286 Here we report that Spata6, an evolutionarily conserved testis-specific gene, encode

287 in-1 isoforms, differing by the inclusion of an evolutionarily conserved three-nucleotide microexon i

288 ASKalpha phosphorylates cytosolic G6PD6 on an evolutionarily conserved threonine residue, thereby s

289 FOXO3 is an evolutionarily conserved transcription factor that ha

290 ational and modeling analyses indicated that an evolutionarily conserved, truncated leucine zipper mo

291 In this report, we show that an evolutionarily conserved tryptophan residue (Trp-73)

292 uires a gene-regulatory program supported by an evolutionarily conserved type of nuclear receptor.

293 We show that mutations ablating an evolutionarily conserved, Tyr-lined pocket in human P

294 Iduna is an evolutionarily conserved ubiquitin E3 ligase that has

295 phase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that contro

296 Despite being an evolutionarily conserved, ubiquitous, highly ordered

297 GL2-binding partner and show its key role in an evolutionarily conserved VANGL2-p62/SQSTM1-JNK pathwa

298 ify GEN-1, a Holliday junction resolvase, as an evolutionarily conserved WDR-23 substrate and find th

299 igins of pacemaker cardiomyocytes, we reveal an evolutionarily conserved Wnt signaling mechanism that

300 ition to its catalytic domain, PHD2 contains an evolutionarily conserved zinc finger domain, which we