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1 ure-confirmed cases of typhoid fever lead to an excess of 0.046 perforations per clinical typhoid fev
2 tal models led to parameter estimate bias in an excess of 1,000% of true values, while the new model
6 reduction in income-related inequality, from an excess of 191.7 YLL per 100 000 (68.6-314.8) between
11 r every 1000 women exposed to this strategy, an excess of 3.5 neonatal deaths occurred, and the risk
12 known bis-alpha-diketone was condensed with an excess of 4-bromo-1,2-diaminobenzene in the presence
14 e the hydrophobic domain of the membrane and an excess of a bicyclo[6.1.0]nonyne (BCN)-cross-linker c
15 onucleotide sequence even in the presence of an excess of a sequence with a single-base-pair mismatch
20 n improvement in the quality of care without an excess of adverse events related to more aggressive m
23 nduced cytidine deaminase (AID) and observed an excess of AID signature mutations in immortalised cel
24 ivated terminal alkenes without the need for an excess of alkene and with 2-aminopyridine as an ammon
26 omplished double C-H activation by employing an excess of alkyne, where both annulation and hydroaryl
27 om a functional perspective, we did not find an excess of alleles contributing to height despite bein
28 found that the source of this enrichment was an excess of alleles that increased sensitivity to the e
29 lassemia is characterised by the presence of an excess of alpha-globin chains, which contribute to er
31 icle neutralization lead us to conclude that an excess of ammonium enabled particle formation and gro
32 ock these intermolecular reactions by adding an excess of an azide capping agent that intercepts the
35 produce, in a sequential one-pot operation, an excess of any one of four possible diastereoisomers f
36 ever, when the coated samples are exposed to an excess of aqueous electrolyte, an increase in the amo
37 ctive only with electron-rich arenes, unless an excess of arene is used, which limits synthetic appli
41 uNPs] ratio was determined, corresponding to an excess of AuNP surface relative to the molar GSNO amo
44 al lineCPh(pCF3))(CO)2] (6) upon addition of an excess of benzonitrile and by the temperature-depende
46 es HPV27/57, the unusual wart type HPV7, and an excess of Betapapillomavirus types (P = .002), compar
51 proposed that obesity, generally defined by an excess of body fat causing prejudice to health, can n
53 wo distinct mutant phenotypes were observed: an excess of buds on the protonema, and abnormal cell di
56 excess of diabetes or cancers, but there was an excess of cataract surgery (in 3.8% of the participan
62 r, one species (Drosophila sechellia) showed an excess of cis-regulatory divergence that we argue mos
63 -7 subunits was accelerated by co-expressing an excess of ClC-7 subunits carrying an accelerating mut
66 divergence across population pairs involving an excess of coding genes with specific molecular functi
67 olumes required for these techniques lead to an excess of coenriched organic or inorganic materials.
68 er specificity, tracers were coinjected with an excess of cold proteins of the same or opposite recep
70 s leading to clinical sequelae like pain and an excess of comorbidity including cardiovascular diseas
71 ed connection pruning at later ages, and not an excess of connection formation, underlies the hyperco
74 ed by severe inflammatory symptoms caused by an excess of cytokines, particularly KSHV-encoded viral
75 (2+) on cell cycle progression and show that an excess of cytosolic Mn(2+) alters S-phase transit, in
76 ate that 14% of cases could be attributed to an excess of damaging de novo or recessive variants.
79 mental disorders (NDDs) were identified with an excess of de novo mutations (DNMs) but the significan
81 DYRK1A truncating mutations (P=0.00851) and an excess of de novo mutations (P=2.53 x 10(-10)) among
82 lly, WES (n = 18) was very informative, with an excess of de novo mutations identified in genes predi
83 d 91 genes, including 38 new NDD genes, with an excess of de novo mutations or private disruptive mut
86 sed difference in liability and demonstrated an excess of deleterious autosomal copy-number variants
89 quence analysis revealed these tumors harbor an excess of deletions, with a deletions:substitutions r
93 Thus, simply upon mixing the dendralene and an excess of dienophile at ambient temperature in a comm
95 e these models to then identify loci showing an excess of differentiation as a means of identifying p
96 reatment of triphenylphosphine (Ph(3)P) with an excess of diisopropyl azodicarboxylate at 0-25 degree
97 In addition, the reaction of diynols with an excess of dimethyl disulfide in the presence of NBS g
101 Independent analyses of enhancers showed an excess of DNVs in associated genes (27 genes versus 3
102 se Bicc1-depleted eggs produced embryos with an excess of dorsal-anterior structures and overexpresse
105 R complex to regulate lipid storage and that an excess of ecdysone disrupts the whole process, probab
106 nti-DM4 B-Fabs and blocking experiments with an excess of either B-Fab or huDS6 were used to determin
109 annel currents from receptors assembled with an excess of either the alpha4 or beta2 subunit, forming
110 oidal stability over a wide range of pHs, to an excess of electrolytes, and in the presence of growth
113 fission is potently inhibited in vitro when an excess of endophilin co-assembles with dynamin around
114 The key property controlling evolvability is an excess of enzymatic activity relative to the strength
116 ard deviations from the genome-wide average: an excess of European ancestry at 1p36 and 14q32, and an
117 ut it is unclear whether this is mediated by an excess of extracranial vascular disease (i.e. atheros
119 FMRP, particularly as recent studies suggest an excess of FMRP targets among genes implicated in idio
120 e between alpha- and beta-globin chains with an excess of free alpha-globin chains causing ineffectiv
121 ce, however, showed toxic effects because of an excess of free cholesterol (FC) in macrophages, which
122 (Malus x domestica) trees naturally produce an excess of fruitlets that negatively affect the commer
123 12%) on placebo (p=0.0002) was mainly due to an excess of gastrointestinal adverse effects, and there
125 nts, and among DNA-based movements there was an excess of genes moving onto the X chromosome as well.
126 rosophila and mammals, consistently detected an excess of genes moving out of the X chromosome and ga
127 AS data (the top 5% of SNPs) were tested for an excess of genes spanned by large, rare CNVs in the ch
128 use many biologically defined gene sets have an excess of genes with longer or shorter gene locus len
129 enetic analyses showed that all subtypes had an excess of genetic risk for Alzheimer's disease (all P
130 ed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affecte
133 onditions with low Fe(3+) concentrations and an excess of H(2)O(2) as well as acidic conditions were
137 at are not associated with gamma-ray bursts, an excess of high-velocity (roughly 30,000 kilometres pe
146 though studies of standard models often find an excess of hybrid male sterility factors, we found no
147 ween plasma electrons and aqueous ions yield an excess of hydroxide ions (OH(-)), making the solution
149 eclampsia cases and 3,854 controls and found an excess of iciHHV-6 in the cases (odds ratio of 2.8, 9
152 retinal connectome govern this computation: an excess of inhibitory inputs over excitatory, with bot
154 reduced estrogen sensitivity by introducing an excess of interaction partners into the receptor/estr
155 2 pg/mL target concentration in samples with an excess of interfering DNA and in a total analysis tim
156 t there is elevated nucleotide diversity and an excess of intermediate frequency alleles at this locu
159 use an optimized membrane typically contains an excess of ionophore, but lower than expected selectiv
161 etic, a large lattice constant together with an excess of La can stabilize an antiferromagnetic LaMnO
163 termediate that dominates in the presence of an excess of ligand, and (2) transmetalation via an acti
164 variants by in vivo complementation revealed an excess of loss-of-function alleles in individuals wit
166 n is under purifying selection, resulting in an excess of low-frequency variants and a negative corre
167 l baseline spirometry (n = 12,039), we found an excess of lung cancers during screening in the CT arm
169 a heterogeneous clinical entity and includes an excess of males who harbor variants on the X-chromoso
171 s at high cardiovascular disease risk, found an excess of MIs among patients in the valsartan arm.
172 didate neurodevelopmental disease genes with an excess of missense and/or likely gene-disruptive (LGD
175 no major offsetting adverse events, such as an excess of myalgias, elevation of hepatic aminotransfe
176 Y(3)N@I(h)-C(80) and Gd(3)N@I(h)-C(80) with an excess of N-ethylglycine and formaldehyde provided tr
180 y cyclin B1 destruction reflects the loss of an excess of non-CDK1-bound cyclin B1 in late prometapha
183 Blocking antigen-expressing tumors with an excess of nonradiolabeled alphaGPC3 resulted in decre
184 rter, a phenotype that could be explained by an excess of nonreducing ends leading to a reinforced xy
185 s have greatly reduced genetic diversity and an excess of nonsynonymous mutations, consistent with se
188 Altogether, these findings indicate that an excess of NPM-ALK activation and signaling induces ap
189 ch a racemic mixture can be transformed into an excess of one enantiomer with the aid of chiral auxil
190 for overcoming this challenge: (1) employing an excess of one reagent; (2) electronic differentiation
192 ed the respiration rate, which suggests that an excess of oxaloacetate is converted to aspartate and
194 enyl)imidazole-2-ylidene) in the presence of an excess of para-hydrogen ( p-H(2)) and a substrate (4-
196 sis, 638 (55%) of 1162 sarcoma probands bore an excess of pathogenic germline variants (combined odds
200 tive Tajima's D for nonsynonymous mutations, an excess of polymorphism, and a spike in the levels of
201 identifying 56 candidate elicitors that have an excess of positively selected residues in a backgroun
203 eterious autosomal CNVs (p = 7 x 10(-4)) and an excess of private deleterious single-nucleotide varia
204 unding, cells reversibly switch to producing an excess of proliferating daughters until the wound has
205 f 1213 CHD parent-offspring trios identified an excess of protein-damaging de novo mutations, especia
206 ing minute amounts of infectious prions with an excess of PrP(C) and boosting the conversion by cycle
207 r, lysis could be competitively inhibited by an excess of purified trehalose dimycolate and was aboli
208 otypes in cortical progenitors, resulting in an excess of radial glia cells at the expense of interme
211 We searched 18,668 protein-coding genes for an excess of rare deleterious genetic variation using wh
212 s with treatment-resistant schizophrenia had an excess of rare disruptive variants in gene targets of
214 and rapid human population growth has led to an excess of rare genetic variants that are expected to
215 ent explosive population growth, notable for an excess of rare genetic variants, suggesting that many
216 same intracellular loop of NaV1.7, we found an excess of rare variants in a case-control variant-bur
217 llapsing analyses to identify loci harboring an excess of rare variants with functional connections t
219 ll other reported AEs, with the exception of an excess of renal and urinary AEs among patients assign
220 In addition, consistent with other cancers, an excess of retinoblastoma diagnosed in boys suggests a
227 MMRD/polymerase-mutant cancers rapidly amass an excess of simultaneous mutations ( approximately 600
230 l inhibition (sIPSC and mIPSC) and generated an excess of somatostatin(+) (SST) (MGE-derived) and vas
231 d dimorphic species are predicted to produce an excess of sons, whereas mothers in poor condition sho
232 ndrome and are traditionally associated with an excess of striatal dopamine in the basal ganglia.
234 udy drug at EOS, and, between days 3 and 30, an excess of stroke and systemic embolic events were obs
239 nce is perturbed in latd mutants, leading to an excess of superoxide and hydrogen peroxide and a corr
240 ormation via a mutagenic mechanism involving an excess of T>G substitutions, but not involving a prep
242 rees C, an excess of unlabeled mouse IgG, or an excess of Tau antibodies reduced uptake in slices by
244 us analysis of 474 microlensing events found an excess of ten very short events (1-2 days)-more than
246 chondria, the mtLSU lacks bL36m, accumulates an excess of the assembly factors MTG1, GTPBP10, MALSU1
247 mice have an increase in NK-cell number with an excess of the CD11b(low)CD27(high) NK subset, indicat
250 Despite this requirement for crossovers and an excess of the double-strand DNA breaks that are the i
251 0.5 (square root of its concentration) with an excess of the electrophiles ClSiMe3, 1-bromobutane (n
252 re we show that conditions that prevent that an excess of the ER resident chaperone (and UPR target g
255 for the growth of B. subtilis and shows that an excess of the molecule is also harmful for the bacter
261 ples from women with TFI, but there was also an excess of the second-highest titer component in TFI c
262 abundance has been shown to be inhibited by an excess of the small regulatory protein, SlrA, and her
263 GATA1/HSP70 and globin/heme imbalance, with an excess of the toxic free heme leading to reactive oxy
264 and plasma from patients with SPG5 revealed an excess of the toxic LXR ligand, 3beta-HCA, while pati
266 s to capture energy through respiration, but an excess of this critical cofactor is toxic to bacteria
267 er the enrollment of 252 patients because of an excess of thromboembolic and bleeding events among pa
268 I 48 transition plan protected patients from an excess of thrombotic and bleeding events and should b
269 vascular scaffolds (BVS) are associated with an excess of thrombotic complications compared with meta
272 , domestic populations were characterized by an excess of unique polymorphisms in two categories gene
273 d spleen uptake at 24 hours, indicating that an excess of unlabeled antibody effectively blocked PD-L
274 ontaining a 5' single-stranded overhang with an excess of unlabeled DNA to initiate thermodynamically
276 xenografts 24 h after injection of 13, while an excess of unlabeled ligand blocked 13 from binding to
277 rmore, temperature reduction to 4 degrees C, an excess of unlabeled mouse IgG, or an excess of Tau an
281 he phosphate groups of phospholipids and add an excess of up to three positive charges per phosphate
285 ogenic/likely pathogenic: 18%, P<0.0001) but an excess of variants of uncertain significance (24%, P<
287 n and neovascularization, causing a lack and an excess of vessels, respectively, are hallmarks of hum
290 are overweight are at high risk if they have an excess of visceral adipose tissue-a condition often a
291 r class I inhibition during development, and an excess of vitamin B12 coenzyme, which is essential fo
295 erate MSH2-deficient intestinal crypts among an excess of wild-type crypts (Lgr5-CreERT2;Msh2(flox/-)
296 tions, such as CAPS in this study, that have an excess of zeroes in addition to being positively skew