ライフサイエンスコーパス: analgesic effect

1 o their anti-inflammatory, anti-pyretic, and analgesic effect.

2 nistration of mu opioids fails to produce an analgesic effect.

3 sary for associative tolerance to morphine's analgesic effect.

4 eous administration of RTX had a generalized analgesic effect.

5 s in the CNS to produce a centrally mediated analgesic effect.

6 idenced by induction of a centrally mediated analgesic effect.

7 ive opioid receptor agonist with very potent analgesic effect.

8 stricted sodium channel may have a selective analgesic effect.

9 er the addition of MgB(2), indicating potent analgesic effect.

10 une cells, and CB2 agonists normally have no analgesic effect.

11 yl-induced hyperalgesia while preserving its analgesic effect.

12 9L and morphine resulted in a dose-dependent analgesic effect.

13 accounted for 25% of the variance in placebo analgesic effects.

14 ave been shown to possess antinociceptive or analgesic effects.

15 to a favourable pharmacokinetic profile and analgesic effects.

16 rs (CBRs) have been implicated in the opioid analgesic effects.

17 ability of the opioid antagonist to produce analgesic effects.

18 ctive muscarinic agonists display pronounced analgesic effects.

19 ioside in mice rapidly attenuates morphine's analgesic effects.

20 nergic receptors (alpha(2)ARs) leads to mild analgesic effects.

21 mical pathways in exerting their supraspinal analgesic effects.

22 ists has been shown to result in synergistic analgesic effects.

23 nectin (APN), a circulating adipokine, shows analgesic effects.

24 Both positive and negative emotion may have analgesic effects.

25 inoids and opioids has been shown to enhance analgesic effects.

26 among other drug groups, as having potential analgesic effects.

27 Each pathway would produce analgesic effects.

28 respectively, which also contributed to its analgesic effects.

29 nized for their potent anti-inflammatory and analgesic effects.

30 h gaps to clinical translation of Anakinra's analgesic effects.

31 tor mechanisms appear to underlie Anakinra's analgesic effects.

32 he treatment of OIC without compromising the analgesic effects.

33 enous adenosine action at A1R and leading to analgesic effects.

34 the ACC in vivo produces both anxiolytic and analgesic effects.

35 and to exhibit CB1-mediated hypothermic and analgesic effects.

36 ENK for opioid receptor binding affinity and analgesic effects.

37 report and loperamide produced a significant analgesic effect (2-fold increase in response times) whe

38 KOR agonists exhibit analgesic effects, although the adverse effects produced

39 nation of PNGB and LFCNB provided equivalent analgesic effect and significantly lowered the risk of n

40 ine causes addiction, tolerance to its acute analgesic effects, and profound physical dependence by s

41 how different frequencies of SCS produce the analgesic effect are unclear.

42 ir broad anti-inflammatory, antipyretic, and analgesic effects are applied against symptoms of respir

43 These analgesic effects are many times greater than unmodified

44 a novel mechanism that acupuncture produces analgesic effects at least partially via APN/AdipoR2-AMP

45 f 12d was demonstrated by suppression of the analgesic effect by pretreatment with idazoxan.

46 onizing mu opioid-induced analgesia or a net analgesic effect by reducing the hyperalgesia during opi

47 Morphine mediates its euphoric and analgesic effects by acting on the mu-opioid receptor (M

48 Morphine exerts its acute rewarding and analgesic effects by activation of inhibitory guanine nu

49 conclude that CBD might produce some of its analgesic effects by direct effects on neuronal excitabi

50 That this analgesic effect can be achieved with easy-to-administer

51 s alfentanil bolus has a clinically relevant analgesic effect compared with placebo in patients under

52 , the H(2) S(2) prodrug offers much-elevated analgesic effects compared to the H(2) S prodrug in vivo

53 ticals, opioids differ in their rewarding or analgesic effects depending on when they are applied.

54 ncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caff

55 require arrestin recruitment, whereas their analgesic effects do not.

56 eption, altruistic behavior had an intrinsic analgesic effect for the recipient.

57 ant women (effect size: large; GRADE: high), analgesic effects for osteoarthritis (effect size: small

58 d with an enhanced sensitivity to the opioid analgesic effect (IL-1beta, P = 0.0218; TNF-alpha, P = 0

59 he resolvin precursor 17-HDHA shows a strong analgesic effect in animal models of osteoarthritis and

60 onsubtype-selective alpha2AR agonist, had no analgesic effect in D79N mice, whereas the analgesic pot

61 oxylase (QHGAD67) release GABA to produce an analgesic effect in rodent models of pain.

62 inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic

63 this technique we demonstrate a significant analgesic effect in transgenic mouse models of SCD and c

64 M9 exhibited a strong analgesic effect in vivo, and its analgesic tolerance wa

65 h synaptically and behaviorally in producing analgesic effects in a PLA(2)-dependent fashion, support

66 Moreover, 4a produced analgesic effects in a rodent model of acute inflammator

67 l facilitate follow-up testing of Anakinra's analgesic effects in an expanded clinical trial, respond

68 G9a in diminished MOR expression and opioid analgesic effects in animal models of neuropathic pain.

69 oid cannabidiol (CBD) has been shown to have analgesic effects in animal studies but little is known

70 nomolar IC50), and has been shown to produce analgesic effects in animals.

71 ls, HUP-A treatment demonstrates significant analgesic effects in both regimens.

72 Consistent with its analgesic effects in humans, sanshool treatment in mice

73 al models; however, they exhibit only modest analgesic effects in humans.

74 Notably, AOC3 inhibitors provoked analgesic effects in inflammatory pain models in vivo, s

75 -dependent anxiolytic, antiinflammatory, and analgesic effects in mice by increasing endocannabinoid

76 ecrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as i

77 BCFTP did not have analgesic effects in Mrgpr cluster knockout (Mrgpr(-/-))

78 ckout (Mrgpr(-/-)) mice, indicating that the analgesic effects in MrgprX1 mice were MrgprX1 dependent

79 flares, reduced nocifensive licking and had analgesic effects in nerve injury-induced chronic neurop

80 nce in antiemetic effects in pregnant women, analgesic effects in osteoarthritis, and glycemic contro

81 s unnatural cutaneous sensations with potent analgesic effects in pain syndromes.

82 The results suggest that CBD can exert analgesic effects in part by directly inhibiting repetit

83 at P and 3 alpha-Diol at moderate doses have analgesic effects in part via membrane actions within th

84 est validated target in OA pain, with proven analgesic effects in preclinical and clinical studies, a

85 ITI-333 exhibited dose-dependent analgesic effects in rodent models of acute pain.

86 denosine kinase inhibition produces powerful analgesic effects in rodent models of experimental neuro

87 de deactivation in vivo and exerted profound analgesic effects in rodent models of nociceptive and in

88 e lead compound identified, 18g, showed good analgesic effects in several animal models of both acute

89 mu opioid receptor, the most responsible for analgesic effects in the central nervous system.

90 e rotarod test and statistically significant analgesic effects in the formalin test for acute inflamm

91 NK gene transfer into the OT did not produce analgesic effects in the tail-flick test.

92 of Fcgr1 in sensory neurons produced similar analgesic effects in these models.

93 c agonists can produce both hyperalgesic and analgesic effects in vivo.

94 Selective blockade of Bdnf translation has analgesic effects in vivo.

95 ogical profile ASIC channels to exert strong analgesic effects in vivo.

96 ctive muscarinic agonists resulted in robust analgesic effects, indicating that muscarinic analgesia

97 The analgesic effects induced by combination of alcohol and

98 The cannabinoid-induced analgesic effect is absent in mice lacking the alpha3 Gl

99 on patterns demonstrate that this subjective analgesic effect is associated with reductions in nocice

100 This analgesic effect is attributed to activation of peripher

101 Its analgesic effect is mainly attributed to its metabolite,

102 rodent dorsal root ganglion (DRG) show their analgesic effect is mediated by inhibition of N-type (Ca

103 In Experiment 2, we tested whether this analgesic effect is mediated by the brainstem nucleus ra

104 This ingestion analgesic effect is reversed when the hedonic valence of

105 We further revealed that EA produced analgesic effects mainly via APN/AdipoR2-mediated AMPK p

106 ric fluid without delay, suggesting that its analgesic effect may be unaffected if consumed orally as

107 stem, suggesting that at least part of their analgesic effect might be of central origin.

108 in states, and have shown that NR2B-mediated analgesic effects might be supra- rather than intra-spin

109 e found to be expressed, to show an enhanced analgesic effect, no opioid-induced tolerance, and to pr

110 Neither this significant analgesic effect nor these fMRI findings were seen in th

111 effects of acupuncture may contribute to the analgesic effect observed in genuine acupuncture analges

112 duction of IFN-B, may partly account for the analgesic effect observed.

113 Upon withdrawal of both conditions, analgesic effects observed prior to withdrawal were dimi

114 In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine

115 adenosine A1 receptor agonist replicated the analgesic effect of acupuncture.

116 flammatory cytokines that may counteract the analgesic effect of ADU-S100.

117 We demonstrated that this analgesic effect of AM404 is mediated by its direct inhi

118 Tolerance to the analgesic effect of an opioid is a pharmacological pheno

119 To that end, we tested the analgesic effect of Anakinra during a standardized, expe

120 on of TGF-beta1, but not IL-10, reversed the analgesic effect of BMSCs.

121 The findings suggest that the analgesic effect of BreEStim is not likely attributed to

122 The underlying mechanisms involved in the analgesic effect of BreEStim were considered to result f

123 The analgesic effect of clinically used exogenous opioids, s

124 did not alter the tail-flick latency or the analgesic effect of deltorphin II.

125 Finally, the analgesic effect of donepezil was markedly reduced by a

126 which was associated with a decrease in the analgesic effect of endogenous inhibitory G-protein-coup

127 Strikingly, the analgesic effect of hCS in our experiments was maintaine

128 spinal GIRK channels selectively blunts the analgesic effect of high but not lower doses of intrathe

129 spinal GIRK channels selectively blunted the analgesic effect of high but not lower doses of the mu-o

130 onist icilin in vitro and to investigate the analgesic effect of icilin in a neuropathic pain model i

131 cord likely plays a predominant role in the analgesic effect of intrathecal clonidine on neuropathic

132 carinic receptors play a greater role in the analgesic effect of intrathecal clonidine.

133 t that spinal nitric oxide (NO) mediates the analgesic effect of intrathecal clonidine.

134 The analgesic effect of intrathecally administered morphine

135 letion of the Mrgpr cluster also blocked the analgesic effect of intrathecally applied bovine adrenal

136 n, produced strong aversion and canceled the analgesic effect of low-dose ketamine.

137 Finally, we show that TRPM8 mediates the analgesic effect of moderate cooling after administratio

138 se studies tested whether IS potentiates the analgesic effect of MOR microinjected in the DRN, as pre

139 n DRG neurons not only potentiated the acute analgesic effect of morphine but also attenuated morphin

140 for treating bone cancer pain and improving analgesic effect of morphine clinically.

141 t as inhibiting JNK in reducing the enhanced analgesic effect of morphine in beta-arr2-/- mice to +/+

142 e, we examine the effect of tolerance to the analgesic effect of morphine on ischemic tolerance in mi

143 fferent JNK inhibitors reversed the enhanced analgesic effect of morphine, a known phenotype of beta-

144 arkable potentiation and prolongation of the analgesic effect of morphine, suggesting that muOR desen

145 R-TRPM3 signaling pathway contributes to the analgesic effect of morphine.

146 during the pain challenge and the resulting analgesic effect of mu-opioid receptor activation was mo

147 These results demonstrate a novel analgesic effect of non-informative vision of the body.

148 termine the receptor subtype involved in the analgesic effect of NT69L and morphine.

149 diurnal variation in the reward behavior or analgesic effect of opioid administration.

150 constipation (OIC) without compromising the analgesic effect of opioids.

151 mouse and human dorsal root ganglia, and the analgesic effect of our inhibitor is linked to A1R.

152 Our findings suggest that the analgesic effect of paracetamol is mediated mainly by di

153 al of emotional experiences also mediate the analgesic effect of perceived control over pain.

154 praisal view of control and suggest that the analgesic effect of perceived control relies on activati

155 inal correlates associated with the headache analgesic effect of rTMS at left prefrontal cortex (LPFC

156 This study correlates the demonstrated analgesic effect of rTMS in the treatment of MTBI-HA wit

157 Behavioral results confirmed the expected analgesic effect of seeing the body, while fMRI results

158 Importantly, the analgesic effect of several antidepressant drugs, includ

159 ical studies that have demonstrated that the analgesic effect of spinally administered lipid-soluble

160 which spinal mu opioid receptors mediate the analgesic effect of systemic mu opioids.

161 In contrast, the analgesic effect of the agonist (trans)-3,4-dichloro-N-m

162 disinhibition, supporting the view that the analgesic effect of the GluN2B antagonist on neuropathic

163 It has been generally assumed that the analgesic effect of this biologic therapy results from a

164 y self-reported pain intensity, and that the analgesic effects of a competing task were influenced by

165 binoid signaling is also responsible for the analgesic effects of acetaminophen against inflammatory

166 amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffei

167 nates cells expressing this receptor and the analgesic effects of alpha2-AR agonists.

168 Tolerance to the analgesic effects of an opioid occurs after its chronic

169 The analgesic effects of BMAs are modest, and they should no

170 3, downstream of MOR activation improves the analgesic effects of both endogenous and exogenous MOR a

171 noradrenergic cell groups contribute to the analgesic effects of both NMDA receptor antagonists and

172 The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A)

173 of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor.

174 Instead, the enhanced analgesic effects of cannabinoids and opioids may result

175 effects of morphine is also required for the analgesic effects of cannabinoids.

176 l insight into the topical mechanisms of the analgesic effects of capsaicin and the strategies to imp

177 plays a modulatory role in the mediation of analgesic effects of certain compounds, for example tric

178 Finally, the analgesic effects of combining Cereport and loperamide w

179 of this study is to evaluate the preemptive analgesic effects of dexamethasone (DEX) alone or combin

180 e Kv7 inhibitor, XE991, and DHEAS eliminated analgesic effects of DHEAS in late phase responses in th

181 tonic pain in animals and for evaluating the analgesic effects of drugs.

182 trathecal administration of APN mimicked the analgesic effects of EA.

183 study aimed to examine whether APN regulates analgesic effects of electroacupuncture (EA) in the comp

184 ation of Gbetagamma signaling to enhance the analgesic effects of endogenous opioid peptides suggesti

185 eys is the source of the ACh involved in the analgesic effects of epidural neostigmine and could be m

186 Last, we tested the analgesic effects of epidural ULF currents in 20 subject

187 of novel mechanisms relating to the visceral analgesic effects of guanylate cyclase-C (GC-C) agonists

188 ibilities for dissociating the secretory and analgesic effects of GUCY2C agonism.

189 del, but it is a potential mechanism for the analgesic effects of icilin in other pain models.

190 signaling element that mediates the superior analgesic effects of IL4-10 FP.

191 pheral opioid receptors and tolerance to the analgesic effects of intraarticular morphine.

192 DM results have demonstrated the significant analgesic effects of lapatinib, suggesting that lapatini

193 tify the neural circuitry that underlies the analgesic effects of left DLPFC rTMS, and to examine how

194 ggest that drugs seeking to recapitulate the analgesic effects of loss of function of Nav1.7 will nee

195 the cellular sites for the spinally mediated analgesic effects of MOR activation and the potential an

196 iors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transg

197 e, but also reduced their sensitivity to the analgesic effects of morphine and led to faster developm

198 esting either a decreased sensitivity to the analgesic effects of morphine and/or basal hyperalgesia.

199 hine and the development of tolerance to the analgesic effects of morphine remained unaltered by the

200 has been hypothesized that tolerance to the analgesic effects of morphine results from the developme

201 xaggerated responses to cocaine, reduces the analgesic effects of morphine, and abolishes the effects

202 How hnRNP K contributes to the analgesic effects of morphine, however, is largely unkno

203 cated in the development of tolerance to the analgesic effects of morphine.

204 and, in some cases, reverse tolerance to the analgesic effects of morphine.

205 analgesia, they are unlikely to mediate the analgesic effects of morphine.

206 lammatory response that directly opposes the analgesic effects of morphine.

207 ts in the mu opioid receptor gene change the analgesic effects of morphine.

208 binds with beta-arrestin 2 and modulates the analgesic effects of morphine.

209 how that the mu opioid receptor mediates the analgesic effects of morphine; they further suggest that

210 1bf/f/p mice exhibited significantly reduced analgesic effects of mu and delta opioid receptor agonis

211 agonists, and provide insights into the non-analgesic effects of mu opioids.

212 decrease the development of tolerance to the analgesic effects of mu-opioid receptor agonists, which

213 ents may contribute to the anesthetic and/or analgesic effects of N(2)O.

214 This nAChR is a candidate for the analgesic effects of nicotine as well as the frog toxin

215 oid analgesia, is proposed to facilitate the analgesic effects of nonserotonergic RM terminals in the

216 Recent data have demonstrated potent analgesic effects of one factor (glial cell line-derived

217 Many of the analgesic effects of opiate drugs and of endogenous opio

218 e prevailing hypothesis is that the intended analgesic effects of opioid drugs are mediated by u-opio

219 The powerful analgesic effects of opioid drugs have captivated the in

220 Mu opioid receptors (MOR) mediate the analgesic effects of opioid drugs such as morphine.

221 Tolerance to the analgesic effects of opioids is a major problem in chron

222 te opioid-induced somnolence, to augment the analgesic effects of opioids, to treat depression, and t

223 pain relief in humans while maintaining the analgesic effects of opioids.

224 e (including drug craving), reinforcing, and analgesic effects of oxycodone in human volunteers diagn

225 Finally, exendin-4 did not alter the analgesic effects of oxycodone, suggesting that activati

226 opioid use disorders and it may enhance the analgesic effects of oxycodone.

227 study compared the magnitude and duration of analgesic effects of smoked marijuana and dronabinol und

228 We discovered that analgesic effects of sound depended on a low (5-decibel)

229 ion is not simply the sum of the independent analgesic effects of spinal kappa and delta opioid syste

230 on-B (IFN-B) signaling were required for the analgesic effects of STING agonists in male mice.

231 It has been postulated that the analgesic effects of TCAs are determined by their abilit

232 endent contributions of GIRK channels to the analgesic effects of the -opioid receptor-selective agon

233 ation, providing a neurobiological basis for analgesic effects of the CB2 receptor in this model of O

234 dered by the development of tolerance to the analgesic effects of the drug.

235 are insensitive to the ataxic, sedative, and analgesic effects of the novel hypnotic drug, gaboxadol.

236 mutant receptor could be used to elicit the analgesic effects of the opioids without the accompanyin

237 nvolved in mediating the neuromodulatory and analgesic effects of the peptide.

238 f this study was to evaluate and compare the analgesic effects of the preemptive administration of ib

239 The analgesic effects of these compounds involve long-term d

240 While the analgesic effects of these drugs are mediated by mu-opio

241 V1 antagonists in various types of pain, the analgesic effects of two TRPV1 antagonists with similar

242 The findings that the analgesic effects of various antidepressant drugs are di

243 We evaluate here the analgesic effect on rats of epidurally administered RTX,

244 Vision of the body produced clear analgesic effects on both subjective ratings of pain and

245 neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive moda

246 lectroacupuncture of the acupoints generated analgesic effects on MO-induced visceral hypersensitivit

247 ateral prefrontal cortex (DLPFC) can produce analgesic effects on postoperative and laboratory-induce

248 ICa(V) in DRG neurons is unlikely to mediate analgesic effects or contribute directly to the pathogen

249 clear whether the evidence indicates genuine analgesic effects or results from domain-general effects

250 rols as to their capacity to predict placebo analgesic effects, placebo-induced activation of mu-opio

251 Although most opiates exert their analgesic effects primarily via mu opioid receptors, a n

252 atecholamine neurons may mediate part of the analgesic effect produced by systemic administration of

253 lation in primary sensory neurons diminishes analgesic effects produced by systemic and intrathecal o

254 SBI-810's analgesic effects require NTSR1 and betaarr2 but not NTS

255 hindered by development of tolerance to the analgesic effects, requiring dose escalation for persist

256 ly-Phe-Leu-Ser(beta-D-Glc)-CONH(2), produces analgesic effects similar to morphine, even when adminis

257 atively small study, but the dose-responsive analgesic effects suggest that NP2 may be effective in r

258 ing EGFR suppressed GCH1 and BH4 and exerted analgesic effects, suggesting a molecular link between E

259 ne applied to skin-harvest sites produced an analgesic effect that reduced narcotic requirements comp

260 limbs, but corpus callosotomy eliminated the analgesic effect that was ipsilateral, but not contralat

261 However, in addition to the desired analgesic effects, this TRPV1 antagonist significantly i

262 mu-Opioid agonists mediate their analgesic effect through GPCRs that are generated via al

263 that virtual nature exposure enables genuine analgesic effects through changes in nociceptive and som

264 114, and 121 have the potential of producing analgesic effects through MOR partial agonism with reduc

265 Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor 1 (CB

266 thesia demonstrated additional postoperative analgesic effects versus general anesthesia only.

267 neuropeptide oxytocin (OT) exerts prominent analgesic effects via central and peripheral action.

268 The analgesic effect was assessed by prolongation of the paw

269 Importantly, this analgesic effect was maintained even in animals with lat

270 or agonists decreased VMR; importantly, this analgesic effect was preserved after 6 d of twice daily

271 brain during the pain challenge to show that analgesic effects were associated with underlying brain

272 No significant analgesic effects were observed for clinical pain severi

273 ned in alpha7 knockout mice, suggesting that analgesic effects were potentially mediated through alph

274 prefrontal cortex (L-DLPFC) tDCS induced an analgesic effect, which was explained by reduced perfusi

275 n of Galpha(q) signaling enhanced morphine's analgesic effects while reducing hyperalgesia and tolera

276 uce better biological profiles (e.g., higher analgesic effect with significantly less adverse side ef

277 assay in mice, the pyridomorphinans produced analgesic effects with varying potencies and efficacies

278 been implicated in the formation of placebo analgesic effects, with initial reports dating back thre

279 to occupy this pathway's entrance exhibited analgesic effects without inducing hyperthermia.