ライフサイエンスコーパス: analog

1 n a 100 g scale to provide the dihydroindole analog.

2 eaction provides a functionalized nucleoside analog.

3 , such as caspase-1 substrate and Bradykinin-analog.

4 o stall with eIF5B and a nonhydrolyzable GTP analog.

5 PfPKG, without losing affinity for the cGMP analog.

6 3 informed the development of around 500 H23 analogs.

7 on of harmine to synthesize 29 harmine-based analogs.

8 istent mechanical recovery of the homochiral analogs.

9 ion and identified previously unknown active analogs.

10 lmonary disorders in humans and animal model analogs.

11 AngII) and two strongly beta-arrestin-biased analogs.

12 additive quantities of the single-component analogs.

13 corporated than ATP and two other nucleotide analogs.

14 s at lower binding energies than their rigid analogs.

15 f water containing 6:2 FTS or its structural analogs.

16 ly resembling those of the heterochiral KFE8 analogs.

17 contain lysine and its sterically demanding analogs.

18 hotophysics reminiscent of their heavy-metal analogs.

19 ere potently desensitized by the epibatidine analogs.

20 efficiency of inhibition for five nucleoside analogs.

21 lude BINAP, Me-Duphos, Josiphos, and related analogs.

22 further optimization to design dual-targeted analogs.

23 osides, and C2'- and C4'-modified nucleoside analogs.

24 eatment of MTC with radiolabeled minigastrin analogs.

25 al development of fibrillation-resistant hCT analogs.

26 responding heterocyclic or heterosubstituted analogs.

27 ed excision compared with similar nucleoside analogs.

28 rATP and of its naturally occurring damaged analog 1,N (6)-ethenoadenosine (1,N (6)-erA) on transles

29 ional dosimetry whether improved minigastrin analog (177)Lu-DOTA-(d-Glu)(6)-Ala-Tyr-Gly-Trp-Nle-Asp-P

30 pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9.

31 her polypeptide tracers such as somatostatin analogs (2.1-2.6 mSv/100 MBq) and are beneficial for app

32 Knoevenagel reaction and imine-linked 2D COF analog (2D-C=N-PPQV1, E(g) =2.3 eV), unambiguously provi

33 ) depresses the pK(a) of the bound substrate analog 4-fluoro-3-hydroxybenzoate (4F3HB) by 1.6 pH unit

34 labeling with the modified, nontoxic uridine analog 5-ethynyl uridine (5-EU) in Arabidopsis (Arabidop

35 synthesis of an active azido-modified ribose analog, 5-azidoribose (5-AR), as well as the synthesis o

36 ilizing enzyme by a small molecule glutamine analog (6-diazo-5-oxo-l-norleucine [DON]).

37 pacious inorganic sublattice of the expanded analogs accommodates larger pyrazinium-based cations wit

38 erved with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the

39 These analogs act as chain terminators after they are incorpor

40 without adenosine or a non-hydrolyzable ATP analog, adenosine 5'-(gamma-thio)-triphosphate (ATPgamma

41 The cyclosporine-analog alisporivir has recently been shown to inhibit SA

42 Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-a

43 Even though all tracer analogs allowed tumor identification with SPECT and fluo

44 ls have the ability to incorporate thymidine analogs along with the natural A, T, G and C bases durin

45 ly of carbon pai-systems, ynamides and their analogs, along with alkynyl carbonyl derivatives, are th

46 Compound A and its optimized analogs also improved viability and function in primary

47 These FCF analogs also suppress HER2 expression at a concentration

48 , Matrigel(TM), a complete basement membrane analog, also causes the clustering of AQP4 and beta-DG.

49 man BRAF(KD) in complex with MEK and the ATP analog AMP-PCP, revealing interactions between BRAF and

50 ne (a substrate) and a phosphate-glutathione analog (an irreversible inhibitor) bound in the active s

51 ntions that may be used include progesterone analogs and short-term (weeks) corticosteroids.

52 compared them with those of other vitamin E analogs and the soy isoflavone genistein, a natural agon

53 fluorescently labeled fatty acids or glucose analog, and analyzed by confocal microscopy.

54 uantitative analysis of substrate, substrate analog, and products is carried out by quantitative, onl

55 x with reduced CdRP, a nonreactive substrate analog, and using a sensitive discontinuous assay, we de

56 nts are stable relative to their anthocyanin analogs, and are of growing interest in food application

57 te of mutation, were sensitive to nucleotide analogs, and displayed reduced replicative fitness compa

58 rements using synthetic PNAG oligosaccharide analogs, and in vitro biofilm dispersal assays.

59 ial cells transfected with locked nucleotide analog antagonists (LNAA).

60 Nucleoside analogs are commonly used in the treatment of cancer and

61 Compared to parental FCF, these analogs are more effective in decreasing viability and p

62 We show that CTP analogs are readily incorporated into a growing primer b

63 the design of a series of inositol phosphate analogs as crystallization inhibitors, among which 4,6-d

64 of mini-Ins-a human des-octapeptide insulin analog-as a structurally minimal, full-potency insulin.

65 erapeutic potential of unacylated ghrelin or analog AZP-531.

66 studies have implicated BC200 and the rodent analog BC1 as negative regulators of translation in both

67 le small-molecule inhibitors, such as lysine analogs, bind unselectively to kringle domains and are t

68 Whether exposure to BPA or its structural analogs bisphenol S (BPS) and bisphenol F (BPF) is assoc

69 omeric, AMP-PNP-DnaA (a non-hydrolysable ATP-analog bound-DnaA) was oligomeric, primarily dimeric.

70 omain, PfD, in its apo, cGMP-bound, and cGMP analog-bound states, we elucidated its inhibition mechan

71 rases were unable to efficiently process the analog, but a complementary luciferase was identified vi

72 alyze methylation of slightly bulkier lysine analogs, but lack the activity for analogs that possess

73 ion to the corresponding N-acetylglucosamine analog by the epimerase N-acetylgalactosamine-4-epimeras

74 e DIO model, VDR activation by the vitamin D analog calcipotriol reduced liver inflammation and hepat

75 These mexiletine analogs can be exploited as mechanistic probes and for c

76 ly if their biological affinities and modern analogs can be identified.

77 The hydrophilic capsaicin analog Cap-EA activated a cTRPV1-A578E mutant, suggestin

78 We therefore designed an aldehyde-containing analog capable of trapping Ser239 in beta(3) tubulin, pr

79 ative competence-stimulating peptide (dnCSP) analogs capable of intercepting the competence regulon i

80 ike monofunctional CDDO-Me, the bifunctional analog, CDDO-Im, has a second reactive site (imidazolide

81 a state-of-the-art NFA, Y6, and its selenium analog, CH1007, has been conducted which revealed that t

82 g that the COX product PGE(2) and the PGI(2) analogs cicaprost decreased Alternaria extract-induced I

83 RTI-36, the analog closest in structure to epibatidine, was the most

84 t step towards enabling application-specific analog computing platforms to solve computationally hard

85 ecological uncertainties associated with non-analog conditions resulting from the introduction of an

86 overcome these limitations by utilizing the analog conductance tunability of memristors.

87 Bacterial natural products (NPs) and their analogs constitute more than half of the new small molec

88 ve than the isostructural [Zn(tpyPY2Me)](2+) analog containing the redox-inactive Zn(II) ion.

89 We propose a new analog content-addressable memory concept and circuit to

90 , compared with the NiPc-based and NH-linked analogs, CoPc-based and O-linked MOFs have lower activat

91 regano oil and improved carvacrol and thymol analogs could be considered to supplement current HIV th

92 UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoyla

93 ML) patients and treated with the nucleoside analog DAC induced genome-wide acetylation changes in H3

94 n complex with the nonhydrolyzable substrate analog dCMPNPP and the products 5-Me-dCMP and dCMP.

95 We discovered that compound A analogs decreased GLT-induced cytosolic calcium influx i

96 For this, analog design was used to highlight the most suitable an

97 t with subnanomolar potency in AgrC-I, while analogs designed to contain a disrupted beta-turn were d

98 nd arrestin variants to investigate how CCL5 analogs differ from CCL5 in their capacity to elicit bot

99 udy shows that potent C-C chemokine ligand 5 analogs differ from each other and from the parent chemo

100 Presence of a nonmetabolizable cAMP analog during culture period counteracted the effect of

101 In vitro, an apelin receptor agonist analog elicited endothelial nitric oxide synthase activa

102 Several analogs exhibited improved functional potency (cAMP, bet

103 (ts)T is thereby a "smart" thymidine analog, exhibiting a 28-fold brighter fluorescence inten

104 highly stratified basins, whereas no modern analog exists for OAEs.

105 Finally, we validate the theory in a fully analog experiment in which seven electronic oscillators

106 Fluorescent base analogs (FBAs) are powerful probes of nucleic acids' str

107 e shown to alter the cutoff frequency of the analog filter, indicating a potential use as tunable 3-D

108 se as tunable 3-D printed organic electronic analog filtering elements for biosensors.

109 om the last deglaciation, which is a partial analog for modern warming.

110 Amorphous analogs for MHPs have so far been restricted to high pre

111 rs, for example, (99m)Tc-labeled PSMA tracer analogs for radioguided surgery.

112 e prepared and evaluated several subglutinol analogs for their immunomodulatory activities.

113 e glasses studies are appropriate structural analogs for understanding the atomic arrangement of sili

114 h based on analog forecasting, called kernel analog forecasting (KAF), which avoids assumptions on th

115 nonparametric statistical approach based on analog forecasting, called kernel analog forecasting (KA

116 process for rapidly constructing nucleoside analogs from simple achiral materials.

117 Two key analogs, GAT591 (6r) and GAT593 (6s), exhibited augmente

118 Another analog, GAT592 (9j), exhibited moderate ago-PAM potency

119 Resistance to nucleoside analog gemcitabine frequently used in first-line therapy

120 croscopic deformation in comparison to their analogs generated from statistical copolymers.

121 ree, N-acetylmannosamine-bound and substrate analog GlcNAc-bound crystal structures (2.33, 2.20, and

122 ous environment to their extensively-studied analogs graphene-based membranes; however, challenges su

123 synthetic natriuretic peptides (NP), and NP analogs has yielded mixed results.

124 -EM) structure of EEEV complexed with the HS analog heparin.

125 lective for glucose in the presence of close analogs (i.e., glucose-6-phosphate), and can detect gluc

126 er, creating the context for a "Moore's Law" analog in fibers?

127 captured image, like the brain, by executing analog in-memory neural net computing.

128 ral replication as seen with nucleoside/tide analogs in other viral infections.

129 study to evaluate JNJ-6379 +/- nucleos(t)ide analogs in patients with chronic HBV infection, which is

130 apy (PRRT) with (177)Lu-labeled somatostatin analogs in patients with somatostatin receptor-expressin

131 tion strategy was employed to prepare A5A(1) analogs in which Thr4, the residue involved in the depsi

132 gies MinION to detect 11 different thymidine analogs including CldU, BrdU, IdU as well as EdU alone o

133 ion dynamics has mostly relied on nucleotide analog incorporation that does not label quiescent cells

134 RDV is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps

135 Highly potent chemokine analog inhibitors act via the modulation of receptor des

136 ymerases are commonly targeted by nucleotide analog inhibitors for the treatments of various human di

137 e converter of unimodal (population-wide or 'analog') input to bistable (subpopulation-specific or 'd

138 Incorporation of these NulO analogs into LOS maintains gonococci susceptible to comp

139 e of transporting exogenous spermine and its analogs into the cell and, in response, decreasing exces

140 ng radiolabeled somatostatin receptor (SSTR) analogs is a common approach in advanced neuroendocrine

141 py using (177)Lu-labeled somatostatin ligand analogs is a well-established treatment for neuroendocri

142 In this method, a short pulse of nucleoside analog labels replicative regions in the cells of intere

143 idomide and its immunomodulatory drug (IMiD) analogs, lenalidomide, and pomalidomide, dose-dependentl

144 Ceramide analogs like HPA-12 may function as metabolic probes to

145 in multigram syntheses of d- or l-nucleoside analogs, locked nucleic acids, iminonucleosides, and C2'

146 gh not strongly activated by the epibatidine analogs, LS alpha4- and alpha2-containing receptors were

147 and 100-fold more potent than its structural analogs lycoricidine and lycorine, respectively.

148 6-nsp10 in complex with the methylated Cap-0 analog m(7)GpppA and either SAM or SAH.

149 19 disease, it is possible that WDB002 or an analog may exert useful antiviral activity through its a

150 -labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for P

151 For the first time, the potential of analog memory synapses to generate precisely timed spike

152 rning systems using nanoscale and stochastic analog memory synapses.

153 Importantly, the JH analog methoprene, but not bovine insulin (to restore II

154 ormamido)propanoic acid, DB28, as well as an analog, methyl 3-([2,6-dioxo-1,2,3,6-tetrahydropyrimidin

155 ether combination treatment with gut hormone analogs might recapitulate the efficacy and mitigate the

156 ng exosite and a C-terminal transition-state analog moiety targeted to the active site.

157 ure initially (13.5%); topical prostaglandin analogs (n = 2887/5120 [56.4%]) and laser trabeculoplast

158 lyte, the NaTiOPO(4) anode and Prussian blue analog Na(1.88) Mn[Fe(CN)(6) ](0.97) .1.35H(2) O cathode

159 Sixty-eight patients with purine analog-naive classic HCL were randomly assigned 1:1 to c

160 Isoprene is the 2-methyl analog of 1,3-butadiene and is a possible human carcinog

161 shown that [(18)F]3F4AP, a radiofluorinated analog of 4AP, also binds to K(V)1 channels and can be u

162 enamel mineralization as only a recombinant analog of a MMP20-cleavage product of amelogenin was cap

163 Since chi((0)) < 0 is the missing electric analog of diamagnetism, this work opens the door to new

164 In the animal analog of ECT, neurogenesis in the dentate gyrus (DG) of

165 vidence was presented showing that a smaller analog of ES1, ES24, targets the Sec61-translocon, and c

166 Aldafermin, an engineered analog of fibroblast growth factor 19, inhibits bile aci

167 Producing a kinetically trapped analog of I(T) by deleting the N-terminal six amino acid

168 lly resistant methylene bisphosphonate (PCP) analog of InsP(8); PCP analogs of other PP-InsP signalin

169 l-Theanine is an amino acid analog of l-glutamate and l-glutamine derived from vario

170 sal intermediate arcopallium (AId), an avian analog of mammalian deep cortical layers with involvemen

171 plied to the (177)Lu-labeled tumor-targeting analog of minigastrin, [Nle(15)]MG11.

172 naloxone methiodide, a membrane impenetrable analog of naloxone, did not affect the NSC differentiati

173 Octopamine, the invertebrate analog of norepinephrine, is known to modulate a large v

174 However, PFOA, which is the carboxylate analog of PFOS, revealed a very close K(A) value (3.41 x

175 o +60 mV in the presence of U46619, a stable analog of prostaglandin H(2) Half-maximal effective pote

176 Here we identify the analog of quadrupole order in Maxwell's equations for a

177 It is an analog of sphingosine-1-phosphate (S1P) and targets S1P

178 Finally, we found that C18, an analog of the CFTR corrector compound Lumacaftor, induce

179 Here we report the effect of aldafermin, an analog of the gut hormone FGF19, versus placebo on the g

180 The lateral horn, the insect analog of the mammalian cortical amygdala, is the main t

181 ons connecting the antennal lobe, the insect analog of the mammalian olfactory bulb, to higher-order

182 inent in the mushroom body calyx, the insect analog of the mammalian piriform cortex and a center for

183 The Nobeoka Trust is an on-land analog of the modern splay fault at shallow depths (~ 8

184 including a d-amino acid-containing peptide analog of the substrate in the substrate-containing solu

185 A peptide analog of transmembrane domain 2 (TM2) of CXCR4 interfer

186 oped a new tracer, an (18)F-labeled difluoro-analog of UCB-J ((18)F-SynVesT-1, also known as (18)F-SD

187 o-fluorinated (OF) and meta-fluorinated (MF) analogs of (18)F-para-fluorinated (PF)-NB1, a 3-benzazep

188 We estimated observational analogs of 6-year intention-to-treat and per-protocol ri

189 We also synthesized N-methylated analogs of [Formula: see text] and HE which were used in

190 in vitro biological activity of a series of analogs of A54145 factor D (A5D) and A54145 factor A(1)

191 hibitors were identified to be precursors or analogs of ABTS.

192 We also observed plant analogs of animal complexes with distinct molecular asse

193 nd biological evaluation of several close-in analogs of bryostatin 1.

194 Recently, synthetic analogs of chemically fueled assemblies have emerged, bu

195 to be necessary components of the behavioral analogs of depression and schizophrenia-like cognitive d

196 ionality provides a means of developing flow analogs of electronic circuit components such as fluidic

197 ed with attractive surface patches acting as analogs of functional groups are used to assemble colloi

198 The fluorescently labeled analogs of GalNAc-conjugated PNAs were internalized by H

199 We conclude that the N-methylated analogs of HE and [Formula: see text] may be used as a s

200 e population suppression approaches, genetic analogs of insecticidal techniques that reduce the numbe

201 affold to synthesize alpha-particle-emitting analogs of L1, (213)Bi-L1 and (225)Ac-L1, to evaluate th

202 bisphosphonate (PCP) analog of InsP(8); PCP analogs of other PP-InsP signaling molecules were ineffe

203 roline (GPO) amino acid triad are biomimetic analogs of the collagen triple helix, a fold that is a h

204 By contrast, analogs of the maturation programs, such as dormancy and

205 We report that block heterochiral analogs of the model amphipathic peptide KFE8 (Ac-FKFEFK

206 nctional theory calculations for engineering analogs of this class of fluorophores are offered.

207 ion enhanced responses of several structural analogs of U46619 with modifications to a similar extent

208 Allosteric kinase inhibitors, such as cGMP analogs, offer enhanced selectivity relative to competit

209 , little is known about the effects of these analogs on brain functions.

210 owing challenge of HeLa cells with the dsRNA-analog poly(I:C), PGAM5 oligomers and high levels of PGA

211 These analogs produced a structure-activity relationship profi

212 The epibatidine analogs produced protracted activation of high sensitivi

213 Structural analysis of lead analogs provided important insights as to the molecular

214 imate Optimization Algorithm (QAOA) using an analog quantum simulator.

215 ffect of lysophosphatidic acid (LPA) and its analog, Radioprotein-1, on gamma-radiation-induced colon

216 The migration of each of these radionuclide analogs (RAs) was shown to be dependent upon their chemi

217 n vitro assays, ACh and non-hydrolysable ACh analogs repressed the expression of connexin43 and conne

218 m albumin (HSA) and resveratrol (RES) or its analog (RESAn1) were investigated by surface plasmon res

219 oblastic leukemia (ALL) by conferring purine analog resistance.

220 ferring the digitally trained weights to the analog resistive memory devices will not result in signi

221 he cyclization of a tripeptide and an arodyn analog resulting in >=70% conversion to the desired cycl

222 Antibacterial studies with these four analogs revealed that, contrary to a previous report, re

223 ter oxidation catalyst and its fastest known analog [Ru(EtO-tpy)(bpy)(H(2)O)](2+) (2), capable of 10

224 Here we present synthesis of the SAM analog S-adenosyl-l-ethionine (SAE) and show SAE is a me

225 ng changes in knee pain assessed by a visual analog scale (-11.5 in the zoledronic acid group vs -16.

226 cy was assessed through comparison of visual analog scale (VAS) scores before and 1 month after FICS.

227 ed scores on the CRS disease severity visual analog scale (VAS), 22-item Sino-Nasal Outcome Test (SNO

228 mary outcome was pain measured by the visual analog scale (VAS).

229 rate to severe pruritus (>=5 of 10 on visual analog scale [VAS]) due to PSC, PBC, or SSC were recruit

230 composition (by DXA) and appetite (by visual analog scale appetite perceptions in response to a fixed

231 oQol 5-dimensional descriptive system visual analog scale score.

232 The mean global health, EQ5D-3L, Visual Analog Scale, and Functional Pain scores were comparable

233 The Visual Analog Scale, Functional Pain Scale, and EQ-5D-3L measur

234 pain scores determined using a 100 mm visual analog scale, length of hospital stay, and patient-repor

235 assessed before and after surgery via visual analog scales and functional MRI.RESULTSBariatric surger

236 hunger and fullness) were recorded by visual analog scales before and after a standardized breakfast

237 ase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduces DNA damage repair gene ex

238 ablished cell lines that exclusively express analog-sensitive CRK9 (CRK9(AS) ).

239 T cells from mice that expressed a PP1 analog-sensitive form of CSK (CskAS) corroborated these

240 dk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type C

241 Analysis of DPO analogs showed that a hydroxyl or carbonyl group at the

242 the problem of storing associations between analog signals in the presence of correlations, using me

243 by binary Boolean logic, or as multi-valued analog signals under conditions where substrate resource

244 uct S-adenosylhomocysteine (SAH), or the SAH analog sinefungin (SFG).

245 upregulating and releasing the interleukin-1 analog Spatzle, which then acts on Toll receptors on R5

246 y of the synaptic device to traverse several analog states, where at least 50 conductance values are

247 ddition of ATP or nonhydrolyzable nucleotide analogs stimulated PPR65-catalyzed RNA-editing activity

248 Reactions performed using GTP analogs substituted with different chemical moieties at

249 get for antiviral drugs including nucleoside analogs, such as the prodrugs mericitabine and sofosbuvi

250 e structural similarity with their molecular analogs, suggest that transition metal catalysts contain

251 st speed, good reliability, scalability, and analog switching property simultaneously.

252 where primaquine and its recently introduced analog tafenoquine are required for the elimination of m

253 d binding efficacy of second-generation TDZD analogs (TDZD-10 and Tideglusib) that bind GSK3beta as n

254 tes as part of a complex mixture of chemical analogs, termed taxoids, which complicates its productio

255 mechanism, such that incorporated nucleoside analogs terminate chain elongation if the resulting prim

256 how using two independent approaches--an ATP analog that can drive CFTR channel gating but is unsuita

257 tly, remdesivir, a broad-spectrum nucleoside analog that is effective against other group 1 and 2 cor

258 Structural modifications of Q121 generated analogs that activated RET irrespective of GFRa1 express

259 abeling methods rely on exogenous pyrimidine analogs that are only incorporated into RNA in cells exp

260 ytic and antidepressant-like effects of GHRH analogs that could involve modulatory effects on monoami

261 rine TTLL6 bound to tetrahedral intermediate analogs that delineate key active-site residues that mak

262 ion of a novel series of tetrahydroquinoline analogs that exhibit >50-fold selectivity for BD2 versus

263 te groups was delineated by using desulfated analogs that exhibit relatively reduced affinity.

264 er lysine analogs, but lack the activity for analogs that possess larger aromatic side chains.

265 ation was used to develop phosphorylated hCT analogs that showed modified fibrillation that depended

266 synthesized, and tested a series of novel PP analogs that were evaluated for inhibition of CDPK1 enzy

267 In this study, we have developed potent FCF analogs through structural modification of FCF, coined U

268 n (MIC) values around 2.5 muM), with several analogs thus approaching the activity of natural pyridom

269 acoustic topological insulator exhibiting an analog to the quantum valley Hall effect (QVHE).

270 ctronic characteristics that is an important analog to well-explored Cu-In-S NCs.

271 MR in conjunction with fluorinated substrate analogs to directly measure pK(a) values and to monitor

272 We used these analogs to examine RET-GFRa1 interactions and show that

273 Development of analogs to reinforce the beta-turn resulted in our first

274 (124)I-, and (131)I-trametinib, pure tracer analogs to trametinib, were synthesized in more than 95%

275 s structure, free and bound to the substrate analog uridine 5'-monophosphate.

276 Gemcitabine (GMT) is a nucleoside analog used in the treatment of a variety of solid tumor

277 Single-agent purine analog, usually cladribine, has been the standard first-

278 anded 7-mer bubble positions the RNA and NTP analog UTPalphaS, while NT scrunches into an NT loop.

279 We perform operations on these analog values by manipulating substrate concentrations a

280 nilides was synthesized, and the most potent analog was selected through an in vitro inhibitory assay

281 on dose of the corresponding (212)Pb-labeled analogs was determined using the biodistribution data.

282 A library of analogs was synthesized and studied in vitro and in vivo

283 at fluorescent lipids and a fluorescent iron-analog were trafficked to lipid-laden and iron-laden mac

284 ent recognition specificity for PNG over its analogs were also observed.

285 The proteolytic stabilities of 1 and its analogs were determined by incubation with Pronase.

286 ase inhibitors and 37 nucleoside/heterocycle analogs were evaluated to identify ENT interactions.

287 ructure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold inc

288 amine (+)-5 and two diastereomeric tricyclic analogs, were evaluated as potential sparteine surrogate

289 olling R(N) Many amino acids, as well as Glc analogs, were found to potently inhibit the R(N) stimula

290 uorescent dye or biotin to the alkyne of the analog, which can then be used to detect incorporation o

291 lly bound to adenosine 5'-triphosphate (ATP) analogs, which is expected to induce opening of the slid

292 t, in difference to resistance to nucleotide analogs, which is mainly associated with few specific mu

293 efficient access to a library of bryostatin analogs, which per our design retain affinity for PKC bu

294 Puromycin is an amino-acyl transfer RNA analog widely employed in studies of protein synthesis.

295 Moreover, JG-231, a JG-98 analog with improved microsomal stability effectively su

296 epidermidis AIP signals and five non-native analogs with distinct activity profiles in the AgrC-I re

297 in through incorporation of noncanonical Phe analogs with distinct electrostatics at two positions.

298 stal structure and enables the design of AZ1 analogs with enhanced potency in enzymatic assays.

299 ty, prompting additional efforts to generate analogs with improved solubility and enhanced potency.

300 Binding of LAMR by the laminin-beta1 analog YIGSR promotes NCC migration.