ライフサイエンスコーパス: anaphase

1 osis and subsequently the central spindle in anaphase.

2 l types and demonstrated their resolution in anaphase.

3 cleation in dividing Drosophila cells during anaphase.

4 romosomes segregate as a compact mass during anaphase.

5 nkage or bending of the spindle in shortened anaphase.

6 signal is silenced to allow progression into anaphase.

7 the genome be duplicated completely prior to anaphase.

8 ned between mother and daughter cells during anaphase.

9 hroughout mitosis and the central spindle in anaphase.

10 and delays the transition from metaphase to anaphase.

11 ated between segregating chromosomes) during anaphase.

12 opoisomerase II prevents their resolution in anaphase.

13 cytoplasmic surface of the SPBs during late anaphase.

14 and defective chromosome segregation during anaphase.

15 ch elicits severe chromosome interlinking in anaphase.

16 ment of quasi-diagonal metaphase spindles in anaphase.

17 emodeling between prophase, prometaphase and anaphase.

18 ed into small, nondeveloping polar bodies at anaphase.

19 time they are made until their separation at anaphase.

20 f collapse and recovery before proceeding to anaphase.

21 ientation and anchoring at the first meiotic anaphase.

22 hromatid pairs, which separate accurately at anaphase.

23 ing to the formation of chromatin bridges at anaphase.

24 e poles, giving the appearance of successful anaphase.

25 ase plates as well as lagging chromosomes at anaphase.

26 and centrosomes upon tension release during anaphase.

27 egate cleanly to different daughter cells at anaphase.

28 set and slow spindle elongation during early anaphase.

29 ed to its movement to the central spindle in anaphase.

30 n initiates sister chromatid segregation and anaphase.

31 n metaphase and MKLP2-dependent transport in anaphase.

32 evated rates of chromosome missegregation in anaphase.

33 ules and chromosomes are strongly coupled in anaphase.

34 omography unexpectedly revealed spermatocyte anaphase A does not stem solely from kinetochore microtu

35 simultaneous pole-to-chromosome shortening (anaphase A) and pole-to-pole elongation (anaphase B).

36 o interchromosomal compaction defects during anaphase, abnormal organization of chromosomes into a si

37 Following anaphase, ac-SMC3 is deacetylated by HDAC8.

38 show that resolution of human rDNA occurs in anaphase after the bulk of the genome, dependent on tank

39 hromosomes, and its deacetylation by Hos1 in anaphase allows re-use of Smc3 in the next cell cycle.

40 pleted of KBP exhibit lagging chromosomes in anaphase, an effect that is recapitulated by KIF15 and K

41 her cell, and late changes occurring between anaphase and abscission that potentially involve differe

42 on of a diffusible "wait" signal that delays anaphase and gives the cell time to correct the error.

43 anaphase), spindle midzone/cleavage furrow (anaphase and telophase), and midbody (cytokinesis) durin

44 livered into the daughter cell (dSPB) during anaphase and the SPB that remains in the mother cell.

45 Aberrant SKAP expression can prolong anaphase and this may contribute to developmental defect

46 n of actin around centrosomes as cells enter anaphase and to a corresponding reduction in the density

47 side of the SPBs during metaphase and early anaphase and to the cytoplasmic surface of the SPBs duri

48 is-segregation / aneuploidy due to premature anaphase, and cytokinesis failure leading to genome dupl

49 produces higher elongation rates after early anaphase, and exhibits frequent spindle collapses.

50 hase Release (FEAR) ensures robust timing of anaphase, and we verify our findings in living cells.

51 cross-linking protein PRC1 decreases during anaphase as chromosome segregation slows.

52 e a function of chromosome separation during anaphase, assisted by a midzone Aurora B phosphorylation

53 oMan (recruits PP1 onto mitotic chromatin at anaphase)-associated phosphatases PP1/PP2A.

54 d together with the same spindle pole during anaphase B spindle elongation.

55 ng (anaphase A) and pole-to-pole elongation (anaphase B).

56 in an acceleration of spindle elongation in anaphase B.

57 ximal edge of the kinetochore cluster during anaphase based on single-particle averaging of super-res

58 mitosis, exhibit the formation of ultra-fine anaphase bridges and micronuclei.

59 educed telomere-dysfunction-induced foci and anaphase bridges, indicating improved telomere capping.

60 a new subclass of human ribosomal ultrafine anaphase bridges.

61 bly checkpoint kinase Mps1 not only inhibits anaphase but also corrects erroneous attachments that co

62 romotes cyclin B destruction at the onset of anaphase by removing specific inhibitory phosphorylation

63 ic checkpoint complex" (MCC), which prevents anaphase by targeting Cdc20, the activator of the anapha

64 t of half of the nucleus into the bud during anaphase causes the active form of the MEN GTPase Tem1 t

65 tractile actin belt at the apex that governs anaphase cell flattening.

66 shown KIF4A is activated by Aurora B at the anaphase central spindle.

67 zation and bundling activity of Mklp2 at the anaphase central spindle.

68 In anaphase, centrosomes lose PLK-1 and SPD-2 and transitio

69 abnormal chromosome condensation, augmented anaphase chromatin-bridge formation, and micronuclei in

70 t in the rates of kinetochore detachment and anaphase chromosome mis-segregration, and in metaphase t

71 Slowing down anaphase chromosome motion delayed Cyclin B1 degradation

72 Anaphase chromosome movement is thought to be mediated b

73 and Ndc80 submodules add copies to form an "anaphase configuration" kinetochore.

74 nts to measure nucleolar protein dynamics in anaphase, consolidate a model that explains the differen

75 In anaphase, CPC binding promotes the microtubule-dependent

76 end joining (alt-EJ), which accounts for Xi anaphase defects in the absence of macroH2A1.2.

77 the prometaphase-to-metaphase transition and anaphase defects such as lagging and bridging chromosome

78 ic H2B S6 antibodies in mitotic cells caused anaphase defects with impaired chromosome segregation an

79 s results in Kif4 mislocalization and causes anaphase defects.

80 Implementation of this anaphase delay is reflected in PKCepsilon activation fol

81 crotubule interactions and generates a "wait anaphase" delay when any defects are apparent [1-3].

82 ics such as cell shape, cell size, metaphase/anaphase delays, and mitotic abnormalities including spi

83 ochore components prevents the error-induced anaphase delays.

84 ere we found that Cdk1 remains active during anaphase due to ongoing APC/C(Cdc20)- and APC/C(Cdh1)-me

85 to daughter cells was not due to changes of anaphase duration or nuclear shape but solely to the dow

86 on in by-passing the delay and resolution at anaphase entry that is associated with non-disjunction a

87 proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromos

88 e stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but

89 feature tilted metaphase spindles, lack this anaphase flattening mechanism and as a consequence maint

90 Our model is that during anaphase, "free" importins, whose gradient inversely cor

91 chromatin bridges and lagging chromosomes in anaphase, frequently leading to cytokinesis failure, mul

92 gging X chromosome, a distinctive feature of anaphase I in C. elegans males, is due to lack of chromo

93 re pairing can promote proper segregation at anaphase I of partners that have failed to become joined

94 g sister chromatids separate precociously in anaphase I revealed no direct role of these proteins on

95 h that they migrate away from one another at anaphase I.

96 hromatid arms when the homologs segregate at anaphase I.

97 logous chromosomes until their separation at anaphase I.

98 t exhibits a delay in cohesin removal during anaphase I.

99 a highly penetrant failure to transition to anaphase I.

100 ister-chromatid cohesion at the metaphase II/anaphase II transition.

101 tric partitioning event occurs shortly after anaphase II, and both microtubules and actin partition i

102 ase I, unequal chromosome segregation during anaphase II, and subsequent formation of polyads.

103 t can slide away from the cell middle during anaphase in a myosin V-dependent manner.

104 push or restrict chromosome movement during anaphase in different cellular contexts, but how these a

105 pindle push chromosomes apart during meiotic anaphase in oocytes.

106 all chromosomes have aligned and enter into anaphase in the absence of PP1 activity.

107 unexpected events of error correction during anaphase in wild-type or mutant cells.

108 that C. elegans oocytes delay key events in anaphase, including AIR-2/Aurora B relocalization to the

109 bmodules of the kinetochore are added during anaphase, including the microtubule binding module Ndc80

110 C regulator that promotes the assembly of an anaphase inhibitor through a sequential multi-target pho

111 Overall our studies reveal that anaphase inhibitors are diffusible and active outside th

112 ase and kinetochores in mitosis can generate anaphase inhibitors to efficiently preserve genomic stab

113 ity of the KNL1 phosphodomain to produce the anaphase-inhibitory signal synergistically, when it recr

114 cascade: (1) a cellular limit on the maximum anaphase-inhibitory signal that the cascade can generate

115 Complex/Cyclosome) to degrade inhibitors of anaphase initiation.

116 osome (APC/C), whose action is necessary for anaphase initiation.

117 which targets for degradation inhibitors of anaphase initiation.

118 mulation of Cdc5 at the daughter SPB in late anaphase is controlled by Bfa1.

119 ested that during C. elegans female meiosis, anaphase is mediated by a kinetochore-independent pushin

120 te and duration of spindle elongation during anaphase is poorly understood.

121 The temporal signal, commencement of anaphase, is mediated by mitotic cyclin-dependent kinase

122 es the frequency of CA, multipolar spindles, anaphase-lagging chromosomes, and micronuclei.

123 impairs the localization of Aurora B during anaphase, leading to induction of aneuploidy.

124 uencies of lagging, merotelic chromosomes in anaphase, leading to segregation defects at telophase.

125 cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and o

126 of the Rho-interacting kinase citron to the anaphase midzone.

127 Prior to anaphase of budding yeast, the ribosomal DNA (RDN) conde

128 os1 has a more immediate effect in the early anaphase of budding yeast.

129 tein that is translationally repressed until anaphase of MII.

130 Chromosome distribution at anaphase of mitosis and meiosis is triggered by separase

131 erlapping microtubules, during metaphase and anaphase of mitosis.

132 se 1 (PP1) to kinetochores to promote timely anaphase onset [12].

133 , and stabilizes securin and cyclin to delay anaphase onset [13-17].

134 he recruitment of Ase1 to the midzone before anaphase onset and slow spindle elongation during early

135 Chromosome segregation and anaphase onset are initiated through the action of the m

136 faithful chromosome segregation by delaying anaphase onset even when a single kinetochore is unattac

137 ttachment to spindle microtubules, and delay anaphase onset in response.

138 Proper spindle positioning at anaphase onset is essential for normal tissue organizati

139 which enriches at attachment sites prior to anaphase onset to dampen chromosome motion.

140 ), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spi

141 neuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing addi

142 events chromosome missegregation by coupling anaphase onset with correct chromosome attachment and te

143 w via two distinct cortical Myosin flows: at anaphase onset, a polarity induced, basally directed Myo

144 -C2alpha causes spindle alterations, delayed anaphase onset, and aneuploidy, indicating that PI3K-C2a

145 From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most s

146 protein phosphatase 1 (PP1) to chromatin at anaphase onset, in a similar manner as RepoMan.

147 one chromosome is unattached, but for timely anaphase onset, it must promptly respond to silencing me

148 und that both properties declined sharply at anaphase onset, long before natural disassembly.

149 At anaphase onset, Sgo1 function of cohesion protection mus

150 At anaphase onset, the cap disassembles as the cortical flo

151 Cytokinesis begins upon anaphase onset.

152 tection and timely chromosome segregation at anaphase onset.

153 kinetochores to spindle microtubules before anaphase onset.

154 ter kinetochore component recruited prior to anaphase onset.

155 tly center themselves in the XY-plane before anaphase onset.

156 nd that completion of the dance is linked to anaphase onset.

157 an association between cortical contact and anaphase onset.

158 tants support chromosome alignment but delay anaphase onset.

159 an bind both PP1 and microtubules to promote anaphase onset.

160 when cohesin Scc1 is cleaved by separase at anaphase onset.

161 se oscillations begin to subside soon before anaphase onset.

162 struction of securin and cyclin and delaying anaphase onset.

163 osome bound to Cdc20 (APC/C(Cdc20)) to delay anaphase onset.

164 te meiotic chromosome segregation and timely anaphase onset.

165 egregation of chromosomes to the poles after anaphase onset.

166 hromosome missegregation, but too many delay anaphase onset.

167 genome stability while also ensuring timely anaphase onset.

168 rometaphase I and fail to either progress to anaphase or attempt spermatid-residual body partitioning

169 duplicated centrosomes, and vulnerability to anaphase or mitotic catastrophe.

170 ientation mechanism which corrects erroneous anaphase orientations during telophase.

171 Our results suggest that, before anaphase, PLK-1 and SPD-2 respectively confer strength a

172 Failure to degrade B-type Cyclins during anaphase prevented mitotic exit in a Cdk1-dependent mann

173 ation fails to form a stable midzone in late anaphase, produces higher elongation rates after early a

174 lls and revealing a mechanism that regulates anaphase progression.

175 e centromeric SC in meiotic prophase and, in anaphase, promotes the proper segregation of partner chr

176 The Anaphase Promoting Complex (APC) coactivator Cdh1 drives

177 ted by a meiosis-specific coactivator of the anaphase promoting complex (APC/C) E3 ubiquitin ligase,

178 yzed by a massive enzyme machine, called the Anaphase Promoting Complex.

179 The anaphase promoting complex/cyclosome (APC/C) controls un

180 is mediated by increased destruction by the anaphase promoting complex/cyclosome (APC/C) during meio

181 ta-independent-acquisition (DIA) data of the anaphase promoting complex/cyclosome (APC/C) during mito

182 The anaphase promoting complex/cyclosome (APC/C) E3 ligase c

183 Anaphase promoting complex/cyclosome (APC/C) is reported

184 Assembly Checkpoint (SAC) that inhibits the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin l

185 e chromosome segregation by inactivating the anaphase promoting complex/cyclosome (APC/C) until all c

186 cycle onset is controlled by activity of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisub

187 mitotic E3 ubiquitin ligase, known as Cdc20-anaphase promoting complex/cyclosome (APC/C), and stabil

188 MCC inhibits the ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), whose acti

189 MCC), which inhibits Cdc20 to inactivate the Anaphase Promoting Complex/Cyclosome (APC/C).

190 pindle assembly checkpoint, which results in anaphase-promoting complex (APC) inhibition.

191 cells, revealing a link between CYP24A1 and anaphase-promoting complex (APC), a key cell cycle regul

192 etochores into the cytoplasm, inhibiting the anaphase-promoting complex (APC).

193 lo-like kinase 1 (PLK1), transitions through Anaphase-promoting complex (APC/C) bound to Cell divisio

194 Geminin is targeted for degradation by the anaphase-promoting complex (APC/C) from anaphase through

195 ctive interphase promoters(6,7), recruit the anaphase-promoting complex (APC/C) to specific transcrip

196 nd thereby promoting SPOP degradation by the anaphase-promoting complex activator FZR1.

197 discuss the functions and mechanisms of the anaphase-promoting complex in neurogenesis, glial differ

198 Here, we show that PANS1 targeting by the anaphase-promoting complex is required to trigger chromo

199 tween the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclosome (activated by th

200 lti-subunit E3 ubiquitin ligase known as the anaphase-promoting complex or cyclosome (APC/C [2]).

201 role for a master cell-cycle regulator, the anaphase-promoting complex or cyclosome (APC/C), in the

202 R1-Bub3, Mad2, and Cdc20, which inhibits the anaphase-promoting complex or cyclosome bound to Cdc20 (

203 The anaphase-promoting complex, or cyclosome (APC/C), is a l

204 They arrest with hallmarks of defective anaphase-promoting complex/cyclosome (APC/C) activation,

205 efects in germinal vesicle breakdown (GVBD), anaphase-promoting complex/cyclosome (APC/C) activation,

206 ntriole disengagement depend on separase and anaphase-promoting complex/cyclosome (APC/C) activity, w

207 Transient interactions between the anaphase-promoting complex/cyclosome (APC/C) and its act

208 o-EM and biochemistry show that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two

209 duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to it

210 , and TPX2 were rescued by inhibition of the anaphase-promoting complex/cyclosome (APC/C) by proTAME,

211 Here we show that Arabidopsis anaphase-promoting complex/cyclosome (APC/C) coactivator

212 The differential regulation of anaphase-promoting complex/cyclosome (APC/C) coactivator

213 The anaphase-promoting complex/cyclosome (APC/C) is a large,

214 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ub

215 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ub

216 The anaphase-promoting complex/cyclosome (APC/C) is an evolu

217 The anaphase-promoting complex/cyclosome (APC/C) is the E3 u

218 The anaphase-promoting complex/cyclosome (APC/C) orchestrate

219 ostnatal deletion of Cdh1, a cofactor of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin l

220 The checkpoint system acts on the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin l

221 Here we show that the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiq

222 ation of the ANAPC1 gene, a component of the anaphase-promoting complex/cyclosome (APC/C), in all aff

223 example, the cell cycle regulatory E3, human anaphase-promoting complex/cyclosome (APC/C), relies on

224 procal circuit with the cell cycle E3 ligase anaphase-promoting complex/cyclosome (APC/C), which also

225 Here, studying the 1.2-MDa E3 ligase anaphase-promoting complex/cyclosome (APC/C), which cont

226 gulated by multiple mechanisms including the anaphase-promoting complex/cyclosome (APC/C), which is t

227 mitotic spindle, and a regulatory component, anaphase-promoting complex/cyclosome (APC/C).

228 checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cyclosome (APC/C).

229 ase by targeting Cdc20, the activator of the anaphase-promoting complex/cyclosome (APC/C).

230 proteins inhibit Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C).

231 ate receptor CDT2/DTL, and components of the anaphase-promoting complex/cyclosome (APC/C).

232 MCC formation inhibits the anaphase-promoting complex/cyclosome (Cdc20-APC/C), ther

233 The anaphase-promoting complex/cyclosome and its coactivator

234 At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc

235 This is achieved through inhibition of the anaphase-promoting complex/cyclosome by a kinetochore-de

236 proliferation, including most targets of the anaphase-promoting complex/cyclosome complex, a set of g

237 ing from our screen, we demonstrate that the Anaphase-Promoting Complex/Cyclosome directly engages th

238 ndle assembly checkpoint remained active and anaphase-promoting complex/cyclosome function was inhibi

239 a meiosis-specific targeting subunit of the anaphase-promoting complex/cyclosome that regulates mult

240 f endoreplication entrance by activating the anaphase-promoting complex/cyclosome to initiate the ubi

241 ts the action of the ubiquitin ligase APC/C (Anaphase-Promoting Complex/Cyclosome) to degrade inhibit

242 ic exit, MCPH1 isoforms were degraded by the anaphase-promoting complex/cyclosome-CDH1 E3 ligase comp

243 Anaphase-promoting complex/cyclosome-CDH1 target protein

244 bility of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent mann

245 of the model to demonstrate that Cdc14 Early Anaphase Release (FEAR) ensures robust timing of anaphas

246 formation and longer spindles, revealing new anaphase roles for Kif4 in mouse oocytes.

247 n of mitotic chromosomes as they prepare for anaphase segregation.

248 complex (MCC), which is the diffusible wait anaphase signal [9, 11, 12].

249 lex/cyclosome by a kinetochore-derived "wait anaphase" signal known as the mitotic checkpoint complex

250 cells are fused with interphase cells, "wait anaphase" signals are diluted, resulting in premature mi

251 Here we report that "wait anaphase" signals are indeed able to diffuse outside the

252 Our findings uncover an anaphase-specific function for these effector kinesins t

253 The anaphase spindle determines the position of the cytokine

254 pt for kinesin-6 Klp9, which is required for anaphase spindle elongation.

255 se ingredients power the oscillations of the anaphase spindle in budding yeast, but in A. gossypii, t

256 plane is largely set by the position of the anaphase spindle, it is important to understand how spin

257 d distributed to kinetochores (metaphase and anaphase), spindle midzone/cleavage furrow (anaphase and

258 ic reconstruction revealed that the analyzed anaphase spindles all contain microtubules with both end

259 We find that metaphase and anaphase spindles elongate at the same rate when confine

260 ccurs when chromosomes approach the poles of anaphase spindles, and is mediated by a microtubule-inde

261 In anaphase spindles, antiparallel microtubules associate t

262 r efficient dissolution of cohesion in early anaphase; subsequent Smc3 deacetylation, triggered by Sc

263 perturbations were observed when advance to anaphase, suggesting the importance of topoisomerase II

264 her to align all chromosomes before entering anaphase synchronously.

265 This increase of H3K27ac in anaphase/telophase is required for posttranscriptional a

266 ometaphase, histone acetylation, and CTCF in anaphase/telophase, transcription in cytokinesis, and lo

267 is reactivated during nuclear reformation in anaphase/telophase.

268 n H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase.

269 s within the spindle during prometaphase and anaphase, thereby locally regulating factors that promot

270 the anaphase-promoting complex (APC/C) from anaphase through G(1)-phase, however, accumulating evide

271 hatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevi

272 arase, a protease responsible for triggering anaphase, to generate newly near-tetraploid cells.

273 ts in a pronounced delay at the metaphase-to-anaphase transition after chromosome alignment.

274 n-6, has critical roles during the metaphase-anaphase transition and cytokinesis.

275 atids together from S phase to the metaphase-anaphase transition and ensures accurate segregation of

276 only stopped as cells approach metaphase-to-anaphase transition and growth resumes in late cytokines

277 PP1 therefore facilitates the metaphase-to-anaphase transition by promoting APC/C(CDC20)-dependent

278 spindle architecture during the metaphase to anaphase transition in cells.

279 oducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly

280 clin B, securin and geminin at the metaphase-anaphase transition, followed by slow proteolysis of oth

281 At the metaphase-anaphase transition, MPS1 S281 dephosphorylation is dela

282 of the genome segregates at the metaphase to anaphase transition, resolution of the ribosomal DNA (rD

283 At the metaphase-to-anaphase transition, the CPC dissociates from centromere

284 ed to play an important role in metaphase-to-anaphase transition.

285 ntil its cleavage triggered the metaphase-to-anaphase transition.

286 Scc1 subunit of cohesin at the metaphase-to-anaphase transition.

287 from the G2/M transition until the metaphase-anaphase transition.

288 iRNA caused decreased ratios of metaphase-to-anaphase transition.

289 n and showed defects during the metaphase-to-anaphase transition.

290 redistributes to the spindle midzone during anaphase, transitioning from stretches along microtubule

291 in mitotic checkpoint signaling, preventing anaphase until all chromosomes are properly attached to

292 e spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle.

293 e spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle.

294 the mitotic checkpoint system, which delays anaphase until chromosomes attach correctly to the mitot

295 is connection and ensures it persists during anaphase, when sister chromatids must transit into daugh

296 Our data show that in anaphase, when the spindle elongates, PP1/Repo-Man promo

297 in G2 phase and released to the cytoplasm in anaphase, where it accumulates at the bud neck.

298 that the Dam1 submodule is unchanged during anaphase, whereas MIND and Ndc80 submodules add copies t

299 the microtubule (MT)-rich central spindle in anaphase, which is required to properly define the cell

300 ed how micronuclei arise from cells entering anaphase with lagging chromosomes, cellular mechanisms a