ライフサイエンスコーパス: ancestry

1 ons of East Asian, South Asian, and European ancestry).

2 2,836 HPC cases, 2,206 controls of European ancestry).

3 88 [37.7%] women; 1060 [81.9%] with European ancestry).

4 egories and phenotypic variables and genetic ancestry.

5 and 3,417,456 (13.34%) of non-Hispanic black ancestry.

6 ion admixture and estimate genome-wide local ancestry.

7 l practicing dairy pastoralism regardless of ancestry.

8 oroughbred racehorse, including Y chromosome ancestry.

9 s in current genetic studies are of European ancestry.

10 ropean, African, and Native American genetic ancestry.

11 zheimer's disease in populations of European ancestry.

12 ntified in probands of Non-Hispanic European ancestry.

13 des up to 15% of individuals of non-European ancestry.

14 h extra steps to rule out confounding due to ancestry.

15 that was specific to individuals of African ancestry.

16 ects and 65,079 control subjects of European ancestry.

17 ions than LUADs from individuals of European ancestry.

18 poor performance in persons of non-European ancestry.

19 mains unexplored in populations with African ancestry.

20 sed on geographical region and self-reported ancestry.

21 All six patients were of recent African ancestry.

22 pean ancestry than in individuals of African ancestry.

23 ral sequences that did not arise from common ancestry.

24 onsortia, including participants of European ancestry.

25 eijing carried genomic segments of Denisovan ancestry.

26 a population-based cohort of mainly European ancestry.

27 pulations including populations with African ancestry.

28 y (HCM) in patients of predominantly Chinese ancestry.

29 controls who were unrelated and of European ancestry.

30 ci were identified in individuals of African ancestry.

31 -complete turnover of Neolithic European dog ancestry.

32 ed on 435 cases and 671 controls of European ancestry.

33 years and all participants were of European ancestry.

34 susceptibility in populations of East Asian ancestry.

35 between populations of European and African ancestry.

36 s9478496) in populations with native Mexican ancestry.

37 als showing an excess of taurine or indicine ancestry.

38 ntified previously using samples of European ancestry.

39 kidney donors self-reporting recent African ancestry.

40 up-front cancer care for patients of African ancestry.

41 = 6.62 x 10(-8)) with each allele of African ancestry.

42 17 509 unrelated individuals of the European ancestry.

43 dmixture pattern of North American and Asian ancestry.

44 orating the results from samples with Latino ancestry.

45 dence between nations due to shared cultural ancestry.

46 as robust susceptibility loci shared across ancestries.

47 enetic architecture of CD was similar across ancestries.

48 nd 9,038 controls of East Asian and European ancestries.

49 in European Americans and African Americans ancestries.

50 ng individuals of both sexes and three major ancestries.

51 ugar in over 235,000 individuals of European ancestries.

52 ng and more common in individuals of African ancestry (~10% and ~1% minor allele frequency, respectiv

53 lation-based cohorts including 6662 European ancestry, 2702 African ancestry, and 360 Hispanic ancest

54 .6%) participants were of non-Hispanic white ancestry, 5,971,598 (23.3%) of Hispanic ancestry, and 3,

55 d meta-analyzed with 196,269 men of European ancestry (7,917 prostate cancer cases and 188,352 contro

56 variants in TET2 in PAH patients of European ancestry (9/1832) compared with control subjects (6/7509

57 ophilid network structures arise from common ancestry, a response to the species' past climate, other

58 stry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is

59 Individuals of African ancestry (AA) experience the disease more severely and w

60 uropean ancestry (EA, n= 69,819) and African ancestry (AA, n = 15,603) individuals.

61 ly estimates contamination rates and genetic ancestries across populations and contamination scenario

62 yse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the nu

63 to prioritize informative markers for multi-ancestry admixed populations by utilizing feature select

64 eople with Anatolian and South-East European ancestry admixed with people in the Near East.

65 r prospective cohort study of 3,029 European-ancestry adults recently diagnosed with T2D (n = 795) or

66 451 186 UK Biobank participants of European ancestry (aged 40-70 years), followed up from baseline a

67 assessed among 4847 adults of white European ancestry, aged 45 through 79 years, participating in the

68 sults were observed in survivors of European ancestry, albeit with reduced magnitudes of hypomethylat

69 5q35.1, indicating that each Native American ancestry allele was associated with a 0.15-L increase in

70 Does ancestry also influence the risk of miscarriage (pregnan

71 Based on local genomic ancestry analyses, we reconstruct taurine and indicine a

72 e findings will translate to people of other ancestries and exposed to environmental risk factors tha

73 are aggregation of large samples of diverse ancestries and longitudinal studies of growth trajectori

74 lation-ascertained case subjects of European ancestry and 14,810 ancestrally matched control subjects

75 e GTEx v8 release and describe the impact of ancestry and admixture on gene expression, eQTLs, and GW

76 have been focused on individuals of European ancestry and are underrepresented in other populations i

77 dentifying loci with unusually strong shared ancestry and detect 12 genome-wide significant signals.

78 method integrates the estimation of genetic ancestry and DNA contamination in a unified likelihood f

79 ition, of the 343 carriers who provided both ancestry and family history information, 44% did not hav

80 duals for BRCA testing: self-reported Jewish ancestry and family history of breast, ovarian, prostate

81 ociation between Indigenous American genetic ancestry and HER2(+) breast cancer suggests that the hig

82 apsing glomerulopathy in patients of African ancestry and high-risk APOL1 genotype infected with SARS

83 sidering DTC testing to learn more about his ancestry and his risk for metabolic syndrome.

84 y of African individuals to understand human ancestry and improve health.

85 clinical treatment of individuals of African ancestry and indicate that neutrophil thresholds to acce

86 variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,77

87 lence is strongly associated with Indigenous ancestry and low socioeconomic status.

88 quantify uncertainty and describe the mosaic ancestry and patterns of geographic mixing that characte

89 ariants that are more common in non-European ancestry and those at low frequency in populations.

90 AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO sus

91 have been identified in patients of European ancestry and we know relatively little of the genetics o

92 llennium BC, who had primarily North African ancestry and who-along with an approximately contemporar

93 06,536 UK Biobank participants with European ancestry and without dementia at enrollment.

94 data into networks as node-level attributes (ancestry) and edges (relatedness, parentage) to test lin

95 63.7 [7.9] years; 857 [79.9%] with European ancestry) and the melanoma cohort included 1295 patients

96 hite ancestry, 5,971,598 (23.3%) of Hispanic ancestry, and 3,417,456 (13.34%) of non-Hispanic black a

97 cluding 6662 European ancestry, 2702 African ancestry, and 360 Hispanic ancestry participants.

98 2 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino

99 ed to populations of European and East Asian ancestry, and there were many predicted loss-of-function

100 nificant, increasing Native American genetic ancestry appeared to account for part of the observed mo

101 200 BC, in part from Iberia; Iranian-related ancestry arrived by the mid-second millennium BC, contem

102 In Sicily, steppe pastoralist ancestry arrived by ~2200 BC, in part from Iberia; Irani

103 Once accounted for, ancestry-associated differences spanned all molecular fe

104 Local ancestry, defined as the genetic ancestry at a genomic location of an admixed individual,

105 ults are concordant between local and global ancestry-based adjustments, we identify distinct advanta

106 y compromise the transferability of European ancestry-based genetic disease risk and polygenic scores

107 ults show that integrating host traits, host ancestry, bioclimatic data and microhabitat characterist

108 ly replicated in 1,645 survivors of European ancestry but with attenuated magnitude (EF reduction = 0

109 ect largely contains individuals of European ancestry, but the v8 release also includes up to 15% of

110 individuals from 38 families across multiple ancestries carrying the nonsense c.757delG (p.Ala253Glnf

111 om Senegal and South Africa yielded distinct ancestry clusters.

112 l mosquitoes to identify a single underlying ancestry component linked to human preference.

113 to previous work(4), we find no support for ancestry contributed by a population related to North Am

114 dy suggests that the ecology, and not common ancestry, contributes to diversity in social structure i

115 analyses were replicated in 19,183 European-ancestry controls and 2,850 incident T2D cases in the Wo

116 Local ancestry, defined as the genetic ancestry at a genomic l

117 ical records including maternal and paternal ancestry, demographic factors, and reproductive history.

118 In Sardinia, nearly all ancestry derived from the island's early farmers until t

119 study were that only PCOS cases of European ancestry diagnosed by National Institutes of Health (NIH

120 We included 56,068 women of European ancestry diagnosed with first invasive breast cancer fro

121 Average Indigenous American (IA) ancestry differed by subtype.

122 scape of EAS LUADs and highlighted important ancestry differences between the two cohorts.

123 ading cause of cancer death and shows strong ancestry disparities.

124 nomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited

125 on MR analysis in a large sample of European ancestry do not support a causal association of total 25

126 Whether ancestry drives molecular differences that underlie disp

127 this can be explained by genuine Neanderthal ancestry due to migrations back to Africa, predominately

128 sease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestr

129 sed co-morbidity burden compared to European ancestry (EA) populations.

130 16 African Americans (AA) and 89 of European Ancestry (EA) with SVs in comparison with 408 AA and 262

131 c Global Array (MEGA(EX))-genotyped European ancestry (EA, n= 69,819) and African ancestry (AA, n = 1

132 arcinoma (LUAD) in individuals of East Asian ancestry (EAS; n = 305), we found that East Asian LUADs

133 The lack of a paternal ancestry effect suggests underlying mechanisms relate mo

134 We evaluated ancestry effects on mutation rates, DNA methylation, and

135 We find cross-population signals of African ancestry enrichment at the major histocompatibility locu

136 nalysis for population structure and genomic ancestry estimates for heterogeneous datasets.

137 s have been found in populations of European ancestry (EUR).

138 e sequencing data among survivors of African ancestry, first based on ejection fraction (EF) as a con

139 tes from individuals of African and European ancestry following activation of three TLR pathways (TLR

140 ) using an existing algorithm to infer local ancestries for all individuals in a family, assuming (co

141 onents, testing 1187 individuals of European ancestry for approximately 470 000 methylation sites thr

142 than would be expected given the genome-wide ancestry frequencies.

143 d 7752 controls without NKTCL of Han Chinese ancestry from 19 centres in southern, central, and north

144 tification of loci that contain more or less ancestry from a given source population than would be ex

145 3, and 5 derived a major proportion of their ancestry from each of 4 ancestral populations.

146 Additionally, we see substantial ancestry from elsewhere in Europe entering Scandinavia d

147 cancer cases and 5,788 controls) of European ancestry from Northern California Kaiser Permanente were

148 These groups also harbor ancestry from sources we cannot fully model with the ava

149 for genetic testing and who were of European ancestry from the ENGAGE AF-TIMI 48 (Effective Anticoagu

150 flow from individuals deriving part of their ancestry from the Pontic steppe at the onset of the Bron

151 related middle-aged participants of European ancestry from UK Biobank, a population-based cohort stud

152 (5,205 cases and 3,232 controls of European ancestry) from databases of Genotypes and Phenotypes.

153 iduals (6644 of European and 2166 of African ancestry) from the Collaborative Study on the Genetics o

154 1,731 potential ancestry-specific and trans-ancestry genetic drivers of SLE.

155 d States and often include information about ancestry; genetic traits; and, increasingly, disease ris

156 nalyses, we reconstruct taurine and indicine ancestry genome-wide and along chromosomes.

157 Venous Thrombosis (INVENT) consortium multi-ancestry genome-wide association study (GWAS) meta-analy

158 found only in individuals of recent African ancestry, greatly increase risk of multiple types of kid

159 t least one human population from five major ancestry groups.

160 nts in Stage 2 studies (N = 293 787) in five ancestry groups.

161 Inference of genome ancestry identifies ~23% of the Gala genome as of hybrid

162 thods have been developed to infer the local ancestries in a set of unrelated individuals, a few of t

163 equences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Instit

164 that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe.

165 high degree of genetic variation and complex ancestry in Arabian horses from the Middle East region.

166 ed the persistence of Magdalenian-associated ancestry in hunter-gatherer populations outside of Spain

167 data to investigate the taurine and indicine ancestry in southern European cattle, based on a dataset

168 Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to te

169 ts from 408,883 individuals of white British ancestry in the UK Biobank, and we use these IBD segment

170 ntrol status was demonstrated, adjusting for ancestry, in independent training and test sets.

171 dent samples of SJLIFE survivors of European ancestry, including 34 nonirradiated male survivors trea

172 cattle breeds of taurine, indicine and mixed ancestry, including three breeds from Central Italy know

173 tudy of Latinos, we find that Amerindigenous ancestry increased by an average of ~20% spanning 1940s-

174 ts previously associated with MS in European ancestry individuals.

175 nd problematic drinking, in 435,563 European-ancestry individuals.

176 t, in the presence of contamination, genetic ancestry inference can be substantially biased with exis

177 he easy and inexpensive application of local ancestry inference in breeding programmes will facilitat

178 mANC, that can improve the accuracy of local ancestry inference in large pedigrees by: (1) using an e

179 Ancestry inference including the proportion of an indivi

180 IMs with the maximum information content for ancestry inference, admixture mapping, forensic applicat

181 Coupling of cell ancestry information with other molecular readouts repre

182 of an admixed population requires the use of ancestry informative markers (AIMs) from reference ances

183 cient feature selection strategy to retrieve ancestry informative variants with different allele freq

184 However, the spread of these ancestries into the western Mediterranean, where they ha

185 eages, whereas on the paternal side a Steppe ancestry is clearly visible.

186 OL1 genotyping in donors with recent African ancestry is considered.

187 at present, no more than 56-62% of Sardinian ancestry is from its first farmers.

188 ntamination exclusion threshold when genetic ancestry is misspecified.

189 RSs have been developed in women of European ancestry, it is important to understand the limitations

190 Although separated by geography and ancestry, key commonalities in the two patient transcrip

191 do detect cosmopolitanism (people of diverse ancestries living side-by-side) in the heartlands of the

192 We provide a local ancestry map for admixed individuals in the GTEx v8 rele

193 with 10 712 European epilepsy cases and 6746 ancestry-matched controls.

194 rom 1162 Swedish schizophrenia cases and 936 ancestry-matched population controls.

195 o identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational a

196 We also performed European-ancestry meta-analyses for smoking status in the MVP and

197 .4) for sporadic miscarriage in our European ancestry meta-analysis and three genome-wide significant

198 revealed improved prediction based on trans-ancestry meta-analysis results for admixed African (Nage

199 e of replication in the UK Biobank (European ancestry n ~ 320,000), while colocalization analyses lev

200 Here we report a multi-ancestry (N = 293,051) genome-wide association meta-anal

201 ociation study (GWAS) in cohorts of European ancestry (n = 527).

202 r telomere length in individuals of European ancestry (n = 9190) and from GWA studies of blood-cell t

203 blood-cell traits, also in those of European ancestry (n ~ 173,000 participants).

204 We further trace the evolutionary ancestry of distinct plant virus lineages to primordial

205 mented a suite of tools to resolve the local ancestry of each chromosomal locus based on reference pa

206 rental haplotypes, which revealed the inbred ancestry of infections and non-Mendelian inheritance.

207 population, and determined the most probable ancestry of Lacandon Maya HLA class I and class II haplo

208 The results indicate that the major ancestry of modern sled dogs traces back to Siberia, whe

209 The ancestry of present-day Moroccans is unknown and may be

210 ca TPSs in related grasses supports a common ancestry of selected pathway branches.

211 The shared, but temporally distant, ancestry of the banded mongoose and domestic ferret allo

212 about the geographical origin and subspecies ancestry of the founders.

213 DNA contamination and is agnostic to genetic ancestry of the intended or contaminating sample.

214 L by combining information inferred from the ancestry of the mice, ranging from RNA-Seq data and publ

215 ch population, underscoring the influence of ancestry on disease mechanism and also providing key ins

216 ves: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse pa

217 in LEP was common in individuals of African ancestry only, and its association with lower leptin con

218 inkage disequilibrium (LD) structures across ancestries or borrowing information between distinct but

219 B cell populations suggests either a common ancestry or a shared sustained imprint by the environmen

220 elp us understand the extent to which shared ancestry or independent evolution shape adaptive phenoty

221 However, ancestry- or race-specific reference panels may be neede

222 scarriages than women of Mestizo or European ancestry (P < .001).

223 r leptin concentrations was specific to this ancestry (P = 2 x 10(-16), n = 3,901).

224 rly growth have to date centered on European-ancestry participants and outcomes measured at a single

225 sk score were performed among 6,567 European-ancestry participants of the Penn Medicine Biobank (medi

226 n independent set of 8145 unrelated European ancestry participants showed consistent effect sizes in

227 effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic va

228 nitial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident

229 e Healthy Eating Index, or both, in European ancestry participants.

230 try, 2702 African ancestry, and 360 Hispanic ancestry participants.

231 n rule (beginning 1516 CE), Caucasus-related ancestry penetrated the Near East.

232 e-wide association study of sCJD in European ancestry populations (patients diagnosed with probable o

233 ss index, or type 2 diabetes risk in African-ancestry populations.

234 llele frequencies<0.05) in Asian and African ancestry populations.

235 otations such as IMPACT to improve the trans-ancestry portability of genetic data.

236 ion using IMPACT resulted in increased trans-ancestry portability of polygenic risk scores from Europ

237 Poor trans-ancestry portability of polygenic risk scores is a conse

238 r prediction accuracy than those of European ancestry, potentially due to their less complex genomic

239 PS, principal component analysis (PCA)-based ancestry prediction has been widely used.

240 These African ancestry-predominant alleles may help explain the increa

241 In the AA population, the African ancestry-predominant HLA-DRB1*08:04 and HLA-DRB1*11:02 a

242 ants were identified in Non-Hispanic African ancestry probands.

243 However, the genome-wide ancestry profiles of all four individuals are most simil

244 factor of 1.20 with every 10% increase in IA ancestry proportion (95% CI, 1.07-1.35; P = 0.001).

245 ciated variants highly correlated with local ancestry, providing a resource to enhance functional fol

246 ersity measures such as race, ethnicity, and ancestry (REA) to stratify study participants and patien

247 Steppe-pastoralist-related ancestry reached Central Europe by at least 2500 BC, whe

248 We demonstrated that cancer subtypes and ancestry-related technical artifacts are important confo

249 United States, populations with non-European ancestry remain understudied, and thus little is known a

250 Neanderthal ancestry remains across modern Eurasian genomes and intr

251 nd of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these p

252 nalyses were performed in adults of European ancestry residing in northern Europe, and it is unknown

253 or (ii) collateral evolution in which shared ancestry results from either ancestral polymorphism or i

254 tient data of 282,871 white British European ancestry samples, we show that SPACox can efficiently an

255 to power a rapid approach for inferring the ancestry shared between individual genomes and to quanti

256 y supporting the notion that Native American ancestry significantly contributes to NMO susceptibility

257 , race, the first 10 principal components of ancestry, smoking, diabetes, and hormone therapy use.

258 Furthermore, when inferring sub-European ancestry, SP clearly showed bias, unlike the proposed ap

259 e projection of new samples into a reference ancestry space, and the ability to reveal and adjust for

260 osomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreport

261 Finally, potential ancestry-specific and non-specific drug candidates were

262 ty, we were able to identify 1,731 potential ancestry-specific and trans-ancestry genetic drivers of

263 , and provides a generalizable framework for ancestry-specific GPS assessment.

264 ugh a rigorous analytical framework, explore ancestry-specific patterns of molecular alterations in c

265 The resulting ancestry-specific results were combined via meta-analysi

266 have been understudied for low-frequency and ancestry-specific variants.

267 o identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an I

268 orks were randomly assorted based on genetic ancestry, suggesting weak behavioural reproductive isola

269 d subjects from Pune, India of Indo-European ancestry; T1D (n = 262 clinically defined, 200 autoantib

270 s had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 x 10(-6)).

271 were more common in individuals of European ancestry than in individuals of African ancestry.

272 41 was more common in individuals of African ancestry than in individuals of European ancestry, where

273 duals carry a stronger signal of Neanderthal ancestry than previously thought.

274 lymphoma (DLBCL) in individuals of European ancestry through a large genome-wide association study (

275 tiple hybrid zones, we use signals of shared ancestry to identify and refine multiple putative regula

276 riers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies th

277 of 100,028 unrelated individuals of European ancestry, using SNP and CGH array datasets.

278 The risk of miscarriage by ancestry was assessed using multivariate logistic regres

279 However, African genetic ancestry was not associated with AD risk or control amon

280 trios of European, Colombian, and Taiwanese ancestry was performed to determine the contributions of

281 east 2500 BC, whereas Iranian farmer-related ancestry was present in Aegean Europe by at least 1900 B

282 tudy participants) of predominantly European ancestry, we conducted 2-sample single-variable Mendelia

283 tate data, professional licensing lists, and ancestry websites, and exposure measurements may be used

284 ted for age, sex and principal components of ancestry were analyzed.

285 tic changes associated with human specialist ancestry were concentrated in a few chromosomal regions.

286 can ancestry than in individuals of European ancestry, whereas rs9565267 and rs151041509 were more co

287 have been identified with admixed subspecies ancestries, which therefore over time, should be natural

288 = 2.8 x 10(-8)) in 246 survivors of African ancestry, which was successfully replicated in 1,645 sur

289 up, they represent a heterogenous mixture of ancestries who can self-identify as any race defined by

290 cts individuals of African or Middle Eastern ancestries who have on average a reduced number of circu

291 f the 100 million individuals of South Asian ancestry who carry MYBPC3(Delta25) and would previously

292 t reports have described patients of African ancestry who developed nephrotic-range proteinuria and A

293 sample of healthy working adults of European ancestry who volunteered to enroll in a health-promotion

294 Among patients of European ancestry with heart failure with reduced ejection fracti

295 nd 172 172 controls) in veterans of European ancestry with independent replication in up to 4972 case

296 ave begun with the arrival of people sharing ancestry with Near Oceanic groups (i.e., Austronesian-sp

297 bining results from the samples with African ancestry with summary statistics from the Psychiatric Ge

298 tal cluster for catalysis, implying a common ancestry with TPSs hypothesized to evolve from IDSs anci

299 quency/selection pressure among (or between) ancestries without requiring computationally expensive i

300 A PRS developed for European-ancestry women is also predictive of breast cancer risk