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1 type II PKA interaction with AKAPs (A-kinase anchoring proteins).
2 ity with an IC(50) of 811 +/- 0.56 nM of the anchoring protein.
3 xR/KxR/K) in the first 44 amino acids of the anchoring protein.
4 he PP1 catalytic subunit copurified with the anchoring protein.
5 r a flexible cross-linking, scaffolding, and anchoring protein.
6 -1070) interfaces directly with sites on the anchoring protein.
7 of scaffold proteins referred to as A-kinase anchoring proteins.
8 x formation between group I mGluRs and their anchoring proteins.
9 cadherins and their associated cytoskeletal anchoring proteins.
10 ltimolecular signaling complexes by A-kinase anchoring proteins.
11 rected in large part by distinct scaffold or anchoring proteins.
12 P-dependent protein kinase (PKA) through its anchoring proteins.
13 otemporal signaling is largely controlled by anchoring proteins.
16 here the N0 area homologous to dual A-kinase-anchoring protein-1 or the acyl-CoA signature motif were
17 ATR-S435A construct or deletion of A kinase-anchoring protein 12 (AKAP12) impeded platinum adduct cl
18 lls coexpressing FLC markers [CD68, A-kinase anchoring protein 12 (AKAP12), cytokeratin 7, epithelial
22 tudies, we demonstrate that protein kinase A anchoring protein 13 (AKAP13), a scaffold protein with G
24 iation with IPF susceptibility near A-kinase anchoring protein 13 (AKAP13; rs62025270, odds ratio [OR
26 This autoinhibitory complex, with A-kinase anchoring protein-15 (AKAP15) bound to the DCT, is hypot
27 argeted to GluA1 through binding to A-kinase anchoring protein 150 (AKAP150) in a complex with PSD-95
30 cultures because of its binding to A kinase-anchoring protein 150 (AKAP150), a scaffold for specific
32 ising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein 150 (AKAP150), and protein kinase A.
34 sensitization of TRPV1 activity by A-kinase anchoring protein 150 demonstrates a critical role for s
35 t al illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2
36 ls, and regulatory protein AKAP150 (A-kinase anchoring protein 150) enhances the activity of TRPV4 ch
37 mplex containing PKA and I-1 by the A-kinase anchoring protein 18 (AKAP18) facilitates this regulatio
38 ban in a complex that also contains A-kinase anchoring protein-18, protein kinase type A-RII, and pro
41 mechanism are under the control of A-Kinase Anchoring Protein 220 (AKAP220; product of the Akap11 ge
42 t NF546 is blocked by disruption of A-kinase anchoring protein 5 (AKAP5) function in arterial myocyte
43 egions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to
46 The multivalent neuronal scaffold A-kinase-anchoring protein 79 (AKAP79) is known to bind PKC and i
47 g the interaction between TRPV1 and A kinase anchoring protein 79 (AKAP79), a scaffolding protein ess
48 , often in conjunction with protein kinase A anchoring protein 79 (AKAP79; AKAP150 in rodents), which
49 coimmunoprecipitated with B-Raf and A-kinase anchoring protein 79, and AVP increased this interaction
55 ted protein 97 (SAP97) that contain A-kinase anchoring protein 79/150 (AKAP79/150), protein kinase A,
57 required the binding of the protein kinase A anchoring protein-79 (AKAP79) to the carboxyl terminus o
59 ic deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of inflammato
60 ree alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which cause gam
61 In the present study, we identified A-kinase-anchoring protein 95 (AKAP95) as a caspase 3-binding pro
62 e identified cAMP-dependent protein kinase A anchoring protein 95 kDa (AKAP95) as a potential fidgeti
63 ent, screening, and discovery of (novel) PKA anchoring proteins, a plethora of methodologies is avail
64 that, in combination with a protein kinase A anchoring protein (AKAP 95) and CSR-BPs participate in f
65 may be through compound binding to A kinase anchoring protein (AKAP) 1, modulating its localization
66 uding SAP97 and PSD-95, and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a P
67 motif with SAP97 and protein kinase A (PKA)-anchoring protein (AKAP) 5, which anchor the receptor in
68 tion with the PKC-targeting protein A-kinase anchoring protein (AKAP) 79 and interferes with ionomyci
70 f the AMPAR-linked scaffold protein A-kinase anchoring protein (AKAP) 79/150 is required for its targ
72 CaN is recruited to the channel by A-kinase anchoring protein (AKAP) 79/150, which binds to the LTCC
74 Here, we assessed the role of BIG2 A kinase-anchoring protein (AKAP) domains in the regulation of TN
75 e include the presence in BIG2 of 3 A kinase-anchoring protein (AKAP) domains, one of which is identi
77 c, and proto-Lbc), a unique protein kinase A-anchoring protein (AKAP) guanine nucleotide exchange reg
78 DE4), protein kinase A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an immediat
81 en identified by RII overlays as an A-kinase anchoring protein (AKAP) that localizes the cAMP-depende
84 silencing approaches identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector of OxPL ac
85 ) and beta-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits
90 ss spectrometry, we have identified A kinase-anchoring protein (AKAP)150 and the protein phosphatase
96 on domain to interact with multiple A-kinase anchoring proteins (AKAP) that localize it to different
97 tep mechanism that links rut-AC1 to A-kinase anchoring proteins (AKAP)-sequestered protein kinase A a
98 We further find that a specific A-kinase anchoring protein, AKAP-Lbc, is a major contributor to t
99 rotein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15), and the most rapid sites of
103 veal that ablation of the kinase/phosphatase anchoring protein AKAP150 impairs insulin secretion in m
104 emonstrate the critical role of the A-kinase anchoring protein AKAP150 in PKA-dependent modulation of
105 was found to be associated with the A kinase anchoring protein AKAP150 suggesting the existence of a
106 and Cbeta, with or without the prototypical anchoring protein AKAP18alpha, revealed that the dimeriz
107 We have discovered that the protein kinase A anchoring protein AKAP220 interacts with the cytoskeleta
108 we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminal
109 e plasma membrane via the involvement of the anchoring protein AKAP79, which is constitutively associ
112 ffolded to Ca(V)1.2 channels by the neuronal anchoring protein AKAP79/150, and that overexpression of
113 orming alpha subunit of BKCa and an A-kinase-anchoring protein (AKAP79/150) for beta2 agonist regulat
115 s, we show that the plasma membrane targeted anchoring protein AKAP9/Yotiao displays unique specifici
123 ulatory type II (RII) subunits with A-kinase-anchoring proteins (AKAPs) confers location, and catalyt
127 ent protein kinase (PKA) by protein kinase A-anchoring proteins (AKAPs) facilitates local protein pho
131 s and peptide disruptors of protein kinase A anchoring proteins (AKAPs) implicated PKA regulatory sub
132 cludens-1 (PDZ)-domain proteins and A-kinase anchoring proteins (AKAPs) increased receptor diffusion,
135 disruption of the binding of PKA to A-kinase anchoring proteins (AKAPs) inhibited currents through AR
136 ation of protein kinase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAMP respons
137 sation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate locali
153 proteins, including by multivalent A-kinase anchoring proteins (AKAPs) that bind protein kinase A an
154 aling is conferred in large part by A-kinase anchoring proteins (AKAPs) that localize protein kinase
155 pore-forming subunit is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dependent pr
156 means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize kinase acti
158 lar compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily di
159 strates by interacting with protein kinase A anchoring proteins (AKAPs), the present study was undert
181 II PKA holoenzyme, whereas dual-specificity anchoring proteins also bind the type I (RI) regulatory
182 ensity protein-95 (PSD-95), a putative NMDAR anchoring protein and core component of the PSD, at exci
183 agment uncouples AC5/6 interactions with the anchoring protein and prevents PKA-mediated inhibition o
185 domain, which shares homology with A-kinase anchoring proteins and interacts with the regulatory sub
187 ther proteins such as R7-binding protein, R9-anchoring protein, and the orphan receptors GPR158 and G
188 ce formed a gradient when trapped by surface-anchoring proteins, and they could be sensed by syntheti
189 4 integrins are type I PKA-specific A-kinase anchoring proteins, and we now find that type I PKA is i
190 NaKA), the Na(+) channel NaV1.6, and the AIS anchoring protein ankyrin-G, as well as an increase in l
191 tebrate AIS as judged by accumulation of the anchoring protein Ankyrin1, presence of a specialized ac
192 st MetRS is part of a complex containing the anchoring protein Arc1p and the glutamyl-tRNA synthetase
194 Of importance, we illustrated that A-kinase anchoring proteins are crucial for BCAM/Lu receptor acti
195 N-terminal kinase (JNK), Bax, and the 14-3-3 anchoring proteins, as well as the responsiveness of the
196 ardiac myocytes, the muscle protein kinase A-anchoring protein beta (mAKAPbeta) coordinates cAMP-depe
197 ts that the scaffold protein muscle A-kinase anchoring protein beta (mAKAPbeta) serves as a nodal org
198 aN bind the scaffold protein muscle A-kinase-anchoring protein beta (mAKAPbeta), which is localized t
199 scaffold protein mAKAPbeta (muscle A-kinase anchoring protein beta), such that increased SRF phospho
200 , but instead led to enhanced AKAP (A-kinase anchoring protein) binding with preferential localizatio
202 iquitination and degradation of crucial NR2B-anchoring proteins by the ubiquitin-proteasome system.
204 equence of forming this aberrant ion channel-anchoring protein complex is enhanced Ca(V)1.2-LQT8 curr
206 unofluorescence techniques, we show that the anchoring protein contributes to PKD activation in two w
207 ses, understanding the role of accessory and anchoring proteins could provide insights into pathogeni
208 The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized pools of P
210 of posttranslational modifications on the IF-anchoring protein desmoplakin (DP) that play an essentia
211 KAP79 on PP1 are substrate dependent, as the anchoring protein did not inhibit PP1 dephosphorylation
214 ized active epsilonPKC when not bound to its anchoring protein epsilonRACK (receptor for activated C-
215 ced translocation of both epsilonPKC and its anchoring protein, epsilonRACK to a new cytosolic site.
216 igate ternary complex with Npt2a and the PKA-anchoring protein ezrin to facilitate PTH-responsive cAM
218 decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and glycine receptors, gephyr
219 decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and glycine receptors, gephyr
220 that dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellu
223 we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac
224 This occurs through a mechanism whereby the anchoring protein functions like a subunit of Ca(V)1.2-L
225 e in brain AC activity, indicating that this anchoring protein functions to directly regulate cAMP pr
227 (A)R-subunits, GlyR alpha1-subunit and their anchoring protein, gephyrin, on terminals of rat spinal
228 on and association with isoform-specific PKG-anchoring proteins (GKAPs), which target the kinase to s
230 motes the binding of the mitochondria to the anchoring protein, glucose-related protein 75, at the gr
234 disruption of GluR2 binding to its synaptic anchoring protein (GRIP), resulting in a switch of GluR2
236 pathogen adhesins and host glycosaminoglycan-anchoring proteins (heparan sulfate proteoglycans) has l
237 activated C kinase 1 (RACK1), a scaffolding/anchoring protein implicated in various cellular functio
239 g cells and to uncover the role of clustered anchoring proteins in organizing these activity microdom
240 exhibit delayed recruitment of putative CAR anchoring proteins including the glucan synthase Bgs1.
241 ity or its ability to interact with A kinase anchoring proteins inhibited the activity of the Rac GTP
242 protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly blocked seroto
245 sphatases to a seven-residue sequence of the anchoring protein is the predominant molecular event und
246 pendent protein kinase with protein kinase A-anchoring proteins is well described and involves a kina
247 t NHERF2, acting as a novel protein kinase G-anchoring protein, is required for cGMP inhibition of NH
249 s in the compartmentation of cAMP signaling, anchoring protein kinase A (PKA) to specific cellular or
251 es indicate that the proto-oncogene A-kinase anchoring protein-Lbc is up-regulated in FLC and functio
252 t while still interacting with the chromatin-anchoring protein LEDGF at a distinct surface formed by
253 reviously described how the protein kinase A-anchoring protein mAKAP serves as a scaffold for the cAM
255 x maintained by the muscle-specific A-kinase anchoring protein (mAKAP) that includes PKA, PDE4D3 and
256 silon scaffolded to muscle-specific A kinase-anchoring protein (mAKAP), along with PKCepsilon and PKD
257 be scaffolded to a muscle-specific A kinase anchoring protein (mAKAPbeta) in heart and NRVMs, and mA
258 drial recruitment, association with the Drp1-anchoring protein Mff (mitochondrial fission factor), an
260 rly, Homer1b/c proteins, which are prominent anchoring proteins of mGluR1/5 and are highly expressed
264 anchoring using a competing muscle A-kinase anchoring protein peptide inhibited the hypertrophy of c
266 sistent with the suggestion of a DNA-binding anchoring protein present at these sites, although such
267 ow that the Rho-GTPase Rac contains A-kinase anchoring protein properties and forms a dynamic cellula
268 ent of its regulatory subunit or an A-kinase anchoring protein, providing an additional mechanism to
271 d AKAP150(-/-) mice reveals that loss of the anchoring protein results in decreased AMPA receptor-ass
272 lated binding of RSK3 to the muscle A-kinase anchoring protein scaffold, defining a novel kinase anch
273 KAP-Lbc in which increased expression of the anchoring protein selectively amplifies a signaling path
275 e and amplify the intracellular PKA-A-kinase anchoring protein signaling network and suggests a new s
276 all sacculi retain a functional form of this anchoring protein such that purified fibres can be ancho
277 -tubule complexity and reduced expression of anchoring proteins such as junctophilin-2 (Jph2) that no
278 otypes, while expressing PTPIP51, an ER-Mito anchoring protein, suppresses Parkin-mediated mitophagy.
279 eleted a major neuron-specific mitochondrial anchoring protein Syntaphilin (SNPH) from the mouse.
280 iggered by the bulk release of mitochondrial anchoring protein syntaphilin via a new class of mitocho
282 I3K heterodimer and IRS-1, it is an A-kinase anchoring protein that binds the type I regulatory subun
283 oring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal
284 Synapse-Associated Protein 97 (SAP97) is an anchoring protein that in cardiomyocytes targets to the
286 ase anchoring protein 79 (AKAP79) is a human anchoring protein that organizes cAMP-dependent protein
287 provide strong evidence that p23 acts as an anchoring protein that retains PKCdelta at the perinucle
288 y a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory sub
289 voltage-gated Nav1.6 and Kv7.3 subunits and anchoring proteins to analyze the functional and structu
290 ich are often spatially compartmentalized by anchoring proteins to increase signalling specificity.
291 ylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essent
293 ion: RAB32, a ras family member and A-kinase-anchoring protein, was methylated in 14 of 25 (56%) MSI-
294 ither freely diffusible or bound to A kinase anchoring proteins, we demonstrate that the difference i
295 enhance PKA's affinity for protein kinase A anchoring proteins, which alters its subcellular distrib
296 rning the localization of PopZ, a chromosome-anchoring protein whose unipolar to bipolar localization
298 member of a large family of protein A-kinase anchoring proteins with important roles in the organizat
299 dal binding groups address this challenge by anchoring proteins without loss of function and without