ライフサイエンスコーパス: ancient

1 an primate genomes retain the remnants of an ancient A3 retrocopy: A3I.

2 memory representations is an evolutionarily ancient ability.

3 stinct from cellular homologs, suggesting an ancient acquisition of this enzyme.

4 ECMs, we identify T-Plastin, one of the most ancient actin bundling proteins, as an actin stabilizer

5 miR-128-1-dependent energy storage may link ancient adaptation to famine and modern metabolic malada

6 vertebrate skull-triggered a pathway for an ancient adaptive radiation and expansion into morphospac

7 s and automatically completing the breaks in ancient Akkadian texts from Achaemenid period Babylonia.

8 the two castes, tribal groups have very high Ancient Ancestral South Indian (AASI) contributions.

9 ERK7 is an ancient and autoactivating member of the mitogen-activat

10 The cells are evolutionarily ancient and carry conserved principles of function, whic

11 and our data suggest that this kinase has an ancient and central role in regulating ciliogenesis thro

12 Multidrug (MDR) efflux pumps are ancient and conserved molecular machineries with relevan

13 malian antiviral protein viperin is far more ancient and conserved than previously appreciated.

14 Spiralia is a large, ancient and diverse clade of animals, with a conserved e

15 bcommissural organ and Reissner's fiber [12]-ancient and enigmatic organs of the brain ventricular sy

16 Apoptosis is an ancient and evolutionarily conserved cell suicide progra

17 ent compensation statistics, consistent with ancient and experimental systems.

18 Pleurodonta (Squamata: Iguania) is an ancient and frequently-studied lizard clade for which ph

19 N(4)-acetylcytidine (ac(4)C) is an ancient and highly conserved RNA modification that is pr

20 gesting that the strain sensing mechanism is ancient and highly conserved.

21 of microbial pathogens and microbiomes from ancient and historical human and non-human remains.

22 acilitate side-by-side analyses, we identify ancient and lineage-specific roles for Edn signalling.

23 leles in European populations using archaic, ancient and modern human samples.

24 elter, Honduras, that are closely related to ancient and modern maize from South America.

25 2b1, U2e2a, U8b1b1 and K1a4a) shared between ancient and modern mitogenomes.

26 ng of information processing in evolutionary ancient and modern visual pathways.

27 The role of anthropogenic influences in both ancient and more recent dissemination of B. pseudomallei

28 k of phylogeographic signal agrees with both ancient and more recent trading networks having shaped t

29 battle between microbes and their viruses is ancient and ongoing.

30 Silicosis is an ancient and potentially fatal pneumoconiosis caused by e

31 ce of multiple alleles associated with LP in ancient and present-day eastern African populations, the

32 erimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpa

33 individuals are genetically most similar to ancient and present-day populations from the north Peruv

34 s on its native range highlight a mixture of ancient and recent processes, with the effects of paleoc

35 attern that is in striking contrast to other ancient and similarly sized domains, such as Epidermal G

36 ed ecological and morphological diversity in ancient annelids.

37 Sacred lotus (Nelumbo nucifera) is an ancient aquatic plant of medicinal value because of anti

38 The complement system is an ancient arm of the innate immune system that plays impor

39 r of cheetah mtDNA is approximately twice as ancient as currently recognised.

40 d-living tetrapods, seem to exhibit a mix of ancient as well as modern features.

41 group and demonstrated its global spread and ancient association with primates.

42 iron micrometeorites may be an indicator for ancient atmospheric CO(2) and surface pressure; and coul

43 e thus been proposed to quantitatively track ancient atmospheric conditions.

44 e high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previous

45 All ancient bacterial genomes from prehistoric (agro-)pastor

46 she ate aquatic resources, and is related to ancient Beringian and Russian gray wolves and her clade

47 ria, plants and animals, comprising the most ancient binding feature of the LOTUS domain family.

48 Both are ancient biological assemblies that were already present

49 The ability to sequence genomes from ancient biological material has provided a rich source o

50 ity of questions that are approachable using ancient biomolecules, and plant research has been a cons

51 Preserved ancient botanical evidence in the form of rice phytolith

52 We generated genome-wide data for 93 ancient Caribbean islanders dating between 3200 and 400

53 Ancient Caribbean people avoided close kin unions despit

54 Osteocytes are an ancient cell, appearing in fossilized skeletal remains o

55 nario for how viruses likely originated from ancient cells, and explain technical and conceptual bias

56 quitin-mediated autophagy, an evolutionarily ancient cellular antimicrobial system.

57 Our results suggest that two ancient chemosensory systems with different inputs and o

58 Ancient Chinese poetry is constituted by structured lang

59 guably has the most constrained structure in ancient Chinese poetry, and presented each poem twice as

60 "co-phylogenetic" patterns are signatures of ancient co-speciation events and illustrate the cohesive

61 t to have assembled from the fragments of an ancient collision.

62 Complement proteins are ancient components of innate immunity that have emerged

63 Finally, the mitogenomic results suggest ancient connections between freshwater basins of East As

64 moters in other animals, suggesting it is an ancient conserved signal.

65 FXGs suggests that axonal translation is an ancient, conserved mechanism for regulating the proteome

66 al functions in Drosophila melanogaster than ancient, conserved ZAD-ZNF genes.

67 Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural

68 g superior mechanical properties to those of ancient Damascus steel(12).

69 Inspired by ancient Damascus steels(11-14)-which have hard and soft

70 f life, which suggests that it represents an ancient defense mechanism against viral infections.

71 the disordered region of the evolutionarily ancient developmental regulator Vts1/Smaug drives self-a

72 A phylogeny of DOG1 haplotypes revealed ancient divergence of these functional variants associat

73 Ancient DNA (aDNA) analysis provides a powerful means of

74 hod called ContamLD for estimating autosomal ancient DNA (aDNA) contamination by measuring the breakd

75 fragments is one of the challenges defining ancient DNA (aDNA) research.

76 During the last decade, the analysis of ancient DNA (aDNA) sequence has become a powerful tool f

77 Our ancient DNA analysis also revealed that a Viking expedit

78 dentify another optimal skeletal element for ancient DNA analysis and add to a growing toolkit of sam

79 per, we use collagen mass fingerprinting and ancient DNA analysis of some of the first stratified and

80 esearch while maximizing the likelihood that ancient DNA analysis will produce useable results.

81 evaluate this model, we generate genome-wide ancient DNA data for 70 individuals from 21 Sardinian ar

82 New ancient DNA data from the archipelago of Vanuatu shed li

83 Although ancient DNA data have become increasingly more important

84 Our comparisons with available modern and ancient DNA datasets from South Asia indicate that the B

85 Here, we review the development of the ancient DNA discipline and the role of plant research in

86 methodological innovations, such as improved ancient DNA extraction methods and next-generation seque

87 Using ancient DNA from a subset of these fossils, along with m

88 In the field of human history, ancient DNA has provided answers to long-standing debate

89 Ancient DNA has provided new insights into many aspects

90 Ancient DNA has significantly improved our understanding

91 Using ancient DNA in combination with geostatistical technique

92 eement between archaeozoological studies and ancient DNA means that the possibility that those hunter

93 Here we present an ancient DNA record from Hall's Cave, Texas, that documen

94 Ancient DNA research has benefited from the identificati

95 t human remains, including those who conduct ancient DNA research, face precisely this challenge as i

96 we offer five practical recommendations for ancient DNA researchers: (1) formally consult with commu

97 The ancient DNA revolution of the past 35 years has driven a

98 ined with novel types of genetic data (e.g., ancient DNA), have provided unprecedented insights into

99 This review illustrates how ancient DNA, especially ancient genomes, has inspired re

100 s coincides with breakthroughs in processing ancient DNA, providing the first opportunity to assess a

101 rmers and hunter-gatherers as estimated from ancient DNA, suggesting that unreliable yields in these

102 t these hypotheses have not been tested with ancient DNA.

103 ortant role in fostering ethical research on ancient DNA.

104 ate the ossicles as an alternative source of ancient DNA.

105 ationships is hindered by the degradation of ancient DNA.

106 insight into HIV-1 in 1960s DRC, and, as an ancient-DNA calibrator, it validates our understanding o

107 Here, we generated genome-wide ancient-DNA data from the Balearic Islands, Sicily and S

108 We sequenced 27 ancient dog genomes and found that all dogs share a comm

109 ctions, and the present repurposing of these ancient drugs.

110 anNFP1, and PanNFP2 These genes evolved from ancient duplication events predating and coinciding with

111 for hundreds of millions of years following ancient duplication events.

112 Phylogenetic analysis revealed that the ancient duplication of EXO70A, one of which is always hi

113 We resolve two distinct ancient duplications based on patterns of chromosomal co

114 information about the movement of goods and ancient economies, yet our understanding of critical asp

115 Takabuti, was a female who lived in ancient Egypt during the 25th Dynasty, c.660 BCE.

116 Although numerous papyri from ancient Egypt have been collected and preserved over the

117 rformed on black inks apposed on papyri from ancient Egypt, additional chemical elements such as lead

118 paramagnetic probes in historical bitumen in ancient Egypt.

119 ghted in the red and black inks preserved on ancient Egyptian papyri from the Roman period (circa 100

120 for future occurrences of this haplogroup in ancient Egyptian remains.

121 Neither H4 nor H4a1 have been reported in ancient Egyptian samples, prior to this study.

122 ovenance of mummified baboons recovered from ancient Egyptian temples and tombs.

123 ck matter employed in the funeral context by ancient Egyptians is a complex mixture of plant-based co

124 A system-wide MATRIX survey identified the ancient eIF5A as a pH-regulated translation factor that

125 evealing a novel physiological role for this ancient endosomal agent.

126 n how a particular trait once favoured in an ancient environment might become maladaptive upon enviro

127 Reconstruction of these ancient environments has depended heavily on carbon isot

128 Landscape-scale reconstructions of ancient environments within the cradle of humanity may r

129 acyl-tRNA synthetases (ARSs) are ubiquitous, ancient enzymes that charge amino acids to cognate tRNA

130 Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that play a fundamental role in protein

131 nt and diversified doubly-wound superfold of ancient evolutionary origin.

132 litated movement exemplified in Beirut by an ancient family with Egyptian-Lebanese admixed members.

133 ead in the plant kingdom and evolved from an ancient family.

134 rast to modern-day flood mitigation efforts, ancient farmers used floodwaters to develop otherwise ma

135 for at least 3.4 billion years, yet how the ancient field was produced is still unknown.

136 The archaic characteristics of this ancient fish lineage place it in a key phylogenetic posi

137 ry and must have evolved from a small set of ancient folds.

138 Intriguingly, ancient fossil hominins also exhibit substantial phalang

139 Its paralogs, which arose from ancient gene duplications of RAD51, have evolved to regu

140 We describe a conserved, likely ancient, gene regulatory network that intriguingly opera

141 There are now near-complete ancient genome sequences for three pathogens of consider

142 ine for the imputation of common variants in ancient genomes at 0.05-1 x coverage.

143 eplaced local wolf populations.(4) Moreover, ancient genomes from the Yana basin and the Taimyr penin

144 Although most studies of ancient genomes have focused on vertebrates, particularl

145 However, few studies have used complete ancient genomes to examine species responses to climate

146 We demonstrate the utility of integrating ancient genomes with archaeometric datasets in a spatiot

147 view illustrates how ancient DNA, especially ancient genomes, has inspired researchers to rethink the

148 This procedure, when tested on ancient genomes, outperforms a single-step imputation fr

149 iminate reference bias in ultra-low coverage ancient genomes.

150 encing, have enabled the sequencing of whole ancient genomes.

151 cation in light of recent contributions from ancient genomics.

152 re likely to be somatically shared than were ancient germline ones.

153 our understanding of critical aspects of the ancient glass industry is fragmentary.

154 Earth's ancient grasslands and savannas-hereafter old-growth gra

155 exceptional 'genomic potential'-hundreds of ancient haplotypes bear insertion or deletion polymorphi

156 mportant clues regarding the survival of the ancient He and W signatures in Earth's mantle.

157 ence for milk, meat, and plant processing by ancient herding societies in eastern Africa.

158 tudies of paleoclimatology and environmental ancient history.

159 dicates that it may have been involved in an ancient horizontal gene-transfer event.

160 At least 4 small, ancient HSV-1 x HSV-2 interspecies recombination events

161 its performance under conditions typical of ancient human DNA research, and compare it to previous n

162 quencing and new aDNA protocols, hundreds of ancient human genomes have become available.

163 Our knowledge of ancient human population structure in sub-Saharan Africa

164 DNA recovery from ancient human remains has revolutionized our ability to

165 Contemporary researchers who work with ancient human remains, including those who conduct ancie

166 ninsula is transforming our understanding of ancient human societies in their ecological contexts.

167 position in contemporary hybrid zones versus ancient hybrid lineages is unknown.

168 try on the Z chromosome is seen in two other ancient hybrid lineages.

169 we find that patterns of ancestry in old or ancient hybrids are remarkably predictable from contempo

170 f steroid hormone receptors, we show that an ancient hydrophobic interface, conserved for hundreds of

171 sistent with Fe-oxidation states measured on ancient igneous rocks.

172 Genomic studies conducted on ancient individuals across Europe have revealed how migr

173 Here we report genome-wide data from 174 ancient individuals from The Bahamas, Haiti and the Domi

174 ements, we generated genome-wide data for 11 ancient individuals from the island of Efate dating from

175 alyzed them in conjunction with 34 published ancient individuals from Vanuatu and elsewhere in Oceani

176 Here we report genome-wide data from 20 ancient individuals, and co-analyze it with previously r

177 we co-analysed with 89 previously published ancient individuals.

178 IL-17RA to IL-17RE represents a genetically ancient intercellular network regulating local tissue ho

179 nt questions concerning sustainability in an ancient international economy and offers a valuable hist

180 an attempt to uncover the genomic signal of ancient introgression and infer the divergent phylogenet

181 essful in detecting the genomic signature of ancient introgression.

182 a indicate that the Brahmin caste has higher Ancient Iranian and Steppe pastoralist contributions tha

183 ause the best studied obligate symbioses are ancient, it is especially challenging to identify early

184 l sources that list the Umbri among the most ancient Italic populations.

185 ah circulated in parallel throughout Israel (ancient Judea).

186 We found that the evolutionary ancient koniocellular (K) pathway in LGN and area MT exh

187 Cells in the evolutionary ancient koniocellular LGN pathway and in area MT show hi

188 graphy, and hides entire mountain ranges and ancient lakes.

189 sils spanning seven million years shows that ancient large-herbivore assemblages were functionally di

190 ve in fossil-like form the legal thinking of ancient lawmakers.

191 Proteins' interactions with ancient ligands may reveal how molecular recognition eme

192 rigid fragment found in the most common and ancient ligands.

193 eductase catalytic subunits represent a more ancient lineage of DMSORs compared to aerobic arsenite o

194 trophic methanogenesis, constitutes the most ancient lineage.

195 To preserve these ancient lineages, our results are being applied in the c

196 otifs for understanding traits shared across ancient lineages.

197 ty and even confer cooperativity, because an ancient linkage between the oxygen binding site and the

198 ined how methylation has persisted since the ancient loss of DnmtX.

199 Here we report ancient maize genomes (2,300-1,900 cal.

200 l cellulose, suggesting expansins evolved in ancient marine microorganisms long before the evolution

201 ds disappeared, thereby indicating a complex ancient Martian hydrosphere capable of supporting a vast

202 ation and the long-term sustainability of an ancient Maya city.

203 The ancient Maya serve as an intriguing example of this rese

204 l effects by identifying ingredients used in ancient meals.

205 show that DIX-dependent polymerization is an ancient mechanism conserved between kingdoms and central

206 solitary species suggests the presence of an ancient mechanism, ancestral to the evolution of reptile

207 onent (where geochemical depletion refers to ancient melt extraction) common to most oceanic island b

208 The main sources of information regarding ancient Mesopotamian history and culture are clay cuneif

209 Teneurins are ancient metazoan cell adhesion receptors that control br

210 Ancient microbes invented biochemical mechanisms and ass

211 ents as well as providing a fossil record of ancient microbial ecosystems.

212 the archipelago of Vanuatu shed light on the ancient migrations that shaped the history of human sett

213 a methodological standard for investigating ancient mobility in complex societies.

214 human enamel bioapatite, from 137 well-dated ancient Mongolian individuals spanning the period c. 440

215 show that modern haemoglobin evolved from an ancient monomer and characterize the historical 'missing

216 ) and 28 pre-Roman individuals (obtaining 19 ancient mtDNAs) excavated from the necropolis of Plestia

217 we report genome-wide data analyses from 110 ancient Near Eastern individuals spanning the Late Neoli

218 es that can be implemented by evolutionarily ancient neural systems to generate escape behavior, to w

219 rent evolution of TPSs from IDSs since their ancient occurrence and points to the possibility of a wi

220 This link is an ancient one, developed through shared neural circuits th

221 vast diversity of eukaryotes, implying both ancient organization and functional unity.

222 Our study shows that an ancient origin associated with a dispersal history facil

223 ytosis, this work supports an evolutionarily ancient origin for these processes and establishes Naegl

224 the earliest history of Earth-supporting an ancient origin of high (3)He/(4)He.

225 RNAP-encoding Caudovirales and suggests the ancient origin of this enzyme in this group, underscorin

226 nging because of their diverse functions and ancient origin.

227 eir appearance during evolution indicates an ancient origin.

228 major tetrapod groups, often with remarkably ancient origins (~100-200 million years ago).

229 a fish virus, and an algal virus indicating ancient origins and suggesting diverse means of altering

230 that generate cadherin-based junctions have ancient origins, with conserved elements shared between

231 higher thrust sheets of the Himalaya, and in ancient orogens elsewhere.

232 d ecological legacies of both the recent and ancient past are key to understanding the forces shaping

233 Ancient pathogen DNA may provide new evidence to redefin

234 loping field, highlight the contributions of ancient pathogen genomics to multidisciplinary endeavors

235 fforts to sequence the genomes of additional ancient pathogens, with the potential to broaden our und

236 unique window into the culinary cultures of ancient people, resource use, and environmental effects

237 Finally, we review recent applications of ancient plant genomic research.

238 An evolutionarily ancient plant hormone receptor complex comprising the al

239 Here, we identify SOSEKI as ancient polar proteins across land plants.

240 ecotypes, which are the result of a simple, ancient polymorphism segregating within a diverse popula

241 Both gene flow and selection-mediated ancient polymorphisms are prevalent in the genus Populus

242 We identified 45 candidate genes with ancient polymorphisms maintained by balancing selection.

243 ical techniques, we produce detailed maps of ancient population movements, which allow us to visualiz

244 ich we foresee will enable future studies of ancient populations' movements, and their putative effec

245 ry can yield insights in terms of modern and ancient populations, allowing us to address questions re

246 ction of wild edible mushrooms for use is an ancient practice.

247 However, the biological functions of these ancient primary DR sequences remain largely unknown.

248 e led to an imbalance of this evolutionarily ancient process, coinciding with a steep rise in immune-

249 s that body odour production in humans is an ancient process.

250 conceivable that seeds recalled or renovated ancient programs of stress-induced growth arrest that we

251 of genomic instability that appear to be an ancient property of primate genomes.

252 sphoesterase motif defines an evolutionarily ancient protein domain present in several enzymes that h

253 rters constitute one of the largest and most ancient protein superfamilies found in all living organi

254 search has demonstrated that the analysis of ancient proteins can address this challenge(6-8).

255 Here, we analyse ancient proteins from human dental calculus recovered fr

256 fossil invertebrate biominerals provides an ancient record of composition, potentially clarifying ev

257 Matalpha2) evolved by coding changes in this ancient regulator, followed millions of years later by c

258 ess the footprints of local adaptation in an ancient relictual species, informing future conservation

259 on by creating favourable contacts with more ancient residues on the opposing subunit.

260 tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, referred to as astr

261 h century reveals a possible, nondocumented, ancient restoration of this mummy by pure bitumen.

262 preserved 'primitive', 'Nordic', and other 'ancient' retrotypes that were present both in archaeolog

263 pressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role t

264 s, RPLP1 and RPLP2 (RPLP1/2), which form the ancient ribosomal stalk, were discovered decades ago but

265 Our data suggest MALT1 has an ancient role modulating neural circuit function downstre

266 In total, these results expand the ancient role of iron in biochemistry and highlight a pos

267 H4a1 has also been reported in ancient samples from Bell Beaker and Unetice contexts in

268 c-3',5'-adenosine monophosphate (cAMP) is an ancient second messenger but organizing signaling select

269 ally profiling joint chondrocytes, revealing ancient selection and recent constraint and drift on kne

270 dard functional brain organisation for these ancient sensory-motor behaviours, favouring the right he

271 e callers do not fully account for errors in ancient sequences and additional quality controls can be

272 Recent studies extend understanding of this ancient signaling pathway and describe the development a

273 Thus, Sas4 links BBs with an ancient signaling pathway known to promote the accurate

274 The habenula, an ancient small brain area in the epithalamus, densely exp

275 Yet the most ancient stem-salamanders, known from mid-Jurassic rocks,

276 genomic comparisons suggest that the earlier ancient strains were not host specific, differed in path

277 The claustrum is therefore an ancient structure that was probably already present in t

278 that a very small portion of this large and ancient supergene harbors conserved trans-species SNPs l

279 A new study of an ancient supergene in several ant species suggests that r

280 Discovery of such a feeding behavior in this ancient, terrestrial, and omnivorous animal provides dir

281 It is at the center of the vast majority of ancient textiles preserved under nonextreme conditions,

282 onstrate that the guard cell toolkit is more ancient than has been appreciated previously.

283 Since ancient times it is known that melancholia and sleep dis

284 ory lung disease have been appreciated since ancient times.

285 has been used for structural materials since ancient times.

286 f adults to digest milk to survive famine in ancient times.

287 een valued as a powerful antimicrobial since ancient times.

288 mponents, have a historical record dating to ancient times.

289 decrypt a new, independent, phylogenetically ancient Torix Rickettsia endosymbiont found constantly i

290 Desiccation tolerance is an ancient trait, lost from vegetative tissues following th

291 repository for extant marine organisms with ancient traits.

292 ose an evolutionary hypothesis that involves ancient transfers from legume hosts in the common ancest

293 gasdermin and rcd-1 This report documents an ancient transkingdom relationship of cell death executio

294 likely shaped the mitochondrial gene pool of ancient Umbri over time, since early Neolithic, includin

295 11-15], evidence of lateralized behaviors in ancient vertebrates might yield clues about the evolutio

296 P2 and GBP5 have already been active against ancient viral pathogens as they suppress the maturation

297 Finally, we confirmed an ancient whole-genome duplication that took place in a co

298 hat early vertebrate evolution was shaped by ancient whole-genome duplications, the number, timing an

299 feather represents a primary covert from the ancient wing of Archaeopteryx.

300 In July 2016, a mummified carcass of an ancient wolf (Canis lupus) pup (specimen YG 648.1) was d