コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
2 pleted, precision oncology remains unproven, and as such, a hypothesis in need of rigorous testing.
3 defining signature of aggregation-prone tau, and as such, a possible target for therapeutic intervent
4 he ligand specificity of individual NK cells and as such, a subset of NK cells can respond, expand, a
6 5beta1, the primary receptor for fibronectin and, as such, a crucial determinant for the characterist
7 reflects that seen in "proto-Kranz" species, and, as such, a key step toward engineering C4 rice has
10 rm enabling LC-MS-based proteomic workflows, and as such, addresses an unmet need in the LC-MS proteo
11 he was America's pioneer surgical historian and, as such, afforded surgeons their earliest measure o
12 ctively powered for statistical comparisons, and as such, all the analyses are descriptive in nature.
13 se total exogenous carbohydrate availability and, as such, allow higher exogenous carbohydrate oxidat
14 pressure threshold at which eruptions occur, and as such, an overpressure eruption triggering mechani
15 ural production center for the global market and, as such, an important source of greenhouse gas (GHG
16 such as that observed in Williams syndrome, and, as such, animal models involving vitamin D intoxica
17 and human tBregs express low levels of CD20 and, as such, anti-CD20 mostly enriches for these cells.
18 d Stenotrophomonas maltophilia at this time, and, as such, antimicrobial susceptibility testing of th
19 l carbon losses through the aquatic pathway, and as such, aquatic exports are fundamental to the unde
20 rmation is relayed within the nervous system and as such, are essential for normal neurological funct
21 are important sites of tertiary interaction and as such, are integral to RNA macromolecular structur
22 ith opposite experience-dependent plasticity and as such, are well positioned to foster experience-de
23 of the ionic atmosphere around nucleic acids and, as such, are a natural route for testing quantitati
24 omote tumor evolution and cancer progression and, as such, are associated with poor clinical outcomes
26 rminants of breast-milk nutrient composition and, as such, are determinants of the nutritional exposu
27 key roles in many Ca(2+) signaling pathways and, as such, are emerging novel therapeutic and insecti
28 chemical fuels into useful electrical energy and, as such, are expected to play a major role in a sus
29 ly specific biosynthesis of glycosidic bonds and, as such, are important both as drug targets and for
30 nsposons are closely related to retroviruses and, as such, are important models for the study of vira
31 rees of freedom to the conduction electrons, and, as such, are intimately related to the low temperat
32 e host when administered in adequate amounts and, as such, are labeled "probiotics." We review some o
33 idespread invasion and resistance to therapy and, as such, are managed clinically as if they are one
34 t also affect performance at work and school and, as such, are members of the group of severe allergi
36 ate transcription in response to fatty acids and, as such, are potential therapeutic targets for thes
38 ed to regulate the cellular microenvironment and, as such, are promising approaches for tooth develop
39 iency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplem
40 vent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed d
41 d stuck at a prehearing stage of development and, as such, are unable to process sound information.
42 extremely resilient to temperature increases and, as such, are uniquely suited to promoting protein s
43 will be useful in regulating these processes and, as such, are valuable research tools and potentiall
44 gnaling proteins during megakaryocytopoiesis and, as such, became a critical regulator in the tempora
45 s have a genetic basis in nonhuman primates, and, as such, begin to fill the gaps in our understandin
46 ion twinning but is distinct from the latter and, as such, broadens the known mechanisms of plasticit
47 s, epigenetic changes are reversible events, and as such, can be amenable to pharmacological interven
50 so contribute to tissue-selective expression and, as such, can function as an important locus for the
51 e profoundly stressful for the human infant, and, as such, can lead to significant alterations in bra
52 ted AdvFBs exhibit pro-angiogenic properties and, as such, communicate with VVECs, in a process invol
53 the fission yeast Schizosaccharomyces pombe and, as such, competitively inhibits thioredoxin-mediate
54 r susceptibility factor for tumor cell death and, as such, constitutes a potential biomarker that cou
55 groups in terms of their observed covariates and, as such, control for confounding in estimating trea
56 sition between the two stiffening mechanisms and, as such, control the dominant power-law scaling beh
57 ead and robust effects on vascular function, and as such, could be a viable treatment option for impr
58 es a noninvasive assessment of proliferation and, as such, could be a valuable imaging biomarker in o
59 re more likely to differ between individuals and, as such, could be relevant in the study of various
60 ermini derived from heterologous transposons and, as such, could promote excision of large genomic re
61 e follicle and multi follicle spatial scales and, as such, could represent a core mechanism underlyin
62 ne, is a key integrator of stress responses, and, as such, CRH gene variation may contribute to indiv
63 promiscuous with respect to peptide binding, and, as such, CTL can often recognize related epitopes.
64 ing DbetaH leads to reduced DbetaH activity, and as such, disulfiram might not be an effective treatm
66 to and recruits ELF3 for degradation by COP1 and, as such, dynamically gates the formation of the eve
67 teristic of a well-evolved metabolic enzyme, and as such, E. coli GmhB is set apart from most HAD pho
68 icated in eliminating infected CD4+ T cells, and as such, elite suppressors may represent a model of
69 at ES cells can generate endoderm in culture and, as such, establish this differentiation system as a
70 etaxel-related tearing is not caused by LDO, and as such, evaluation or stenting of the duct is not c
72 e adaptable to homologs in disease organisms and, as such, extendable to strategies to combat infecti
73 imited to reactions that are found in nature and, as such, facilitate fewer types of transformation t
74 he information content of these measurements and, as such, facilitate the elucidation of mechanisms a
75 lumns between 0.3 and 0.8 m have been used), and as such, fast separations are possible, comparable t
76 are the primary component in primordial ECM and, as such, FN assembly is a critical component in the
77 triggers irreversible structural evolution, and as such, forms a detrimental cycle constantly consum
78 n quantitative phase imaging time-lapse data and, as such, functions in label-free mode, without the
79 he most susceptible nucleotide to oxidation, and as such, G-rich sequences that form G-quadruplexes c
81 n is a cornerstone of optical communication, and as such, governs the overall speed of data transmiss
82 safety and efficacy end points were assessed and, as such, had no prespecified primary end point, and
85 sses in which O2 availability is compromised and, as such, has become an increasingly attractive ther
86 lso expressed in tumors and tumor cell lines and, as such, has been classified as a cancer-germline o
87 nstruction increases experimental complexity and, as such, has been the source of recent controversy.
88 avenue by which experience can guide choice and, as such, has broad implications for the study of de
89 r G-quadruplexes (GQ) relative to duplex DNA and, as such, has found a wide range of applications in
90 known to have a Zn ribbon-embedded wHTH fold and, as such, has potential roles both as a metal-depend
91 totransporters of Enterobacteriaceae) family and, as such, has serine protease activity and causes cy
92 or targets of a pathogenic immune response, and as such, have been implicated in the pathogenesis of
93 ble example of these highly prized compounds and, as such, have attracted considerable attention in t
94 d individual picoliter reaction compartments and, as such, have great potential for quantitative high
95 romote Alzheimer's disease neuropathogenesis and, as such, have implications for use of isoflurane in
96 oligonucleotides for binding to DNA and RNA and, as such, have potential utility as probes in molecu
97 r to their mammalian NOS (mNOS) counterparts and, as such, have provided insight into the structural
99 tor of Hh signaling, is an NRF2 target gene, and as such, hyperactivation of NRF2 impairs Hh signalin
100 sisted by a person who injects drugs (PWID), and as such, IDU could be considered as a dynamic behavi
101 ith a number of neurodegenerative disorders, and as such, in vivo analysis of dopamine in the presenc
102 negative regulator of neuronal regeneration and, as such, inhibiting its activity has been considere
103 isplays an elevated basal activity in vitro, and as such, inverse agonists may be therapeutically ben
104 fective inhibitor of oral anaerobic bacteria and as such, is a good candidate for treatment of period
105 the full blood odor in mammalian carnivores and as such, is a key candidate as a food/alarm cue in b
107 that is lethal upon transmission to Tg mice and as such, is reminiscent of the prion causing kuru, w
108 regulator of actin cytoskeletal architecture and, as such, is a candidate target for preventing cance
109 vert a fibroblast to a skeletal muscle cell, and, as such, is a model system in developmental biology
110 range of DNA-modifying enzymes and compounds and, as such, is a useful addition to the toolbox of bio
111 DNA) phages, herpesviruses, and adenoviruses and, as such, is a viable antiviral therapeutic target.
112 ts a short-term mutational response to AFB1, and, as such, is an early detection metric for AFB1-indu
113 o support salivary gland replication in vivo and, as such, is an important tool that can be used to e
114 re of the plant material being reconstructed and, as such, is applicable to a wide variety of plant s
116 d as a key regulator of epithelial phenotype and, as such, is deeply involved in epithelial to mesenc
117 ast cancer is typically an incurable disease and, as such, is disproportionately responsible for deat
118 n in other porous materials (e.g., zeolites) and, as such, is easily scalable and industrially releva
119 nitiator of the classical complement pathway and, as such, is essential for efficient opsonization an
120 ly the result of these isolated TiO(2) sites and, as such, is expected to occur on other surfaces whe
121 rization of a calcium complex with palytoxin and, as such, is expected to support the investigation o
122 (~pL) and low (~yoctomole) detection limits and, as such, is ideal for applications that require hig
123 acilitates the release of viruses from cells and, as such, is important for the replicative efficienc
124 nd proliferation of hematopoietic stem cells and, as such, is not only essential for steady-state hem
125 rects the development of the next generation and, as such, is profoundly different from somatic cell
126 F-1 alpha) is a prototypic target of the UPP and, as such, is stabilized under conditions of proteaso
127 +)-binding component of the troponin complex and, as such, is the Ca(2+)-dependent switch in muscle c
128 s not utilized in this streptococcal species and, as such, is under no selection pressure to maintain
130 roperty as a dual coactivator of AR and PKM2 and as such, it is a potent inducer of castration and th
131 ers, cancer, and neurodegenerative diseases, and as such, it is an essential target in medicine and c
132 ptation corrects for movements' inaccuracies and as such, it is critical in maintaining optimal motor
133 tolerate a diverse collection of reactants, and as such, it is expected that the new scaffolds and a
134 tant component of the human immune response, and as such, it is important to understand how pathogeni
135 a model native fish species in our analysis, and as such, it is likely that the lionfish invasion has
136 nt of contact between the host and pathogen, and as such, it is likely to play an important role in m
137 se can strikingly differ between subregions, and as such, it is possible that these patterns differen
139 an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties.
140 one of the best-studied viruses of all time, and as such, it serves as a testbed to extend our biolog
141 rophil mobilization to sites of inflammation and, as such, it could represent a therapeutic target fo
142 nough to easily handle the largest data sets and, as such, it is a useful tool to add into computatio
143 of enzymes that catalyze substrate oxidation and, as such, it plays a key role in various biological
144 y is associated with several human diseases, and as such, its inhibition offers an exciting opportuni
145 rade numerous extracellular matrix proteins, and as such, its potential involvement in diseases of th
146 kemia virus type 1 (HTLV-1) is a retrovirus, and, as such, its genome becomes chromosomally integrate
147 ction and composition of cerebrospinal fluid and, as such, its many functions of the central nervous
148 ed for multiple cytokine signaling pathways, and as such, JAK inhibitors hold promise for treatment o
149 ts, this remains a relatively rare disorder, and as such, large-scale clinical trials have not been c
150 ) rapidly degrades 85% of administered 5-FU, and as such, limits the amount of drug available for con
151 es to PDAC pathogenesis by activating c-Myc, and as such, LINC00346 may serve as a potential biomarke
152 often restricted to classical model systems and, as such, little is known about the evolution of the
153 ences MMO expression in terrestrial systems, and, as such, local Cu mineralogy might provide an expla
154 proteins in linking the OM to the cell wall and, as such, maintenance of structural integrity preven
155 central for the progression of many diseases and, as such, makes metalloenzymes attractive targets fo
157 ESET gene is important to neuronal survival and, as such, may be a promising treatment in HD patient
158 the broadest spectrum of antifungal coverage and, as such, may be considered for empiric therapy of e
159 coordinating synapse formation and function and, as such, may be critically involved in the pathogen
160 ary step for efficient viral RNA replication and, as such, may be important for mediating a switch in
161 NOD2-dependent signal transduction pathways and, as such, may be involved in the pathogenesis of NOD
162 und to be potent anti- Wolbachia antibiotics and, as such, may be useful in the treatment of filarial
163 independent AD disease-modifying mechanisms and, as such, may contribute to the benefits of dietary
164 r inhibiting prostate cancer bone metastasis and, as such, may enhance the therapeutic activity of do
165 that promotes MED1 association with Mediator and, as such, may facilitate a novel feed-forward action
166 easures the mobility of water within tissues and, as such, may function as a surrogate marker for bot
168 terindividual variation in toxicity response and, as such, may more accurately reflect the range of r
169 cellular localization of the exchange factor and, as such, may participate in the signaling mediated
170 strated that both S100A4 and UA act as DAMPs and, as such, may play a critical role in promoting some
171 pha release by plasmacytoid dendritic cells, and, as such, may play an important role in propagation
172 following treatment with DNA-damaging agents and, as such, may play roles in modulating the efficacy
173 eurodegeneration seen in Parkinson's disease and, as such, may provide a marker for cognitive decline
174 to rebalance epigenetic histone modification and, as such, may provide the rationale for the design o
175 melanoma from a primary to metastatic tumor and, as such, may represent a useful therapeutic tool in
176 l for cancer cell proliferation and survival and, as such, may represent a vulnerability that can be
177 ng FcalphaRI inhibited neutrophil activation and, as such, may represent an additional attractive nov
178 proteins function as corepressors for SNAIL and, as such, may serve as a platform for the assembly o
179 c is an essential cofactor required for life and, as such, mechanisms exist for its homeostatic maint
181 e control of the acute inflammatory response and, as such, modulates the transmigration of neutrophil
182 often the rate-limiting step of translation and, as such, most (but not all) examples of translation
183 cell niches (classically the hematopoietic), and as such, MSCs participate in organ homeostasis, woun
184 for regulating numerous signaling pathways, and, as such, mutations disrupting ciliogenesis result i
185 es to the host cell differentiation program, and as such, native HPV virions are only produced in viv
186 antiviral activity in HIV-1-infected humans, and as such, novel approaches harnessing the anti-HIV-1
187 ) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine ou
188 or stable isotope tracer exposure is limited and, as such, offers a great advantage for human studies
189 n of these solutions can be very challenging and as such, only a small proportion of them are typical
190 dity and mortality for both mother and child and, as such, optimal treatment strategies are required
192 ffs that the model embodies are fundamental, and, as such, our modeling framework has potentially wid
193 an oscillating magnetic field in the sample and, as such, permits quantitative, frequency-selective
194 CR signaling in response to immune complexes and, as such, plays a decisive role in regulating Ab res
195 tramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disass
196 re that is insensitive for regional disease, and as such, poor for capturing the early onset of lung
198 by the presence of a significant background, and, as such, predetection background suppression is sub
199 a limiting factor for these solid catalysts, and as such, productivity remains high up to 25 degrees
200 teraction between Xist RNA and PRC2 proteins and, as such, prompt a reappraisal of the mechanism for
201 among the closest living relatives to humans and, as such, provide a crucial comparative model for in
202 xidation/reduction under biologic conditions and, as such, provide a means for control of protein act
203 i protein signals are required for BM homing and, as such, provide a new example of the association b
204 -alpha-syn-induced neurodestructive immunity and, as such, provide a sound rationale for future Parki
205 e among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits
206 show that MSCI is essential for male meiosis and, as such, provide insight into the differential seve
207 eared toward reporting of proteomics results and, as such, provided only limited support for metaboli
208 pans the breadth of oncology subspecialties, and, as such, providers in these subspecialties should b
209 f animal movement data to inform such models and as such, provides some insight into the impact of im
210 ties emerge from the behavior of individuals and, as such, provides a mechanistic explanation of conn
211 iral MHC class I ligands for any bat species and, as such, provides an important avenue for monitorin
212 which accomplishes complete adenoma removal and, as such, provides unique advantages over other surg
214 eparin derivatives counteract this mechanism and, as such, represent potentially appealing compounds
215 h in response to proteins produced by plants and, as such, represents a new paradigm for interspecies
216 processes that determine mutualism stability and, as such, represents a significant step in understan
217 that vascularize the gut, liver and pancreas and, as such, represents an ideal model in which to inve
218 trotransposon activity identified in mammals and, as such, represents an important additional data po
219 es of wax deposition during leaf development and, as such, represents an important step in the study
220 -12 to regulate T-helper 1 and 2 lymphocytes and, as such, seems to underlie the pathogenesis of vari
221 ural framework within the cellular cytoplasm and, as such, serve an important role in epithelial cell
222 ass that is required for antibiotic activity and, as such, serves as an important point for the explo
223 fine a quantitative scale for ChIP-Seq data, and as such, several approaches making use of exogenous
224 independently predictive of postoperative AF and as such, should be integrated into the clinical deci
226 S-nitrosothiols such as S-nitrosoglutathione and, as such, should be considered as a source of RBC-de
227 et of sequenced yeast mutant alleles to date and, as such, should be singularly useful for gene and g
228 dia spp. are obligate intracellular bacteria and, as such, should be targeted by CD8(+) T cells.
229 potential window free from parasitic signals and, as such, significantly restrict the conditions wher
230 KIF13B transports VEGFR2 to the EC surface, and as such, specific inhibition of polarized VEGFR2 tra
231 umor cells remain dependent on Src signaling and as such, Src inhibition suppresses growth of Ras/Src
232 MR analysis of a threading tetraintercalator and, as such, structurally characterizes a new topology
233 umented archaeological site in North America and, as such, substantially revises the timing of arriva
234 erns of input from sensory and motor neurons and, as such, suggest that interneuron position is a det
235 onenzymatically to pneumococcal pathogenesis and, as such, suggest that it is not a redundant bystand
236 ALL subtypes differ at the functional level, and, as such, T-ALL treatments are uniformly applied acr
237 sically plausible models of neural circuitry and, as such, takes us closer to a mechanistic understan
238 ls occurs around individual dendritic cells, and as such, that CD8Treg mediated killing of CD4Th1 cel
239 ate their dauer-like infective larval stage, and as such, the DAF-12 ligand binding domain has been i
240 ction in an autocrine and paracrine fashion, and as such, the host cell lineage responsible for the p
241 a are similar to those of the human placenta and as such, the pregnant sheep offers an excellent mode
242 omas with and without extraocular extension, and as such, the presence of peritumoral lymphatics is n
243 um one of the most complex plant structures, and as such, the regulation of its development has remai
244 -analyses reported follow-up to only 1 year, and as such, the relative long-term safety and efficacy
246 formation, the area compressibility modulus and, as such, the bending rigidity of the membrane is co
247 are influenced by protein-water interactions and, as such, the energetics of protein function are nec
248 at faithfully recapitulate these infections, and, as such, the host or bacterial factors that govern
249 to diffuse throughout the film architecture, and, as such, the major focus of this work is to define
250 for competition-defense tradeoffs is limited and, as such, the mechanisms by which consumers regulate
251 Patients with AFP >400 ng/mL were excluded, and, as such, the Milan group was modified to include on
252 idered equivalent to a highly repetitive BAC and, as such, the optimized method detailed here should
254 -free, TLS can work in an error-prone manner and, as such, the regulation of these pathways requires
255 mic entities in various cellular mechanisms, and as such, their availability, manipulation and queria
256 embling DBS-acids have different pKa values, and as such, their self-assembly is triggered at differe
257 larly Ras and Raf, are encoded by oncogenes, and as such, their structures and functions can be modif
258 re diverse and often mechanically demanding, and as such, their teeth should maintain a functional mo
259 oclasts fail to organize their cytoskeleton, and, as such, their bone-resorptive capacity is arrested
260 subwavelength plates control the near field and, as such, their superlensing properties originate fr
261 librium nature of cotranslational processes, and as such, there exist theoretical tools that offer a
262 d various autoimmune inflammatory disorders, and as such, there is a need for molecular probes to stu
263 or the maintenance of metabolic homeostasis, and as such, these arthropods have formed symbioses with
264 an provide integrated exposure measurements, and as such, these matrices can potentially be used as n
265 athology of multiple neurological disorders, and as such, these proteins are established therapeutic
266 DH2 activities are a major factor in cancer, and as such, these results implicate SIRT3 as a potentia
267 vement perception, including mirror neurons, and, as such, these findings argue against a mirror syst
268 on, blood clotting, and signal transduction, and as such, they are common targets of therapeutic agen
269 te atomic oxygen [O((3)P)] upon irradiation, and as such, they have been used to create a condensed p
270 tractive moiety in modern organic synthesis, and as such, they have been utilised in a diverse range
271 etastasis rely heavily on cellular motility, and as such, they have put PLD at center stage in cancer
272 ing signals are segment and strain specific, and as such, they have the potential to impact reassortm
273 heir static or single-component counterparts and as such, they hold higher potentialities in terms of
274 llular transport of vesicles and organelles, and as such, they play a role in neurological disease, c
275 s can lead to excitotoxic cell damage/death, and as such, they play a role in numerous neuropathologi
276 ing the translation of mRNA of target genes, and as such, they play an important role in plant develo
277 les in orchestrating immunity and tolerance, and, as such, they are key targets for immunotherapy.
278 y somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in norm
280 e continuously threatened by pathogen attack and, as such, they have evolved mechanisms to evade, esc
281 in-induced Akt activation in hepatic tissue, and, as such, they question any nonredundant role for Tr
282 t depend on intact and dynamic microtubules, and, as such, they represent downstream targets of micro
283 ms were specific examples of complex systems and, as such, they should display characteristics includ
284 oved resolution in frequency-domain signals, and as such, this result is important for more efficient
285 in kidney transplant patients is warranted, and as such, this review will focus on the incidence, su
286 lective high-affinity molecular recognition, and as such, this system provides a fascinating challeng
287 e in the rate of ATP synthesis in the retina and, as such, this decline may be linked to the progress
288 hereby preventing viral entry into the cells and, as such, this study demonstrates a potential new st
289 o primary and acquired erlotinib resistance, and as such, treatments based on EGFR inhibition may not
290 ation and intercellular movement of viruses, and as such, understanding viral assembly has great pote
291 Fox genes are associated with human disease and, as such, various animal models have been generated
292 an effective strategy for prevention of GVHD and, as such, warrants consideration for future clinical
293 displays a superior pharmacokinetic profile and, as such, was more effective in both the acute murin
294 existence of a stable multiprotein complex, and as such, we evaluated whether the MDM2 Nutlin had si
295 both mechanical and electrical stimulation, and as such, we foresee it finding applications in the s
296 g the innovation systems of both industries, and as such, we suggest potentially useful changes to th
297 is of major importance for decision making, and, as such, we emphasize the need for the functioning
298 ely show clonemate cotransmission into ants, and, as such, we find support for kin selection to drive
299 lane images (Z stacks) throughout a specimen and, as such, we report here the successful development
300 functions may be remnants from the RNA world and, as such, would be part of the evolutionary past of