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1 n the rapid retraction of the spreading drop and thereby a more than twofold decrease in contact time
2 Ship1 inhibition enhanced calcium signaling and thereby abrogated an anergic response to BCR stimula
6 ulum (ER)-based protein folding in the heart and thereby activates an unfolded protein response senso
9 ion imaging systems, could be used to access and thereby advance our understanding of supercoil dynam
10 hat governs immune-response gene expression, and thereby advocate targeting PD-L1 translocation to en
12 s, suppress recognition of other substrates, and thereby affect degradation of its menu of substrates
13 trate cell-type-specific expression patterns-and thereby affect phenotypically relevant molecular pat
15 xibility of residues involved in SAM binding and thereby affects the molecular mechanism of riboswitc
16 es the conformational states sampled by OMPs and thereby affects their recognition by both chaperones
17 of vaccines, immunization and related issues and thereby aims to inform a broad scientific audience a
21 wth by activating similar signaling in vivo, and thereby also improve responsiveness to immune checkp
24 that interact with ATI protein in inclusions and thereby anchor the complex for multiple rounds of mR
25 D8(+) T cells impairs TCR-driven activation, and thereby anti-tumor effector responses, tantamount to
26 tants for experimental studies of resistance and thereby assist in the development of next-generation
28 ates the activity of protein phosphatase 2A, and thereby attenuates the phospho-Ser-127 modification
29 onferred GA 3-oxidase activity to CsGA1ox/ds and thereby augmented its potential to form bioactive GA
31 e hepatic portal and peripheral circulations and thereby avoid the complications of life-long insulin
32 viral restriction factor TDRD7 inhibits AMPK and thereby blocks HSV-1 replication independently of th
33 nd abrogates AM-dependent bacteria clearance and thereby causes extreme susceptibility to pneumococca
34 that can lead to the failure of body organs and thereby causing damage to the tissues resulting in d
36 hilic olefin facilitates chloride ionization and thereby circumvents simple elimination pathways.
37 lls, significant disruptions in myelination, and thereby cognitive and behavioral disabilities seen t
38 imensional (2D) (15)N-(1)H NMR correlations, and thereby combining an enhanced spectral resolution wi
39 itor, upregulates inflammatory genes in DTPs and thereby confers susceptibility to anti-inflammatory
40 ere also present in >=7 affected individuals and thereby considered to be of sufficient high confiden
41 nced as differences in the gFET conductivity and thereby constituted the signal transduction mechanis
42 nevertheless impairs the function of B cells and thereby contribute to the failure to produce neutral
43 ant larval subsidies to neighboring habitats and thereby contribute to the long-term sustainability o
44 show that the Reissner fiber acts on CSF-cNs and thereby contributes to establish body axis morphogen
46 upling with near-zero hole-transfer coupling and thereby contributes to the lowering of charge-transf
47 amplifying the motion of the organ of Corti, and thereby contributing to the sensitivity of mammalian
48 s induce DELLA repressor protein degradation and thereby control a number of critical developmental p
49 which CDK substrate phosphorylation occurs, and thereby control the temporal ordering of cell cycle
50 , SCF(FBXW7) targets HsSAS-6 for degradation and thereby controls centriole biogenesis by restraining
51 rmation of the adaptor protein Collybistin-2 and thereby controls Collybistin-2-interactions with pho
52 urn creates intranuclear polarity in emerin, and thereby controls nuclear actin filaments that spatia
54 CysC is upregulated under obesity conditions and thereby counteracts inflammation of peripheral insul
55 selectively reduces oxidized actin monomers and thereby counteracts MICAL1, an enzyme known to depol
56 ration-quiescence decision in daughter cells and thereby couples protein production with cell prolife
58 tion of COVID-19 patients in an early stage, and thereby, decelerating or even preventing the spread
59 r of PG polymerization by the FtsWI synthase and thereby define an essential regulatory step in the p
60 d provide an experimental system to separate and thereby define the cytoplasmic and nuclear stages of
61 e angiogenic process in normal dermal wounds and thereby delays healing, whereas the stimulation of d
62 S. rosetta C-type lectin gene, rosetteless, and thereby demonstrate its necessity for multicellular
63 to monitor liver-attenuation more accurately and thereby detect liver steatosis as a sign of liver da
65 systematic investigation of the above issues and thereby development of optimal strategies for accura
68 iation is shaping patterns of introgressions and thereby directly influences the consequences of link
70 hat GPR139 functions via the G(q/11) pathway and thereby distinctly regulates cellular effector syste
71 a conformation that does not bind nucleotide and thereby down-regulates ATP hydrolysis of the complex
72 x that activates C-terminal Src kinase (CSK) and thereby down-regulates kinases involved in proximal
73 up or down, altering viscoelastic properties and thereby driving immiscibility between different cond
74 bound HSP70 dimers, which leaves them intact and thereby eliminates an inhibitory effect of TOMM34 on
75 TMO alkylates RNA at high levels in seconds, and thereby enables time-resolved, single-molecule, thro
76 ity to accommodate other types of omics data and thereby enabling multi-omics comparison and visualiz
77 in tumour B cells from patients with cancer and thereby enabling them to prime T cells, we develop a
78 ing dramatic reductions in acquisition times and thereby enabling us to probe fast interaction kineti
79 the newly identified RBD mutations cooperate and thereby enhance affinity with the effector-binding s
80 unction may contribute to AXL overexpression and thereby enhance AXL-dependent downstream signaling a
82 mpaired allospecific memory T cell responses and thereby enhanced donor hematopoietic chimerism and T
83 diminishes features of plaque vulnerability and thereby enhances plaque stability in advanced lesion
84 get effects, decreasing unwanted toxicities, and thereby enhancing a drug's therapeutic efficacy.
86 nd that CRT regulates energy balance in IECs and thereby epithelial integrity and barrier function.
89 reciprocal space in this class of materials, and, thereby, establish PdGa as an ideal topological chi
90 l death, inflammation, and immune responses, and thereby exert both adaptive and maladaptive roles in
92 at late stages will reduce synthetic effort and thereby expedite broader exploration of the magic me
93 performance fall short to accurately predict and thereby explain the actually observed development pa
94 ijack cellular WW domain-containing proteins and thereby exploit the modular functions of these host
95 pyl transferase catalyzing this modification and thereby extend the list of known tRNA modification e
96 oss-bridge the corral-bound LYVE-1 molecules and thereby facilitate leukocyte adhesion and transmigra
97 inding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subseq
98 sist whole genome sequencing of P. malariae, and thereby facilitate the implementation of much-needed
99 ess might increase developmental flexibility and thereby facilitate the rapid evolution and expansion
100 amounts of H(1) and H(2) in a confined space and thereby facilitating the HCR amplification analysis
102 dwork for a more coherent concept of empathy and thereby for a more fruitful debate over the role of
104 trate the potential to generate new myocytes and thereby fulfill an essential central criterion for h
106 p)(3) in an expanded-pore framework analogue and thereby gain additional insight into the O(2) adsorp
107 ful tool to tune intermolecular interactions and thereby gain an extra level of control over the soli
108 s prior to submitting their viral sequences, and thereby gain confidence that their submissions will
109 these nanomachines under turnover conditions and thereby gain detailed mechanistic insights into thei
110 n be used on adolescent DNA methylation data and thereby generate a score for in utero cigarette smok
111 bility to perform insertion/deletion editing and thereby generate mature forms of some mitochondrial
112 the low cholesterol concentration of the ER and thereby has an essential role in cholesterol homeost
114 rts a synergistic effect on PDCD4 expression and thereby helps maintain a balance between inflammatio
115 evates the toe box dorsally above the ground and thereby holds the toes in a constantly dorsiflexed p
116 ls how key proteins are delivered to the AIS and thereby how they may contribute to its functional pl
118 tations constituting the GRI parameter space and thereby identify the optimal design ranges that yiel
119 ve receptor recognition by meningococcal Tfp and thereby, identify a potential antibacterial target.
120 hogenic effect of LRRK2 on protein synthesis and thereby impact neuronal loss is a key unresolved que
121 ptic transfer function to second-order cells and thereby impacts retinal signal processing during the
122 ulates the position of the coding nucleotide and thereby impacts the identity of the incoming nucleot
123 tion primarily to inhibit projection neurons and thereby impose network gain control, an important bu
127 groups on the surface of fullerenes (C(60)) and thereby improve the solubility of the fullerene in p
132 pression of thrombin-induced phosphorylation and thereby inactivation of Cofilin1, an actin-depolymer
133 sts (RBF; <30 years) near human communities, and thereby inadvertently increased the risk of wildfire
134 nsion for both signal extraction and scoring and thereby increase the specificity for precursor ident
137 increases perceptions of the virus's growth and thereby increases support for social distancing.
139 maturation and separation at mitotic entry, and thereby increases the frequency of mitotic errors.
140 fraction effects or other diffraction planes and thereby increases the sensitivity by reducing the (s
142 oadens the coverage of milk oligosaccharides and thereby increases utility use of a spectrum library-
143 rel3 missense variants on synapse formation, and thereby, increases understanding of the complex etio
144 entrations and decreasing AT BCAA catabolism and thereby increasing plasma BCAA concentrations.TRIAL
147 SUMOylation inhibitors rescue FXR signaling and thereby increasing the efficacy of OCA against HSC a
148 ticoids directly up-regulate DPP4 expression and thereby induce migration in macrophages, potentially
149 where they can be placed at the Fermi energy and thereby induce new correlated electronic phases in t
152 cifically, CDC42u stimulated mTORC1 activity and thereby induced neuroprogenitor formation, whereas C
153 lates the harm threatened by a common enemy, and thereby induces a phoretic mite to become a protecti
157 ize C-terminal acidic sorting motifs in AATs and thereby instructs Rsp5 to ubiquitinate proximal lysi
158 for the greenhouse effect and energy crisis, and thereby it plays a critical role in solving environm
159 and increasing TREM2 cell surface expression and thereby its function(s) might have therapeutic benef
160 itions by improving uteroplacental perfusion and thereby justify further investigation into PPARgamma
161 olled LAMTOR targeting to the cell periphery and thereby late endosome recycling and had a major impa
164 he interaction of the CaM N-domain with RyR2 and thereby likely cause the arrhythmogenic phenotype of
165 s as a gatekeeper of presequence translocase and thereby maintains quality control of inner membrane
167 nscriptional regulation, and RNA processing, and thereby mediating developmental and metabolic proces
168 tor (TNF-alpha) and interleukin-1 (IL-1beta) and thereby mimicking the chronic neuroinflammatory envi
169 using best-practice Web security approaches and thereby minimize risks of unauthorized data access a
170 oteins to remain mainly in the reduced state and thereby minimizes potential futile oxidation-reducti
172 phytoene synthesis and carotenoid transport and thereby modulates carotenoid accumulation in the chl
173 and utilization of the reactive, changeable, and thereby 'moldable' nano-sized inorganic phases by mi
175 a role in influencing intracellular chloride and thereby neuronal parameters such as membrane potenti
177 ic Meridional Overturning Circulation (AMOC) and thereby northward heat transport to the Arctic.
179 senger RNA (mRNA) transcripts they regulate, and thereby often fail to identify the cellular processe
180 had direct positive effects on root biomass, and thereby on microbial growth and microbial biomass ca
183 oscope's ability to block out-of-focus light and thereby perform optical sectioning through a specime
184 cants may also impair cholesterol metabolism and thereby possibly contribute to neurodevelopmental to
185 pamycin may extend the benefits of ketamine, and thereby potentially sheds light on mechanisms that c
186 fast decay from the LES to the ground state and thereby preclude detection of the CSS and the invert
187 ing mechanisms from being explicitly tested, and thereby precludes meaningful predictions on the cons
188 ng of MED12 remodels the active site of CDK8 and thereby precludes the inhibition of ternary CDK8 com
193 d that GS-6207 inhibits HIV-1 by stabilizing and thereby preventing functional disassembly of the cap
194 xidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome
196 ntally enables nuclear NF-kappaB DNA-binding and thereby pro-inflammatory responses in monocytes and
200 growth factor beta (TGFbeta)-dependent genes and thereby promote growth and survival of human TNBC ce
203 rylation and the uncoupling EphB1 from Cav-1 and thereby promoted phosphorylation of Cav-1 by Src.
204 cNAcylation inhibits PKM2 catalytic activity and thereby promotes aerobic glycolysis and tumor growth
205 override host control of a sensory decision, and thereby promotes fitness of both the host and the mi
207 structures in the bacterial plasma membrane and thereby promotes rapid permeabilization of the plasm
209 tivation recruits the second messenger NAADP and thereby promotes the opening of Ca(2+) -permeable tw
210 limit tumor progression by stabilizing LATS and thereby promoting activity of the Hippo tumor suppre
211 steoclast number by attenuating respiration, and thereby, promoting mitochondrial apoptotic death of
214 s indicate that REST activates TH expression and thereby protects neurons against Mn-induced toxicity
215 p in mesotrypsin decreases protease activity and thereby protects the pancreas against unwanted SPINK
216 demonstrate that human transcript diversity (and thereby protein isoform diversity) remains under-cha
217 compute sequence-specific percolation lines and thereby provide a thermodynamic framework for harden
218 echanism to antagonize the infection of RSV, and thereby provide the first evidence that autophagy ca
219 d identification of correlates of protection and thereby provides a small animal experimental framewo
220 e on the spirally-configured leading strand, and thereby pull the preceding DNA segment through the d
221 tions of temperature-corrected growth rates, and thereby quantifying the influence of factors other t
222 t least two mechanisms: by complexing Fe(2+) and thereby raising pe, and by making hematite more nega
224 gh per-dot Mn contents (>30% of all cations) and thereby realize exceptionally strong exciton-Mn exch
225 promote rapid Cdk8-dependent Notch turnover, and thereby reduce Notch-dependent transcription at othe
226 y modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure an
227 als can avoid phase changes in such mixtures and thereby reduce the energy intensity of these thermal
228 y low mate densities did best to move slowly and thereby reduce the risk of missing their stray partn
233 lation and inhibition of Kv3.1beta channels, and thereby reduces the firing of the parvalbumin neuron
234 erates by inhibiting the destruction complex and thereby reducing destruction complex-phosphorylated
239 hat interacts with numerous binding partners and thereby regulates fundamental biological processes.
242 increases or decreases replication capacity, and thereby replication rates, thus shortening or length
243 a significant role in the infection process and thereby represent promising antivirulence targets.
244 vents, or as propagating intercellular waves and thereby represent the substrate for astroglial excit
246 ctions of how climate change will alter FLSs and thereby reshape plant communities and ecosystems.
248 its neutrophils to the site of tissue damage and thereby results in a positive feedback loop, amplify
249 may be useful in overcoming these drawbacks and thereby reveal the full potential of bacteriocins.
250 rately count, distinguish by molecular mass, and thereby reveal the relative abundances of different
252 nd EPFL9 help to coordinate ovule patterning and thereby seed number with gynoecium and fruit growth
253 ential expression in the glandular trichomes and thereby seem to be potential candidate genes for fut
256 tical layers represent perceptual hypotheses and thereby shed light on the computational architecture
257 leviating the need for dilute MB injections, and thereby shortening the acquisition time of ULM imagi
258 biostrip offers a limit of detection of 10pM and thereby shows great promise for detection of DA leve
259 and Ag, which lowers the d-band center of Pd and thereby significantly enhances its CO tolerance, as
260 tic splice sites into the nascent transcript and thereby significantly expand the neural transcript r
261 on-linear, long-term dynamics of vegetation, and thereby soil organic matter, that occur in response
263 polysulfides target the caspase-9/3 cascade and thereby suppress cancer cell apoptosis, and highligh
264 subunit 2 (TSC2) exploit the PLD-PA pathway and thereby sustain mTORC1 activation at the lysosome in
265 GAPDH, NAMPT can translocate to the nucleus and thereby sustain the stress-induced NMN/NAD(+) salvag
267 e composition, microstructure and dimensions-and thereby the catalytic activity-of the nanofibres wer
271 ria gain access to the systemic circulation, and thereby the placenta, resulting in local inflammatio
272 ause migraine attacks are hardly predictable and thereby the premonitory phase is difficult to catch,
274 driving lytic granule fusion at the synapse and thereby the release of perforin and granzymes toward
275 chromatin fluidity, the structural behaviour and thereby the role/function of the N-terminal domain (
276 acterized, those that maintain the symmetry, and thereby the stability of the synapse, remain unknown
277 site, thus making Tyr74 more easily exposed and thereby the target for a second phosphorylation step
278 f pepsin at the food-gastric fluid interface and thereby the total amount of pepsin in the food parti
281 eukocyte integrins in adhesion and migration and, thereby, their significance for hemostasis and immu
282 hibited expression of NF-kappaB target genes and thereby thwarted progression of disseminated HL-60 l
285 to the discovery of new catalytic processes and thereby to one of the fastest growing areas of organ
286 cterial load associated with hRV coinfection and thereby to prevent secondary NTHI-induced diseases o
287 age, and fracture in concrete infrastructure and thereby to reduce indirectly the enormous carbon foo
288 n landscape contributing to loss of function and, thereby, to hepatic copper toxicosis in Wilson dise
289 ssive cerebrospinal fluid (CSF) accumulation and thereby treated with neurosurgical CSF diversion wit
290 y 38 member 9 (SLC38A9) destabilizes the LFC and thereby triggers GAP activity of FLCN:FNIP2 toward R
291 ole of miRNAs on proliferation and apoptosis and thereby uncover the key miRNAs during the process of
294 stimulates mTOR complex 1 (mTORC1) activity and thereby up-regulates transcription factors required
295 ater matrixes (tap, river, and groundwater), and thereby validated for repeatability (RSD% 1-10%), ac