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1 undational description of the virus kinetics and thus a deeper understanding of their clinical manife
3 pathway for accurate antibiotic prescribing and thus a novel route to tackling the global challenge
4 utor to early oligomer and fibril formation, and thus a potential critical mechanism in the etiology
6 logic PDAC therapies confer marginal benefit and, thus, a significant unmet clinical need exists for
7 t are exposed on the surface of a nucleosome and thus access silent genes that are inaccessible to ot
8 sychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to
10 ets or Gpx4 depletion promotes 8-OHG release and thus activates the TMEM173/STING-dependent DNA senso
13 eral previously unexplained features of SWRs and thus advances the understanding of memory-related dy
15 kinase, leading to eIF2alpha phosphorylation and thus affecting the status of the cytosolic protein s
17 gands can thus promote RNA folding in cells, and thus allow single mRNA imaging with fluorogenic apta
18 d by SIRT1, which promptly inactivates OTUD3 and thus allows timely induction of innate antiviral imm
19 helped in shielding the two opposite charges and thus also the high polarity of zwitterions with sepa
20 nging the density of several ionic currents (and thus AP repolarization) causing altered Ca(2+) dynam
21 reater than in age- and sex-matched controls and thus appears to represent a transitional state from
22 CO(3) (-) and NaCl reabsorption in the mTAL, and thus are at the nexus of the regulation pathways for
24 eceptors for autophagy-mediated ER turnover, and thus are critical for ER homeostasis and suppression
25 e, are painful and cover small surface areas and thus are not suitable as a long-term treatment optio
26 attachment and subsequent biofilm formation, and thus are promising in circumventing bacterial infect
27 ow levels or only under specific conditions, and thus are underrepresented in non-tissue-targeted or
28 yclones are increasing in intensity and size and, thus, are poised to increase in importance as distu
32 ative representation and precision medicine, and thus, automatic ranking to figure out the most infor
35 wed with a distinct pharmacological profile, and, thus, be targeted to develop innovative pharmacolog
36 V13 followed by PPSV23 is safe, immunogenic, and thus beneficial in the majority of IBD patients, tho
37 des that contain more of the native sequence and thus better mimic the oligomers formed by full-lengt
38 he rapid optimization of DAR for a given ADC and thus better understand its potential toxicity and po
39 gic parameters indicates that blood function and thus blood cell integrity were maintained throughout
42 ases of experimental data in related systems and thus can be applied to the study of agents with unch
43 ed on simulated and real human genomic data, and thus can be practically used for privacy-preserving
44 lets can be related with the presence of HTN and thus can be used as a biomarker to detect this medic
45 traviolet light by the lens of the human eye and thus can be utilized to discover defects in vitamin
46 ing retrograde actin flow to the environment and thus can potentially operate interchangeably and sim
47 gene expression that affect cancer behaviour and, thus, cancer progression, growth or establishment.
48 ecorate NETs are in an inactive conformation and thus cannot participate in further catalytic events.
50 the abundance of ABC transporter A1 (ABCA1) and thus cholesterol efflux and increasing the abundance
51 lationships limits experimental development, and thus computation is necessary to guide the structura
52 reversal potential determines ion occupancy, and thus, conductivity, of the selectivity filter gate t
54 y exert axon guidance and nerve regeneration and thus contribute to the stability of the peripheral n
55 s, XBP-1s may directly upregulate KSHV ORF21 and, thus, contribute to the pathogenesis of KSHV-MCD an
56 leakage of deeply sequestered carbon dioxide and thus contributed to the lower atmospheric carbon dio
57 o phagocytes and activated endothelial cells and thus contributes to the anaemic and ischaemic compli
59 ating therapies are all orally administered, and thus convenient for patients, they have different mo
61 has benefits for abatement of predation risk and thus could have been driven by fear of predation ove
62 nly occur in supine and sleeping conditions, and thus, CSR treatment is applied to those specific sta
63 neurons in which tyrosine hydroxylase (TH), and thus DA biosynthesis, was conditionally ablated usin
64 their presence would inform recurrence risk and thus decisions on anticoagulation duration has large
66 mulations of off-flavour volatile substances and thus demonstrated the best retention of sensory and
67 cruitment of diacylglycerol binding proteins and, thus, differing downstream phosphorylation patterns
68 a single motor to perform simple operations and thus do not fully utilize the potential of the Maker
70 ight heavily contribute to microbial biomass and thus drive the responsiveness of arctic ecosystems t
71 ween the plastic and its surrounding milieu, and thus drives every interaction that this synthetic ma
73 localization, which is generally overlooked and thus emphasize the need to use cellularly derived an
74 promote binding of inosine without cleavage and thus enable high affinity capture of inosine in RNA.
77 B permeability in murine glioblastoma models and thus enhance the release of tumor-specific biomarker
78 cortical space which likely aids processing and thus enhances performance on intact sensory systems.
79 loop decreases breast cancer aggressiveness and thus enhances the efficacy of antiangiogenic therapy
80 e file line, keeping the cells from clumping and thus ensuring equal exposure to the laser irradiatio
82 fic function to rpl10a in the immune system, and thus exemplify the advantages of the zebrafish model
84 serve to increase JMS-053's plasma half-life and thus extend the delivery of the compound to tumors.
85 ion was used to amplify the detection signal and thus extend the dynamic range of the quantitation.
86 imental analogue models of dyke propagation, and thus facilitate a better understanding of the seismi
87 to ensure the survival of infected monocytes and thus facilitate viral dissemination within the host.
89 l to retrieve ENM-related hazard information and thus fill knowledge gaps in a comprehensive way in r
90 proach for the identification of active SHs, and thus for deciphering the role of lipid homeostasis d
93 arge of H1N1 HA can explain this discrepancy and thus further associate electrostatic charge with imm
94 the effect of rotational axis position (RAP and thus g-gradient) during short-arm human centrifugati
95 ed us to track the movements of traffickers, and thus gain a better understanding of illegal trade ro
96 ace (PES) associated with chemical reactions and thus govern reactivity trends and regioselective pre
97 anized assembly of single cells into tissues and, thus, govern the development and physiology of mult
98 ssure, leading to reduced effective pressure and thus greater acceleration when compared to thicker i
100 dation products under atmospheric conditions and thus greatly affect their atmospheric transport and
101 lated into different functional proteoforms, and thus greatly increase the functional diversity of pr
102 atic in n, the length of the input sequence, and thus greedy heuristics are applied to speed up the e
105 ya salminicola, has no mitochondrial genome, and thus has lost the ability to perform aerobic cellula
106 is usually driven by pan-neuronal promoters and thus has not been selectively targeted to LC neurons
108 s may reduce the diversity of study samples, and thus have an impact on the generalizability of scien
109 g imaging agents possess "always-on" signals and thus have poor signal correlation with immune respon
110 "druggable" in a direct pharmacologic manner and thus have proven difficult to target in the clinic.
111 reactivates backtracked elongation complexes and thus helps suppress their interference with replicat
112 -vitro data suggest that high concentrations and thus high doses are needed for COVID-19 infections,
113 , generating different mobile acidic protons and thus high on/off photoswitchable proton conductivity
114 maintaining fast excitation energy transfer, and thus high trapping efficiency, within the complex.
115 ivalent to about 0.5-1% of fatty acids (FAs) and thus higher than typically found in human milk and c
117 how precisely where these interactions occur and thus improve our understanding of cellular regulatio
118 of solar irradiance is converted into heat, and thus improved heat removal becomes an important fact
119 the ear, the brain, the blood, and the lung, and thus in highly diverse and dynamic environments.
123 3 association with select target transcripts and thus indirectly stabilizes mRNA of a known virulence
124 er intervals and reporting a single blended (and thus inflated) estimate for the average increase in
126 suppresses coordinated electrical activity (and thus insulin secretion) in the rest of the islet.
128 a small molecule with defined rate constants and, thus, K(d) of their interaction-allowed us to asses
129 may improve functional outcome and survival, and thus knowledge on MRI features of treatment-associat
130 thought to be relatively inert (unreactive) and thus leach small amounts of polyaromatic hydrocarbon
132 gnetic alignment in structured environments, and thus likely confers a selective advantage in natural
133 ns, indicating that they are surface located and thus likely involved in the initial step in mucin br
134 ll experience the biggest temperature swings and thus likely see the most changes to host-parasite dy
135 natural biological effects (no larval phase and thus limited larval dispersal) and putative anthropo
136 t biotic competition restricts resource use, and thus limits realized niche breadth and geographic ra
137 cant risk factor for cardiovascular disease, and, thus, limits its application for the treatment of o
138 h non-European ancestry remain understudied, and thus little is known about the genetic architecture
139 e not identified in the overgrown cartilage, and thus local cartilage overgrowth likely results from
140 ed highly consistent with bactericidal rates and thus MALDI-TOF MS might be able to replace the LB ag
141 s that mimic cues used in nonsexual contexts and thus manipulate female behavior to generate mating o
143 14q32, modulate this immunoevasion strategy, and thus may act as effect modifiers of the HSV1-AD asso
144 ring at temperatures above room temperature and thus may be considered the first crystalline steroid
145 bers of the FHL family can bind to CHIKV HVD and thus may be involved in viral replication.IMPORTANCE
146 abilities may rely more on auditory feedback and thus may be less adept at updating their stored moto
147 in a significant number of plastic particles and thus may be major conduits of microplastics to lake
148 down-regulation of key fibrogenic mechanisms and thus may have an important role in limiting fibrosis
151 numerous G protein-coupled receptors (GPCRs) and thus mice lacking the stimulatory subunit of G-prote
152 chtii ACC by RNAi induced similar phenotypes and thus mimics the effects of SPT-enol, supporting the
153 ays a significant role in cancer progression and thus modeling it will advance our understanding of c
154 igenic mutations in both summers and winters and thus monitoring the virus in both seasons may be imp
155 7 degrees C, leading to more folded Broccoli and thus more fluorescent Broccoli-BI complexes in cells
156 are smaller in size than competing methods (and thus more interpretable) and are significantly enric
157 re mitochondrial inner membrane surface area and thus more protonic capacitance for transmembrane-ele
158 ound to be more sensitive among the studies, and thus more suitable for diagnostic screening studies.
159 tify those tumors with the most elevated LIP and thus most likely to succumb to LIP-targeted interven
160 red by RECON MSD over multiple conformations and thus multiple local residue environments during desi
161 has different functions throughout infection and, thus, must be temporally and precisely regulated fo
162 to regulate exposure of myosin-binding sites and, thus, myosin cross-bridge recruitment and force pro
163 ver, the inability to control axon guidance, and thus neuronal network architecture, has limited inve
165 ients with epilepsy are treatment resistant, and thus new, more effective therapies to achieve seizur
166 ctable outcome representations were unstable and thus non-decodeable, due to spurious negative correl
168 naturally pro-angiogenic and proreparative, and thus numerous techniques have been attempted to impr
169 tion of peripheral insulin-sensitive tissues and, thus, obesity-associated deterioration of glucose m
171 ed changes of the levels of several proteins and thus of the metabolic pathways linked to the early a
172 (N) that could stimulate plant productivity and thus offset soil carbon losses from tundra ecosystem
173 efficacy, convenience and tissue penetrance, and thus often offer important advantages over biologics
174 lations requires extensive isolation efforts and thus only rarely covers large geographic areas or ti
175 for spatially directed behavioral responses and, thus, only after remapping must have taken place.
176 al path lengths, and short measurement times and thus outperforms previous research type EC-QCL setup
177 layers do not require any contact patterning and thus overcome the main drawback of insulating passiv
178 because they require less metabolic change, and thus perhaps also less genetic change than other cro
179 ole in purifying water from toxic impurities and, thus, played a role in the formation of the aquatic
180 od chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology.
182 dicative of beta-amyloid (Abeta) aggregation and thus potential biomarkers for Alzheimer's (AD).
183 ows for tuning of the polymer hydrophobicity and thus potentialize its behavior, including degradatio
184 olished after pharmacological PKA inhibition and thus potentially attributable to increased PKA activ
186 habenula (LHb) is hyperactive in depression, and thus potentiating inhibition of this structure makes
187 e based on today's acrotelm characteristics, and thus predict if those recent rates of C accumulation
190 to impact a small fraction of the tRNA pool and thus presumed to not directly impact translation.
191 apeutic venue to target the ageing phenotype and, thus, prevent or mitigate ageing-related diseases.
193 Nodes in a fiber have isomorphic input trees and thus process equivalent dynamics and synchronize the
196 caused by genetically engineered pathogens, and thus protect against the potential misuse of synthet
197 n the canonical 122 degrees C limit to life, and thus provide a rare opportunity to study the transit
199 lerates a great variety of functional groups and thus provides a simple and step-efficient method for
200 irs, performed excellently against all tests and thus provides a valuable component for machine-drive
202 and electronic properties of isolated atoms and thus providing a platform for tailoring heterogeneou
203 to modern health care's onerous bureaucracy, and thus pulls physicians from the most important humani
204 associated SNP, it may suggest a regulatory (and thus putative causal) role of the SNP mediated throu
205 g further the substrate load on proteasomes, and, thus, putting further stress on their capacity for
207 sed growth rates may shorten trees' lifespan and thus recent increases in forest carbon stocks may be
208 ere with normal K(v)11.1 forward trafficking and thus reduce functional K(v)11.1 channel densities.
210 hat defects in syntabulin-mediated transport and thus reduced formation and maturation of synapses ar
211 many MAGEs bind to E3 RING ubiquitin ligases and, thus, regulate their substrate specificity, ligase
212 brane fluidity governs the insertion of PlsX and thus regulates the biosynthesis of phospholipids in
214 s, nucleosides are lipid bilayer impermeable and thus rely on dedicated transport systems to cross bi
216 -L1-expressing triple-negative breast cancer and thus represent a novel class of drugs that mimic imm
218 of pregerminal center B cell self-tolerance and thus represents a druggable pathway to treat antibod
220 ely the first mammals to evolve eusociality, and thus required adaptations to conserve energy and tol
221 the interfacial shear stress to a high level and thus results in significantly enhanced load transfer
222 ng frost events induce farm gate price drops and thus revenue reductions of up to 2.05% per hour of e
223 outcome in patients after ischaemic stroke, and thus S44819 cannot be recommended for stroke therapy
224 er reduce available data or are error-prone, and thus, scalable methods that do not discard data and
225 Pin1 can establish BRCAness in cancer cells and thus sensitize cells to PARP inhibitor treatment.See
226 nemia or malaria), the mechanical properties and thus shape responses of cells to complex viscoelasti
229 (fMRI) are capable of resolving such changes and thus should be explored further as markers of diseas
231 have a lower lumenal pH than cgl160 mutants, and thus show substantially increased pH-dependent NPQ a
232 in good agreement with the experimental ones and thus show the potential of computational chemistry f
233 63 (Lys63)-linked polyubiquitination of MAVS and thus shuts off innate antiviral immune response.
234 hods for ligand-GPCR interaction recognition and thus significantly improves the coverage and sensiti
236 cal and/or non-canonical NF-kappaB pathways, and thus stimulates naive and co-stimulates IL-33-activa
237 structures for both homo and heterobilayers, and thus strongly suggests the nonexistence of the m-ter
238 the cell division rate of the studied cells and thus suggest an important role in context-specific o
239 hout any detectable change in gene sequences and thus suggest that chromosomal translocations alone m
240 s that are more common in high-ploidy tumors and thus support altered selection pressures upon WGD.
241 o degrade RNAs encoding growth-phase factors and, thus, support the maturation phase of oogenesis.
244 restation affects terrestrial energy cycling and thus surface temperature directly by altering surfac
245 mpatholysis are preserved in healthy ageing, and thus the age-related impairment in functional sympat
246 AP waveform has never been directly studied, and thus the AP waveform shape and propagation through t
248 t, we found that brain aromatase expression, and thus the capacity to synthesize neuroestrogens, rema
249 nmental variability affects species turnover and thus the change in BEF slope with scale; (5) connect
250 the composition of oceans and the atmosphere and thus the climate, the microbial world is bound to ch
251 w the high rates required for effective DBS, and thus the contribution of activation of STN neurons t
252 uence the longitudinal stiffness of the foot and thus the curvature-stiffness relationship of the tra
253 rin moieties over the surface of the devices and thus the detection limit of the devices has been ach
254 min during weekdays and ~25 min on weekends, and thus the difference between weekend and weekday slee
255 atial distribution of charge and spin states and thus the energy and dynamics of QD optical transitio
259 horn neurons are spinal projection neurons, and thus the majority of Tacr1(CreER) are local interneu
260 n affects Antarctic ice mass loss estimates, and thus the precipitation contribution should be unders
262 digital control of the processing parameters and thus the resulting alloy's microstructure, for examp
264 ve ROS1 inhibitors have yet to be developed, and thus the specific adverse effects of ROS1 inhibition
265 ed or derived from fluorinated electrolytes, and thus, the effect of the LiF source on Li electrode b
266 the application of very high electric fields and thus their EC strengths DeltaS(EC) /DeltaE and Delta
267 mes with the intracellular signaling network and thus their regulation is poorly understood; this als
268 lly depend on "inferred germline" sequences, and thus their relationship to authentic naive human B c
269 cognizing a large number of foreign antigens and thus, their genetic diversity plays a critical role
272 macodynamics of cocaine are derived in vivo, and thus this work has widespread implications for under
276 -CSF as a key inducer of the chemokine CCL22 and thus, to our knowledge, identify a novel role for th
278 ty was independent of motor-related activity and thus tracked specifically the learning of reward pre
280 associated with the ensuing negative outcome and thus trigger salutary turns on the subsequent trip.
281 ve almost identical electrochemical behavior and thus typically emit within approximately the same po
282 rise from accumulation in nanomineral phases and thus unambiguously reflect the primary composition o
283 can be carried out under mild acid catalysis and thus under far milder conditions than known so far.
284 ation of many viral and bacterial pathogens, and thus, understanding the mechanism of NSP2-mediated v
287 ired convective and diffusive O(2) delivery, and thus V O(2) , especially within fast-twitch oxidativ
289 present in a progenitor subspecies O. nivara and thus was acquired early during the evolution of rapi
290 ulated by the transcription factor Ppargamma and thus we identify a role of Ppargamma as regulator of
291 microfiltration membranes to resist fouling, and thus, we address a major challenge for oil-water sep
293 conserved short peptides) of each subfamily, and thus were further used to annotate new genomes for C
295 ur results are obtained in nonhuman primates and thus will play a leading role in driving the use of
296 licable to other types of cellular reactions and, thus, will be an indispensable tool for transformin
297 ncover that this interaction with ubiquitin, and thus with modified substrates, can be modulated by o
299 adaptive changes in single-species studies, and thus would be expected to show decreased constraint
300 ve acute EQS for at least one micropollutant and thus would have to rely on dilution by receiving wat