ライフサイエンスコーパス: androgenic

1 Is T-stimulated neuronal activation androgenic?

2 at are regulated by testosterone (T) and its androgenic (5alpha-dihydrotestosterone; DHT) or estrogen

3 s that could be potential in vivo targets of androgenic action during puberty.

4 In addition to the inhibition of androgenic activation of the AR, forced expression of FO

5 chemicals for their potential estrogenic and androgenic activities.

6 ndergone conventional biotreatment had lower androgenic activities.

7 Analyses included in vitro assays for androgenic activity (binding to goldfish testis androgen

8 onate-androst-5-ene-7,17-dione] that have no androgenic activity and could also block the Adiol-induc

9 t and wood GCI profiles were correlated with androgenic activity and neurotransmitter enzyme inhibiti

10 tenediol or Adiol) is a natural hormone with androgenic activity and that two potent antiandrogens, h

11 Reduced in vitro androgenic activity appears to be related to steroid rin

12 Because increased androgenic activity has been linked to prostate cancer a

13 itself may represent a natural hormone with androgenic activity in human prostate cancer cells.

14 tivity while having only moderate to minimal androgenic activity in vivo.

15 The androgenic activity of Adiol itself, however, is poorly

16 In vitro androgenic activity of the AD and T solutions decreased

17 ity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.

18 on levator ani muscle, dissociated from the androgenic activity on ventral prostate, after oral dosi

19 , but our workflow's prioritization based on androgenic activity prediction reduced the number of fea

20 reporter gene assays for estrogenic and anti-androgenic activity were performed on bottled water extr

21 to 4 mg/kg) administration of HB showed low androgenic activity when tested in the Hershberger assay

22 fects (cyto-genotoxicity, estrogenic or anti-androgenic activity) in vitro at relevant consumer-expos

23 All effluents and wood contained androgenic activity, particularly in nonpolar fractions,

24 ved from testosterone and have markedly less androgenic activity, promote tissue growth and enhance t

25 hat certain photoproducts retain significant androgenic activity, which has implications for exposure

26 ause hair loss may be a surrogate measure of androgenic activity-possibly a determinant of coronary a

27 the androgen receptor as well as the highest androgenic activity.

28 x-specific effects of phthalates having anti-androgenic activity.

29 rein is provided information on the anabolic-androgenic agents androstenedione, dehydroepiandrosteron

30 ne, one of the most commonly abused anabolic androgenic agents.

31 lyses conclude that finasteride treatment of androgenic alopecia (AGA) is safe but do not assess qual

32 receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

33 Acne and androgenic alopecia are prevalent but unreliable markers

34 onducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly

35 finasteride (Propecia) for the treatment of androgenic alopecia is unknown.

36 He was on treatment for androgenic alopecia with topical 5% Minoxidil applicatio

37 ed to treat benign prostatic hyperplasia and androgenic alopecia, but the role of 5alpha-dihydrotesto

38 HDL, and increased risks of prostate cancer, androgenic alopecia, spinal stenosis, and hypertension;

39 y been used for decades for the treatment of androgenic alopecia.

40 wing prolonged topical minoxidil therapy for androgenic alopecia.

41 tions, such as acne vulgaris, hirsutism, and androgenic alopecia.

42 wing prolonged topical minoxidil therapy for androgenic alopecia.

43 Synthetic androgenic anabolic steroids (AAS) are banned compounds

44 Androgenic anabolic steroids (AAS) are commonly abused b

45 Self-administration of large doses of androgenic-anabolic steroids (AAS) in a significant port

46 ranes as a potential site of intersection of androgenic and Akt1 signaling.

47 ve in established rodent models that measure androgenic and anabolic properties of these agents.

48 s, we evaluated associations between sixteen androgenic and corticosteroid metabolites during pregnan

49 As brain testosterone plays both androgenic and estrogenic actions due to its conversion

50 the fetal pancreatic responses to MI-TP, and androgenic and estrogenic contributions to such response

51 Both androgenic and estrogenic steroids have been implicated

52 differentially influence the availability of androgenic and estrogenic substrates, depending on the r

53 potential adverse events while retaining the androgenic and gonadotropin suppressive actions.

54 kinase may be an important new link between androgenic and growth factor signaling and a novel thera

55 yl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects

56 c acid biosynthesis and to the metabolism of androgenic and neuroactive 3alpha-hydroxysteroids.

57 Androgenic and pregnenolone steroids were significantly

58 The level of oestrogenic, androgenic and progestagenic activity observed is not co

59 (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects.

60 r action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo.

61 ed reporter gene assays revealed estrogenic, androgenic, and dioxin-like activity in AF extract corre

62 vitro bioassays for (anti)estrogenic, (anti)androgenic as well as retinoic acid- and vitamin D-like

63 s exclusively on testosterone, utilizing the androgenic C-19 methyl group as both the carbon source a

64 e ages of 4-13 years, a period marked by the androgenic changes of adrenarche.

65 were included in the analysis (61 women with androgenic COC use, 59 with antiandrogenic COC use, 60 w

66 ntial implications for the choice of current androgenic compounds and the development of future agent

67 represent potential markers for screening of androgenic compounds in the zebrafish embryo.

68 .6-4.8 ng DHTEq L(-1)) but concentrations of androgenic compounds were largely unable to account for

69 ctive and inactive nucleosomes under varying androgenic conditions showed that the relative CK2 activ

70 These results provide new insights into androgenic control of c-Fos and use of PKC inhibitors in

71 rostate growth and differentiation are under androgenic control, and prior studies suggested that tum

72 our model by using in vitro and in vivo anti-androgenic data for procymidone, vinclozolin, and linuro

73 (S)-7c exhibited an overall partial androgenic effect but full anabolic effect via oral admi

74 gene, whereas, we provided evidence that the androgenic effect is mediated by E2F1 protein through a

75 ications on 17beta-HSD3 inhibitory activity, androgenic effect, and metabolic stability.

76 apoptosis, and present a new model for this androgenic effect.

77 emicals individually for their possible anti-androgenic effect.

78 nism and can be used as a measure of central androgenic effect.

79 hromosome-encoded oncogene in addition to an androgenic effect.

80 Importantly, minimal androgenic effects (increased tissue weights) were obser

81 these chemicals have been shown to have anti-androgenic effects both in vitro and in vivo.

82 on, fairly little attention has been paid to androgenic effects in a female system, and even fewer st

83 gestins, such as levonorgestrel (LNG), exert androgenic effects in mammals by activating the androgen

84 ood testosterone levels or produces anabolic androgenic effects is not known.

85 rogen in fish supporting the contention that androgenic effects of certain progestins contribute to t

86 l and laboratory changes primarily reflected androgenic effects of prasterone.

87 Androgenic effects were found at LNG concentrations >/=4

88 steroid hormones leads to estrogenic and/or androgenic effects which may be important in age-related

89 Tibolone has estrogenic, progestogenic, and androgenic effects.

90 otective action on mammary gland may involve androgenic effects.

91 to modulate estrogenic, androgenic, and anti-androgenic effects.

92 an mixture risk assessment approach for anti-androgenic exposures in fetal life.

93 FL-AR to drive cell growth and expression of androgenic genes.

94 Through molecular screening of an androgenic gland (AG) cDNA library prepared from the cra

95 In isopods, the Insulin-like Androgenic Gland hormone (IAG) induces male differentiat

96 linked duplications of the gene encoding the androgenic gland hormone, a major component of male sexu

97 m the first larval stage on, long before the androgenic gland primordia begin to differentiate, and e

98 ould prevent an autocrine development of the androgenic glands so that females differentiate instead:

99 rate for the first time that p66Shc mediates androgenic growth signals in androgen-sensitive human pr

100 ), which is transcriptionally induced by the androgenic hormone 5alpha-dihydrotestosterone (DHT).

101 tic prostate epithelial cells in response to androgenic hormones and has found widespread use in canc

102 Genes regulated by androgenic hormones are of critical importance for the n

103 tress conditions, such as trauma-hemorrhage, androgenic hormones have immunosuppressive effects, lead

104 hese data suggest that DHT and perhaps other androgenic hormones may protect normal females against t

105 Androgenic hormones modulate the production of reproduct

106 NA in situ hybridization and is regulated by androgenic hormones.

107 d sensitivity to and endogenous synthesis of androgenic hormones.

108 ostate gland is an important target organ of androgenic hormones.

109 ivity, but testosterone is both anabolic and androgenic in doses that adolescents might receive.

110 rogen, whereas multi-copies of motif A exert androgenic inducibility for a heterologous promoter inde

111 G had a significant inhibitory effect on the androgenic inducibility of the PSA promoter.

112 These data suggest that the androgenic induction of endothelial MMP2 is a critical r

113 n PCNA immunoreactivity, suggesting that the androgenic induction of PCNA is mediated through the and

114 ately 60%) in prostate cancer (CaP) leads to androgenic induction of the ETS-related gene (ERG) expre

115 bird vocal control center, HVC, requires the androgenic induction of vascular endothelial growth fact

116 oncentrations may not accurately reflect the androgenic influence within specific tissue microenviron

117 Our results suggest androgenic influences on clinical progression of breast

118 ver, moieties modulating the actions of this androgenic insulin-like growth factor were yet to be rev

119 Androgenic male sex hormones, such as testosterone, migh

120 s were sensitive to testosterone but not its androgenic metabolite dihydrotestosterone.

121 oupled with the documented effects of DHEA's androgenic metabolites on visual-spatial performance, su

122 cations have been ascribed to compounds with androgenic or estrogenic properties, little attention ha

123 analogs exhibit estrogenic, antiestrogenic, androgenic, or antiandrogenic effects by influencing est

124 Direct estrogenic, androgenic, or steroidogenic mechanisms are unlikely for

125 artial borderline tumor), one patient had an androgenic ovarian tumor and two patients had hyperreact

126 male ovine fetuses to model excess prenatal androgenic overexposure associated with conditions such

127 estosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway

128 ultraviolet radiation or indicate a role for androgenic pathways in the pathogenesis of skin cancers.

129 otential to interact with the estrogenic and androgenic pathways, and could help prioritize chemicals

130 that adult male S. parvus maintain a unique androgenic phenotype, in which androgen receptor (AR) in

131 enzyme catalyzing estrogen biosynthesis from androgenic precursors, can be labeled in vivo with (11)C

132 responsible for catalyzing the production of androgenic precursors, while CYP19 converts testosterone

133 Both men and women produce E2 locally from androgenic precursors.

134 Oestrogenic, androgenic, progestagenic and glucocorticoid activity wa

135 NT-PGC-1alpha is sufficient to link beta(3)-androgenic receptor activation to adaptive thermogenesis

136 us, shaping of the EOD waveform involves the androgenic regulation of a rapidly inactivating splice f

137 However, the molecular mechanism underlying androgenic regulation of Bcl-2 in prostate cancer cells

138 APK), PI3K, and PKCdelta are involved in the androgenic regulation of c-Fos through controlling MEK/E

139 However, an investigation of the androgenic regulation of PCNA protein stability indicate

140 Androgenic regulation of Wnt signaling has been reported

141 liver specificity of the rat Std gene; (ii) androgenic repression of the gene requires the presence

142 Androgenic repression of the Std gene in rat liver can b

143 endogenously produced trophic factors in the androgenic rescue of SNB motoneurons and further suggest

144 ction is a biomarker assay for the undesired androgenic responses in vivo.

145 for physical signals drives the evolution of androgenic sensitivity in select neuromotor pathways.

146 d its emergence is associated with increased androgenic sensitivity within the hind limb musculature.

147 a gender-specific ILP was identified as the androgenic sex hormone in Crustacea.

148 ut older generation progestins have unwanted androgenic side effects in humans.

149 lective anabolic response with minimal or no androgenic side-effects and begin to elucidate the putat

150 th AR (AR-FL), AR-Vs constitutively activate androgenic signaling and are refractory to the current r

151 monstrating a positive feedback mechanism of androgenic signalling in CRPC.

152 Androgenic signals provide feedback at many levels of th

153 al significance of this finding in mediating androgenic skin disorders such as acne, hirsutism, or an

154 e of trkB, trkC, or CNTFRalpha prevented the androgenic sparing of SNB motoneurons when antagonists w

155 The molecular basis for the enzyme's androgenic specificity and unique catalytic mechanism ca

156 ghly substrate selective, it is the hallmark androgenic specificity that sets aromatase apart.

157 oncordant with gene activity specific to the androgenic status.

158 vior after systemic exposure to the anabolic-androgenic steroid (AAS) 17alpha-methyltestosterone (7.5

159 Illicit anabolic-androgenic steroid (AAS) abuse, though an important publ

160 castrated and treated daily with an anabolic-androgenic steroid (AAS) compound (either stanozolol, ox

161 d and treated with 1 of 3 different anabolic-androgenic steroid (AAS) compounds (17 alpha-methyltesto

162 The effects of anabolic-androgenic steroid (AAS) compounds on spatial working me

163 ally intact male rats exposed to an anabolic androgenic steroid (AAS) during puberty.

164 the interactive effects of chronic anabolic androgenic steroid (AAS) exposure and brain serotonin (5

165 In hamsters (Mesocricetus auratus), anabolic-androgenic steroid (AAS) exposure during adolescence fac

166 In hamsters (Mesocricetus auratus), anabolic-androgenic steroid (AAS) exposure during adolescence fac

167 Repeated high dose (5.0 mg/kg) anabolic-androgenic steroid (AAS) exposure during adolescence sti

168 In hamsters, adolescent anabolic-androgenic steroid (AAS) exposure facilitates offensive

169 Prolonged high-dose anabolic-androgenic steroid (AAS) use has been associated with ps

170 edical and psychological effects of anabolic-androgenic steroid (AAS) use, but the specific relations

171 ted in the modulation of adolescent anabolic-androgenic steroid (AAS)-induced aggression.

172 a to hepatocellular carcinoma after anabolic androgenic steroid abuse has been rarely reported.

173 inoma occurring in association with anabolic androgenic steroid abuse should sensitize physicians and

174 e oligonucleotide probes consist on anabolic androgenic steroid haptens (AAS) covalently linked to sp

175 ce waters, two of the most commonly observed androgenic steroid hormones are androstenedione (AD) and

176 Continuous use of anabolic androgenic steroid in high-doses is associated with subs

177 n and unambiguous identification of anabolic-androgenic steroid metabolites are essential in clinical

178 Short-term anabolic androgenic steroid use affects brain neurochemistry, inc

179 Androstenedione is an anabolic androgenic steroid used to increase blood testosterone l

180 Field studies of illicit anabolic-androgenic steroid users suggest that some develop manic

181 ltiple representatives of the acylcarnitine, androgenic steroid, bile acid, nucleotide and amino acid

182 We postulated that exemestane-a mildly androgenic steroid-might have a less detrimental effect

183 Adolescent exposure to anabolic androgenic steroids (AAS) alters the development and act

184 Anabolic androgenic steroids (AAS) are disproportionately used by

185 Anabolic androgenic steroids (AAS) are illicitly administered to

186 Anabolic androgenic steroids (AAS) can promote detrimental effect

187 dministration of excessive doses of anabolic androgenic steroids (AAS) disrupts reproductive function

188 Chronic treatment with anabolic-androgenic steroids (AAS) during adolescence alters the

189 thors examined the effects of three anabolic-androgenic steroids (AAS) during puberty: testosterone,

190 Illicit use of anabolic androgenic steroids (AAS) has become a prevalent health

191 Anabolic androgenic steroids (AAS) have medical utility but are o

192 The illicit use of anabolic androgenic steroids (AAS) is common among recreational a

193 of the hallmarks of illicit use of anabolic androgenic steroids (AAS) is disruption of behaviours un

194 Treatment with anabolic-androgenic steroids (AAS) throughout adolescence facilit

195 Therefore, several commonly abused anabolic-androgenic steroids (AAS) were tested for their ability

196 ns of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascu

197 y is associated with illicit use of anabolic-androgenic steroids (AAS).

198 ndividuals who illicitly administer anabolic androgenic steroids (AAS).

199 Long-term use of anabolic androgenic steroids (AASs) is associated with a high ris

200 Use of anabolic androgenic steroids (AASs) is associated with increased

201 ddition to an action on metabolism, anabolic/androgenic steroids also increase sex drive and mental a

202 preferential substrate specificity for C-19 androgenic steroids and C-24 bile acids.

203 fotransferase (Std) catalyzes sulfonation of androgenic steroids and certain aromatic procarcinogens.

204 ed for the analysis of natural and synthetic androgenic steroids and their selected metabolites in aq

205 Exogenous androgenic steroids applied to pregnant sheep programmes

206 Changes in 5-HIAA levels caused by anabolic androgenic steroids are related to the behavioral change

207 Androgenic steroids are required to maintain the prostat

208 Anabolic androgenic steroids are synthetic derivatives of testost

209 Anabolic androgenic steroids are used to enhance athletic perform

210 Non-androgenic steroids did not change PCNA immunoreactivity

211 Athletes often take androgenic steroids in an attempt to increase their stre

212 de and sulfate metabolites of seven anabolic-androgenic steroids in urine.

213 tients on testosterone, we hypothesized that androgenic steroids induce abnormal scarring and develop

214 ily is responsible for the conversion of C19 androgenic steroids to the corresponding estrogens, a re

215 t are capable of surviving in the absence of androgenic steroids were found to express protein kinase

216 ding the use of illicit substances, anabolic-androgenic steroids, herbal products, and medications.

217 es had increased apoptosis in the absence of androgenic steroids, whereas similarly grown tumors and

218 o survive, grow and spread in the absence of androgenic steroids.

219 lude that the pancreas is a primary locus of androgenic stimulation during development, giving rise t

220 However, a low level of androgenic stimulation may continue, even after castrati

221 Because heightened androgenic stimulation may increase risk of prostate can

222 etastatic prostate cancer has been to reduce androgenic stimulation of tumor growth by removal of the

223 ized as an androgen-responsive gene, and the androgenic stimulation regulates the development and gro

224 hSef expression was not influenced by androgenic stimulation.

225 ate cancer cells and functions downstream of androgenic stimulation.

226 leted medium or in response to physiological androgenic stimulation.

227 Androgenic stimulus in rat prostate modulates its associ

228 ase (CYP17), the enzyme that synthesizes the androgenic substrate for aromatase.

229 Using an ABCA1 promoter-reporter gene assay, androgenic suppression was observed at the transcription

230 Metabolites of androgenic synthetic growth promoters used at confined a

231 winning were likely exclusive to the neural androgenic system because they have no detectible impact

232 (CRPC) which invariably develops after anti-androgenic therapy.

233 strated that the progestins are all strongly androgenic, thereby explaining the masculinization effec

234 tion in Longissimus dorsi muscle confirm the androgenic treatment in experimental animals.

235 o the relative lack of literature concerning androgenic versus estrogenic hormones in environmental m