ライフサイエンスコーパス: anemic

1 trations and were slightly more likely to be anemic.

2 ythropoiesis, though K-Ras(-/-) embryos were anemic.

3 Cdc42GAP-/- mice were anemic.

4 s to decide whether the patient is, in fact, anemic.

5 6471 men (21.7%) and 4659 women (30.4%) were anemic.

6 n and 10.2% of women 65 years and older were anemic.

7 h chronic heart failure (CHF) are frequently anemic.

8 Sixty-one percent of the CHF patients were anemic.

9 dred men (4.8%) and 1,058 women (13.0%) were anemic.

10 , pancreas, and the digestive tract and were anemic.

11 ted that 60% of pregnant women worldwide are anemic.

12 were normal, and the mutant animals were not anemic.

13 all patients, and five of seven were mildly anemic.

14 of subjects were HIV positive and 15.1% were anemic.

15 s frequently delayed, and some donors become anemic.

16 ty-seven percent of the study population was anemic.

17 balamin concentrations; only one subject was anemic.

18 his infection persists and he remains mildly anemic.

19 s likely to smoke (41 versus 52%), were more anemic (23 versus 7%), and were more likely to live in p

20 10 patients (53%) were still anemic 6 months after ICU discharge.

21 % of children in the richest households were anemic, 63.2% of children in the poorest household were

22 es, iron isomaltoside improved PCr t(1/2) in anemic (-8.4 s; 95% CI, -16.7 to -0.2; P=0.04) and nonan

23 ey rats weighing 200-300 g, 38 of which were anemic (80-90 g/L) and 11 with normal hemoglobin levels.

24 50% and 56% of children were classified as anemic according to HemoCue and DBS, respectively (p < 0

25 55% and 47% of females were classified as anemic according to HemoCue and DBS, respectively (p < 0

26 st management (IPM) continues to suffer from anemic adoption rates in developing countries.

27 d that the hypoxic induction of liver Epo in anemic adults was Hif-2alpha dependent.

28 We identified 824 (18%) anemic and 4194 (82%) nonanemic patients.

29 w that mice deleted for Rcor1 are profoundly anemic and die in late gestation.

30 Stat5a/b(-/-) mice are severely anemic and die perinatally, but no link has been made to

31 ic lethality, but double KO embryos are more anemic and die sooner than either single KO.

32 Thereafter, the nu/nu mice became anemic and died, whereas the nu/+ mice produced antimala

33 rine 191 phosphorylation site are runted and anemic and display splenomegaly.

34 acrophage protein null phenotype is severely anemic and embryonic lethal.

35 l erythroblasts and the Rb null phenotype is anemic and embryonic lethal.

36 Syrian hamsters become anemic and exhibit delayed growth following oral infecti

37 wever, IFNgamma-knockout mice did not become anemic and had greater numbers of splenic erythroid prec

38 e, which, like hypotransferrinemic mice, are anemic and incur iron loading, but have functional Tf.

39 on nutriture and a reduced risk of remaining anemic and iron deficient.

40 57BL/6 mice given adult worms rapidly became anemic and lost weight in a manner similar to AWT hamste

41 attributable to ehrlichiosis, both dogs were anemic and neutropenic and the Thai dog was thrombocytop

42 ive outcomes variables were compared between anemic and nonanemic neonates.

43 ravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic h

44 fied as stunted and obese and 1.4% were both anemic and overweight compared with expected prevalences

45 that mutant mice with a reduced serum PA are anemic and prone to phenylhydrazine-induced anemia.

46 phases at two hematocrit (Hct) values: 30% (anemic) and 42% (physiologic; normalized by treatment wi

47 Forty percent of patients were anemic, and 21% either had elevated total plasma homocys

48 a quarter of the world's population remains anemic, and about half of this burden is a result of iro

49 hei ANKA infection compared to asymptomatic, anemic, and control groups.

50 ly 25% smaller than normal littermates, very anemic, and died on the day of birth.

51 W mutant mice are severely anemic, and earlier work suggested that this defect in e

52 ntly older when HU was instituted, were more anemic, and more likely to have BAN or CAM haplotypes.

53 mice, SJL-Kit(W/W-v) mice are MC-deficient, anemic, and neutropenic and have normal T cell compartme

54 Hypoalbuminemic, anemic, and obese patients on MHD had a worse QoL.

55 s died during gestation, frequently appeared anemic, and suffered from a lack of Ter-119-positive ery

56 al apoptosis in anemic rats when compared to anemic animals not undergoing transfusion.

57 sion of fresh blood to 100 g/L hemoglobin in anemic animals offers cardioprotection after acute myoca

58 survival were significantly improved in the anemic animals undergoing fresh blood transfusion compar

59 Anemic animals were randomized to receive fresh blood (w

60 Treatment of anemic animals with Euk-8, a catalytic antioxidant with

61 survival was dramatically decreased in these anemic animals, partially compensated by considerable en

62 fresh blood transfusion compared to control anemic animals.

63 ; 95% CI: -3.99, -0.96) in children who were anemic at baseline and decreased Atlantis delayed scores

64 Overall, 1277 patients (34%) were anemic at baseline, which persisted through discharge in

65 all, 44.6% of women studied (n = 37/83) were anemic at delivery, and 18% of women (n = 11/61) had IDA

66 EKLF(-/-)KLF2(-/-) mice appear anemic at embryonic day 10.5 (E10.5) and die before E11.

67 KLF1(-/-) KLF2(-/-) double knockout mice are anemic at embryonic day 10.5 (E10.5) and die by E11.5, i

68 anemia at one year in patients who were not anemic at entry and who were randomized to enalapril or

69 tudy with blinded end point assessment among anemic (average hemoglobin of 10.4+/-1 g/dL) older adult

70 In anemic awake sheep, stored renitrosylated, but not contr

71 Administration of 3 SCFADs in anemic baboons increased F-reticulocytes 2- to 15-fold o

72 lthy, respectively, in the two cohorts) were anemic based on the World Health Organization criteria.

73 ATF4 null fetuses were severely anemic because of an impairment in fetal-liver definitiv

74 and the animals reached normal age but were anemic because of low erythropoietin levels.

75 weeks, and after 5 weeks the mutants became anemic, began to lose weight, and die.

76 In contrast, in anemic beta-thalassemia intermedia mice, there is altere

77 opoietin therapy randomized to normal versus anemic blood hemoglobin concentration.

78 at women complaining of fatigue who were not anemic but who had reduced or absent iron stores were sy

79 Women who are not anemic but who suffer from fatigue may benefit from iron

80 Surprisingly, the patient's father is not anemic, but he is a smoker with high levels of HbCO ( ap

81 -/-) mice and littermates that were rendered anemic by bleeding.

82 C57BL/6 mouse pups rendered anemic by timed phlebotomy and then given RBC transfusio

83 Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse even

84 lfa overcame much of the QOL deficit seen in anemic cancer patients compared with the norm population

85 the functional status and quality of life in anemic cancer patients receiving chemotherapy, as well a

86 meters, quality of life (QOL), and safety in anemic cancer patients receiving nonplatinum chemotherap

87 al evaluating epoetin alfa versus placebo in anemic cancer patients.

88 Anemic cats with chronic renal failure represent a poten

89 posterior mesoderm of wild-type embryos and anemic cdx4(-/-) mutants, indicating a link between the

90 Mice deficient for HDAC5 show resistance to anemic challenge and altered marrow responsiveness to er

91 echanism contributing to the poor outcome in anemic CHF patients.

92 h overweight or obese mothers, 12.6% have an anemic child and 14% have a zinc-deficient child.

93 on cognition and impaired working memory in anemic children and long-term memory and retrieval in gi

94 and peripheral blood (n = 70) of Mozambican anemic children by quantitative polymerase chain reactio

95 Severely anemic children might particularly benefit from routine

96 he change in the hemoglobin concentration of anemic children was significantly different between fort

97 One hundred forty-one severely anemic children were identified during the baseline asse

98 All severely anemic children were randomly assigned to receive either

99 ts were made in randomly selected 7-12-y-old anemic children with documented Schistosoma haematobium

100 This study found that severely anemic children with Plasmodium falciparum infection hav

101 Among iron-deficient or anemic children, hemoglobin concentrations were improved

102 on effect: 0.90; 95% CI: 0.18, 1.62), and in anemic children, iron increased scores in the Atlantis D

103 deficits were observed in iron-deficient or anemic children, particularly with longer-duration, lowe

104 merican women would have been classified as "anemic" compared with 5.3% of whites.

105 itory factor (MIF) in the development of the anemic complications and bone marrow suppression that ar

106 e to malaria infection and the likelihood of anemic complications.

107 d at the transcriptional level under hypoxic/anemic conditions.

108 1988-1994) revealed that only a minority of anemic CRI subjects in the United States met these K/DOQ

109 Overall risk of mortality in severely anemic critically ill bloodless patients appeared to be

110 In this study of anemic critically ill patients treated with epoetin alfa

111 Anemic critically ill patients treated with IV iron and

112 did not predict pharmacodynamic response in anemic critically ill patients.

113 stored leukodepleted red cells to euvolemic, anemic, critically ill patients has no clinically signif

114 ese data, routine IV iron supplementation of anemic, critically ill trauma patients cannot be recomme

115 CE knockout mice, which lack tissue ACE, are anemic despite having normal renal function.

116 reatments) is superior to no iron therapy in anemic dialysis patients receiving adequate epoetin dosa

117 We report here that fit1 mutants are anemic, display numerous peripheral blood defects, and a

118 Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive

119 The steroid-free group was more anemic early posttransplantation (P=0.004), suggesting a

120 hematocrit level is corrected to healthy in anemic Epo-TAg(h) mice.

121 Stat5a-/-5b-/- embryos are severely anemic; erythroid progenitors are present in low numbers

122 served during acute chest syndromes or acute anemic events (AAE), and extracranial internal carotid a

123 udin et al have identified the rate of acute anemic events (AAEs) and extracranial internal carotid a

124 Acute anemic events are common in children with SCD and preval

125 155-920) per 100 patient-years during acute anemic events for all patients.

126 e (SCD), could occur in the setting of acute anemic events.

127 Our aim was to follow patients discharged anemic from the intensive care unit (ICU) for up to 6 mo

128 according to hemoglobin levels (<12.5 g/dl [anemic group] vs. 12.5 to 14.5 g/dl [nonanemic group]).

129 erence in one-year survival was noted in the anemic groups compared with no anemia group (adjusted ha

130 onsistent with a variable fraction below the anemic Hb concentration, the distribution around the mea

131 e, alleviating anemia, and improving HRQL in anemic (Hb < or = 12 g/dL) HCV-infected patients receivi

132 l infarction was two to five times higher in anemic (Hb <12 g/dl) patients than in people with Hb fro

133 ercent (58.5%) of the children surveyed were anemic (Hb level: 9.75 g/dL [9.59-9.91]).

134 ndomized hemoglobin (Hb) correction study in anemic (Hb</=10.0 g/dl) patients incident to hemodialysi

135 ness of growth factor therapy in maintaining anemic HCV-infected patients on target drug levels durin

136 Mean HRQL scores of anemic HCV-infected patients receiving combination thera

137 intained RBV dose and improved QOL and Hb in anemic HCV-infected patients receiving combination thera

138 life (QOL), and increase hemoglobin (Hb) in anemic HCV-infected patients.

139 iesis-stimulating agents in the treatment of anemic heart failure patients, clinical trial data, to d

140 ic gluconate to improve hemoglobin levels in anemic hemodialysis patients who were receiving adequate

141 Few data exist to guide treatment of anemic hemodialysis patients with high ferritin and low

142 hemoglobin and allows lower epoetin doses in anemic hemodialysis patients with low TSAT and ferritin

143 group (from 60 to 20%) but increased in the anemic hemoglobin group (from 57 to 86%).

144 7, target hemoglobin of 14 +/- 1 g/dl) or an anemic hemoglobin group (n = 18, target hemoglobin 10 +/

145 The anemic hemoglobin group had a progressive increase in er

146 The anemic hemoglobin group had higher CD8 counts compared w

147 Overall, 62.3% of children were anemic (hemoglobin < 110 g/L), and 82.7% of anemia was a

148 sent in 34 (12%) children, and 37 (13%) were anemic (hemoglobin < 110 g/L).

149 SP) on erythropoietin production in severely anemic (hemoglobin < or = 70 g/L) preschool children in

150 with additional iron folic acid if they were anemic (hemoglobin <11 g/dL).

151 concentrations and hematocrit percentages in anemic (hemoglobin concentration <12 g/dL) Indian women

152 lled treatment trial was conducted among 546 anemic (hemoglobin concentration, 7-11 g/dL) children ag

153 es and malaria after iron supplementation in anemic (hemoglobin: 70-109 g/L) children aged 2-35 mo.

154 e 7.7 to 16.4 g/dl) and 184 women (21%) were anemic (Hgb <12 g/dl).

155 The non-anemic hippocampal iron-deficient mouse demonstrated upr

156 omen) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion.

157 Iron supplementation in anemic HIV-infected children has beneficial effects on h

158 No rats were anemic, hypoglycemic, or hypotensive before CCI.

159 cific tolerance of different levels of acute anemic hypoxia.

160 al and urban families were less likely to be anemic if they received fortified milk [odds ratio (OR):

161 nts were significantly less likely to become anemic if uninterrupted postpartum participation lasted

162 Furthermore, Ncoa4(-/-) mice are anemic in perinatal periods and fail to respond to TH by

163 n in nonpregnant Cambodian women screened as anemic.In this 2 x 2 factorial, double-blind, randomized

164 In anemic individuals, iron deficiency often not only decre

165 The anemic intestine is infiltrated by inflammatory macropha

166 e major cause of tissue-iron accumulation in anemic iron-overload disorders caused by hemolytic anemi

167 may be a novel therapeutic target in several anemic iron-overload disorders.

168 kely contributing to an otherwise relatively anemic level of horizontal gene transfer, which neverthe

169 Patients who became anemic (levels of hemoglobin approximately </=10 g/dL) d

170 matopoietic growth factors for patients with anemic low/intermediate-1 IPSS (n = 94), and hypomethyla

171 One symptomatic, G6PD-deficient, anemic male patient was transfused on day 4.

172 m 47.8% were microcytic anemia and 3,323 non-anemic males for the analysis.

173 On the contrary, mild anemic males had higher possibility to be the best 10% p

174 There were 343 mild anemic males in whom 47.8% were microcytic anemia and 3,

175 that as compared with non-anemic males, mild anemic males were more likely to be the worst 10% perfor

176 c regression shows that as compared with non-anemic males, mild anemic males were more likely to be t

177 We treated 8 anemic MDS patients (refractory anemia [RA] and refracto

178 U/L; P<0.01), these patients were moderately anemic (mean+/-SD; hemoglobin =118+/-17 g/L).

179 Anemic men and women were older and had a higher percent

180 OBHRE-Epo corrected the hematocrit level in anemic mice to a normal physiologic level that stabilize

181 rythropoiesis was induced in both normal and anemic mice, a process that was completely reversible.

182 EPO-generating organs of hypoxic or acutely anemic mice, acetate levels rise and ACSS2 is required f

183 In acutely anemic mice, acetate supplementation augments stress ery

184 e marrow cells from phenylhydrazine-treated, anemic mice, we find that both gp55-A and gp55-P induce

185 rythroid spleen cells and reticulocytes from anemic mice.

186 ntly activated in both HSC and MPP1 cells in anemic mice.

187 Although chronically anemic, most animals survived for 2 to 9 months and were

188 GM-CSF) and erythropoietin (epoetin alfa) in anemic, neutropenic patients with myelodysplastic syndro

189 Two-thirds of the infants were mildly anemic, no treatment effects on hemoglobin concentration

190 n (odds ratio: 3.47; 95% CI: 1.51, 7.96) and anemic (odds ratio: 2.92; 95% CI: 1.24, 6.90) children h

191 ut significant gastrointestinal disease were anemic on presentation.

192 icians, and the target patient population is anemic or iron-deficient adult patients with heart disea

193 altered in mice that were thrombocytopenic, anemic, or leukopenic.

194 st this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused

195 2% of children in the poorest household were anemic (p < 0.001).

196 Random assignment of anemic participants to intervention and control arms occ

197 ous and binary outcomes, respectively.Of 179 anemic participants, 136 (76.0%) completed all follow-up

198 a particularly high risk of mortality among anemic patients <65 years of age (P=0.07).

199 ESAs were permitted for anemic patients (hemoglobin [Hb] <10 g/dL) after RBV dos

200 Thirty-eight anemic patients (hemoglobin, median [interquartile range

201 In anemic patients (n = 18), the difference (95% CI) was 20

202 Anemic patients 5 years to 18 years of age receiving mye

203 Anemic patients affected by BT suffer from iron overload

204 Twenty-six anemic patients aged 57+/-11 years were randomized to re

205 in was eventually purified from the urine of anemic patients by Eugene Goldwasser in 1977.

206 Survival was reduced in anemic patients compared with patients with a normal hem

207 reduce the risk of transfusion in moderately anemic patients controlling for patient and ICU factors.

208 ended discontinuation occurred more often in anemic patients during the first year after PCI and in n

209 frequently recommend DAPT discontinuation to anemic patients during the first year, and to nonanemic

210 Anemic patients had a 3-fold higher mortality risk compa

211 More than 50% of anemic patients had a glomerular filtration rate <60 mL.

212 Anemic patients had a postoperative mortality and cardia

213 When compared with nonanemic patients, anemic patients had higher in-hospital mortality (3.0% v

214 ed to trigger red blood cell transfusions in anemic patients in critical care and acute care settings

215 ickled red blood cells (ISCs) of sickle cell anemic patients into the sickle shape.

216 The most anemic patients require regular red blood cell transfusi

217 Strikingly, it also identifies many pre-anemic patients several weeks before anemia becomes clin

218 disruption were significantly more common in anemic patients throughout 2 years after PCI, whereas ph

219 t-effective anemia screening and chronically anemic patients to self-monitor their disease.

220 alence of hypoglycemia in critically ill and anemic patients treated with insulin and tight glucose c

221 Anemic patients were more likely to be receiving diureti

222 Anemic patients were older and had a higher rate of diab

223 It is unclear if blood transfusion in anemic patients with acute coronary syndromes is associa

224 Blood transfusion is controversial for anemic patients with acute myocardial infarction (AMI),

225 sing first-line IV iron monotherapy to treat anemic patients with cancer, which decreases the need fo

226 thropoietin (EPO) on exercise performance in anemic patients with CHF.

227 escribe PS exposure in RBCs of 56 comparably anemic patients with different genetic backgrounds of th

228 Therefore, for anemic patients with hematologic malignancies it is reco

229 Therefore, for anemic patients with hematologic malignancies, it is rec

230 on was assessed in a subset of 37 ambulatory anemic patients with I131-tagged albumin to measure red

231 ersus SC alone (n = 57) for the treatment of anemic patients with lower-risk myelodysplastic syndrome

232 Purpose Most anemic patients with non-deleted 5q lower-risk myelodysp

233 Bone marrow was examined in 29 anemic patients with RA, 9 healthy volunteers, and 6 pat

234 -elevation acute coronary syndrome, although anemic patients with ST-elevation myocardial infarction

235 ded for most hospitalized patients including anemic patients with stable cardiovascular disease (CVD)

236 In the subset of 37 anemic patients, 17 patients (46%) had hemodilution and

237 uation of anemia was found in only 3% of all anemic patients, and better in internal medicine than in

238 s one of the main therapeutics used to treat anemic patients, greatly improving their quality of life

239 microglobulin and, in a subset of moderately anemic patients, improved blood hemoglobin levels.

240 onally, erythropoietin, which is elevated in anemic patients, up-regulates heparanase expression via

241 Benefits were more evident in anemic patients.

242 sis was only slightly elevated (7 to 34%) in anemic patients.

243 sk of both myocardial infarction and MACE in anemic patients.

244 ion for > or = 8 weeks) occurred in 10 of 17 anemic patients.

245 bleeding events were significantly higher in anemic patients.

246 and VO2 relative to values in the untrained anemic phase.

247 Alas2-KOBM animals displayed a severe anemic phenotype characterized by ineffective erythropoi

248 which was previously shown to ameliorate the anemic phenotype.

249 ning the human beta globin gene locus and in anemic phlebotomized baboons.

250 By this definition, we observed anemic phytoplankton populations in the Subtropical Sout

251 between heme b replete and heme b deficient (anemic) phytoplankton.

252 gle-dose (500 mg) mebendazole among severely anemic pregnant women in periurban Karachi, Pakistan.

253 Alzheimer disease etiology in iron-deficient anemic rat pups at the time of hippocampal differentiati

254 of fresh vs. stored blood when transfused in anemic rats after acute myocardial infarction.

255 sed infarct size and myocardial apoptosis in anemic rats when compared to anemic animals not undergoi

256 d that DMT1 protein levels were increased in anemic rats.

257 n improves fatigue and general health in non-anemic repeat adult blood donors with iron deficiency (f

258 pe 1 (RR, 0.78; 95% CI, 0.71, 0.86), or were anemic (RR, 0.70; CI, 0.60, 0.89).

259 oduct improved iron status in iron-deficient anemic soldiers but not in iron-normal or iron-deficient

260 concentrations were lower in iron-deficient anemic soldiers than in those with normal iron status (P

261 ed declines in iron status in iron-deficient anemic soldiers; a group-by-time interaction was observe

262 The severely anemic sph(1J)/sph(1J) mouse has very fragile red cells

263 induced erythropoiesis, such as during acute anemic states (see the related article beginning on page

264 impact upon erythropoiesis, particularly in anemic states that may require output from the spleen.

265 ematocrit (Hct) or hemoglobin to correct for anemic status (e.g., 20.7 +/- 5.7 mumol/L per % Hct [day

266 inerleukin-10, irrespective of iron status, anemic status, and general acute-phase response.

267 sed response of REPCs in fibrotic kidneys to anemic stimulation remain elusive.

268 lycythemic strain (gp55-P), but not from the anemic strain (gp55-A), activates the erythropoietin rec

269 terestingly, we find that the env gene of an anemic strain of Friend virus, Rauscher virus envelope g

270 -/- mice displayed exaggerated recovery from anemic stress and persistent cell cycling consistent wit

271 kt in the endothelium of mice results in non-anemic stress erythropoiesis in the spleen.

272 Inflammation and anemic stress induce the rapid proliferation of SEPs, bu

273 Acute anemic stress induces a physiological response that incl

274 Acute anemic stress induces a systemic response designed to in

275 Anemic stress induces stress erythropoiesis, which rapid

276 appeared to respond appropriately to induced anemic stress.

277 It was possible to predict anemic subjects in the limited prospective blood donor p

278 However, the change in hemoglobin in anemic subjects was greater in the Fe group than in the

279 blast differentiation in vivo and alleviated anemic symptoms in a chronic anemia mouse model by regul

280 ponsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, a

281 ice had increased splenomegaly and were more anemic than corresponding WT mice.

282 ugh rbc-specific Sphk1 Sphk2-KO embryos were anemic, the erythropoietic capacity of hematopoietic ste

283 22 children (24%) remained anemic until Day 28.

284 Patients were classified as anemic using the World Health Organization definition (<

285 tions per 1000 patient-years of follow-up in anemic versus nonanemic patients (both P<0.001).

286 Subjects underwent stratified (anemic versus nonanemic) randomization (1:1) to a single

287 d increased intestinal expression of fpn1 in anemic weh(Tp85c-/-) adults.

288 production, comparable with that observed in anemic wild-type mice.

289 erozygous Lyn(+/up) mice became increasingly anemic with age, indicating that the mutation was domina

290 We enrolled 40 patients (50% anemic) with chronic HF, New York Heart Association clas

291 She was severely anemic, with a hemoglobin level of 6 g/dL, and was found

292 Adult Lyn(up/up) mice were anemic, with dysmorphic red cells (spherocyte-like, acan

293 receiving Sod2(-/-) cells were persistently anemic, with findings suggestive of a hemolytic process.

294 hemoglobin concentrations in rural Cambodian anemic women (aged 18-49 y) who cooked with the iron ing

295 ough the benefits of iron supplementation in anemic women are well recognized, insufficient data are

296 Anemic women had a higher risk of death from any cause (

297 Anemic women had higher creatinine and were more likely

298 Also, anemic women had shorter survival time free of adverse o

299 n multivariate models, but the proportion of anemic women who were iron deficient was considerably lo

300 alone in improving the hemoglobin status of anemic women.