ライフサイエンスコーパス: aneuploid

1 d arrest, permitting primary cells to become aneuploid.

2 such as prostate cancer are also frequently aneuploid.

3 rited the wrong number of chromosomes: it is aneuploid.

4 nd the majority of these variant progeny are aneuploid.

5 ne hepatocytes, human hepatocytes are highly aneuploid.

6 hibit a variety of phenotypes and are highly aneuploid.

7 tems, the heterogametic sex became partially aneuploid after degeneration of the Y or W.

8 normal cells, malignant cells are frequently aneuploid and contain multiple centrosomes.

9 enetic background develop aggressive, highly aneuploid and estrogen receptor alpha-positive (ERalpha+

10 In one gastric cancer, both aneuploid and euploid cells contained large numbers of l

11 ell tracking in chimeric embryos, containing aneuploid and euploid cells, reveal that the fate of ane

12 ely aneuploid, forming mosaics of intermixed aneuploid and euploid cells.

13 The tumors were highly aneuploid and exhibited a metabolic burden similar to th

14 Although many human embryos are aneuploid and genomically imbalanced, often as a result

15 Most human cancers are aneuploid and have chromosomal instability, which contra

16 to pediatric and adult solid tumors that are aneuploid and heterogeneous.

17 ression from meiosis I to meiosis II lead to aneuploid and polyploid gametes, but the regulatory mech

18 n result in tetraploid cells that can become aneuploid and promote cancer.

19 (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistanc

20 he mature hepatocytes in mice and humans are aneuploid and yet retain full ability to undergo mitosis

21 landscape in which atypical spores, such as aneuploids and diploids, are advantageous.

22 ncer, likely occur in cells that are already aneuploid, and influence pathways of tumor progression (

23 Most solid tumors are aneuploid, and it has been proposed that aneuploidy is t

24 Solid tumors are frequently aneuploid, and many display high rates of ongoing chromo

25 Most solid tumors are aneuploid, and many missegregate chromosomes at high rat

26 lial cells, mitotic errors ensued, producing aneuploid, and multinucleated cells.

27 model for Candida infection, suggesting that aneuploids arise due to azole treatment of several patho

28 age-stage, we show that CCFs and nondividing aneuploid blastomeres showing extensive DNA damage are p

29 fragmentation, and selection against highly aneuploid blastomeres to overcome chromosome instability

30 rnative mechanism for dosage compensation in aneuploid budding yeast and human cell lines.

31 We found that aneuploid budding yeast cells are under proteotoxic stre

32 We conclude that aneuploid budding yeast cells mount the ESR, rather than

33 onsequences of aneuploidy on the proteome of aneuploid budding yeast strains.

34 In aneuploid budding yeast, two opposing gene-expression pa

35 ational regulator that is functional in wild aneuploids but defective in laboratory strain W303.

36 Compounds that cause lethality in aneuploid, but not euploid, cells could therefore provid

37 that breast cancer metastases are generally aneuploid, but not tetraploid, and are histopathological

38 and p53+/+ HCT116 tumor cells rapidly become aneuploid by continuing to cycle after cleavage failure.

39 es of mosaicism in embryos diagnosed as full aneuploid by pre-implantation genetic testing.

40 s been consistently associated with a single aneuploid cancer cell lineage that we refer to as DFT1.

41 that GTSE1, a protein found overexpressed in aneuploid cancer cell lines and tumors, regulates MT sta

42 tion with chemotherapy, while PTEN-deficient aneuploid cancer cell lines are sensitive to TTK inhibit

43 Many aneuploid cancer cells also have greater-than-diploid DN

44 cellular consequences of aneuploidy and how aneuploid cancer cells self-adapt to promote tumorigenes

45 that chromosomal gain can promote mitosis in aneuploid cancer cells via Ran.

46 trosome amplification is a common feature of aneuploid cancer cells, we tested whether supernumerary

47 and cell size that was observed in yeast and aneuploid cancer cells.

48 es due to infiltration with normal cells and aneuploid cancer genomes.

49 t the same alterations are not common to all aneuploid cancers.

50 ocytopoiesis, as well as aberrant mitosis in aneuploid cancers.

51 We were able to correctly detect all aneuploid cases with extremely low false positive rates

52 r the first time the existence of individual aneuploid CD31(+) CECs and co-existence of "fusion clust

53 80%) embryos harboring at least one putative aneuploid cell (1% FDR).

54 de screen in yeast to identify a guardian of aneuploid cell fitness conserved across species.

55 ss of aneuploid yeast, is a key regulator of aneuploid cell homeostasis.

56 Most of these aneuploid cell lines had rapid proliferation rates and e

57 ical maturation is disrupted across multiple aneuploid cell lines, leading to a weak metaphase tensio

58 eattachment defect, and selective removal of aneuploid cell populations.

59 cription of metabolic genes, consistent with aneuploid cell state.

60 Aneuploid cells activate the transcription factor TFEB,

61 iques to analyze artificially generated mock aneuploid cells and cells with natural random aneuploidy

62 To determine the fate of aneuploid cells and the developmental potential of mosai

63 ease of enhanced proliferative capacity, and aneuploid cells are frequently recovered following the e

64 model of chromosome mosaicism, we show that aneuploid cells are preferentially eliminated from the e

65 A number of studies indicate that aneuploid cells are present at a high frequency in the b

66 , the mechanisms responsible for eliminating aneuploid cells are unclear.

67 We provide evidence that p21 is activated in aneuploid cells by reactive oxygen species (ROS) and p38

68 hways that are essential for the survival of aneuploid cells could serve as a new treatment strategy

69 d and euploid cells, reveal that the fate of aneuploid cells depends on lineage: aneuploid cells in t

70 The aneuploid cells display increased chromosomal instabilit

71 ome segregation errors and the appearance of aneuploid cells due to the presence of VirD5 could be vi

72 Instead, aneuploid cells exhibit the ESR.

73 Aneuploid cells experience a number of stresses that are

74 While the aneuploid cells generally display a growth disadvantage

75 Indeed aneuploid cells harbor increased levels of reactive oxyg

76 stem and progenitor cell (HSPC) compartment aneuploid cells have reduced fitness and are efficiently

77 a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, p

78 ereas Ccne1(T) mice accumulated near-diploid aneuploid cells in multiple tissues and organs, polyploi

79 12 controls revealed a higher proportion of aneuploid cells in the exposed group (median, 18.8% [int

80 fate of aneuploid cells depends on lineage: aneuploid cells in the fetal lineage are eliminated by a

81 We found no significant enrichment of aneuploid cells in the trophectoderm compared to the inn

82 Aneuploid cells in these mutant mice are likely eliminat

83 icroRNA-based therapeutic strategy to target aneuploid cells in VHL-associated cancers.

84 Notably, the importance of UBP3 in aneuploid cells is conserved.

85 uman tumors, but the molecular physiology of aneuploid cells is not well characterized.

86 Overall, the proportion of aneuploid cells is progressively depleted from the blast

87 ckpoint activity, increased mitotic defects, aneuploid cells marked by a specific transcriptional sig

88 ide screen uncovered a general dependency of aneuploid cells on a pathway of ubiquitin-mediated endoc

89 ntaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) th

90 cells was observed in confluent cultures in aneuploid cells relative to their diploid counterparts.

91 tion provide a window of opportunity whereby aneuploid cells rise in frequency, only to decline to ba

92 e demonstrate that certain drugs that act on aneuploid cells synergize with inhibitors of Aurora B to

93 Our results suggest that aneuploid cells that accumulate during aging in some mam

94 nerate a diverse population of proliferative aneuploid cells that have the potential to contribute to

95 expression profile of actively proliferating aneuploid cells to that of euploid cells grown into stat

96 Finally, we observed that aneuploid cells up-regulate immune response genes and do

97 and a 70-gene signature derived from primary aneuploid cells was defined as a strong predictor of inc

98 he strongest inducers of the ESR, the ESR in aneuploid cells was masked when stationary phase euploid

99 In three tumors, aneuploid cells were detected by FACS.

100 multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in canc

101 of mutability to select specific tumor-prone aneuploid cells, and open unique avenues toward the unde

102 s were identified with altered expression in aneuploid cells, including overexpression of the cellula

103 e-specific phenotypes and global stresses of aneuploid cells, including oxidative and proteotoxic str

104 Most solid tumors contain aneuploid cells, indicating that the mitotic checkpoint

105 more find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequenc

106 However, in a second gastric cancer with aneuploid cells, no somatic L1 insertions were found.

107 at the ESR causes selective ribosome loss in aneuploid cells, providing an explanation for the decrea

108 eight-cell division, we efficiently generate aneuploid cells, resulting in embryo death during peri-i

109 lic conditional gene knockouts in diploid or aneuploid cells, such as pluripotent stem cells, 3D orga

110 are used in gene-expression comparisons with aneuploid cells, the CAGE signature is no longer evident

111 s encoded on excess chromosomes aggregate in aneuploid cells, which is suppressed when expression of

112 sely resembles the stressed state of primary aneuploid cells, yet CIN is not benign; a subset of gene

113 in vivo, mechanisms exist to select against aneuploid cells.

114 polyploid cells is error-prone and produces aneuploid cells.

115 rturbed condensation similar to that seen in aneuploid cells.

116 les can predict protein level attenuation in aneuploid cells.

117 lantation embryos are mosaics of euploid and aneuploid cells.

118 in aggregates accumulate within lysosomes in aneuploid cells.

119 nuously elevated levels of DNA damage affect aneuploid cells.

120 wild-type p53 suppresses the accumulation of aneuploid cells.

121 and cell proliferation were downregulated in aneuploid cells.

122 owever, these models are based on studies in aneuploid cells.

123 nation for the decreased cellular density of aneuploid cells.

124 , the CAGE signature is no longer evident in aneuploid cells.

125 d against cancer, by removing neoplastic and aneuploid cells.

126 ition exhibits a propensity for occurring in aneuploid cells.

127 s as a major cause of protein aggregation in aneuploid cells.

128 ogy, we identified mechanisms that eliminate aneuploid cells.

129 into the underlying molecular physiology of aneuploid cells.

130 propose that the ESR serves two purposes in aneuploid cells: protecting cells from aneuploidy-induce

131 haracteristics in K562: copy numbers (CN) of aneuploid chromosome segments at high-resolution, SNVs a

132 ed cytotoxic compounds by means of different aneuploid chromosome stoichiometries.

133 Whereas it is known that each aneuploid chromosome stoichiometry can give rise to a di

134 en by up-regulation of a gene encoded on the aneuploid chromosome.

135 A dominant karyotype with three aneuploid chromosomes was observed in 25 cells, while tw

136 nors, identifying 813,122 crossovers and 787 aneuploid chromosomes.

137 ning-FISH (SE-iFISH), to detect a variety of aneuploid circulating rare cells (CRCs), including CTCs

138 immune system in preventing the outgrowth of aneuploid clones in tissue culture.

139 udy, we have combined a detailed analysis of aneuploid clones isolated from laboratory-evolved popula

140 We found that aneuploid clones rise to high population frequencies in

141 lectively blocked proliferation of wild-type aneuploids compared to euploids.

142 ereas the remaining 14 individuals (38%) had aneuploid compositions.

143 Although most aneuploid conceptions are thought to originate from meio

144 herapies because of a general feature of the aneuploid condition-G1 delays.

145 stability of RNF212 and be risk factors for aneuploid conditions.

146 imated with ribosome footprint data from the aneuploid Drosophila S2 cell line, we report that the do

147 duplicated the mutant chromosome and become aneuploid during culture.

148 that the genes involved in dosage-sensitive aneuploid effects also influence sex-biased expression.

149 Aneuploid eggs result from chromosome segregation errors

150 ional NuMA in oocytes are sterile, producing aneuploid eggs with altered chromosome number.

151 his process in meiosis leads to formation of aneuploid eggs.

152 chromosome segregation to the production of aneuploid eggs.

153 data indicate that the chromosomal status of aneuploid embryos (n=26), including those that are mosai

154 norhabditis elegans that fluorescently marks aneuploid embryos after chemical exposure.

155 bset of genes is differentially expressed in aneuploid embryos during the first 30 h of development.

156 to the four-cell stage, whereas only 30% of aneuploid embryos exhibit parameter values within normal

157 Human oocytes frequently generate aneuploid embryos that subsequently miscarry.

158 VF patients who produce an extreme number of aneuploid embryos.

159 n the female germ line by the elimination of aneuploid embryos; and report chromosomal drive against

160 Trisomic and monosomic (aneuploid) embryos account for at least 10% of human pre

161 emonstrated that co-culture of wild-type and aneuploid ES cells or supplementation with extracellular

162 BMP4 rescues the differentiation defects of aneuploid ES cells.

163 experiments confirmed that three out of four aneuploid events isolated from evolved populations were

164 Tumor cells become aneuploid, express increased levels of c-Myc and show el

165 The genetic etiology of non-aneuploid fetal structural abnormalities is typically in

166 ormed exome sequencing on a cohort of 30 non-aneuploid fetuses and neonates (along with their parents

167 The majority of aneuploid fetuses are spontaneously miscarried.

168 e investigate if the survival probability of aneuploid fetuses is affected by the genome-wide burden

169 on, leading to chromosome missegregation and aneuploid fetuses.

170 tion, 2) Niemann-Pick C1 patients accumulate aneuploid fibroblasts, neurons, and glia, demonstrating

171 Aneuploid fission yeast strains also exhibited defects i

172 by allowing tumors to constantly sample the aneuploid fitness landscape.

173 nt strains exhibited growth defects and were aneuploid for chromosome 10.

174 ed intergenomic translocations, and 69% were aneuploid for one or more chromosomes.

175 The process of aneuploid formation in C. albicans is highly reminiscent

176 of the normal vertebrate brain are diversely aneuploid, forming mosaics of intermixed aneuploid and e

177 1, results in a reduction of the S phase and aneuploid fractions, implying a functional role for thes

178 egation and providing a mechanism to prevent aneuploid gamete formation.

179 meiotic chromosome segregation that produce aneuploid gametes increase dramatically as women age, a

180 lures in step-wise cohesin removal result in aneuploid gametes, preventing the generation of healthy

181 chromosome segregation errors that generate aneuploid gametes.

182 ed bivalent formation and crossing over, and aneuploid gametes.

183 e moderately compensated at the mRNA level - aneuploid gene expression is shifted towards wild-type l

184 Comparing the properties of aneuploid genes from the two cell lines suggests that se

185 293 cell lines to study the dynamics of this aneuploid genome in response to the manipulations used t

186 can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease.

187 Aneuploid genomes, characterized by unbalanced chromosom

188 ce phenotype that permits the propagation of aneuploid genomes.

189 to the decreased proliferative potential of aneuploid hematopoietic cells.

190 id not observe cancer but instead found that aneuploid hematopoietic stem cells (HSCs) exhibit decrea

191 Aneuploid hPSCs show altered levels of actin cytoskeleta

192 rentiation and apoptosis between diploid and aneuploid hPSCs shows that trisomy 12 significantly incr

193 Here, we show that aneuploid hPSCs undergo DNA replication stress, resultin

194 the ongoing chromosomal instability seen in aneuploid hPSCs.

195 some condensation and segregation defects in aneuploid hPSCs.

196 ly when combined, also show efficacy against aneuploid human cancer cell lines.

197 ytosis, and this defect was also observed in aneuploid human cells.

198 analysis of post-implantation development of aneuploid human embryos.

199 esion defects and aneuploidy, whereas in two aneuploid human glioblastoma cell lines, targeted correc

200 ading cause of chromosome mis-segregation in aneuploid human tumour cells that continually mis-segreg

201 and then undergo ploidy reversal and become aneuploid in a dynamic process called the ploidy conveyo

202 eas nonregenerating adult tissues are highly aneuploid in these mice, HSCs and other regenerative adu

203 ndeed, in many plant species, populations of aneuploid individuals can be easily obtained from triplo

204 The proportion of additive versus aneuploid individuals differed from that found previousl

205 Nevertheless, some aneuploid individuals survive despite the strong genetic

206 for the same pair of chromosomes without an aneuploid intermediate.

207 rofiled transcriptome abundance in naturally aneuploid isolates compared to isogenic euploid controls

208 esult indicates that selection of a specific aneuploid karyotype can result in the adaptation of hepa

209 Most solid tumors have aneuploid karyotypes and many missegregate chromosomes a

210 Cancer cells display aneuploid karyotypes and typically mis-segregate chromos

211 In this study, we found that 3% of random aneuploid karyotypes in yeast disrupt the stable inherit

212 Overall, our work identified biomarkers of aneuploid karyotypes, which suggest insights into the un

213 comparable translational compensation in the aneuploid Kc167 cell line.

214 30% of clinically recognized conceptions are aneuploid, leading to spontaneous miscarriages, in vitro

215 While it is still unclear whether new stable aneuploid lines will arise from these populations, our d

216 ution (the S genome of Aegilops searsii) and aneuploid lines.

217 Interestingly, mildly aneuploid (<5 chromosomes lost or gained) populations re

218 ome instability is somehow suppressed in the aneuploid lymphomas or that selection for frequently los

219 Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities,

220 multiparameter flow cytometry using multiple aneuploid model systems such as cell lines, patient samp

221 able to produce a targeted autosome loss in aneuploid mouse embryonic stem cells with an extra human

222 ene ortholog regulation was recapitulated in aneuploid mouse neurons carrying human chromosome-21, im

223 uranoside) as a pharmacological inhibitor of aneuploid murine fibroblast proliferation.

224 Indeed, specific degeneration of aneuploid neurons accounts for 90% of neuronal loss in A

225 We identified aneuploid neurons, as well as numerous subchromosomal CN

226 ar experiments were performed in diploid vs. aneuploid non-transformed human primary cells.

227 ce, have a significantly higher frequency of aneuploid nuclei relative to wild-type controls in the c

228 m and transmit human chromosome 21 to create aneuploid offspring.

229 nation are at an increased risk of producing aneuploid offspring.

230 e of recurrent miscarriages, infertility, or aneuploid offspring.

231 us chromosome segregation, and production of aneuploid oocytes.

232 ment protein SYCP3 produce viable, but often aneuploid, oocytes.

233 res, with some isolates generating up to 46% aneuploid or diploid spores.

234 The majority of B-ALL cases are aneuploid or harbor recurring structural chromosomal rea

235 proportion are of mixed ancestry and/or are aneuploid or polyploid.

236 A central question is whether aneuploid phenotypes are the consequence of copy number

237 patients identifies clinical correlations of aneuploid plasma DNA profiles with poor survival, increa

238 biopsies and mapped aberrations in multiple aneuploid populations arising in primary and metastatic

239 A clonal KIT amplicon was present in aneuploid populations sorted from the primary tumor and

240 the corrected chromosome outgrew co-existing aneuploid populations, enabling rapid and efficient isol

241 dent models to study mechanisms resulting in aneuploid pregnancies.

242 Chromosomally unstable cancer lines and aneuploid primary cells also share an increase in glycol

243 that they are required for the formation of aneuploid progeny and can facilitate adaptation to chron

244 lyploid titan cells can generate haploid and aneuploid progeny that may result in systemic infection.

245 ehaviour leading to continuous production of aneuploid progeny with low viability and high cellular d

246 sulted in unequal DNA segregation and viable aneuploid progeny.

247 ome segregation errors and the production of aneuploid progeny.

248 d hepatocytes are required for production of aneuploid progeny.

249 The mutants grew slowly, became polyploid or aneuploid rapidly, and also lost chromosomes at a high r

250 Our data show that aneuploid rearrangements occurred early in tumour evolut

251 n, SNVs and indels (both corrected for CN in aneuploid regions), loss of heterozygosity, megabase-sca

252 nded clinical evaluation of 1269 euploid and aneuploid samples utilizing this high-throughput assay c

253 ng gene expression levels between normal and aneuploid samples.

254 gregation patterns to be ascertained even in aneuploid spores.

255 eotoxic stress is a universal feature of the aneuploid state and reveals protein aggregation as a for

256 gle or multiple chromosomes to show that the aneuploid state causes non-genetic phenotypic variabilit

257 However, how cells respond to the aneuploid state has remained controversial.

258 duality is a universal characteristic of the aneuploid state that may contribute to variability in pr

259 tress response as a universal feature of the aneuploid state.

260 onsistent explanation for the maintenance of aneuploid states in a population.

261 cell-division genes or by acquiring certain aneuploid states.

262 c plasticity conferred by access to multiple aneuploid states.

263 Aneuploid strains are prone to aggregation of endogenous

264 Furthermore, 10 of 14 aneuploid strains display a cell cycle entry delay that

265 Aneuploid strains exhibited a general fitness defect rel

266 ies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic

267 l proliferation defects, with many different aneuploid strains exhibiting a delay in G1, a cell cycle

268 utic or antifungal drugs, we found that some aneuploid strains grew significantly better than euploid

269 d signature and improves the fitness of most aneuploid strains.

270 erone family, Hsp90, are compromised in many aneuploid strains.

271 romoblot, and genetic analysis of engineered aneuploid strains.

272 aploid cell populations senesce and generate aneuploid survivors--near diploids monosomic for chromos

273 while laboratory strains used as a model for aneuploid syndromes do not.

274 n, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number

275 e aberrant testis architecture, males of the aneuploid Tc1 mouse strain produce viable sperm and tran

276 We developed aneuploid tetraploid maize lines that contain three copi

277 somes involved in TFs were more likely to be aneuploid than chromosomes not involved in TFs in the sa

278 tumor, there were many more L1 insertions in aneuploid than in euploid tumor cells.

279 "fusion clusters" of endothelial-epithelial aneuploid tumor cells among enriched non-hematopoietic C

280 al adenocarcinoma tissue, revealing a highly aneuploid tumor genome with extensive blocks of increase

281 cancer types, we find that, for most, highly aneuploid tumors show reduced expression of markers of c

282 Both groups included diploid and aneuploid tumors.

283 of heterozygosity and mutations in BCL9L in aneuploid tumors.

284 n synthesis inhibitors that selectively kill aneuploid tumour cells and repress translation of specif

285 discovers sub-clonal methylation patterns in aneuploid tumour genomes, thus defining epiclones that c

286 Highly aneuploid tumours are common in epithelial ovarian cance

287 Our data show that even though aneuploid tumours select for particular and recurring ch

288 or heterogeneity was significantly higher in aneuploid versus diploid cases, and so were gains of the

289 Furthermore, these tumors were aneuploid with double-stranded DNA breaks and end-to-end

290 similar to that previously characterized in aneuploid yeast and cultured cells.

291 Paradoxically, existing studies based on aneuploid yeast and mouse fibroblasts have shown that an

292 Consistently, aneuploid yeast exhibited increased plasma-membrane stre

293 Many aneuploid yeast strains adapt to DNA damage and undergo

294 All aneuploid yeast strains analyzed to date harbor elevated

295 We show that 10 of 14 aneuploid yeast strains exhibit a growth defect during G

296 Protein aggregate formation in aneuploid yeast strains is likely due to limiting protei

297 itiation and elongation are impaired in some aneuploid yeast strains.

298 or gene deletions that impair the fitness of aneuploid yeast, is a key regulator of aneuploid cell ho

299 ing out karyotype-specific dosage effects in aneuploid yeast-cell populations with random and diverse

300 urther proteasome-mediated proteotoxicity in aneuploid yeast.