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1 s in the formation of tetraploid rather than aneuploid cells.
2 ptosis, leading to a greater accumulation of aneuploid cells.
3 , the CAGE signature is no longer evident in aneuploid cells.
4 regated during cell division, giving rise to aneuploid cells.
5 d against cancer, by removing neoplastic and aneuploid cells.
6 ith a marked decrease in the accumulation of aneuploid cells.
7 ition exhibits a propensity for occurring in aneuploid cells.
8 ty (CIN) is a hallmark of cancer, leading to aneuploid cells.
9 HIF1A inhibition decreased the proportion of aneuploid cells.
10 intrinsic complexity and the poor fitness of aneuploid cells.
11 rapeutically-relevant cellular dependency of aneuploid cells.
12 tissue in mosaic gastruloids when mixed with aneuploid cells.
13 induction of cell death and the formation of aneuploid cells.
14 autophagy, which may support the survival of aneuploid cells.
15 to comprehensively identify and characterize aneuploid cells.
16 s as a major cause of protein aggregation in aneuploid cells.
17 ogy, we identified mechanisms that eliminate aneuploid cells.
18  into the underlying molecular physiology of aneuploid cells.
19  in vivo, mechanisms exist to select against aneuploid cells.
20  polyploid cells is error-prone and produces aneuploid cells.
21 rturbed condensation similar to that seen in aneuploid cells.
22 les can predict protein level attenuation in aneuploid cells.
23 lantation embryos are mosaics of euploid and aneuploid cells.
24 in aggregates accumulate within lysosomes in aneuploid cells.
25 nuously elevated levels of DNA damage affect aneuploid cells.
26 wild-type p53 suppresses the accumulation of aneuploid cells.
27 and cell proliferation were downregulated in aneuploid cells.
28 owever, these models are based on studies in aneuploid cells.
29 nation for the decreased cellular density of aneuploid cells.
30  cytokinesis, and formation of polyploid and aneuploid cells.
31  these genes are involved in the survival of aneuploid cells.
32 its traits that are shared between different aneuploid cells.
33  checkpoint activity and high percentages of aneuploid cells.
34  7 was used to identify small populations of aneuploid cells.
35 80%) embryos harboring at least one putative aneuploid cell (1% FDR).
36  multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in canc
37 21WAF1/CIP1-infected cells and inhibition of aneuploid cell accumulation; and an alteration of the ma
38                                              Aneuploid cells activate the transcription factor TFEB,
39                                              Aneuploid cells also exhibit elevated RAF/MEK/ERK pathwa
40 iques to analyze artificially generated mock aneuploid cells and cells with natural random aneuploidy
41 nown exceptions to the involvement of p53 in aneuploid cells and that tissue context may be important
42                     To determine the fate of aneuploid cells and the developmental potential of mosai
43 depletion also resulted in the appearance of aneuploid cells and the formation of internuclear chroma
44  aurora result in the generation of severely aneuploid cells and, in the case of aurora, monopolar sp
45 of mutability to select specific tumor-prone aneuploid cells, and open unique avenues toward the unde
46                                              Aneuploid cells are characterized by incomplete chromoso
47 uloids' grown in confined geometry show that aneuploid cells are depleted from embryonic germ layers,
48 se embryos and human gastruloids showed that aneuploid cells are eliminated from the epiblast by p53-
49 ple quality control pathways may explain why aneuploid cells are especially sensitive to loss of UBR4
50 ease of enhanced proliferative capacity, and aneuploid cells are frequently recovered following the e
51  model of chromosome mosaicism, we show that aneuploid cells are preferentially eliminated from the e
52            A number of studies indicate that aneuploid cells are present at a high frequency in the b
53 , the mechanisms responsible for eliminating aneuploid cells are unclear.
54 ines of evidence that blastocysts containing aneuploid cells are worthy of in vitro fertilization tra
55 /+ or p53-/-) had an increased percentage of aneuploid cells as well as an increase in cells with sup
56 loid mouse cells could not, we conclude that aneuploid cells become drug resistant via specific chrom
57  that nondisjunction does not directly yield aneuploid cells, but rather tetraploid cells that may su
58 pe mechanics provide a fitness advantage for aneuploid cells by promoting nuclear deformation resilie
59 We provide evidence that p21 is activated in aneuploid cells by reactive oxygen species (ROS) and p38
60                                   Individual aneuploid cells can be eliminated from developing tissue
61 id cells, yet those with a low proportion of aneuploid cells can develop to term at rates similar to
62                                Chromosome 21 aneuploid cells constitute approximately 4% of the estim
63 ransplantation therapies in which the use of aneuploid cells could be detrimental.
64 hways that are essential for the survival of aneuploid cells could serve as a new treatment strategy
65 d and euploid cells, reveal that the fate of aneuploid cells depends on lineage: aneuploid cells in t
66                                  Segmentally aneuploid cells derived from targeted chromosome excisio
67 oncluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetr
68                                          The aneuploid cells display increased chromosomal instabilit
69                                      Cycling aneuploid cells display lower karyotype complexity compa
70          Further investigation revealed that aneuploid cells displayed decreased proteasome activity
71  the recent observation of inappropriate and aneuploid cell division in cell lines expressing high le
72 ome segregation errors and the appearance of aneuploid cells due to the presence of VirD5 could be vi
73 of chromosome mosaicism to trace the fate of aneuploid cells during pre-implantation development.
74  turn, results in increased apoptosis of the aneuploid cells during subsequent cell division cycles.
75                                     Instead, aneuploid cells exhibit the ESR.
76                                              Aneuploid cells exhibited aberrant spindle geometry and
77                                              Aneuploid cells experience a number of stresses that are
78                                We found that aneuploid cells experience DNA replication stress in the
79 de screen in yeast to identify a guardian of aneuploid cell fitness conserved across species.
80 dent apoptosis limits the formation of these aneuploid cells following DNA damage.
81 ese observations suggest a selective loss of aneuploid cells from human embryos, but the underlying m
82 t the same mechanisms lead to the removal of aneuploid cells from mosaic embryos.
83 unrestrained propagation of tetraploids into aneuploid cells, further undermines genomic stability an
84                                    While the aneuploid cells generally display a growth disadvantage
85 l RNA sequencing reveal that the RS-mediated aneuploid cells generated by TAK-931 intensively activat
86                                       Indeed aneuploid cells harbor increased levels of reactive oxyg
87  stem and progenitor cell (HSPC) compartment aneuploid cells have reduced fitness and are efficiently
88 ss of aneuploid yeast, is a key regulator of aneuploid cell homeostasis.
89 romosomal missegregation and accumulation of aneuploid cells in 53BP1-/- p53+/+ and 53BP1-/- p53-/- t
90  a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, p
91 tment also reduced the steady-state level of aneuploid cells in HPV-16 E7-expressing cell populations
92 ereas Ccne1(T) mice accumulated near-diploid aneuploid cells in multiple tissues and organs, polyploi
93  pathway in many tumors, but the presence of aneuploid cells in some normal human and mouse tissues i
94 o that in control embryos, the percentage of aneuploid cells in ST embryos did not significantly chan
95 om death and allowed for the accumulation of aneuploid cells in the epidermis.
96  12 controls revealed a higher proportion of aneuploid cells in the exposed group (median, 18.8% [int
97  fate of aneuploid cells depends on lineage: aneuploid cells in the fetal lineage are eliminated by a
98        We found no significant enrichment of aneuploid cells in the trophectoderm compared to the inn
99                                              Aneuploid cells in these mutant mice are likely eliminat
100 ted against suggests that the persistence of aneuploid cells in tumors requires not only chromosome m
101 icroRNA-based therapeutic strategy to target aneuploid cells in VHL-associated cancers.
102 s were identified with altered expression in aneuploid cells, including overexpression of the cellula
103 e-specific phenotypes and global stresses of aneuploid cells, including oxidative and proteotoxic str
104                                We found that aneuploid cells increased in a concentration- and time-d
105                    Most solid tumors contain aneuploid cells, indicating that the mitotic checkpoint
106 ggest that the generation and maintenance of aneuploid cells is a widespread, if not universal, prope
107                       Selective targeting of aneuploid cells is an attractive strategy for cancer tre
108           Notably, the importance of UBP3 in aneuploid cells is conserved.
109 that the fitness ranking between euploid and aneuploid cells is dependent on context and karyotype, p
110 uman tumors, but the molecular physiology of aneuploid cells is not well characterized.
111                   Overall, the proportion of aneuploid cells is progressively depleted from the blast
112 more find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequenc
113 n prostate cancers, a subpopulation of small aneuploid cells lacking epithelial markers is enriched f
114 ed the UVSSA protein using CRISPR-Cas9 in an aneuploid cell line, HEK293, and determined the function
115                             Cancer cells and aneuploid cell lines can acquire resistance against mult
116                                Most of these aneuploid cell lines had rapid proliferation rates and e
117 ical maturation is disrupted across multiple aneuploid cell lines, leading to a weak metaphase tensio
118 ckpoint activity, increased mitotic defects, aneuploid cells marked by a specific transcriptional sig
119  early human embryo, including management of aneuploid cells, may paradoxically promote embryo develo
120                                     However, aneuploid cells might instead be glia, nonneural, or dyi
121     However, in a second gastric cancer with aneuploid cells, no somatic L1 insertions were found.
122 ide screen uncovered a general dependency of aneuploid cells on a pathway of ubiquitin-mediated endoc
123 totic centrosomes, may induce an increase of aneuploid cell population and contribute to tumorigenesi
124 hat these cells could propagate to create an aneuploid cell population.
125 neuploidy in 13 of 15 patients (87%) who had aneuploid cell populations detected in premalignant epit
126 on status of the p16 promoter in flow-sorted aneuploid cell populations from 21 patients with premali
127                                              Aneuploid cell populations from 32 patients with Barrett
128 alysis confirmed the presence of significant aneuploid cell populations.
129 e patients (75%) had allelic loss at 9p21 in aneuploid cell populations.
130 ploid) cell fractions, and the appearance of aneuploid cell populations.
131 eattachment defect, and selective removal of aneuploid cell populations.
132 ntaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) th
133  propose that the ESR serves two purposes in aneuploid cells: protecting cells from aneuploidy-induce
134 at the ESR causes selective ribosome loss in aneuploid cells, providing an explanation for the decrea
135                        The mutation rates of aneuploid cells ranged from 10(-4) to 10(-6), but no dru
136 e oxygen species (ROS) mitigating enzymes in aneuploid cells reduced the levels of ROS but caused an
137  cells was observed in confluent cultures in aneuploid cells relative to their diploid counterparts.
138 chromosome 3q that occurs in HPV16-infected, aneuploid cells represents a pivotal genetic aberration
139                                          The aneuploid cells result from aberrant mitosis as multipol
140  in cells undergoing mitotic slippage and in aneuploid cells resulting from aberrant mitosis.
141 eight-cell division, we efficiently generate aneuploid cells, resulting in embryo death during peri-i
142                    Simulation of the fate of aneuploid cells revealed that these cells could propagat
143 tion provide a window of opportunity whereby aneuploid cells rise in frequency, only to decline to ba
144 cription of metabolic genes, consistent with aneuploid cell state.
145      Flow cytometry revealed emergence of an aneuploid cell subpopulation.
146 lic conditional gene knockouts in diploid or aneuploid cells, such as pluripotent stem cells, 3D orga
147 e demonstrate that certain drugs that act on aneuploid cells synergize with inhibitors of Aurora B to
148                     Our results suggest that aneuploid cells that accumulate during aging in some mam
149 ome segregation can lead to the formation of aneuploid cells that harbor an imbalanced complement of
150 nerate a diverse population of proliferative aneuploid cells that have the potential to contribute to
151 are used in gene-expression comparisons with aneuploid cells, the CAGE signature is no longer evident
152 portantly, CRAF and MEK inhibition sensitize aneuploid cells to DNA damage-inducing chemotherapies an
153 expression profile of actively proliferating aneuploid cells to that of euploid cells grown into stat
154                                          How aneuploid cells tolerate chromosome arm gains or losses
155                    Finally, we observed that aneuploid cells up-regulate immune response genes and do
156 ere, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromo
157 and a 70-gene signature derived from primary aneuploid cells was defined as a strong predictor of inc
158 he strongest inducers of the ESR, the ESR in aneuploid cells was masked when stationary phase euploid
159 uncover the genetic dependencies specific to aneuploid cells, we conducted a comprehensive, genome-wi
160             We also found that many of these aneuploid cells were able to continue to grow and form c
161                             In three tumors, aneuploid cells were detected by FACS.
162           Co-assay profiling showed that the aneuploid cells were mainly associated with the two lumi
163 although p53 could suppress the formation of aneuploid cells, which could have a role in tumorigenesi
164 AK-931 induce RS, generating senescence-like aneuploid cells, which highly expressed inflammatory cyt
165 s encoded on excess chromosomes aggregate in aneuploid cells, which is suppressed when expression of
166 ndirect, and confounded by selection against aneuploid cells, which reduces observable diversity.
167  chromosome missegregation rates to generate aneuploid cells with CIN.
168  methods for rapid and accurate detection of aneuploid cells with local copy number deletion or ampli
169                             The existence of aneuploid cells within the mammalian brain has suggested
170 sely resembles the stressed state of primary aneuploid cells, yet CIN is not benign; a subset of gene
171 lantation embryos are mosaics of euploid and aneuploid cells, yet those with a low proportion of aneu

 
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