ライフサイエンスコーパス: aneuploidy

1 h midzone organization by EWSR1/FLI1 induces aneuploidy.

2 athway could influence the risk of embryonic aneuploidy.

3 may occur at the transition from euploidy to aneuploidy.

4 gation without deleterious outcomes, such as aneuploidy.

5 osomes can contribute to chromosome-specific aneuploidy.

6 which can increase the chance of developing aneuploidy.

7 whole-chromosome gains and losses, known as aneuploidy.

8 spindle morphogenesis and dynamics, inducing aneuploidy.

9 ciated with chromosome instability (CIN) and aneuploidy.

10 tics of development, and genetic testing for aneuploidy.

11 isition of tolerance to antifungal drugs via aneuploidy.

12 ociation between histone gene expression and aneuploidy.

13 on cellular defects that are associated with aneuploidy.

14 mitosis as well as protecting cells against aneuploidy.

15 approach can accurately detect low levels of aneuploidy.

16 rotein levels, leading to mitotic errors and aneuploidy.

17 eve optimal chromosome alignment and prevent aneuploidy.

18 rved deletions, duplications, and chromosome aneuploidy.

19 ults in chromosome missegregation leading to aneuploidy.

20 eguard against chromosome missegregation and aneuploidy.

21 sperm have reduced levels of DNA damage and aneuploidy.

22 rise to embryos that fail to develop due to aneuploidy.

23 with the same Gleason score and no predicted aneuploidy.

24 st and causes chromosome mis-segregation and aneuploidy.

25 n the fidelity of chromosome segregation and aneuploidy.

26 ide a second safeguard against brain somatic aneuploidy.

27 osis maintains genome stability and prevents aneuploidy.

28 neuploid cells and cells with natural random aneuploidy.

29 explore cellular mechanisms associated with aneuploidy.

30 h lead to chromosome gains/losses and random aneuploidy.

31 the development of genomic instability with aneuploidy.

32 ous to normal cells because of the burden of aneuploidy.

33 , succumb to enhanced tumour development and aneuploidy.

34 hments that could lead to missegregation and aneuploidy.

35 ty is essential for its function in limiting aneuploidy.

36 synapsis, thereby minimizing transmission of aneuploidy.

37 nd treatment responses of diseases caused by aneuploidy.

38 r activities by producing massive chromosome aneuploidy.

39 ar organization in health and sex chromosome aneuploidy.

40 ome segregation errors to the development of aneuploidy.

41 , and the most frequent survivable autosomal aneuploidy.

42 a B during anaphase, leading to induction of aneuploidy.

43 , affects the genesis of chromosome-specific aneuploidy.

44 surprisingly, this only rarely causes lethal aneuploidy.

45 idies and 23 (31%) embryos possessed meiotic aneuploidies.

46 changes, including 56 with whole chromosome aneuploidies.

47 gation leads to abnormal chromosome numbers (aneuploidy)(1-8).

48 GSs on 11 RGDs including four sex-chromosome aneuploidies (47,XXX; 47,XXY; 47,XYY; 45,X) that affect

49 or segmental as compared to whole-chromosome aneuploidies (70.8% versus 97.18%, respectively).

50 dicate that while FISH tended to over-report aneuploidies, a modified 2-probe approach can accurately

51 Defects in this process lead to aneuploidy, a common feature of cancer cells and the cau

52 Aneuploidy, a condition characterized by chromosome gain

53 Aneuploidy, a condition characterized by whole chromosom

54 omere features can translate into non-random aneuploidy, a hallmark of cancer and genetic diseases.

55 les from patients with cirrhosis to quantify aneuploidy, a possible outcome of polyploid cell divisio

56 increased loss of a minichromosome; elevated aneuploidy; a down-regulation of the protein levels of c

57 evelopment could help explain the paradox of aneuploidy abundance in tumors despite somatic fitness c

58 Chromosome errors, or aneuploidy, affect an exceptionally high number of human

59 aneuploidy is debated, with reports showing aneuploidy affects 5% to 60% of hepatocytes.

60 ring that 55 (74%) embryos possessed mitotic aneuploidies and 23 (31%) embryos possessed meiotic aneu

61 Identification of chromosomal aneuploidies and copy number variants that are associate

62 rage whole-genome sequencing to detect fetal aneuploidies and copy-number variants (CNVs) at ~1 Mb re

63 FTLD-causing mutations in human MAPT induce aneuploidy and apoptosis in the mammalian brain.

64 and multipolar spindle formation, leading to aneuploidy and apoptosis, which could relate to depletio

65 nic mice led to aberrant mitosis followed by aneuploidy and apoptosis.

66 re, we investigated the relationship between aneuploidy and cancer development using cells engineered

67 To examine the relationship between aneuploidy and cancer progression, we analyzed a series

68 pindle assembly checkpoint (SAC) can lead to aneuploidy and cancer.

69 ights into the complex relationships between aneuploidy and carcinogenesis.

70 orms of epithelial cancer is associated with aneuploidy and carcinogenesis.

71 tached/misattached chromosomes, resulting in aneuploidy and cell death.

72 ionally, we demonstrate that miR-26a induces aneuploidy and centrosome defects and enhances tumorigen

73 Although excess centrosomes can lead to aneuploidy and chromosome instability in tumor cells, ho

74 Testing for aneuploidy and CNVs is routine during the investigation

75 After exclusion of fetuses with aneuploidy and CNVs, 610 fetuses with structural anomali

76 % were of high quality and scorable for both aneuploidy and CNVs.

77 gnatures show that whole genome duplication, aneuploidy and complex rearrangements are common.

78 uently observed in tumors, where it promotes aneuploidy and contributes to invasive phenotypes.

79 e review the molecular mechanisms underlying aneuploidy and discuss its contributions to B-ALL initia

80 Recent studies show that aneuploidy and driver gene mutations precede cancer diag

81 a separate cluster for which chromosomal-arm aneuploidy and driver mutations are mutually exclusive.

82 Topo II dysfunction promotes aneuploidy and drives cancer.

83 Aneuploidy and epigenetic alterations have long been ass

84 orrelated with the tissue-specific levels of aneuploidy and genetic heterogeneity observed in primary

85 merary centrosomes, and this correlates with aneuploidy and genetic instability.

86 ells characteristically show a high level of aneuploidy and genomic instability.

87 expression-based score that correlates with aneuploidy and has prognostic value in many types of can

88 e in uncovering the cellular consequences of aneuploidy and how aneuploid cancer cells self-adapt to

89 characterise chromosome-specific patterns of aneuploidy and identified extensive structural variation

90 in the tyrosinemic livers were generated by aneuploidy and inactivating mutations.

91 Variability increases with degree of aneuploidy and is partly due to gene copy number imbalan

92 mples from their parents, after exclusion of aneuploidy and large CNVs.

93 Our analysis revealed that the aneuploidy and micronucleation frequency is conserved be

94 remature progression through mitosis, marked aneuploidy and mitotic catastrophe.

95 ically unstable due to increased chromosomal aneuploidy and more aggressive.

96 s, PicoPLEX and RepliG performing better for aneuploidy and SNP calling, respectively.

97 contribute to increased incidence of oocyte aneuploidy and spontaneous abortion in aging females.

98 st; n = 390), we determine the origin of the aneuploidy and the diagnostic predictive value of segmen

99 mosomal instability (CIN), which resulted in aneuploidy and tumor formation.

100 t enables the loss of HJURP to induce severe aneuploidy and, ultimately, apoptotic cell death.

101 ive association between driver mutations and aneuploidy, and a characteristic set of mutations that i

102 study relationships among liver polyploidy, aneuploidy, and adaptation, mice lacking E2f7 and E2f8 i

103 of the proteome imbalance that is caused by aneuploidy, and also predicted a relationship between pl

104 ed CIN25 and CIN70 gene expression patterns, aneuploidy, and defects in mitosis.

105 wed extensive gene amplifications, pervasive aneuploidy, and fission of chromosomes 30 and 36.

106 mosome missegregation events, propagation of aneuploidy, and genetic heterogeneity in xenograft model

107 ivation and we previously showed DNA damage, aneuploidy, and senescence in somatotroph adenomas, we s

108 This process is tightly controlled to avoid aneuploidy, and we previously showed that active Ran coo

109 py-number data, we demonstrate that specific aneuploidies are associated with distinct outcomes, and

110 ionally been based on assumptions that these aneuploidies are lethal or associated with poor quality

111 ies, the origin and characteristics of these aneuploidies are still relatively unknown.

112 Gene dosage alterations caused by aneuploidy are a common feature of most cancers yet pose

113 High levels of cancer aneuploidy are frequently associated with poor prognosis

114 Driver mutations and chromosomal aneuploidy are major determinants of tumorigenesis that

115 Chronic inflammation and chromosome aneuploidy are major traits of primary liver cancer (PLC

116 dian of 15 years, increasing extent of tumor aneuploidy as predicted from the tumor transcriptome was

117 The aim of this study was to characterise aneuploidies associated with equine EPL.

118 hanism for EWSR1/FLI1-dependent induction of aneuploidy associated with mitotic dysfunction and the i

119 Gene expression-aneuploidy association studies have previously been cond

120 ty and gene co-regulation on gene expression-aneuploidy associations.

121 r, our results indicate a close link between aneuploidy, autophagy, and apoptosis to refine the embry

122 o this end, we extended an approach to infer aneuploidies based on dosage-associated changes in gene

123 We test the hypothesis that aneuploidy brings about resistance to chemotherapies bec

124 servation of common transcriptome changes of aneuploidy by averaging out karyotype-specific dosage ef

125 ized by in situ co-examination of chromosome aneuploidy by FISH and immunostaining of multiple biomar

126 Chromosome arm aneuploidies (CAAs) are pervasive in cancers.

127 during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress

128 and psychiatric disorders in sex chromosome aneuploidies can inform appropriate management of these

129 uniform driver of malignancy, and different aneuploidies can uniquely influence tumor progression.

130 cell line, we report that the dose effect of aneuploidy can be further compensated at the translation

131 These results suggest that aneuploidy can directly cause epigenetic instability and

132 Aneuploidy can instigate tumorigenesis.

133 Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in hum

134 Alteration of normal ploidy (aneuploidy) can have a number of opposing effects, such

135 instability, the process that gives rise to aneuploidy, can promote tumorigenesis by increasing gene

136 Here, we investigate how aneuploidy causes both slow proliferation and poor disea

137 To protect from aneuploidy, cells possess mechanisms to delay anaphase o

138 century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts

139 oprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of mic

140 rized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosom

141 alization of Aurora B, and greater levels of aneuploidy, compared with noninduced cells.

142 rmation, the genome-destabilizing effects of aneuploidy confer an evolutionary flexibility that may c

143 BR1 allelic effects beyond protein level and aneuploidy contribute to disease heterogeneity in both M

144 nge of genetic causes, including chromosomal aneuploidy, copy number variations (CNVs; which are dete

145 Aneuploidy correlates with slowed proliferation and drug

146 h carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required

147 ifferent meiotic errors, we fit our model to aneuploidy data from 11,157 blastocyst-stage embryos.

148 Aneuploidy, defined as abnormal chromosome number or som

149 Aneuploidy, defined as chromosome gains and losses, is a

150 Aneuploidy, defined as whole chromosome gains and losses

151 the diagnostic predictive value of segmental aneuploidy detection in TE biopsies toward the ICM's chr

152 nt oocytes exhibit an increased frequency of aneuploidy, digyny, progressive delays in preimplantatio

153 However, the prevalence of aneuploidy dramatically declines as pregnancy progresses

154 the first time the presence and emergence of aneuploidy-driven FLC heteroresistance in human CM, asso

155 ic catastrophe, chromosome mis-segregation / aneuploidy due to premature anaphase, and cytokinesis fa

156 To model the acquisition of aneuploidy during early carcinogenesis, chromosome misse

157 into how homeostatic DSB controls respond to aneuploidy during meiosis.

158 m females aged 9 to 43 years and report that aneuploidy follows a U-curve.

159 The germinated progeny exhibited aneuploidy for multiple chromosomes and showed improved

160 sequencing (scL-WGS) analyses, which showed aneuploidy frequencies at least an order of magnitude lo

161 lows for the accurate detection of segmental aneuploidies from in vitro fertilization embryo biopsies

162 w the existence in budding yeast of a common aneuploidy gene-expression signature that is suggestive

163 ental stress response" (ESR) and the "common aneuploidy gene-expression" (CAGE) signature, in which m

164 n-selection balance dependent on the rate of aneuploidy generation per cell division.

165 of gene expression in cancer can arise from aneuploidy, genome disorganization or abnormal DNA methy

166 ion scale and identifies genes implicated in aneuploidy, genome instability and cancer susceptibility

167 turn promotes chromosome missegregation and aneuploidy, hallmarks of cancer.

168 Aneuploidy has been reported to occur at remarkably high

169 The majority of these aneuploidies have never been reported in live born equin

170 eoformans var. neoformans (serotype AD) such aneuploidies have resulted in loss of heterozygosity, wh

171 the predominant mitotic origin of segmental aneuploidies in preimplantation embryos and develop a ri

172 paraffin-embedded colon tissue, we detected aneuploidy in 15 of 37 samples with fLGD (40.5%).

173 hromatin-based system required for inducible aneuploidy in a human pathogen.

174 gene knockdowns that lead to an increase in aneuploidy in checkpoint-deficient human cancer cells.

175 of MLPA aids the identifications of CNV and aneuploidy in childhood B-ALL.

176 These results point to a key role of aneuploidy in driving aggressive disease in primary pros

177 If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise viability in offspr

178 gulating pathways associating with increased aneuploidy in hematopoietic progenitor cells.

179 The high degree of aneuploidy in HepG2 renders traditional genome variant a

180 Genomic analysis revealed high rates of aneuploidy in heteroresistant colonies as well as in rel

181 ygotic cell division contribute to pervasive aneuploidy in human embryos.

182 This study also confirms aneuploidy in LP cells, provides antigens that may be he

183 may shed light on the early consequences of aneuploidy in mammalian cells.

184 sequently, Miwi-deficient mice show elevated aneuploidy in metaphase II and spermatid death.

185 We present the first evidence of aneuploidy in naturally occurring equine EPLs at a simil

186 features defined clone-specific chromosomal aneuploidy in polyclonal populations.

187 Furthermore, we found a high level of aneuploidy in post-mitotic differentiated tissue.

188 our work provides a high-resolution view of aneuploidy in preimplantation embryos, and supports the

189 Sequencing System (RealSeqS) that can detect aneuploidy in samples containing as little as 3 pg of DN

190 The high incidence of aneuploidy in the embryo is considered the principal cau

191 an excellent model for studying the role of aneuploidy in tumorigenesis.

192 are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more

193 that promoted chromosome missegregation and aneuploidy, including incomplete replication of DNA, cen

194 dle alterations, delayed anaphase onset, and aneuploidy, indicating that PI3K-C2alpha expression is r

195 es in aneuploid cells: protecting cells from aneuploidy-induced cellular stresses and preventing exce

196 ther than the CAGE signature, in response to aneuploidy-induced cellular stresses, resulting in selec

197 ther, these results support the concept that aneuploidy-inducing gene deficiencies contribute to cell

198 volved in chromosome segregation can lead to aneuploidy induction.

199 within the tumor suppressor gene FHIT Taking aneuploidy into account, we reanalyzed K562 RNA-seq and

200 for metastatic melanoma, we found that tumor aneuploidy inversely correlates with patient survival.

201 nct outcomes, and the acquisition of certain aneuploidies is in fact linked with a favorable prognosi

202 Instead, recent studies suggest that aneuploidy is a context-dependent, cancer-type-specific

203 Aneuploidy is a feature of many cancers.

204 Aneuploidy is a hallmark of cancer, although its effects

205 Aneuploidy is a hallmark of most human tumors, but the m

206 function is unclear, and the degree of liver aneuploidy is debated, with reports showing aneuploidy a

207 the plasticity of the embryo in dealing with aneuploidy is fundamental to normal development, the mec

208 Aneuploidy is highly detrimental during development yet

209 Thus, aneuploidy is not a uniform driver of malignancy, and di

210 tually all cell types and cellular contexts, aneuploidy is not a universal promoter of tumorigenesis.

211 amage without generating mitotic errors, and aneuploidy is not commonly observed in cirrhotic livers.

212 Aneuploidy is physiologically associated with significan

213 , compared with other tumor types, extensive aneuploidy is relatively rare in prostate cancer.

214 Aneuploidy is the leading contributor to pregnancy loss,

215 Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, ye

216 Abnormal chromosome number, or aneuploidy, is common in early mammalian embryos, althou

217 the cellular and organismal consequences of aneuploidy, it is important to determine how altered gen

218 However, much less is known about how aneuploidy itself contributes to tumour formation and pr

219 ains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability.

220 t as confounders between gene expression and aneuploidy, leading to spurious correlations between the

221 oupled with the endocytic defect inherent to aneuploidy, leads to a marked alteration of intracellula

222 serve specific genetic variations, including aneuploidy levels and SNPs.

223 Further, scL-WGS tends to underestimate aneuploidy levels, especially in a polyploid background.

224 for any dysplasia, colon segment resection, aneuploidy, male sex, and age was classified as weak.

225 Even though embryos with CIN-derived complex aneuploidies may arrest between the cleavage and blastoc

226 MM both accounts for the impact of purity on aneuploidy measurements and identifies a new association

227 ity, eliciting mitotic failures that trigger aneuploidy, mitosis-dependent DNA damage responses, p53

228 Our method thus allowed the detection of aneuploidy mosaicism, and provides a solid basis which c

229 rity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutatio

230 Mosaic-variegated aneuploidy (MVA) syndrome is a rare childhood disorder c

231 BUB1B are responsible for mosaic variegated aneuploidy (MVA), a human congenital disorder characteri

232 ades of phenotype-driven research, 80-90% of aneuploidy-negative holoprosencephaly individuals with a

233 Aneuploidy occurs within a significant proportion of chi

234 n zygotes survive to birth, primarily due to aneuploidies of meiotic or mitotic origin.

235 tion leads to rDNA bridges, rDNA damage, and aneuploidy of an rDNA-containing acrocentric chromosome.

236 investigating the immediate consequences of aneuploidy on cell physiology, we identified mechanisms

237 The effect of aneuploidy on liver function is unclear, and the degree

238 iseases, complementing current screening for aneuploidies or carrier screening for recessive disorder

239 Fetuses with confirmed aneuploidy or a causal pathogenic copy number variant we

240 tionary model for the dynamics of cells with aneuploidy or other fitness-reducing mutations during he

241 n the multitude of diseases linked to either aneuploidy or protein aggregation, this study could serv

242 otoplast regenerants tested were affected by aneuploidy or structural chromosomal changes.

243 We propose that, similar to aneuploidy or tetraploidy, haploidy triggers a p53-depen

244 ling that two mechanisms could underlie this aneuploidy peak: rapid expansion of the engrafted HSPC p

245 d aneuploidy rates ranging from 0.01 to 0.05 aneuploidies per gamete; crossovers partially protected

246 ironment is favorable to retrotransposition, aneuploidy predisposes tumor cells to L1 insertions, and

247 s virtually eliminated from cells exposed to aneuploidy-promoting cues.

248 The study of individuals with sex chromosome aneuploidies provides a promising framework for studying

249 in oocytes and could contribute to the high aneuploidy rate observed during female meiosis, a leadin

250 Sperm donors had aneuploidy rates ranging from 0.01 to 0.05 aneuploidies

251 h resolution, SNVs and Indels (corrected for aneuploidy), regions with loss of heterozygosity, phased

252 , the developmental consequences of specific aneuploidies remain unexplored.

253 e common in solid tumors, different forms of aneuploidy represent the initiating oncogenic lesion in

254 Aneuploidy rescue can restore euploidy but may result in

255 can significantly improve the prediction of aneuploidy risk in the ICM in over 86% of clinical cases

256 ly used to study how maternal ageing impacts aneuploidy risk, however the differences in reproductive

257 um biomarkers (AMSB), identified through the aneuploidy screening programme, are frequent incidental

258 2,208 samples sent for non-invasive prenatal aneuploidy screening to detect CMV and precisely measure

259 = 0.94, specificity = 0.92), chromosome 7/10 aneuploidies (sensitivity = 0.90, specificity = 0.88), a

260 ve PCR-based assay called Repetitive Element AneupLoidy Sequencing System (RealSeqS) that can detect

261 Loss of SSD1 recapitulates myriad aneuploidy signatures previously taken as eukaryotic res

262 general and seemingly detrimental effect of aneuploidy, slowed proliferation, provides a selective b

263 We show that the CAGE signature is not an aneuploidy-specific gene-expression signature but the re

264 mere data and DNA index correlated well with aneuploidy status at higher sensitivity than cytogenetic

265 asurement of DNA index in order to identify, aneuploidy status in our cohort.

266 Sex chromosome aneuploidies, such as Turner syndrome (X0) and Klinefelt

267 These events likely contribute to aneuploidy suppression.

268 cribe here an original mode of generation of aneuploidies that could be very common in oocytes and co

269 Aneuploidy that arises during meiosis and/or mitosis is

270 Aneuploidy, the gain or loss of chromosomes in a cell, i

271 Aneuploidy, the presence of an abnormal number of chromo

272 he preferred method for studying single cell aneuploidy, this method was applied in a second step, on

273 The MLPA telomere kit was used to identify aneuploidy through detection of whole chromosome loss or

274 ugh our understanding of the contribution of aneuploidy to cancer initiation and progression is incom

275 e find that BCL9L dysfunction contributes to aneuploidy tolerance in both TP53-WT and mutant cells by

276 We show that aneuploidy tolerance is enabled via a role for Ssd1 in m

277 Efforts to exploit aneuploidy tolerance mechanisms and the BCL9L/caspase-2/

278 ic fungi - what gives rise to differences in aneuploidy tolerance remains unclear.

279 nt a mechanistic understanding of eukaryotic aneuploidy tolerance.

280 chromosome instability (CIN), which leads to aneuploidy, translocations, and other chromosome aberrat

281 development of human embryos bearing common aneuploidies using a recently established culture platfo

282 ance of large autosomal CNVs and chromosomal aneuploidies using a standard CNV detection algorithm no

283 colorectal cancer in patients with fLGD and aneuploidy was 5.3 (95% CI, 1.542-24.121) within a mean

284 Aneuploidy was associated with lethality even among men

285 Aneuploidy was detected in 12/55 EPLs (21.8%), and 0/15

286 By comparison, aneuploidy was detected in 14 of 15 samples with flat HG

287 Aneuploidy was detected in 49% of liquid biopsies from a

288 Acquired aneuploidy was frequently detected in recurrent gliomas

289 prevalent meiotic origin of whole-chromosome aneuploidies, we show that sub-chromosomal abnormalities

290 to understand how cells develop tolerance to aneuploidy, we subject disomic (i.e. with an extra chrom

291 Aneuploidies were detected in both placental and fetal c

292 o the prevention chromosomal instability and aneuploidy which frequently occur in cancer cells.

293 rrors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or cell

294 y and paclitaxel treatment induces excessive aneuploidy, which in turn results in elevated cell death

295 Aneuploidy, which refers to unbalanced chromosome number

296 normalities, chromosome mis-segregation, and aneuploidy, which then lead to apoptosis.

297 e were found to exhibit increasing levels of aneuploidy with decreasing Tau gene dosage.

298 Combining aneuploidy with somatic mutation detection and eight sta

299 Our analysis revealed widespread mosaic aneuploidies, with 59 of 74 (80%) embryos harboring at l

300 d the DNA mutations and chromosome arm-level aneuploidy within tumours with low, intermediate and hig