ライフサイエンスコーパス: anhedonia

1 impact of lateral hypothalamic stimulation (anhedonia).

2 tology common across these conditions (e.g., anhedonia).

3 ility to stress-induced social avoidance and anhedonia.

4 buting to the generation of symptoms such as anhedonia.

5 ockout mice were resilient to stress-induced anhedonia.

6 MDD and were associated with suicidality and anhedonia.

7 -related motivation, and questionnaire rated anhedonia.

8 wed depression-like behavior but no signs of anhedonia.

9 s in association with reduced motivation and anhedonia.

10 mal responses to behavioural challenges, and anhedonia.

11 e hippocampus protects rats from CUS-induced anhedonia.

12 ced reward-contingency learning with greater anhedonia.

13 depression-associated dendritic atrophy and anhedonia.

14 erence in the two-bottle free-choice test of anhedonia.

15 this area correlates with depressed mood and anhedonia.

16 ficantly with clinical ratings for avolition/anhedonia.

17 ic antidepressants to reverse stress-induced anhedonia.

18 ecreases in sucrose preference, a measure of anhedonia.

19 ard learning compared with patients with low anhedonia.

20 ating symptoms that include hopelessness and anhedonia.

21 the novel object location task and increased anhedonia.

22 ide a new psychological conceptualization of anhedonia.

23 in relation to this new conceptualization of anhedonia.

24 ses behavioural signs of anxiety and induces anhedonia.

25 in multiple animal models of depression and anhedonia.

26 nt MDD and, more specifically, in those with anhedonia.

27 e reward learning, an important component of anhedonia.

28 d decreased sucrose preference, a measure of anhedonia.

29 er implicated the fronto-striatal network in anhedonia.

30 ch pointed to the symptomatic equivalence of anhedonia.

31 ted the relationship between photoperiod and anhedonia.

32 ypertensive animals showing some symptoms of anhedonia.

33 im stress decreased resulting stress-induced anhedonia.

34 brain glutamate in relation with symptoms of anhedonia.

35 ased passive coping (PC), but not anxiety or anhedonia.

36 echanisms through which stress may influence anhedonia.

37 its and chronic social defeat stress-induced anhedonia.

38 at is typically associated with low mood and anhedonia.

39 duced striatal volume prospectively predicts anhedonia.

40 ed by the EPDS: depressed mood, anxiety, and anhedonia.

41 c sample screened for elevated self-reported anhedonia, 8 weeks of treatment with a kappa-opioid rece

42 rs to a 10 day CSDS regimen known to produce anhedonia (a depressive-like effect) and social avoidanc

43 havior is hypothesized to be associated with anhedonia, a core feature and potential trait marker of

44 r marker of susceptibility to stress-induced anhedonia, a core symptom of depression, and a means to

45 e uptake in the PFC is sufficient to produce anhedonia, a core symptom of depression.

46 Anhedonia, a core symptom of major depressive disorder (

47 onadal hormones to cellular excitability and anhedonia-a key feature in depressive states.

48 were negatively associated with symptoms of anhedonia across both groups.

49 , have complicated our understanding of what anhedonia actually reflects in this patient population.

50 ria1 (-/-) mice provide a potential model of anhedonia, adding converging evidence to the role of glu

51 olling for sex, age, and medical covariates, anhedonia (adjusted hazard ratio, 1.58; 95% confidence i

52 ts reported a sudden increase in anxiety and anhedonia after acute cessation of stimulation.

53 distortions, cognitive disorganization, and anhedonia (all p < 0.02).

54 Negative symptoms (e.g., anhedonia, amotivation, and expressive deficits) are ref

55 ore symptoms of major depressive disorder is anhedonia, an inability to experience pleasure.

56 ontrolled, randomized trial in patients with anhedonia and a mood or anxiety disorder (selective KOR

57 Improvement was most notable on the SANS anhedonia and alogia subscales.

58 as improvement in negative symptoms such as anhedonia and alogia.

59 LT-1 in the CEA is sufficient to induce both anhedonia and anxiety and therefore that a lack of gluta

60 blockade in the CEA would induce symptoms of anhedonia and anxiety in rats.

61 e and negative reactivity mirror symptoms of anhedonia and anxiety that are so often comorbid in mood

62 ntives compared to controls, associated with anhedonia and anxiety, respectively.

63 linically-related symptoms and traits (e.g., anhedonia and apathy), yet no research has explored this

64 everses chronic unpredictable stress-induced anhedonia and behavioral despair, indicating an antidepr

65 n, including dysregulated feeding behaviour, anhedonia and behavioural despair.

66 ocytic glutamate transporter (GLT-1) induces anhedonia and c-Fos expression in areas that regulate an

67 rated that central blockade of GLT-1 induces anhedonia and c-Fos expression in the PFC.

68 is study found that CSDS triggers persistent anhedonia and confirms that DeltaFosB overexpression pro

69 14.8%): 108 (24%) and 77 (17%) patients had anhedonia and depressed mood, respectively.

70 tivity is relevant to the pathophysiology of anhedonia and depression as well as the increasing appre

71 Male rats showed anhedonia and depression-like behavior after 8 weeks of

72 d the fast-acting antidepressant ketamine on anhedonia and depression-like behavior, spine density, a

73 ral (but not ipsilateral) Acb, mitigated the anhedonia and depression-like behaviors in alcohol-withd

74 These rats displayed clear anhedonia and depression-like behaviors, as measured wit

75 tic inhibition of RMTg neurons mitigated the anhedonia and depression-like behaviors.

76 response is interrelated to the progress of anhedonia and despair symptoms of T. gondii-infected sub

77 induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dy

78 and reducing depressive-like states such as anhedonia and dysphoria.

79 authors reviewed the empirical literature on anhedonia and emotional experience in schizophrenia thro

80 e mechanisms underlying the PTSD symptoms of anhedonia and emotional numbing.

81 in mood and cognition, loss of interest and anhedonia and emphasized several features not in DSM inc

82 trate greater efficacy, with the reversal of anhedonia and improved tolerability.

83 Left, but not right, MCAo, elicited anhedonia and increased anxiety and despair.

84 Social stress induces anhedonia and increases risk of depression, although the

85 he relationship between photoperiod and both anhedonia and low mood, while midbrain volume mediated t

86 ar mechanism(s) of testosterone in mediating anhedonia and manipulated extracellular signal-regulated

87 ic disorders, and are related to symptoms of anhedonia and motor retardation.

88 ed significant relationships between CRP and anhedonia and motor slowing.

89 An understanding of anhedonia and other reward-related constructs will facil

90 we show in a mouse model for stress-induced anhedonia and passive coping that these phenomena are as

91 tes negative affective states, which include anhedonia and passive coping.

92 basal ganglia glutamate was associated with anhedonia and psychomotor slowing measured by the finger

93 nflammatory markers were assessed along with anhedonia and psychomotor speed.

94 arly childhood depression is associated with anhedonia and reduced event-related potential (ERP) resp

95 ry markers and depressive symptoms including anhedonia and reduced motivation (RM) were also explored

96 ptors are more susceptible to stress-induced anhedonia and social avoidance compared with wild-type m

97 and circuit processes underlying CES-induced anhedonia and tested them mechanistically.

98 signature of vulnerability to stress-induced anhedonia and the active nature of resilience could be t

99 MRI task to explore the relationship between anhedonia and the temporal difference-related response o

100 tomical features may confer vulnerability to anhedonia and thus, may inform early identification of i

101 sented in support of this new perspective on anhedonia and to demonstrate how cognitive impairments m

102 h assess the frequency of depressed mood and anhedonia) and can be used as a first step to identify p

103 motivation (e.g., sense of purpose, greater anhedonia), and fewer days of intoxication.

104 t baseline using validated scales to measure anhedonia, and a monetary incentive delay (MID) task dur

105 behavior including risk taking, depression, anhedonia, and addiction.

106 maladaptive behavioral stress responsivity, anhedonia, and an increased sensitivity to selective ser

107 together with increased behavioral despair, anhedonia, and anxiety-related behavior in the novelty-i

108 sions that reflect states of depressed mood, anhedonia, and anxiety.

109 e and hypersomnia, but less so with sadness, anhedonia, and appetite loss.

110 onic stress in rats resulted in weight loss, anhedonia, and hyperactivity of hypothalamic-pituitary-a

111 eward processing translationally relevant to anhedonia, and ketamine's modulation of an affective net

112 insufficient alleviation or even increase of anhedonia, and loss of interest.

113 sessing clinically impairing depressed mood, anhedonia, and major depressive episode (MDE).

114 anxious depression, anxious anhedonia, pure anhedonia, and resolved depression.

115 jects exhibited greater depression severity, anhedonia, and treatment nonresponse.

116 ssive symptoms, including social withdrawal, anhedonia, and weight loss.

117 ncreased susceptibility to social aversion, "anhedonia," and learned helplessness and causes impaired

118 Depressed mood, anhedonia, anergia, and apathy were assessed at baseline

119 depressive episode (MDE), such as low mood, anhedonia, anorexia, and weight loss.

120 akups were marked by high levels of sadness, anhedonia, appetite loss, and (for romantic breakups) gu

121 Both family history of MDD and subclinical anhedonia are associated with reduced FA in the bilatera

122 Both positive psychotic symptoms and anhedonia are associated with striatal functioning, but

123 Battery, EEG markers, and fMRI correlates of anhedonia are available, further work is needed for thei

124 Negative symptoms, such as amotivation and anhedonia, are a major cause of functional impairment in

125 ed whether these alterations are specific to anhedonia as compared with low mood and whether they are

126 ubsequent social avoidance and reductions in anhedonia as measured by intracranial self-stimulation.

127 findings help elucidate neural mechanisms of anhedonia, as a step toward identifying potential biosig

128 continuous rather than categorical scale of anhedonia, as in the present study, may permit greater s

129 cognitive disorganization, grandiosity, and anhedonia, as well as parent-rated negative symptoms).

130 rent rodent species, and immobility-based vs anhedonia-based measures of depressive-like behavior.

131 as found to reduce both immobility-based and anhedonia-based outcomes.

132 iated with symptoms of social withdrawal and anhedonia, both of which are strongly modulated by endog

133 KOR stimulation produced anhedonia but had no effect on expression or extinction

134 entral striatum activity was associated with anhedonia but not low mood; however, the combined presen

135 the HC group and correlated negatively with anhedonia but positively with the total hippocampal and

136 ted increases in behavioural measurements of anhedonia, but not increases in measurements of behaviou

137 ukocytes and behavioral responses (anorexia, anhedonia, cachexia) to simulated gram-negative bacteria

138 airment of reward perception and experience (anhedonia) can contribute to psychiatric diseases, inclu

139 ssion of active S6K1 in the mPFC blocked the anhedonia caused by chronic stress, resulting in a state

140 ajor depressive disorder is characterized by anhedonia, cognitive biases, ruminations, hopelessness a

141 Anhedonia continued to significantly predict outcomes (P

142 hresholds, a depressive-like sign reflecting anhedonia (decreased sensitivity to reward), whereas dis

143 icipants provided self-report assessments of anhedonia, depression, and anxiety symptoms.

144 onia severity while controlling for baseline anhedonia, depression, and anxiety symptoms.

145 otypes seen in humans diagnosed with autism (anhedonia, depression, anxiety, and altered social inter

146 ng and olfactory-associated behavior, and an anhedonia/depression-like deficit.

147 -like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness.

148 of ketamine fails to attenuate CSDS-induced anhedonia despite reducing other depression-related beha

149 Anhedonia, disrupted reward processing, is a core sympto

150 tested for behavioral assays of anxiety and anhedonia during estrogen withdrawal.

151 Anxiety and anhedonia emerged as prominent symptom dimensions with p

152 e nucleus accumbens is further decreased and anhedonia emerges.

153 rgoing PCIT-ED showed a greater reduction in anhedonia (F(1,103) = 10.32, p = .002, partial eta(2) =

154 PCIT-ED group showed a greater reduction in anhedonia (F(1,103) = 10.32, p = .002, partial eta(2) =

155 TG mice were also protected against anhedonia following both serotonin and catecholamine dep

156 RT adjustment correlated with self-reported anhedonia for both patients and controls.

157 vity during cognitively demanding tasks; and anhedonia from hypoactivation of the cuneus and posterio

158 or schizophrenia-spectrum disorders-a Social Anhedonia group and a Psychotic-like Experiences group-a

159 Compared to controls, the Social Anhedonia group showed smaller increases in the EPN in r

160 Untreated or poorly controlled anhedonia has been linked to worse disease course and in

161 st three decades, the clinical definition of anhedonia has remained relatively unchanged, although co

162 s functional connectivity studies related to anhedonia have focused on case-control comparisons in sp

163 Anhedonia identifies risk of MACE and ACM beyond that of

164 the NAS produces multiple behavioral signs (anhedonia, impaired extinction) characteristic of experi

165 Such 'musical anhedonia' implies the existence of music-specific brain

166 These findings support the hypothesis that anhedonia in depressed patients reflects the inability t

167 The dopamine system has been linked to anhedonia in depression and both the positive and negati

168 ural prediction error signals could underlie anhedonia in depression and negative symptoms in schizop

169 together with the ventral striatum, underlie anhedonia in depression.

170 o be negatively correlated with low mood and anhedonia in females while photoperiod was found to be p

171 K2 activity within the dentate gyrus induced anhedonia in gonadectomized rats receiving testosterone

172 It is associated with anhedonia in healthy adolescents and is a behavioral ind

173 al interactions, which predict the degree of anhedonia in individuals.

174 itionally, morphometric results suggest that anhedonia in major depression is related to caudate volu

175 More severe anhedonia in major depressive disorder (MDD) is a negati

176 deletion of AdipoR1 in 5-HT neurons induced anhedonia in male mice, as indicated by reduced female u

177 e, and reduces depression-like behaviors and anhedonia in mice exposed to chronic restraint stress.

178 s social defeat-induced social avoidance and anhedonia in mice.

179 Although 6-OHDA lesions did not induce anhedonia in our model, the dose of AMI utilized had ant

180 sociation between reinforcement learning and anhedonia in patients implies an additional disturbing i

181 m affected anticipatory reward, analogous to anhedonia in patients with schizophrenia and other psych

182 the PFC alone would be sufficient to induce anhedonia in rats.

183 iation of hedonic experience may manifest as anhedonia in schizophrenia.

184 which has been linked to abstinence-induced anhedonia in smokers and may play a critical role in smo

185 Chronic stress induces anhedonia in susceptible but not resilient individuals,

186 TPH2+ neurons and ameliorated stress-induced anhedonia in susceptible rats.

187 forced swim test and was sufficient to cause anhedonia in the absence of chronic stress exposure.

188 Ketamine did not block CSDS-induced anhedonia in the ICSS test.

189 TT, normalized PDE4 activity and ameliorated anhedonia in the R6/2 mice.

190 also relevant in other symptoms like social anhedonia in the schizophrenia disorder spectrum.

191 edicted symptoms of anxiety, depression, and anhedonia in the three study cohorts, and these effects

192 er NAM decreased passive coping and reversed anhedonia in two independent chronic stress models, sugg

193 the sucrose preference deficit, a measure of anhedonia, in rats exposed to chronic unpredictable stre

194 pain and depression, as well as in rats with anhedonia induced by chronic social stress.

195 A group x anhedonia interaction [t(57) = -2.29, P = 0.026] indicat

196 Anhedonia is a core symptom of depression, but the under

197 Anhedonia is a core symptom of major depressive disorder

198 Anhedonia is a transdiagnostic risk factor implicated in

199 -sectional research in adults has shown that anhedonia is associated with reduced dorsal striatal vol

200 tor and indicate that greater stress-induced anhedonia is associated with resistance to antidepressan

201 ce pleasure, evidence is mixed as to whether anhedonia is caused by a reduction in hedonic capacity.

202 Anhedonia is central to multiple psychiatric disorders a

203 An alternative explanation is that anhedonia is due to the inability to sustain positive af

204 Anhedonia is thought to reflect deficits in reward proce

205 agnostic investigation of KOR antagonism for anhedonia is warranted.

206 sdiagnostic sample characterized by elevated anhedonia, KOR antagonism improved the ability to modula

207 In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affe

208 ating and nest-building deficits, as well as anhedonia-like and anxiety-like behaviors.

209 Anhedonia-like behavior (sucrose consumption) was assess

210 uces striatal DA release in association with anhedonia-like behavior in nonhuman primates.

211 Exposure to SPS increased anhedonia-like behaviors and decreased the rewarding pro

212 ucine (DON) ameliorates social avoidance and anhedonia-like behaviors in mice subjected to chronic so

213 cation of cocaine "bingeing" relative to the anhedonia-like deterioration of reward processes during

214 , neither Per3(-/-) nor WT mice exhibited an anhedonia-like phenotype, and neither genotypes exhibite

215 D3 protein (Per3(-/-)) exhibited a transient anhedonia-like phenotype, observed as reduced sucrose pr

216 Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response elem

217 epressant treatment were CREB-dependent, the anhedonia-like symptoms were not mediated by CREB in NAc

218 the contribution of environmental stress to anhedonia (loss of pleasure and/or motivation).

219 nct biological correlates-depressed mood and anhedonia (loss of pleasure or interest).

220 ponses were compared across adolescents with anhedonia, low mood, or both symptoms, cross-sectionally

221 We have previously identified anhedonia, manifest as decreased sucrose preference and

222 Correlates of anhedonia may add to the understanding of the link betwe

223 s, our results suggest that specific musical anhedonia may be associated with a reduction in the inte

224 y of these individuals with specific musical anhedonia may be crucial to understand better the neural

225 easant stimuli correlated negatively with an anhedonia measure.

226 Anhedonia often remains as residual symptom during remis

227 The authors examined the effect of anhedonia on reward expectancy (expected outcome value)

228 mplies an additional disturbing influence of anhedonia on reward-related learning or vice versa, sugg

229 DD were categorized based on the presence of anhedonia, only anhedonic patients had decreased GABA/w

230 tion-like behavior could not be explained by anhedonia or behavioral despair.

231 using on symptoms of depressed mood, apathy, anhedonia, or anergia.

232 not differ in depression severity, anxiety, anhedonia, or body mass index.

233 ipants included mothers with depressed mood, anhedonia, or depression history but who were not in a c

234 Anhedonia, or diminished interest or pleasure in rewardi

235 Anhedonia, or markedly diminished interest or pleasure,

236 ke U50,488H, nalfurafine caused no aversion, anhedonia, or sedation or and a low level of motor incoo

237 to unfavourable circumstances, and that the anhedonia, pessimism and fatigue that often accompany it

238 ession, moderate anxious depression, anxious anhedonia, pure anhedonia, and resolved depression.

239 IL-6 soluble receptor, which correlated with anhedonia (r = 0.301, p = 0.010) in the sample as a whol

240 05), which in turn correlated with increased anhedonia (R=-0.47, P=0.001).

241 r a positive family history of MDD (FH+) and anhedonia (reduced capacity for pleasure) were associate

242 cts of CSDS on sensitivity to reward because anhedonia (reduced sensitivity to reward) is a defining

243 While theorists have argued that anhedonia reflects a reduced capacity to experience plea

244 Rather, anhedonia reflects a set of beliefs related to low pleas

245 Anhedonia remains a major clinical issue for which there

246 but the extent to which this is specific to anhedonia remains poorly understood.

247 link between the core subjective symptom of anhedonia, replicated neuropsychological deficits, elect

248 own, however, whether the pathophysiology of anhedonia represents a viable avenue for identifying bio

249 These results establish that stress-elicited anhedonia requires a neuropeptide-triggered, cell-type-s

250 Dysphoric symptoms, such as sadness and anhedonia, responded best to stimulation of one circuit,

251 e amygdala in anhedonic rats, and tested for anhedonia reversal in the same animals.

252 e to unsuppressed voxel tissue water (w) and anhedonia scores expressed as a continuous variable.

253 ABA/w levels were negatively correlated with anhedonia scores for the whole MDD group (r = -0.50; P =

254 Stress produced anhedonia selectively in SL rats and this was prevented

255 vestigated whether striatal volume predicted anhedonia severity in adolescents.

256 -related motivation, which in turn predicted anhedonia severity in schizophrenia.

257 A dimensional conceptualization posits that anhedonia severity is related to a transdiagnostic conti

258 , and in depressed individuals only, greater anhedonia severity was associated with a reduced reward

259 teral putamen volume prospectively predicted anhedonia severity while controlling for baseline anhedo

260 e response to peer rejection, contributed to anhedonia severity, but only among youth with smaller pu

261 us accumbens volume was inversely related to anhedonia severity.

262 bens and midbrain correlating with increased anhedonia severity.

263 Predictor sets for REMS and anhedonia shared pathways involved in oxidative stress,

264 or vice versa, suggesting that the level of anhedonia should be considered in behavioural treatments

265 The authors conclude that anhedonia should no longer be considered an experiential

266 Moreover, patients with high anhedonia showed diminished reward learning compared wit

267 mple of 28 participants with elevated social anhedonia (SocAnh) and 38 healthy controls from a popula

268 s; (b) people with extremely elevated social anhedonia (SocAnh; n=22); and (c) controls (n=20).

269 ings were confirmed using depressed mood and anhedonia subscores from the Beck Depression Inventory i

270 ermine whether neuroadaptations that produce anhedonia subsequently affect vulnerability to stress-in

271 als and a moderation of this relationship by anhedonia, suggesting reduced reward-contingency learnin

272 tive (i.e., subthreshold social and physical anhedonia) symptom-like PLEs.

273 onresponders showed markedly higher baseline anhedonia symptomatology (including pessimism, loss of p

274 g of prediction error signals contributes to anhedonia symptoms in depression.

275 DD patients had severe suicidal ideation and anhedonia symptoms.

276 e the disabling cognitive and negative (i.e. anhedonia) symptoms of patients with schizophrenia.

277 ic (anxious arousal) or depression-specific (anhedonia) symptoms.

278 review the neural bases of the construct of anhedonia that reflects deficits in hedonic capacity and

279 Anhedonia, the diminished ability to experience pleasure

280 Motivational anhedonia, the failure to translate positive reinforceme

281 Anhedonia, the loss of pleasure or interest in previousl

282 (mGlu(2) and mGlu(3)) reduce stress-induced anhedonia through actions in the PFC, but the mechanisms

283 tors (mGlu2 and mGlu3) reduce stress-induced anhedonia through actions in the PFC, but the mechanisms

284 symptoms of major depressive disorder, from anhedonia to altered cognitive performance.

285 omain-specific deficit in people with social anhedonia towards social affective information, and sugg

286 ying mechanisms of learning facilitation and anhedonia treatment.

287 (IL)-1 receptor antagonist before stress on anhedonia was also determined.

288 -nucleotide polymorphisms (SNPs) with social anhedonia was also observed.

289 Stress-induced anhedonia was assessed in adult male rats using social d

290 ental area, while in healthy controls higher anhedonia was associated with higher ventral tegmental a

291 = 0.026] indicated that in patients, higher anhedonia was associated with lower temporal difference

292 exacerbated in SD-OBx hamsters; LPS-induced anhedonia was exacerbated in LD-OBx hamsters; and photop

293 ed and sustained improvements in anxiety and anhedonia were also noted.

294 lterations with the presence and severity of anhedonia were explored.

295 immobility in the tail suspension test, and anhedonia) were assessed 4 hours, 24 hours, 72 hours, 7

296 Core depressive symptoms (low mood, anhedonia) were measured by the Short Form Survey (SF-36

297 NAc produces depression-like signs including anhedonia, whereas disruption of CREB activity by expres

298 od, we found strong increases in anxiety and anhedonia which lead to decreases in specific cognitive

299 pioid receptor (KOR) antagonism for treating anhedonia with a POM study determining whether robust ta

300 nucleus of the amygdala reversed CES-induced anhedonia without influencing other emotional measures.